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형우진 ( W. J. Hyung ),노성훈 ( S. H. Noh ),이준호 ( J. H. Lee ),최승호 ( S. H. Choi ),민진식 ( J. S. Min ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 위암에서 맥관침습은 중요한 예후인자로 보고되고 있으나 조기위암에서의 의의에 대해서는 연구된바가 없다. 이에 본 연구는 조기위암환자들에서 맥관침습의 임상적 특성과 예후 및 재발에 미치는 영향을 알아보고 이를 통해 조기위암에서 맥관침습의 임상적 의의를 알아보고자 하였다. <방법> 1993년 6월부터 1997년 12월까지 연세대학교 의과대학 외과학 교실에서 조기 위암으로 진단되어 D2 이상의 림프절 곽청술을 포함한 근치적 절제술을 시행 받은 566명
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위암의 침윤과 전이에 관여하는 단백분해 효소 ( uPA , PAI - 1 및 Type 4 Collagenase ) 에 관한 연구
조재용(J . Y . Cho),정현철(H . C . Chung),노성훈(S . H . Noh),김호근(H . K . Kim),박준오(J . O . Park),이종인(J . I . Lee),유내춘(N . C . Yoo),김주항(J . H . Kim),노재경(J . K . Roh),김병수(B . S . Kim),강진경(J . K . Kang),민진식(J . S 대한내과학회 1997 대한내과학회지 Vol.52 No.1
Objectives : Prognosis of gastric cancer is related to invasion and metastasis. Evidence has accumulated that invasion and metastasis in solid tumors require the action of tumor associated proteases, which promote the dissolution of the surrounding tumor matrix and the basement membrane. The serine protease [(urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1)] and type IV collagenase(MMP-9 and MMP- 2) appear to play a key role in these processes. Recent reports have demonstrated that expression of these proteolytic enzymes are elevated in breast and colon cancer and that it can be associated with invasiveness and poor prognosis. We therefore evaluated whether the expression and activation of uPA, PAI-1 and type IV collagenase might be of clinical value in gastric cancer as a tumor/biologically defined risk factor. Methods: In a consecutive series of 160 gastric cancer patients who were enrolled in the Yonsei Cancer Center Study Group, the expression of uPA, PAI-1 and type IV collagenase was determined by ELISA, zymography and mmunohistochemical method. The results were as follows. Results: 1) Both uPA and PAI-1 levels were significantly higher in cancer tissues than no rmal (uPA; 9.4±8.7vs 5.3±3.1 ng/mg protein cytosol, PAI-1;10.9±9.1vs 5.8± 2.9 ng/mg protein cytosol), (p<0.001 respectively). Both high uPA and PAI-1 levels were associated with differentiation of the tumor(p=0.04, p=0.004), and a high PAI-1 level was associated with lymph nodes metastasis at an advanced stage (p=0.003, p=0.04). There was a correlation between the levels of uPA and PAI-1 expression in cancer tissues(r=0.57). 2) The activation ratio of MMP-9 and MMP-2 in cancer tissues 0.32±0.25, 0.27±0.34 were significantly higher than in normal tissue 0.19±0,27, 0.06± 0.16(p<0.001). The MMP-9 activation was associated with lymphnode metastasis and the MMP-2 activation was associated with distant metastasis(p=0.011, p=0.041). 3) In univariate analysis all of the proteolytic enzymes were associated with short relapse free survival, but in multivariate analysis only the high uPA expression was an independent prognostic parameter for short relapse free survival of the gastric cancer patients. Conclusion: These data indicate that uPA, PAI-1 and type IV collagenase were involved in the progression of gastric cancer at different points of time by different mechanisms. The combined expression and activation of these proteolytic enzymes were poor prognostic factors in gastric cancer patients, so new therapy based on these biologic behavior of the tumor in the same stage are clinically applicable. In particular, uPA is a new independent variable for the identification of patients at high risk, therefore therapy targetting uPA can be applied as a new treatment modality for gastric cancer.
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