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위암의 p53 및 nm23-H1 단백의 표현에 관한 면역조직화학적 연구
노은배,최종상 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.1
p53, a nuclear protein, is believed to play an important role, through mutation and overexpression, in the progression of human malignant tumors. And decreased expression of nm23-H1 protein is also believed that it is associated with metastatic potential of malignant tumor. Mouse monoclonal antibody NCL-p53-DO7 (Novocastra Laboratories Ltd., Newcastle, England) which specifically immunoprecipitate p53 protein, and mouse monoclonal antibody NCL-nm23-H1 (Novocastra Laboratories Ltd., Newcastle, England) were used to examine 30 paraffin-embedded gastric carcinoma to find nuclear expression of mutant-form p53 protein and intracellular expression of nm23-H1 protein. The results obtained are as follows: 1. Positivity of p53 protein is more frequent in advanced gastric carcinoma with lymph node metastasis than early gastric carcinoma (p<0.06). There is significant correlation between expression of p53 protein and clinicopathologic finding of gastric carcinoma. But there is no significant correlation between expression of nm23-H1 protein and clinicopathologic finding of gastric carcinoma. 2. There is no significant correlation between expression of p53 and nm23-H1 protein and histopathologic differentiation of gastric carcinoma. 3. There is significant correlation between positivity of p53 and invasion depth of carcinoma. Positive reaction is more frequent in carcinomas with serosa or omental invasion rather than carcinomas with mucosa, submucosa, or muscular invasion (p<0.03). 4. Survival rate of p53 and nm23-H1 negative groups are better than positive groups (p53:p<0.02, nm23-H1:p<0.05)
박인서,조성진,박창서,김영석,노은배,한지현 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.10
임신 초기에 발생하는 급성 신부전의 원인인 패혈성유산은 무균조작과 항생제의 영향으로 현저하게 감소하였다. 임신 말기나 분만시에 발생하는 과도한 출혈이나 임신 중독증 또는 태반 조기박리에 병발하는 경우도 감소되고, 전체 ARF중 임신예는 4%정도이다. 이는 혈관내 혈액 응고현상이 있거나 다량의 출혈이 있을 때, 혈량을 적시에 보충 유지하고, 신장 혈류를 유지함으로써 비가역적인 신피질괴사로 이행하는 것을 예방할 수 있게 되었기 때문이다. 이에 최근 본 교실에서 경험한 제왕절개술후 속발한 급성신부전증 1예를 문헌고찰과 함께 보고하는 바이다. Acute renal failure refers to a serious rapid suppression of renal function, resulting in accumulation of nitrogen wastage materials. To reduce the mortality and chronic sequele, it can`t be overemphasized to avoid and correct several predisposing factors and to manage meticulously if the condition supervenes especially pregnancy and puerperium. We experienced a case of acute renal failure following Cesarean section and reported this case with brief of literatures concerned.
자궁외임신시 혈청 beta-HCG , Progesterone 및 SP1에 관한 연구
조성진,박찬용,박창서,이명아,노은배,한지현 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.12
자궁외임신의 진단을 위한 혈중 SP1의 진단적 의의를 평가하기 위해 정상임신 49예와 자궁외임신 24예를 대상으로 임신 제 5주에서 제 11주의 SP1, -HCG, progesterone치를 이중항체 방사면역측정법으로 측정하여 비교연구 함으로써 다음과 같은 결과를 얻었다. 1. 정상임신군의 연령분포는 20세에서 44세까지로 평균 32.3세이었고, 자궁외 임신군에서는 20세에서 30세까지로 평균 27.6세이었다. 2. 혈중 -HCG측정치(평균치±2표준편차)는 정상임신에서는 임신 제 5주에서 28,741±19,080mIU/ml이었고, 임신이 진행됨에 따라 점차 증가하여 제 10주에 159,185±54,884mIU/ml이었으나, 제 11주에서는 114,068±83,072mIU/ml로 감소하는 양상을 보였다. 그러나 자궁외임신에 있어 혈청 -HCG측정치는 무월경 제 5주에 5,354±3,204mIU/ml, 제 9주에 11,124±7,450mIU/ml로 정상임신에 비해 낮은 수치를 보였다. 3. 혈청 progesterone측정치는 정상임신에 있어 임신 제 5주에 47.96±38.62ng/ml, 임신 제 8주에 48.59±29.12ng/ml로 별다른 증가 양상은 없었고, 제 9주부터는 증가하여 제 11주에 102.76±31.60이었다. 자궁외임신시 혈청 progesterone치는 무월경 제 5주에 22.99±10.52ng/ml, 제 9주에 16.96±1.94ng/ml로 정상임신군보다 낮은 수치를 보였다. 4. SP1도 임신 제 5주에는 0.4±0.24mg/l이었고, 점차 증가하여 제 10주는 8.7±4.80mg/l이었다. 그러나 자궁외임신에 있어서 무월경 제 5주에는 0.033±0.012mh/l, 제 9주에는 0.692±0.210mg/l로 재태기간에 따라 증가하나 정상범위 미만이었다. 5. 혈청 -HCG, progesterone 및 SP1의 예측치는 각각 73.1%, 80.0%, 80.8%이었고, 예민도는 79.2%, 83.3%, 87.5%였으며, 정확도는 85.7%, 89.8%, 89.8%이었다. The ectopic pregnancy has recently become one of the most important issues in obstetrics. The development of diagnostic method, such as, untrasonogram, serial serum beta-HCG measurement has made a great contribution to the treatment of ectopic pregnancies. In order to investigate the various hormonal factors of ectopic pregnancy and contribute to prevention of infertility thereafter, retrospective studies were made on serum beta-HCG, progesterone, and SPI values of 24 cases of ectopic pregnancy, which was diagnosed by biopsy of surgical specimen. The results were obtained as follows. 1. The age in normal pregnancy were ranged from 20 to 44 years and mean age was 32.3 years, but the age in ectopic pregnancy were ranged from 20 to 40 years and mean age was 27.6years. 2. Serum beta-HCG values(mean ±2SD) in normal pregnancy were 24,741±19,080mIU/ml, 159,185±54,884mIU/ml at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 5,354±3,204mIU/ml, 11,124±7,450mIU/ml at 5th and 9th weeks of gestational age. 3. Serum progesterone values in normal pregnancy were 47.96±38.62ng/ml, 97.83±12.62ng/ml at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 22.99±10.52ng/ml and 16.96±1.94ng/ml at 5th and 9th weeks of gestational age. 4. Serum SP1 values in normal pregnancy were 0.4±0.24mg/1,8.7±4.80mg/1 at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 0.033±0.012mg/1, 0.692±0.210mg/1 at 5th and 9th weeks of gestational age. 5. Predictive value, sensitivity, and specificity of serum beta-HCG in ectopic pregnancy were 73.1%, 79.2% and 85.7%. 6. Predictive value, sensitivity, and specificity of progesterone in ectopic pregnancy were 80.0%, 83.3% and 89.8%, respectively. 7. Predictiv value, sensitivity, and specificity of serum SPI were 80.0%, 87.5% and 89.8%, respectively.