신이식 후 호전을 보인 Nephrogenic Fibrosing Dermopathy

김훈수 ( Hoon Soo Kim ),김수한 ( Su Han Kim ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),송상헌 ( Sang Heon Song ),김정섭 ( Jung Sup Kim ),곽임수 ( Ihm Soo Kwak ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.2

Nephrogenic fibrosing dermopathy (NFD) is a rare cutaneous fibrosing disorder that primarily affects patients with a history of renal disease. NFD manifests with induration, thickening and hardening of the skin with brawny hyperpigmentation. Lesions are typically symmetrical and usually develop on the limbs and trunk. Flexion contractures of the joints may be a feature of the disease. Histopathological features of NFD include proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers and focal mucin deposition. Although the pathogenesis remains largely unknown, some of the factors implicated in the pathogenesis include renal dysfunction, circulating fibrocytes, vascular injury, and gadolinium which is a contrast material used in magnetic resonance imaging. Currently, no definitive or uniformly effective therapies are available for the treatment of NFD. We herein describe the case of a 44-year-old female NFD patient who undergoes significant improvement of skin lesions and associated joint contracture after renal transplantation. (Korean J Dermatol 2010;48(2):143∼147)

심한 손발바닥 과각화증을 동반한 코스텔로 증후군 1예

김학준 ( Hak Jun Kim ),김우일 ( Woo-il Kim ),이원구 ( Won-ku Lee ),김건욱 ( Gun-wook Kim ),김훈수 ( Hoon-soo Kim ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ),고현창 ( Hyun-chang Ko ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.8

Freshwater Cyclopoid Copepods (Cyclopoida, Cyclopidae) of Korea

Kim, Hoon Soo(김훈수),Chang, Cheon Young(장천영) 한국동물분류학회 1989 Animal Systematics, Evolution and Diversity Vol.5 No.2

도로조명 계산법

김훈,김기훈,Kim, Hoon,Kim, Gi-Hoon 한국조명전기설비학회 2000 조명.전기설비 Vol.14 No.6

Frederick William Baller가 編纂한 漢語敎材 『日日新』

金薰鎬 ( Kim Hoon-ho ) 한국중국언어학회 2021 중국언어연구 Vol.- No.94

淸代官話羅馬字母官話課本(Mandarin Book)有: 馬禮遜的『五車韻府』, 富善的『官話萃珍』, 威妥瑪的『語言自邇集』, 翟理斯的『漢語無師自明』, 鮑康寧的『英華合璧』和『日日新』。 鮑康寧是內地會(the Inland Mission)英國人來華的基督敎傳敎士, 他于1873年抵中國。『日日新』(A Idiom a Lesson)是1920年由英國傳敎士Frederick William Baller(中國名: 鮑康寧)編纂的官話課本(Mandarin Book)。該課本所記的語音了解20世紀初期北京, 南京官話的實際情況。『日日新』在汉语研究史上具有重要的地位。 『日日新』所記載的北京官话口語和今天的北京话的音系已无异, 与其他同时期出版的北京官话著作如『尋津錄』, 『語言自邇集』, 『約翰福音書』, 『华英袖珍字典』及『官話萃珍』『漢語無師自明』, 『英華合璧』的音系相同。在『日日新』的语言特点说明, 『日日新』记載了的20世纪初期北京官话的演变向現代普通話的演变靠拢。 Mandarin Book of the Qing Dynasty contains: 『Dictionary in the Chinese Language』, 『A Character Study in Mandarin Colloquial』, 『A progressive course designed to assist the Student of Colloquial Chinese』, 『Chinese Without a Teacher』, 『A Mandarin Primer』. Frederick William Baller, a Christian missionary who came to China in 1873, arrived in China. 『A Idiom a Lesson』 is a Mandarin Book compiled by the English missionary Frederick William Baller in 1920. This textbook has made a comprehensive study of the actual situation of official dialect in Peking and Nanking in the early 20th century. 『A Idiom a Lesson』 plays an important role in the history of Chinese language research. 『A Idiom a Lesson』 is no different from 『A Character Study in Mandarin Colloquial』, 『A progressive course designed to assist the Student of Colloquial Chinese』, 『Chinese Without a Teacher』 of Mandarin period. The language characteristics of 『A Idiom a Lesson』 indicate that the evolution of Peking dialect recorded by 『A Idiom a Lesson』 in the early 20th century is closer to the evolution of modern Mandarin.

