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      • KCI등재

        Development of radiolabeled somatostatin derivatives for neuroendocrine tumors

        김희권 대한방사성의약품학회 2021 Journal of radiopharmaceuticals and molecular prob Vol.7 No.2

        Neuroendocrine tumor is one of popular diseases, and somatostatin receptor antagonists have been considered as promising agents for neuroendocrine tumors. Imaging of somatostatin receptor is useful approach on the diagnosis and therapy of neuroendocrine tumors. Thus, several radiolabeled somatostatin derivatives have been developed by scientists, and used for patients with neuroendocrine tumors. In particular, some radiopharmaceuticals for neuroendocrine tumors were approved by FDA. In this highlight review, the development of important radiolabeled somatostatin derivatives is described.

      • KCI등재

        Development of radiolabelled histone deacetylase inhibitors for PET imaging study

        김희권 대한방사성의약품학회 2020 Journal of radiopharmaceuticals and molecular prob Vol.6 No.2

        Histone Deacetylases (HDACs) are enzymes that have control gene expression regulation and cell state. In additions, inhibitions of HDACs are associated with growth arrest, differentiation, or apoptosis of tumor cell. Thus HDAC inhibition is one of the interesting biological targets. A variety of HDAC inhibitors has been developed by many scientists, and some of chemical structures related with HDAC inhibitors were modified to give radiolabeled HDAC inhibitors for positron emission tomography (PET) study. In this highlight review, the development of radiolabeled HDAC inhibitors for PET study are described.

      • KCI등재

        Soil Environmental Investigation of Plastic Film House in Chonnam Area

        김희권,박인진,김정근,김상철,Kim, Hee-Kwon,Park, In-Jin,Kim, Joung-Keun,Kim, Sang-Chul 한국토양비료학회 2000 한국토양비료학회지 Vol.33 No.1

        The investigation and the analysis of soil chemical properties, microbial flora and cultural practices in plastic house of 60 farms (pepper 20, cucumber 20, oriental melon 20) were conducted in Chonnam area film. An amount of fertilizer application of farms was more than that of standard fertilizer application. That was phosphate at two and a half times, potassium at twice and manure at three times the amount of standard application. It was inferred that excessive fertilizer application would lead to salts accumulation in soil. Continuous cropping injury would be incurred by excesive salts accumulation in soil. Even if inorganic elements in soil culturing peppers, cucumbers and oriental melons were greater than optimum level, base-saturation degree of soil culturing peppers, cucumbers and oriental melons was 40:18:12, 55:16:14 and 40:27:11 respectively. That was lower than the optimum levels (60:15:5). Therefore, crops would be affected by uptake inhibition by nutrition imbalance. Density of Fusarium is related to plant decease in soil i.e. pepper $26.2{\times}10^2\;cfu\;g^{-1}$, cucumber $75.8{\times}10^2\;cfu\;g^{-1}$ and oriental melon $6.5{\times}10^2\;cfu\;g^{-1}$. B/F of soil planted with pepper, cucumber and oriental melon was 91.2, 80.4 and 18.8, respectively. 시설재배 토양의 화학성, 미생물상 및 경종방법을 조사분석하여 시비관리 개선 및 연작장해의 사전 방지책 마련을 위한 자료를 얻고자 고추, 오이, 참외 재배지 60농가를 조사한 결과는 다음과 같다. 고추, 오이, 참외 재배농가의 시비량은 표준보다 인산은 2~2.5배, 칼리 2배였으며, 퇴비는 오이재배 농가에서 3배정도 많이 시용한 것으로 조사 되었으며 토양중 무기성분 함량이 대부분 적정치 이상이라 할지라도 고추, 오이, 참외 토양의 염기포화도가 40:18:12, 55:16:14, 40:27:11로 적정치의 60:15:5에 미치지 못하였을 뿐만아니라 양분 불균형으로 작물의 흡수 장해가 있었을 것으로 추정 되었다. 시설 하우스 토양의 미생물 B/F 값은 고추 91.2, 오이 80.4, 참외 18.8로 연작 년수가 긴 것으로 조사된 참외 재배토양의 미생물상이 열악한 것으로 나타났다. 토양 pH가 증가할수록 곰팡이와 Fusarium의 밀도는 감소 하고 방선균은 증가 하였으며, 토양 유기물 함양이 증가 할수록 모든 미생물의 밀도가 증가 하였으며 세균은 유의성이 안정 되었다. 세균, 곰팡이, 및 Fusarium의 밀도는 EC가 증과 할수록 감소 하였다. 따라서 시설하우스 재배시는 토양분석후 시비처방에 의해 인산과 칼리를 감비하고 염기포화도를 조절할 수 있도록 시비해야 할 것으로 사료되었다.

      • 닫힌-사슬 운동이 뇌졸중 환자의 체중지지율과 균형능력에 미치는 영향

        김희권,Kim, Hee-Gwon 대한고유수용성신경근촉진법학회 2011 PNF and Movement Vol.9 No.1

        Purpose : The purpose of this study is to analyze the effect of closed-chain exercise on weight supporting rate change within hemiplegic side and static dynamic balance ability in stroke patients. Methods : The subjects of the study were 13 hemiplegic patients who carried out closed-kinematic chain exercise program over 6 weeks. The exercises of the program are stand to sit with stall bar, stair-up & down by a hemiplegic leg and bridging exercise crossing the non-hemiplegic leg onto the hemiplegic leg. Each exercise was carried out over 3 sets of 10reps. Results : The results of this study were summarized as follows: 1. After intervention, there was a statistically significant change in the weight supporting rate within hemiplegic and non-hemiplegic side(P<0.05). 2. After intervention, there was a statistically significant change in the static balance(FICSIT-4) ability(P<0.05). 3. After intervention, there was a statistically significant change in the dynamic balance(FSST, TUG, FRT) ability(P<0.05). Conclusion : The results of the study suggests that closed-chain exercise program in stroke patients improves their weight supporting rate and enhance the static dynamic balance.

