유리체내 트리암시놀론 주입 전 스테로이드 점안 선별검사의 유용성

노영정,김웅재,문정일.Young-Jung Roh. M.D.. Wung-Jae Kim. M.D.. Jung-Il Moon. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.12

Purpose: To evaluate the efficacy of screening of high risk groups with topical steroids due to increased ocular pressure by intravitreal triamocinolone injection (IVTA). Methods: We selected 96 eyes that had undergone IVTA between January 2003 and December 2004. The screening method used was as follows; We administered 4 drops daily of prednisolone (1%) eye drops for 3weeks and included patients with an intraocular pressure increase of less than 5 mmHg for the procedure. Two groups consisting of the post-screening IVTA group (group A) and non-screening group (group B) were classified, and intraocular pressure was measured using a Goldman applanation tonometer at 1 week, 1 month, 2 months, 3 months and 6 months after the procedure. Results: One patient in group A (3.1%) required glaucoma medication compared with 10 patients in group B (17.9%), and one of these group B patients required surgical intervention. Chi-square analysis showed a statistically significant reduction in glaucoma medication use in group A compared with group B (P<0.05). Group B had a higher percentage of patients with an increase of intraocular pressure over 5 mmHg compared with values before the procedure, particularly in the second and third months after the procedure. Conclusions: IVTA after screening resulted in less use of glaucoma medication and a reduced rate of increase in intraocular pressure. Complications due to increased intraocular pressure by IVTA can be minimized by screening high risk groups.

LASIK 수술에서 각막절편의 크기에 따른 임상결과 비교

노영정 ( Young Jung Roh ),주천기 ( Choun Ki Joo ),김재호 ( Jae Ho Kim ) 대한안과학회 2002 대한안과학회지 Vol.43 No.5

특발성 황반 원공에 대한 수술적 치료 후 2년 경과관찰

노영정 ( Young Jung Roh ),김도현 ( Do Hyun Kim ),유진성 ( Jin Seong Yoo ) 대한안과학회 2003 대한안과학회지 Vol.44 No.1

특발성 황반원공과 연관된 전신적 위험인자에 대한 분석

나호 ( Na Ho ) , 노영정 ( No Yeong Jeong ) , 유진성 ( Yu Jin Seong ) 대한안과학회 2004 대한안과학회지 Vol.45 No.5

난치성 포도막염에서 종양괴사인자항체의 치료효과

최석규,노영정,김민호,Suk Kyue Choi,Young Jung Roh,Min Ho Kim 대한안과학회 2007 대한안과학회지 Vol.48 No.2

Purpose: To investigate the effects of Anti-TNF-α (infliximab, Remicade?, Shering-Plough) on refractory uveitis. Methods: A retrospective observational survey was conducted on 12 eyes of 10 patients with refractory uveitis. These patients had no response to immunosuppresants or systemic steroid therapy and were intolerable due to drug toxicity. After an intravenous injection of Anti-TNF-α, best corrected visulal acuity was measured. Improvement in inflammation was then observed at the first, third and last month of follow-up. Results: Patients were observed for a mean period of 15 months. They received anti-TNF-α intravenously, ranging from one to eleven infusions. After infusion with Anti-TNF-α, remission of intraocular inflammation was evident in all patients within 9.7 days. Best corrected visual acuity also improved at the first, third, and last month of follow-up. Two patients were infected by tuberculosis and mumps respectively. Conclusions: There was an effect on refractory uveitis with anti-TNF-α therapy. Many participants may also require further evaluation after treatment.

Nd:YAG 레이저 후낭절개술 후 발생한 황반원공 1예

김인태,노영정,In Tae Kim,Young Jung Roh 대한안과학회 2008 대한안과학회지 Vol.49 No.4

Purpose: To report a case of a macular hole resulting from accidental Nd:YAG laser capsulotomy for cataract, which was treated by vitrectomy. Case summary: A 70-year-old man had decreased visual acuity one day after Nd:YAG laser capsulotomy. By fundus exam, vitreous and macular hemorrhages were observed. After 11 days, intravitreal gas injection was performed, and 3 months later, a macular hole has developed. Pars plana vitrectomy, internal limiting membrane peeling, and gas tamponade were performed, and anatomical occlusion was achieved and maintained for 6 months postoperatively. However, final visual acuity improvement was limited up to 0.08. Conclusions: We experienced an unusual case of macular hole formation from Nd:YAG capsulotomy. Vitrectomy was performed but visual acuity improvement remained limited.

가토에서 버테포르핀을 이용한 각막신생혈관의 광역학치료시 재치료의 효과

전은정,노영정,김영훈,정성근,Eun Jung Jun,Young Jung Rho,Yeong Hoon Kim,Sung Kun Chung 대한안과학회 2008 대한안과학회지 Vol.49 No.9