도립진자 모델에서 칼만 필터의 잡음인자 해석

김훈학(Hoon-Hak Kim) 한국컴퓨터정보학회 2010 韓國컴퓨터情報學會論文誌 Vol.15 No.5

도립진자 시스템에서 칼만 필터링 최적의 결과를 얻기 위해서는 잡음 공분산 행열 Q, 측정잡음 공분산 행열 R과 초기 에러 공분산 행열 P₀와 같은 인자가 필요하다. 이러한 인자는 실제 상황에서 근사화된 값을 사용하거나 정확한 값을 알 수 없기 때문에 칼만 필터의 최적화에 영향을 미치지 않거나 이러한 공분산 행열의 스칼라 이득변화에 덜 민감한 경우를 연구의 대상으로 하고 있다. 또한 상태 측정시 에러를 예측하는 방법으로 구해진 에러 공분산 행열은 상태측정 값 보다는 공분산 행열의 이득과 연관성을 가지게 된다. 따라서 3가지 공분산 행열과 칼만 이득 그리고 에러 공분산 행열 간의 상관관계가 잡음인자인 스칼라 이득과의 연관성을 해석하고자 하였다. 본 연구는 3절에서 도립진자 시스템 모델을 간략하게 정리를 하였고 4절에서는 이러한 모델을 기반으로 하여 컴퓨터 시뮬레이션을 위한 도립진자 시스템에 대한 수학적 동적모델을 구성하고 5절에서는 이러한 인자와 스칼라 이득 값을 이용한 다양한 시뮬레이션 결과를 통하여 잡음인자의 연관성을 해석하였다. The Optimal results of Kalman Filtering on the Inverted Pendulum System requires an effective factor such as the noise covariance matrix Q, the measurement noise covariance matrix R and the initial error covariance matrix P₀. We present a special case where the optimality of the filter is not destroyed and not sensitive to scaling of these covariance matrix because these factors are unknown or are known only approximately in the practical situation. Moreover, the error covariance matrices issued by this method predict errors in the state estimate consistent with the scaled covariance matrices and not the issued state estimates. Various results using the scalar gain δ are derived to described the relations among the three covariance matrices, Kalman Gain and the error covariance matrices. This paper is described as follows: Section III a brief overview of the Inverted Pendulum system. Section IV deals with the mathematical dynamic model of the system used for the computer simulation. Section V presents a various simulation results using the scalar gain.

유기인계 농약 중독 환자에서 초기 적혈구 아세틸콜린에스테라제 활성도의 임상적 의의

김훈,한승백,김준식,이미진,박준석,권운용,어은경,오범진,이성우,서주현,노형근,Kim, Hoon,Han, Seung-Baik,Kim, Jun-Sig,Lee, Mi-Jin,Park, Joon-Seok,Kwon, Woon-Yong,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, Hyung-Keun 대한임상독성학회 2008 대한임상독성학회지 Vol.6 No.1

Purpose: Acute organophosphate (OP) poisoning may be monitored by measuring the acetylcholinesterase (AChE). It is important to assess severity and establish prognostic tests in the early stage of OP poisoning. The aim of this study was to look at the relationship between various clinical aspects of the OP poisoning, prognostic indicators of OP poisoning including Simplified Acute Physiology Score (SAPS) 3, and the associated changes in AChE levels. Methods: Clinical data and initial AChE levels from thirty-seven patients with OP poisoning were prospectively reviewed from 12 teaching hospitals in South Korea from August 2005 to July 2006. Clinical manifestations at the time of arrival such as miosis, respiratory abnormality, salivation, urinary incontinence, GCS score, AVPU scale, need for intubation, and mechanical ventilation requirements were recorded. SAPS 3 was calculated using clinical data and laboratory results. Results: The median level of AChE was 9.8 (1.3-53.6) U/gHb. There was no significant difference in AChE levels between the groups with and without cholinergic symptoms. The median level of AChE of the patients who required intubation and those who did not were 3.5 U/gHb and it 19.7 U/gHb respectively (Mann-Whitney test; p<0.001). The AChE levels were also significantly different (p=0.007) in patients who needed mechanical ventilation compared to those who did not with AChE levels found to be 3.1 U/gHb and it was 14.8 U/gHb, respectively. Level of consciousness assessed using the AVPU scale was correlated with AChE levels (Kruskal-Wallis test; p=0.013). GCS score were correlated with AChE levels (p=0.007, Spearman's rho = 0.454). In addition, the lower the level of initial AChE, the longer the ICU stay (p=0.029, Spearman's rho=-0.380). SAPS 3 was inversely correlated with the initial AChE (p<0.001, Spearman's rho=-0.633). Conclusion: In the acute OP poisoning, low AChE levels appear to help indicate the severity of poisoning. The initial AChE level may be a useful prognostic parameter for acute OP poisoning.

