http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 남성일 (검색결과 119 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
남성일 대한평형의학회 2021 Research in Vestibular Science Vol.20 No.4
Vestibular schwannoma (VS) is commonly encountered in the cerebellopontine angle and benign neoplasms that arise from Schwann cells of the eighth cranial nerve, which can show not only hearing loss but also various vestibular symp-toms. Dizziness is the symptom causing significantly negative effect on quality of life in patients with VS. Here, we will review the dizziness in VS.
-
포스트 코로나 시대에서 법치국가의 역할 -하버마스의 기본권 논의를 중심으로-
남성일 동국대학교 동서사상연구소 2023 철학·사상·문화 Vol.- No.42
This paper looks for new problem of basic human rights in covid-19 Pandemic crisis situation which aggravate into a neglected class’s mass-production and welfare blind spot’s diffusion. In a constitutional states(Rechtsstaat), Basic human rights specified in the constitution naming right to freedom, right to equality, right to pursue happiness, right to society, eta is used in nation administration’ s grounds and principles. Paying attention to this point, the post-Covid-19 era’s problem solution way for great worldwide crisis situation must be sought in a spirit of founding states. A spirit of founding states by Pilgrim Fathers’s Mayflower Compact comes before 150 years than the Declaration of independence. and this Mayflower Compact is analyzed into four conceptual indicators of (1) contractualism (2) civic politics (3) common good (4) rule of law. this Mayflower Compact’s founding states is succeeded in 18 century’s Enlightenment philosophy of Social Contract spirit. After comparing one generation of enlightenment Hobbes and three generation Kant, Habermas propose politics ideal of constitutionalism ’s democratic constitutional states in a alternative view which solved a great and big problems in modern society. Therefore I assert that the basic rights in constitutioal state goes through a series of state’s design process into [civil -> right -> law -> states] of process procedure.
-
-
-
-
남성일,권택규 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.3
Objectives. To investigate the effect of interleukin (IL)-1β on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1β-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms in- volved. Methods. House ear institute-organ of Corti 1 (HEI-OC1) cells were used and exposed to IL-1β with/without dexametha- sone. Glucocorticoid receptor antagonist, RU486, was used to see the role of dexamethasone. PD98059 (an extracel- lular signal-regulated kinases [ERKs] inhibitor), SB203580 (a p38 mitogen-activated protein kinases [MAPK] inhibi- tor), SP600125 (a c-Jun N-terminal kinase [JNK] inhibitor) were also used to see the role of MAPKs signaling pathway(s) in IL-1β-induced MMP-9 expression in HEI-OC1 cells. Reverse transcription-polymerase chain reaction and gelatin zymography were used to measure mRNA expression level of MMP-9 and activity of MMP-9, respectively. Results. Treatment with IL-1β-induced the expression of MMP-9 in a dose- and time-dependent manner. IL-1β (1 ng/mL)- induced MMP-9 expression was inhibited by dexamethasone. Interestingly, p38 MAPK inhibitor, SB203580, signifi- cantly inhibited IL-1β-induced MMP-9 mRNA and MMP-9 activity. However, inhibition of JNKs and ERKs had no effect on the IL-1β-induced MMP-9 expression. Conclusion. These results suggest that the pro-inflammatory cytokine IL-1β strongly induces MMP-9 expression via activa- tion of p38 MAPK signaling pathway in HEI-OC1 cells and the induction was inhibited by dexamethasone.
-
와우 세포주에서 겐타마이신에 의해 유발된 세포자멸사의 특성
남성일,송대규,박성희,이재훈,이우근,김일만,박재식 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.3
Background and Objectives:Aminoglycoside antibiotics are ototoxic. Understanding of the molecular mechanisms underlying the drug-induced ototoxicity, however, has been hampered by limited cell availability. Recently, HEI-OC1 cells, which are of an immortalized cochlear cell line sensitive to ototoxic drugs, have been derived from the auditory sensory organ. This study was performed to confirm whether cultured HEI-OC1 cells can be used to evaluate aminoglycoside-induced ototoxicity and the effect of antioxidants against aminoglycoside-induced colchlear cell damage. Materials and Method:Gentamicin was administered for 3 days in the media containing HEI-OC1 cells. Results:Cell viability was decreased by gentamicin in a dose-dependent manner. The cell number was decreased by 50% 3 days after the exposure to 2 mM gentamicin. Penicillin did not have any significant effect. Flow cytometric analysis revealed that sub G1 arrest representing cellular apoptosis was accelerated by gentamicin treatment but not by penicillin. Expression of p27Kip1, the cyclin-dependent kinase inhibitor, was exclusively increased by gentamicin. Reactive oxygen species were also increased by gentamicin when compared with those of the control or when penicillin was used. Caspase-3 activity became increased according to the elevation of gentamicin concentrations. N-acetyl cysteine, but not vitamin E or vitamin C, ameliorated cell survival dose-dependently against gentamicin. Conclusion:The present study reveals that the HEI-OC1 cell line is a good model to evaluate gentamicin-induced ototoxicity. The results suggest that gentamicin-induced apoptosis may be, at least partially, linked to the overproduction of a reactive oxygen species called. Nacetyl cysteine, a free radical scavenger, that decreases the gentamicin ototoxicity.
-
남성일 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.8
Endolymphatic hydrops (EH) represents a histopathologic finding in which the structures bounding the endolymphatic space are distended by an enlargement of endolymphatic volume. EH primarily involves the cochlear duct and saccule but can involve the utricle and ampullae of the semicircular canals. EH is a consistent finding in patients with Meniere’s disease, however, the reverse is not true. EH may occur as a consequence of a variety of disorders, including DFNA 9, Alport syndrome, serous labyrinthitis, suppurative labyrinthitis, otosyphilis, temporal bone fracture, surgical trauma, neoplasm, immune disorders, otosclerosis, or Paget’s disease. The mechanism of development of hydrops is also unclear. This review provides information to understand the recent pathophysiologic mechanism and causal disoders in EH.
KCI연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
