정보적 접근방법에 의한 실내공간에서의 시각적 선호도: 예측변수들의 물리적 속성과 선호도와의 관계

노정실,김유일 한국조경학회 1999 韓國造景學會誌 Vol.27 No.1

The objective of this study are to figure out the physical attributes of the three predictors in the Informational Approach: complexity, coherence, mystery and to investigate the relationships between these attributes and the preference exploratively. Visual inspection of the scenes relative to their rated levels of the predictors revealed the existence of relationship between these variables and the physical attributes. The following are the summary of the relationship between three predictors and the physical attributes: (1) The level of complexity was associated with the pattern of physical attributes which were the amount of facility, line, shape, color plant and arrangement of the visual elements. (2) The level of coherence was related with the regular arrangement of the visual elements. For example, there was certain pattern founded the color, shape, texture was applied to the various space repetitively and symmetrically. (3) The level of mystery had the relationship with the physical attributes of screen, spatial definition, distance of view, physical accessibility, radiant forest, the depth of space.

Patient Management with Eribulin in Metastatic Breast Cancer: A Clinical Practice Guide

노정실,Fiona Tsui-Fen Cheng,Virote Sriuranpong,Antonio Villalon,B. K Smruti,Janice Tsang,Yoon Sim Yap 한국유방암학회 2016 Journal of breast cancer Vol.19 No.1

Eribulin, an antimicrotubule chemotherapeutic agent, is approved for the treatment of pretreated metastatic breast cancer (mBC) based on the positive outcomes of phase II and phase III clinical trials, which enrolled mainly Western patients. Eribulin has recently been approved in an increasing number of Asian countries; however, there is limited clinical experience in using the drug in certain countries. Therefore, we established an Asian working group to provide practical guidance for eribulin use based on our clinical experience. This paper summarizes the key clinical trials, and the management recommendations for the reported adverse events (AEs) of eribulin in mBC treatment, with an emphasis on those that are relevant to Asian patients, followed by further elaboration of our eribulin clinical experience. It is anticipated that this clinical practice guide will improve the management of AEs resulting from eribulin treatment, which will ensure that patients receive the maximum treatment benefit.

실내공간에서의 시각적 선호도 예측에 관한 연구

노정실,김유일 한국조경학회 1998 韓國造景學會誌 Vol.26 No.2

The visual preference of interiors focusing on lobbies was investigated as a function of six predictor variable on the base of the Informational Approach: complexity, coherence, mystery, spaciousness, brightness, plant. The Common Fcator Analysis of preference ratings yielded six common factors which helped to account for 22.3 percent of the variance in preference response to the scene. Among these factors, the factor defined as 'bright with many plants' was the most preferred and the factor defined as 'simple and closed' was the least preferred. The environmental attributes reflected in six groups of scenes were colour, resting place, window and the six predictors. In the commercial building scenes, complexity, spaciousness, coherence, brightness and mystery out of six predictors accounted for 74 percent of preference variance as the significant contributors. In the business building scenes, three predictors which are brightness, complexity, spaciousness accounted for 84 percent of preference variance. 'The amount of plant' not only influenced the preference indirectly through the intervening variable, complexity, but also was moderately correlated with brightness. The overall pattern of the resulted confirmed the usefulness of the Informational Approach to predict the preference in interiors focusing on lobbies.

공동 주택단지의 복도유형별 주거 환경의식에 관한 연구

김홍규,노정실 대한건축학회 1993 大韓建築學會論文集 Vol.9 No.7

공동주택단지 어린이놀이시설의 설계의도와 이용형태와의 차이점

김홍규,노정실,고원용 한국조경학회 1997 韓國造景學會誌 Vol.24 No.4

This study aims to find out differences between designer's design guidelines and user's actual behavior about play facilities of children playground in multifamily housing site by using the method of Post-Occupancy Evaluation. Korea National Housing Cooperation developed the 18 play facilities and constructed them into children' playground of Bun-dong and Junggae-dong housing site in Seoul. The results are as follows: First, user's behaviors which differed from designer's guidelines were influenced by mechanical and technical problems rather than design. Second, users adjusted their brahvior to play facilities which have a little operational problems. Third. users tried to make dangrous activity instead of designer's guidelines based on the safety. It infers that users want to make creative activities from play facilities. Fourth. designers should have developed play facilities for infants and youth. Fifth. users liked to play more complicated play facilities rather than single facility.

