아네폴주사제와 디프리반주사제의 비교임상시험 : 아네폴주사제의 효능 및 안정성에 대한 평가

남순호,남용택,배선준,김동기,채용호 대한정맥마취학회 1998 정맥마취 Vol.2 No.4

서론: 식품의약안정청 규정에 따라 국내 생산 및 시판허가를 얻기 위한 국내합성 propofol인 아네플주사제 (하나제약)와 완제수입품인 디프리반주사체 (ICI Pharm. 제조, 현대약품 수입)의 비교임상시험을 실시하여 아네폴주사제의 안정성 효능을 평가하기 위항 임상시험 3단계이다. 방법: 전신마취가 필요한 환자중 본 시험 참여데 서면 동의하고 선정/제외 기준에 적합한 환자를 대상으로 아네폴주사제와 다프리반주사제를 맹검법을 이용하여 투여한 후 안전성 및 효능을 평가하였다. 결과: 아네폴군 (55명)과 디프리반군 (52명)간의 효능을 비교하는 의식소실용량 (각각 평균 90㎎ 및 92 ㎎), 의식소실시간 (각각 평균 48초 및 50초), 각성시간 (각각 평균 626초 (10.4분) 및 567초 (9.5분)) 및 정위시간(각각 평균 773초 (12.9분) 및 722초 (12.0분))은 두군간의차이가 없었으며 회복실 체류시간 (각각 평균 28.1분 및 28.3분)도 두군간 차이가 없었다. 또한 안정성을 비교하는 부작용의건수와 부작용의 종류, 전체 피험자 수에 대해 발생한 부작용에 대하여 두군간의 유의성있는 차이는 나타나지 않았으며 양군 모두에서 생명징후의 시간에 따른 변화는 투약전에 비해 통계학적으로 유의한 차이가 있었으나 두군간에는 통계학적으로 유의한 차이는 없었다. 결론: 본 연구의 결과에서 임상시험용 정맥마취제인 아네폴주사제의 효능, 안정성, 이상 반응이 비교시험약제인 디프리반주사제와 유사한 것으로 나타나 디프리반처럼 안전하게 사용할 수 있는 약제라고 사료된다.

기관내 삽관 후 발생한 종격동 기종

남순호,길혜금,김기범,이성진,김도형,구본녀 대한마취과학회 2005 Korean Journal of Anesthesiology Vol.48 No.3

Argininosuccinic Acidemia 환아의 생체 부분 간이식의 마취 경험

남순호,반소영,구본녀,이종호 대한마취통증의학회 2005 Korean Journal of Anesthesiology Vol.49 No.4

We describe our initial experience of the perioperative anesthetic care provided to 8 years old female child with argininosuccinic acidemia undergoing living-related liver transplantation because it is the only available therapy for end-stage liver disease. Induction and maintenance of anesthesia has been conventional method. Arterial catheterized at radial and femoral arteries for continuous blood pressure monitoring and sampling. 18 G central vein catheterization was placed in left subclavian vein for fluid, drug infusion and CVP monitoring. EKG, pulse oxymetry, end-tidal CO2, urine output and body temperature were monitored. CBC, PT, aPTT, serum electrolyte were checked at preanhepatic, anhepatic phase and just after hepatic artery anastomosis. ABGA was checked every 1 hour. The level of serum ammmonia returned to normal range without protein restriction. We describe this case and a brief review of the literature.

슬관절경 시술 후 관절강내 모르핀 투여 효과

남순호,안은경,배선준,조범준,이행철 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.1

Background : Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. However, reports on pain relief with intra-articular morphine after arthroscopic knee operations are conflicting. In this study we examined the analgesic effects of the intraarticular administration of morphine after knee surgery. Methods : In a double-blind, randomized trial, we studied 26 patients who had received one of two injections at the end of surgery. The patients in group M(n=11) received 3 mg of morphine intraarticularly; those in group P(n=15), saline 20 ml intraarticularly as a placebo. Results : Patients in the morphine group had significantly lower pain scores throughout the 24-h postoperative period compared with those in the placebo group(P<0.05). There was less requirement for supplementary analgesics in the morphine group. Conclusions : Low doses of intraarticular morphine can significantly reduce pain after knee surgery without any systemic side effect (Korean J Anesthesiol 1998; 35: 120∼124)