Purpose: This study evaluated the effect and safety of photodynamic therapy (PDT) with verteporfin retreatment on patients with corneal neovascularization. Methods: Corneal neovascularization was induced with a silk suture of the corneal stroma in 24 white rabbits (48 eyes). Four rabbits were examined histologically before performing PDT. Ten rabbits were chosen randomly, one eye from each rabbit was treated with PDT at 50 J/cm2, and the other eye was used as a control. Both eyes of the remaining 10 rabbits were treated with PDT at 150 J/cm2. One week later, one eye was further retreated with PDT at the same intensity. The area of corneal neovascularization was measured and evaluated histologically using light and electron microscopies. Results: The least neovascularized area was observed in the retreated group (P=0.04). The histologic examination revealed fewer new corneal vessels in the retreated group, but the corneal epithelium, stroma, and endothelium showed a normal appearance. Results from electron microscopic examination demonstrated thrombi as well as destruction and nuclear fragmentation of the vascular endothelial cells. However, there were no other changes in the cornea except for vascular endothelial cells, even in the retreated group. Conclusions: In conclusion, these results suggest that PDT with verteporfin retreatment appears to be safe and significantly more effective in patients with regression of corneal neovascularization. J Korean Ophthalmol Soc 2008;49(9):1515-1524

한국인 고혈압 환자에서 고혈압망막병증과 표적기관장애의 동반양상

강승범,노영정,문정일,Seungbum Kang,Young-Jung Roh,Jung-Il Moon 대한안과학회 2010 대한안과학회지 Vol.51 No.9

Purpose: To report the relationship between hypertensive retinopathy and associated target organ damage in Korean hypertensive patients. Methods: A total of 519 hypertensive patients were divided into hypertension retinopathy grades I through IV based on fundus examination. According to the grade of each hypertensive retinopathy, the frequency of target organ damage (cardiovascular disease, chronic kidney disease, and retinal vessel occlusion) and the association with hypertension retinopathy were evaluated. Results: There were 211 patients (40.7%) without hypertensive retinopathy, 226 patients (43.5%) with hypertensive retinopathy grade I, 71 patients (13.7%) with grade II, seven patients (1.3%) with grade III and four patients (0.8%) with grade IV. The numbers of patients with cardiovascular disease were 103 (45.6%) in grade I, 57 (80.3%) in grade II, 3 (42.9%) in grade III, two (50.0%) in grade IV, and 70 (37.4%) in the non-hypertensive retinopathy group. According to four grades, the numbers of patients with cerebrovascular disease were three (1.3%), two (2.8%), zero (0%), and one (25.0%), respectively, with two (0.9%) in the non-hypertensive retinopathy patients. The respective numbers of patients with chronic kidney according to grades I through IV were 14 (6.2%), ten (14.0%), two (28.6%), and four (100.0%), as well as ten (4.7%) in the non-hypertensive retinopathy patients. The respective numbers of patients with retinal vessel occlusion were one (0.4%), two (2.8%), one (14.3%), and one (25.0%), with zero (0%) in the non-hypertensive retinopathy patients. Conclusions: The significance of hypertensive retinopathy should not be overlooked in Korean hypertensive patients due to an association with various target organ damage. J Korean Ophthalmol Soc 2010;51(9):1231-1236

불응성 포도막염에 대한 유리체내 트리암시놀론 주입효과

최석규,노영정,김민호,Suk Kyue Choi,Young Jung Roh,Min Ho Kim 대한안과학회 2006 대한안과학회지 Vol.47 No.3

Purpose: To investigate the effect of intravitreal injection of triamcinolone acetonide (4 mg) on refractory uveitis with cystoid macular edema (CME). Methods: A retrospective observation survey was conducted on 21 eyes of 15 patients with refractory uveitis that had no response to immunosuppresants or systemic steroid therapy. Seven eyes were injected with triamcinolone acetonide intravitreally only, and fourteen eyes were injected during pars plana vitrectomy. At 3 and 12 months after triamcinolone acetonide injection, best corrected visual acuity and thickness of macula were measured by OCT. Results: The average pre-treatment best corrected visual acuity was 0.18±0.08, and the average macular thickness was 534±132 ?m. At 3 months after injection, the results for the same parameters were 0.45±0.18, 345±125 ?m respectively. At 12 months after injection, they were 0.30±0.09, 498±133 ?m respectively. Thus, best corrected visual acuity had improved and macular thickness had decreased at 3 months post-injection for the groups with intravitreal injection of triamcinolone acetonide and intravitreal injection during pars plana vitrectomy. However, these changes in best corrected visual acuity and macular thickness were not observed 12 months after injection. Conclusions: Intravitreal injection of triamcinolone acetonide had a temporary effect on refractory uveitis with cystoid macular edema (CME). However, a study that includes more participants will be necessary for conclusive evaluation.

고도근시에서 발생한 황반원공 망막박리의 유리체절제술 및 일차적 실리콘기름 충전술

김인태,노영정 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: To determine the results of pars plana vitrectomy and silicone oil tamponade to treat retinal detachment caused by macular holes in highly myopic eyes. Mthods: Eighteen highly myopic patients with spontaneous retinal detachment due to macular holes underwent vitrectomy and primary silicone oil tamponade. Preoperative statuses and postoperative results were reviewed. All patients had high myopia with axial lengths longer than 28 mm or had definite staphyloma. The average follow‐up period was 24 months. Results: Successful retinal attachment of the retina was achieved in 17 eyes, though 1 eye had redetached. Of the 17 eyes, 13 eyes achieved anatomical macular hole closure and 7 eyes showed improved visual acuity. Conclusions: Vitrectomy and silicone oil tamponade for retinal detachment due to macular holes in highly myopic eyes produce good anatomical and functional results. J Korean Ophthalmol Soc 49(8):1263-1268, 2008