스키장 이용실태 및 이용자 만족도에 관한 연구 -도시근교형과 리 조트형의 비교-

김지현,노정실,김한도,김유일 한국조경학회 1994 韓國造景學會誌 Vol.22 No.3

This is a comparative study on the use pattern and satisfaction of skiers between the suburban skiing ground and the resort one. The purpose of this study is to provide basic data for the planning and the management of skiing ground. The sites of case study are Yong Pyung Ski Resort (Resort type) and Bears Town(Suburban type). Data were collected from questionaire. A total of 420 questionaires were completed. And data were subjected to following analysis: First, the descriptive statistics(mean, chi-square analysis etc.) were used to compare the characteristics of the users and the use pattern of two sites. Second, factor analysis was utilized to reduce 22 satisfaction items into the smaller number of factors. Third, regression analysis was used to find the factors affecting users' overall satisfaction in each skiing ground. The findings of this study are as follows: First, it was proved that the characteristics of users between tow sites were different in terms of age, income, and skill level. Second, it was proved that the use pattern between two sites were different in terms of travel distance from home, traffic mode, length of stay, accommodation type, and the money spent per day. Third, By a principal component factor analysis several factors of satisfaction are found: In physical terms, they are 'slope and life facilities', 'recreation and lodge facilities', 'accessibility', 'crowding', and 'landscape'. In psychological terms, they are 'skiing skills and thrills', and 'relaxation and freedom'. Forth, As the result of the stepwise regression analysis, it was yielded that 'relaxation/and freedom' was most important factor to predict the overall satisfaction in both skiing ground. And it was proved that not only physical factors but also phychological(need gratifying) factors were important sources of the satisfaction.

Circulating Plasma Biomarkers for TSU-68, an Oral Antiangiogenic Agent, in Patients with Metastatic Breast Cancer

유창훈,김성배,노정실,임석아,임영혁,김지현,안진희,정경해,송홍석,강석윤,박희숙,정현철 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose This study analyzed the role of plasma biomarkers for TSU-68 in a previous phase II trial comparing TSU-68 plus docetaxel and docetaxel alone in patients with metastatic breast cancer. Materials and Methods A total of 77 patients were eligible for this study (38!in the TSU-68 plus docetaxel arm and 39 in the docetaxel alone arm). Blood samples were collected prior to the start of each cycle, and vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)- AA, -AB, -BB, fibroblast growth factor, M30, C-reactive protein (CRP), and interleukin 6 (IL-6) levels were measured using enzyme linked immunosorbent assay. The primary endpoint was progression-free survival (PFS). Results In patients with baseline PDGF-AA " median, median PFS was significantly worse in the TSU- 68 plus docetaxel group than in the docetaxel alone group (5.4 months vs. 13.7 months, p=0.049), while a trend toward a PFS benefit was observed in those with baseline PDGFAA < median (9.7 months vs. 4.0 months, p=0.18; p for interaction=0.03). In the TSU-68 plus docetaxel group, PFS showed significant association with fold changes in CRP (p=0.001), IL-6 (p < .001), PDGF-BB (p=0.02), and VEGF (p=0.047) following the first treatment cycle. Conclusion Baseline PDGF-AA levels and dynamics of VEGF, PDGF-BB, CRP, and IL-6 levels were predictive for the efficacy of TSU-68.