자궁내막 제거술 중 확장매질로 인한 폐부종

남순호,최윤영,홍정숙 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.29 No.6

Dextran are used as distension media to help visualize the uterine cavity during diagnostic and operative hysteroscopy and are also used for volume expansion and their antithrombogenic effect. But dextran have significant side effects including pulmonary edema, coagulation defects, anaphylaxis and acute renal failure. We experienced a case of pulmonary edema following hysteroscopic guided endometrial resection. A 41-year-old female was performed the operation under general anesthesia, and the time of tion was approximately 90 minutes, and 1000 ml of rheomacrodex(10% dextran 40 in 5% dextrose in water) was instilled during the procedure. At the end of the operation, we noted a drop in oxygen saturation, engorgement of neck vein and watery pink tinged sputum in the endotracheal tube. Chest x-ray was taken and showed pulmonary edema. The patient was transferred to the intensive care unit where therapy was instituted including positive pressure mechanical ventilation and negative balanced fluid therapy with intravenous push of furosemide. The patient was extubated after 1 day with ventilator care and transferred to general ward on 2nd postoperative day and discharged on 5th postoperative day without any complication.

2000년 이후 미국의 對 베네수엘라 석유 정책의 질적 고립과 양적 고립 정책

남순호(Nam, Soon-Ho),송영복(Song, Young-Bok) 한국외국어대학교 중남미연구소 2019 중남미연구 Vol.38 No.2

베네수엘라를 이야기할 때 포퓰리즘의 몰락, 부패한 정부의 한계 등과 같은 수식어와 함께 석유에 대한 과도한 의존과 같은 문제들이 주로 지적된다. 그러나 이 논문에서는 베네수엘라가 겪는 오늘날의 문제점 중에 석유에 대하여 주목하였다. 그리고 베네수엘라의 석유 산업과 관련되어 미국이 어떤 분야에서 얼마만큼 영향을 미쳤는지 관찰하였다. 미국은 베네수엘라에 경제 제재를 포함하여 그들의 석유산업에 대한 재정적 투자 및 기술적 지원을 줄여나감으로써 관련 산업 전반에 대한 위축을 조장하였다. 또한, 미국 석유산업의 변화를 통해 석유 자급 능력을 향상함으로써 베네수엘라産 석유의 의존도를 낮추게 되었는데 이는 베네수엘라 석유산업의 양적 위축의 중요 부분을 점한다. 한편 미국은 중남미에 대한 자신들의 영향력을 이용하여 Petrocaribe, ALBA 그리고 Mercosur와 같은 중남미 공동체에서의 베네수엘라産 석유의 고립을 유도하였다. OPEC과 같은 국제기구에서 베네수엘라가 가진 지위의 약화와 이에 따른 경제적 타격도 베네수엘라의 오늘날 경제 위기를 설명하는 중요한 부분이 아닐 수 없다. 이와 함께 미국과 캐나다의 Keystone XL 파이프 프로젝트 등에서 보여준 결과는 베네수엘라의 석유가 더는 아메리카 대륙에서 경쟁력 있는 공급원이 아니란 것을 보여준다. 이러한 미국에 의하여 만들어진 일련의 對 베네수엘라 석유 관련 정책은 오늘날 베네수엘라가 겪고 있는 경제 위기의 주요 원인이다. Excessive dependence on oil in Venezuela economic fundamental problems are pointed out, also populism and the government corruption for discussing today’s crisis of country of Bolivarians. But, in fact, U.S. influence in this situation is involved intimately. The U.S. encouraged Venezuela to recess the overall industry by discontinuing financial investment and technical support for the oil industry, including economic sanctions. Also, The United States has reduced its dependence on Venezuelan oil by improving its ability to self-sufficiency through changes in its oil industry. Meanwhile, The United States exerted its influence on Latin American communities such as Petrocaribe, ALBA, and Mercosur to induce the isolation of Venezuelan oil. Venezuela’s influence in international organizations such as OPEC is descending, and it also explains the current economic crisis in Venezuela. The results of the Keystone XL pipeline project in the U.S. and Canada show that Venezuela’s oil is no longer a competitive energy source in the American continent. As a result, the United States economic policy related to the oil industry to Venezuela is an important issue for the economic crisis of the Republic of Bolivarian Venezuela.