합성생물학의 위해성에 대한 국내 규제법률 검토

김훈기(HOON-GI KIM) 한국환경사회학회 2009 환경사회학연구 ECO Vol.13 No.2

2000년대 초반 미국에서 기존 생명공학기술과 정보기술, 그리고 나노기술이 융합된 합성생물학이란 분야가 등장했다. 합성생물학은 한편으로 난치병, 환경오염, 그리고 에너지고갈 등 현단계 인류가 닥친 난제를 획기적으로 해결할 가능성을 제시하고 있다. 그러나 다른 한편으로 인간과 생태계에 치명적인 영향을 미칠 수 있다는 점에서 위험 문제가 부각되고 있다. 합성생물학은 접근방법에 따라 탑다운 방식과 바텀업 방식으로 구분된다. 탑다운 방식은 자연계에 이미 존재하는 세포나 유전자를 변형시키는 영역이다. 이에 비해 바텀업 방식은 화학물질로부터 생명체의 구성요소를 만들어내는 분야이다. 합성생물학의 위험에 대한 논의는 비의도적으로 또는 환경방출용으로 위험물질이 외부에 노출됐을 때 인간과 생태계에 미치는 영향을 다루는 생물안전성 이슈, 그리고 의도적으로 병균이나 독성물질을 훔치거나 생태계에 방출하는 바이오테러에 관한 생물안보 이슈를 중심으로 진행되고 있다. 먼저 ‘합성 LMO’에 대한 안전성 평가는 ‘기존 LMO’에 대한 규제 법률로 이뤄지기 어렵다는 점이 지적되고 있다. 또한 ‘합성 LMO’가 환경에 방출됐을 때 생태계를 교란할 가능성이 예측할 수 없이 커진다는 우려가 제기됐다. 한편 몇몇 바이러스 유전체가 합성된 일을 계기로 바이오테러의 위험이 급부상하고 있다는 논의가 활발하다. 한국은 조만간 합성생물학 연구가 활발하게 진행될 잠재력을 지녔다. 현재 국내에서 합성생물학의 위험을 통제할 수 있는 법률은 LMO법과 생물무기금지법이다. 그러나 이들은 ‘기존 LMO’가 주요 검토대상이란 점에서 근본적인 한계를 안고 있다. 본 연구에서 두 법률을 검토한 결과 합성생물학의 위험을 통제하기 어렵다는 사실을 확인했다. 한국 정부는 합성생물학의 연구수준을 정확히 파악하는 동시에 그 위험에 대비할 수 있는 법적ㆍ제도적 장치를 마련해야 한다. 또한 LMO의 위해성을 평가하는 기술을 시급히 개발하는 일도 중요한 과제로 남아있다. A new emerging field, Synthetic Biology has appeared in America since 2000. It provides a great possibility for solving diseases, environmental pollution, and energy problems with the tools of existing BT, IT, and NT. However, it also has the potential to be dangerous very seriously to both humans and ecosystem. Synthetic Biology has two kinds of approach, top-down and bottom-up. Top-down approach involves the engineering field for existing natural biological systems. And Bottom-up approach covers the engineering field for biological systems that do not already exist in the natural world. Imaginable hazards associated with Synthetic Biology include (a) bio Biolo issue about the case of the accidental or purposeful release of harmful materials, (b) bio Biolo issue about the case of the purposeful release of harmful materials for terror. The focus about bio Biolo issue is on the impossibility for assessing the risk of that field by existing regulating laws, and the possibility for serious danger to ecosystem. Also the synthesis of virus genome causes . ch concern about the bio Biolo problem, bioterrorism. Korea has the potential to be very active for R&D of Synthetic Biology soon. However, this study concludes that the laws for regulating LMO and biological weapons in Korea have great difficulty in preventing the risk of Synthetic Biology effectively because they were made for existing LMO. The Korean Government should catch the current domestic state of R&D on Synthetic Biology precisely, and prepare for the new systems against the risk as soon as possible. Also it has the urgent problem for developing risk assessment technology.