공동 주택단지내 부대 복리시설의 설치위치에 관한 입주자 의식의 서술연구

박철수,김홍규,노정실 대한건축학회 1995 大韓建築學會論文集 Vol.11 No.11

Outcomes of Palliative Weekly Low-Dose Gemcitabine-Cisplatin Chemotherapy in Anthracycline- and Taxane- Pretreated Metastatic Breast Cancer Patients

김정선,박인혜,이근석,노정실 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4

Purpose: The combination of gemcitabine and cisplatin (GP) hasbeen shown to be safe and efficacious for patients with metastaticbreast cancer (MBC), pretreated with anthracyclines andtaxanes. We assessed the efficacy and safety of weekly low-doseGP in patients with MBC. Methods: We collected clinicopathologicaldata from MBC patients who had been treated with gemcitabine,800 mg/m2 plus cisplatin, 30 mg/m2 intravenously, ondays 1 and 8 every 3 weeks, between January 2001 and November2011 in Korea. Results: The analysis included 294 patientspreviously treated anthracycline- and taxane-based chemotherapiesprior to GP (median age, 48 years [range, 28–78 years];median follow-up duration, 63.9 months). Seventeen patients(5.8%) discontinued GP because of toxicities. The median progression-free survival (PFS) was 3.9 months (95% confidence interval[CI], 3.3–4.4 months) and the median overall survival (OS)was 27.7 months (95% CI, 17.6–37.8 months) months. Statisticallysignificant factors for PFS were performance status (EasternCooperative Oncology Group, ≥2 vs. <2; hazard ratio [HR], 1.37;95% CI, 1.02–1.85; p=0.037), distant disease-free interval (DDFI;≤2 years vs. >2 years; HR, 1.66; 95% CI, 1.28–1.95, p<0.001),time interval from the diagnosis of metastasis to GP therapy (≤1year vs. >1 year; HR, 1.48; 95% CI, 1.13–1.95, p<0.001), andpresence of brain metastasis (HR, 1.47; 95% CI, 1.03–2.10; p=0.031). Similarly, DDFI (≤2 years vs. >2 years; HR, 2.07; 95% CI,1.36–3.14; p<0.001) and the presence of brain metastasis (HR,2.14; 95% CI, 1.27–3.61; p=0.004) were important factors forOS after GP treatment. Conclusion: Weekly low-dose GP chemotherapyappears safe and effective for heavily pretreated MBCpatients.

Prognostic Role of Interleukin-6, Interleukin-8, and Leptin Levels According to Breast Cancer Subtype

조영애,성미경,연지영,노정실,김정선 대한암학회 2013 Cancer Research and Treatment Vol.45 No.3

Purpose Inflammation within the tumor microenvironment has been reported to show an association with poor prognosis in breast cancer. However, the associations may differ according to breast cancer subtype. In this study, we investigated the association between inflammation-related markers and breast cancer recurrence according to patients’ tumor subtypes. Materials and Methods This prospective study included 240 patients who underwent surgery for management of newly diagnosed breast cancer. Levels of inflammation-related markers (interleukin [IL]-1β, IL-6, IL-8, monocyte chemoattractant protein-1 [MCP-1], leptin, and adiponectin)were measured at diagnosis, and the associations between these markers and breast cancer recurrence during a six-year follow-up period were examined using the Kaplan-Meier statistical method. Results Overall, inflammation-related markers showed no association with breast cancer recurrence. However, when data were stratified by tumor subtype, higher levels of some mediators showed an association with poor prognosis among patients with particular subtypes. Compared to patients without recurrence, patients with recurrence had higher levels of circulating IL-6 (p=0.024) and IL-8 (p=0.016) only among those with HER2– tumors and had higher levels of leptin (p=0.034) only among those with estrogen receptor (ER)+/progesterone receptor (PR)+ tumors. Results of survival analyses revealed an association of high levels of IL-6 (p=0.016) and IL-8 (p=0.022)with poor recurrence-free survival in patients with HER2– tumors. In addition, higher leptin levels indicated shorter recurrence-free survival time only among patients with ER+/PR+ tumors (p=0.022). Conclusion We found that certain cytokines could have a differential prognostic impact on breast cancer recurrence according to breast cancer subtype. Conduct of additional large studies will be required in order to elucidate the precise roles of these cytokines in breast cancer progression.