Sufentanil 이 토끼의 심근 분리조직에 미치는 영향

김원옥,남순호,전성식 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.30 No.1

Background: The synthetic narcotic sufentanil has been used in clinical practice for anesthetic induction and maintenance. But there is little information concerning its direct effects on heart. The purpose of this study is to evaluate the direct effects of sufentanil on contracture of ventricular myocardium. Methods: Isometric contraction of isolated right ventricular papillary muscle of rabbit was measured under 0.2 Hz electrical stimulation in Krebs solution. Peak developed force(Fo), maximum rate of rise of developed force(+dF/dt_(Max)), maximum rate of fall of developed force(-dF/dt_(Max)) were analyzed. Results: There were no statistically significant differences in frequency of isometric contraction from the 100% baseline value in time-matched control group. Sufentanil, in concentration of 0.01-0.1 mM, increased F, and -dF/dt_(max) was decreased especially in concentration of 0.1 mM but not +dF/dt_(Max) Fo +dF/dt_(max) and -dF/dt_(max) were statistically different from time-matched control group in concentration of 0.1 mM. Conclusions: We conclude that sufentanil has mild contracture effect on ventricular muscle of rabbit directly.

Fogarty Catheter 를 이용한 일측 폐 마취

오흥근,남순호,홍필훈 대한마취과학회 1982 Korean Journal of Anesthesiology Vol.15 No.3

A method for one-lung anesthesia in which a 14 Fogarty embolectomy catheter is used to occiude a main bronchus is described. The method is quick, simple, effective and reliable. It eliminates most of the problems which occure with the standard technique of using a double-lumen cuffed endotracheal tube. During one-lung mannual ventilation, anesthesia was maintained with ketamine I.V. infussion and pancuronium. Before and after one-lung anesthesia, halothane-nitrous-oxide-oxygen and pancuronium were used. No significant problems regarding blood pressure, pulse rate, EKG and arterial blood gases were encountered in 3 lung cancer cases who had a pneumonectomy, a lung biopsy and a left lower lobectomy.

간행위원회에 보내는 글 : 코출혈과 비인두 손상을 최소화하는 경비 기관삽관법

구본녀,남순호 대한마취과학회 2005 Korean Journal of Anesthesiology Vol.49 No.5

중증근무력증 환자에 대한 흉선절제술시 마취관리

오흥근,남순호,방서욱,사희순 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.2

We have mnanaged the anesthetic and postoperative care in 9 patients with myasthenia gravis who underwent thymectomy and obtained following resultsa : 1) Premedication was glycoprrolate 0.004mg/kg or atropine 0.01mg/kg and hydroxyzine 1∼2mg/k7, I.M. Anesthetic induction was by thiopental 4∼5ml/kg with the inhalation of halothane 1∼2 % or enflurane 4∼5%, and followed by endotracheal intubation. Anesthetic maintanance was done by N_2O and halothane or enflurane. 2) Mean duration from the end of operation to intubation was 11.83±3.37hrs. 5 patients required reintubation. The mean duration from the extubation to re·intubation was 33.11± 21.06hrs for these 5 patients. Over all this entire group of patients were placed on the respirator for a mean of 5.33±1.46dara. 3) Complication occured were 2 cases of cholinergic crisis, 1 cases of lung abscess, 2 cases of dyspnea and 1 case of tension pneumothorax 4) Abstinence of muscle relaxants, adequate respiratory care and the protection from cholinergic crisis weost important factors for successful management.