한국 언론의 젠더 프레임

김훈순(Hoon-Soon Kim) 한국언론정보학회 2004 한국언론정보학보 Vol.27 No.-

이 연구는 한국 언론의 젠더담론을 살펴보기 위해 《조선일보》ㆍ《한겨레신문》 사회면에 실린 여성관련 범죄뉴스의 프레임을 분석하였다. 스트레이트 기사형식을 선호하는 사회면의 범죄기사는 대부분 일화 중심적 뉴스 프레임을 취하고 있었다. 일화 중심프레임의 기사들이 피해 여성의 이미지를 형성하는 프레이밍 기제들은 가해자 중심의 서술 및 여성 피해자의 타자화, 남성필자의 가부장적인 시선, 선정적 묘사, 여성의 신체적 취약성과 수동성 강조, 피해자 여성 비난하기 등이었다. 주제 중심적 프레임 기사의 특성은 선정성 부각과 함께 사회구조 탓하기와 구체적 대안의 부재로 분석되었다. 후속보도가 이어진 하양피살사건에 대한 사례분석의 결과에 의하면, 사건의 내용이 바뀌었음에도 불구하고 사건발생 초기에 설정된 흥미위주의 여성에 대한 선정적 프레임은 지속되었으며, 이는 한국언론의 내재된 여성관을 확인시켜주는 대표적 사례였다. 이러한 결과는 선정성을 강조하는 언론의 상업주의적인 태도와 경직된 취재보도체제에 비롯되며, 특히 남성편향적인 프레임들은 경찰발표를 그대로 받아쓰는 관행적인 뉴스제작 관습과, 남성기자와 남성적인 뉴스조직의 가치판단에 의해서 형성된다. 두 신문은 정치적 노선의 차이에도 불구하고 여성을 다루는 방식에서 여성문제에 대한 무관심을 드러내는 동시에 가부장적인 여성관을 보여준다. 이는 우리사회의 보수세력과 진보세력의 담론 모두가 남성적 담론으로서 여성은 담론상의 위치에서 사회적 약자로서 소외되고 있음을 반증한다. The purpose of this study is to investigate the gender discourse of Korean newspapers. For this, the study analyzes the frames of crime news on Chosun Daily and Hangyurae Newspaper for 2 years. The data are collected using KINDS, and include 265 crime articles involving woman. According to the results of this research, the episodic frames are used in the most of crime news. The five frame devices are founded in the episodic frame articles; the male subjectivity and the female objectivity, the male-oriented perspectives which reporters have, the abused sexual details and sensationalism, the emphasis of women body's fragility which imply woman's unavoidability as victims, and finally, blaming women who are victims of crimes. And in the articles of thematic frames, the similar frame devices are found. In particular, they only emphasize the problem of crime and fail to suggest a concrete resolution. Finally, the study discusses the findings relating to the patriarchal news making convention and the commercialism of newspaper industry. The two newspapers have been pursuing quite different political lines in Korean society. It is generally considered that Hangyurae newspaper is progressive and Chosun Daily is conservative. However, this study reveals that the way dealt with women in the crime news are not different. It is concluded that Korean newspapers still produce the gender discourse based on male-centric perspective and patriarchal ideology.

연구논문 : 한국 생명공학정책의 형성과 과학자집단의 정책 활동: 유전공학육성법 제정에서 "바이오텍 2000" 수립까지

김훈기 ( Hoon Gi Kim ) 한국과학사학회 2010 한국과학사학회지 Vol.32 No.2

Korean government`s support for biotechnology field began in early 1980`s. The main aim was economic growth through the application of biotechnology. Ministry of Science and Technology included genetic engineering as one prominent field in the Development Plan for Economy and Society(1982-1986), and National Assembly established Genetic Engineering Support Act in 1983. Ten years later, the overall ministries started to promote biotechnology in the name of Biotech 2000, and the main aim was still economic growth. But the substantive contents of Biotech 2000 were some distance from the aim of it, and all the more became weak in comparison with the situation in early 1980`s. This article showed that the scientists who were involved in the process of biotechnology policy formation had a decisive effect to the trend of governmental strategy. At first the scientists chose the genetic engineering field intentionally for persuading governmental officials to be worth money. Afterwards they tried to change the name of the field from genetic engineering to biotechnology because they wanted to be supported more broadly. There was some disagreement about the range of support within scientists group when they acted to make the Act. This led the uncommon definition of the field "genetic engineering" through a compromise among scientists. This study would help to understand the characteristics of early biotechnology field in Korea, and suggest the necessity of examining how much the opinion of scientists group has influenced the governmental policy until recently.