      • 고유수용성감각 운동프로그램이 편마비 환자의 균형 수행력에 미치는 효과

        김희권,Kim, Hee-Gwon 대한고유수용성신경근촉진법학회 2013 PNF and Movement Vol.11 No.1

        Purpose : The purpose of this study is to analyze the effect of the proprioceptive exercise program on balance performance in order to the suggest hemiplegic patients the therapeutic intervention. Methods : In this study, Proprioceptive exercise program was applied to 11 hemiplegic patients for 6 weeks as follows: First of all, hemi leg flexion-extension pattern was applied in a supine position. Secondly, alternated leg flexion pattern was applied in a standing posture with one hand support on the unstable platform. Thirdly, rhythmic stabilization techniques were applied in a standing posture on the unstable platform. Results : Significant differences were observed the chronic low back pain patient for VAS, BBS. Chronic low back pain patient improved all test. The results of this study were summarized as follows: 1. After intervention, there was a statistically significant change in the dynamic balance (FSST, TUG, FRT) performance(p<.05). 2. After intervention, there was also a statistically significant change in the static balance (FICSIT-4) performance(p<.05). Conclusion : The result of the study suggests that muscle strength exercise by the intervention of proprioceptive exercise program improves the hemiplegic patients' static and dynamic balance performance.

      • 조직신학

        김희권 장로회신대학교 2002 敎會와 神學 Vol.51 No.-

        크라우스는 하나님 나라라는 상위개념 밑에 교회를 둠으로써, 자기비판과 세상과의 비판적 조우를 통하여 끊임없이 자신을 개혁하는 개혁교회의 신학을 역동적인 성서신학적 술어로 해설하고 있다. 한국교회는 전반적으로 교회를 위한 신학에 의하여 지배되고 있다. 하나님 나라라는 우주적인 지평을 상실하고 교회성장학적 교회운영 욕구에 봉사하는 여러가지 이념적 교육적 자료들이 양산되고 있다. 이에 비하여 하나님 나라라는 포괄적인 개념을 가지고 기독교 신앙의 본지로가 교회의 본질을 이렇게 깊이 천착하는 책이 드물다. 본서는 이런 문제의식을 가진 독자들에게 신선한 도전과 깨우침을 제공할 것이다.

      • 요부 굴곡운동과 요부 신전운동에 의한 요통예방 및 치료

        김희권 목포대학교 스포츠 산업연구소 2004 스포츠 산업연구소 논문집 Vol.3 No.-

        Low back pain is significant problem on today's society and economy with lifetime incidence rate reported between 70-80 percent. The purpose of this study is to present lumbar flexion exercise and lumbar extension exercise for recovering lumbar curve. The apply for the effectiveness which the lumbar flexion exercise is as follows ; 1. Strengthen the abdomen muscles and decrease the pressure which the lumbar facet joint comes to add. 2. Increase the flexibility through to stretch of the lumbar extension muscles. 3. Make broad intervertebral foremen interval and decrease the pressure of the nerve root. The apply for the effectiveness which the lumbar extension exercise is as follow 1. Strengthen the lumbar extension muscles and make the lumbar curve recover to the normal. 2. Decrease the pressure to add for intervertebral disc or posterior longitudinal ligament. 3. Increase the flexibility through to stretch of the lumbar flexion muscles.

      • KCI등재

        치료적 운동프로그램이 편마비 환자의 정적·동적 균형 수행력에 미치는 영향

        김희권,Kim, Hee-Gwon 대한고유수용성신경근촉진법학회 2011 PNF and Movement Vol.9 No.4

        Purpose : The purpose of this study was to analyze the effect of closed kinematic chain exercise and proprioceptive neuromuscular facilitation exercise on the static dynamic balance performance of hemiplegic patients in order to suggest them therapeutic intervention methods. Methods : The subjects of this study were 18 hemiplegic patients grouped into 2 subgroups according to the exercise program. one group of closed kinematic chain exercise carried out sit to stand, Hooklying with pelvic lift(bridging) and stair-up & down by a hemiplegic leg. The other group of proprioceptive neuromuscular facilitation exercise carried out leg flexion-extension pattern in supine position, leg flexion pattern in standing and stabilizing reversal exercise in stating position. Each exercise was carried out over 3 sets of 10reps. Results : The results of this study were summarized as follows: 1. For both groups, there were statistically significant changes in the static balance (FICSIT-4) performance after exercise program (p<.05). 2. For both groups, there were statistically significant changes in the dynamic balance (FSST, TUG, FRT) performance after exercise program (p<.05). 3. In the comparison between both groups, there was no statistically significant difference in the static dynamic balance performance (FICSIT-4, FSST, TUGT, ER) after exercise program. Conclusion : As the results of the study shows closed kinematic chain exercise and proprioceptive neuromuscular facilitation exercise affect the improvement of hemiplegic patients'' static dynamic balance performance, it is supposed that these exercises could be therapeutic exercise program in clinical situations.

      • KCI등재

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