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      • KCI등재

        Forkhead Box C1 (FOXC1) Expression in Stromal Cells within the Microenvironment of T and NK Cell Lymphomas: Association with Tumor Dormancy and Activation

        남지해,양우익,윤선옥 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4

        Purpose Forkhead box C1 (FOXC1) is critical for maintaining bone marrow microenvironments during hematopoiesis, but its role in hematological malignancies remains obscure. Here, we investigated whether FOXC1 regulates tumor dormancy and activation in the microenvironments of T and natural killer (NK) cell lymphomas. Materials and Methods One hundred and twenty cases of T and NK cell lymphomas were included; the immunohistochemical expression of FOXC1 was investigated in stromal cells, and numbers of FOXC1+ stromal cells were counted. Furthermore, the expression of phosphorylated p38 (p-p38) and phosphorylated ERK1/2 (p-ERK1/2) in tumor cells was investigated using immunohistochemistry. Results FOXC1 was variably expressed in C-X-C motif chemokine 12–associated reticular stromal cells, histiocytes, (myo)fibroblasts, and endothelial cells. The phenotypes of cases were categorized as dormant (high p-p38/low p-ERK1/2; n=30, 25.0%), active (high p-ERK1/2/low p-p38; n=25, 20.8%), or intermediate (others; n=65, 54.2%). Lower FOXC1+ stromal cell infiltration was associated with the dormant phenotype, the precursor T lymphoblastic leukemia/lymphoma subtype, and inferior overall survival rates, whereas higher FOXC1+ stromal cell infiltration was associated with the active phenotype and favorable patient prognosis (p < 0.05 for all). Conclusion These results suggested that FOXC1+ stromal cells within the microenvironments of T and NK cell lymphomas might be related to tumor phenotypes.

      • 산후도우미 돌봄 서비스 만족도에 관한 연구

        남지 한국복지행정학회 2011 복지행정논총 Vol.21 No.2

        여성의 임신, 출산, 산후조리는 모든 사람들이 직·간접적으로 경험하게 되는 것이다. 특히 우리나라의 산후조리문화에서 볼 때 대다수 한국 여성들은 전통적 으로 산후조리를 잘하지 못하였을 경우 일상 생활적 경험에서 산후병 증후군이 잘 나타난다고 호소하고 있다. 우리나라 산후조리의 경우 가족 내 돌봄을 받고 산후 건강을 회복하는 전통을 가 지고 있었으나, 현대의 사회구조는 가정 내에서의 전통적 산후조리를 불가능하게 하 였고 퇴원 후에도 여전히 돌봄을 필요로 하는 산욕기에 있는 여성과 모체 외 생활적 응을 하고 있는 신생아는 또 다른 형태의 돌봄을 필요로 하므로 산후조리원이라는 독특한 기관과 전통적 산후조력자인 친정 또는 시어머니의 역할을 대신하면서도 전 문 지식까지 겸비한 형태의 '산후도우미'라는 직업이 생겨났다. 본 연구는 산모의 일반적 특성과 산후조리특성에 따른 산후조리 서비스, 신생 아관리 돌봄 서비스 만족도와 요구도를 분석하여 '산후도우미'가 제 역할을 담당 하기 위해서는 산후도우미의 자격제도 관리 및 훈련과정에서부터 체계화된 전문 교육 프로그램을 개발하고 반드시 이수 하도록 하여 독립적이고도 전문성을 가 진 '산후도우미'를 양성해야 하며 보수교육 차원의 지속적인 교육을 통한 표준화 된 '산후도우미' 질 관리가 필요하겠다. 따라서 전통적인 산후조리의 긍정적인 부분과 산모들의 요구도를 반영해 '산 후도우미'를 이용하는 산모와 신생아의 돌봄 요구 및 건강유지․증진과'산후도우 미'이라는 독특한 조력자의 제도권 내에 정착할 수 있도록 계속적인 연구를 통하여 산후도우미의 산후조리와 신생아 돌봄 서비스 향상을 위한 서비스의 표준 화된 지침서 개발 및 활용과 관련된 연구가 더욱 활발히 이루지기를 바란다. Pregnancy, childbirth, and postpartum care are the life time event that all people experience directly or indirectly. Especially, for our country, the mother's convalescence after giving birth was traditionally taken cared by the family members, but as the society got industrialize, women entered the labor market and the modern social framework, which is urbanization and the trend towards the nuclear family, made the traditional postpartum care to be difficult. In spite of the social atmosphere, the traditional postpartum care culture in Korea was continued, Still, even though it is in a different kind of form, a woman in her postpartum and the newly born infant will be needed to be taken care as it used to be. For this kind of purpose, a unique organization called 'Postpartum Care Center' (Sanhujoriwon) and 'Postpartum caretaker' (Sanhudoumi) has come into being. This is an inevitable result caused by the clinging to our countries unique postpartum care custom, changes on the society, and the family structure. This study, postpartum maternal characteristics according to the general characteristics and postpartum services, and newborn care services managed by analyzing satisfaction and requirement 'Postpartum caretaker' role in the first postpartum assistant to manage the qualifications system and the training process from the systematic development of professional education programs and be sure to complete the with independent expertise 'postpartum caretaker' should foster continuing education through continuing education level of standardized 'postpartum caretaker' will need to be managed. Therefore, the positive part of the traditional postpartum women and also to reflect the needs of 'Postpartum caretaker' to use the maternal and newborn care and health maintenance needs the promotion and 'Postpartum caretaker' in a unique facilitator of the institutional research continues to be settled through the 'Postpartum caretaker's postpartum and newborn care services of a helper service for improving the development and use of standardized guidelines, and I hope to not form a study involving more actively.

      • KCI등재

        간세포암종의 병리진단에 대한 최신 지견

        남지해 ( Ji Hae Nahm ),박영년 ( Young Nyun Park ) 대한소화기학회 2021 대한소화기학회지 Vol.78 No.5

        Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of HCCs can be classified into distinct histopathological subtypes according to their molecular characteristics. Among recently identified subtypes, macrotrabecular massive HCC, neutrophil-rich HCC, vessels encapsulating tumor clusters HCC, and progenitor phenotype HCC (HCC with CK19 expression) are associated with a poor prognosis, whereas the lymphocyte-rich HCC subtype is related to a better prognosis. This review provides up-to-date knowledge on the pathological diagnosis of HCC according to the updated World Health Organization Classification of Digestive System Tumors 5th ed. (Korean J Gastroenterol 2021;78:268-283)

      • KCI등재

        동료멘토링 프로그램이 골관절염 여성노인의 건강보존에 미치는 효과

        남지,성기월 한국지역사회간호학회 2017 지역사회간호학회지 Vol.28 No.3

        Purpose: The purpose of this study was to investigate the effects of peer mentoring program on physical activity, knee joint function, self-care agency and social support, which are health conservation elements in elderly women with osteoarthritis. Methods: This study used a quasi-experimental research design. It is a pretest-and-post 1, post 2 test design of a non-equivalent control group. The subjects were elderly women aged over 65 who were diagnosed with osteoarthritis. A total of 60 patients (experimental group 30, control group 30) who registered with the Senior Welfare Center in City G and in Region D participated in this study. The data were collected from June 29th to September 4th, 2015. The collected data were analyzed with x2 test, Fisher's exact test, independent t-test and repeated measurement ANOVA. Results: The experimental group showed a greater increase in physical activity, knee joint function, self-care agency and social support than the control group. Conclusion: The results indicated that the peer mentoring program is effective in increasing physical activity, knee joint function, self-care agency and social support of elderly women with osteoarthritis.

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