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김효수,김일환,Kim, Hyo-Soo,Kim, Il-Hwan 사상체질의학회 2004 사상체질의학회지 Vol.16 No.3
1. Objectives Facial Palsy(Bell's palsy) is a common disease in oriental medicine. In Sasang Constitutional Medicine, Taeumin have a basic condition by Ganyeol as their inherent symptomatic phamacology. This case is a study about Taeumin's facial palsy in Ganyeol conditions. 2. Methods In treatment of facial palsy, especially in acute stage, We prescribe Yeoldahanso-tang(熱多寒少湯) when a patient with facial palsy is diagnosed as Taeumin by their own characters. 3. Conclusions This case-study shows an efficient results by using Yeoldahanso-tang(熱多寒少湯) in treatment of facial palsy compared with other known treatments.
가족성 고콜레스테롤 혈증 한국인 환자에서의 저비중 지단백 수용체 유전자의 돌연변이 분석
김효수(Hyo Soo Kim),채인호(In Ho Chae),박영배(Young Bae Park),최성준(Sung Choon Choe),한기훈(Ki Hoon Han),채재진(Jae Jin Chae),김성한(Sung Han Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.5
N/A Familial hypercholesterolemia (FH) is a common autosomal dominant disorder caused by a defect in the low-density-lipoprotein (LDL) receptor, disrupting the normal control of cholesterol metabolism. We have collected 86 FH families for over 5 years who met following Dx criteria 1) hypercholesterolemia over 280 mg/dl 2) Achilles tendon xanthoma thicker than 9 mm, and 3) familial tendency, and characterized the pattern of mutations in Korea FH patients. Method : Mutation was screened with linkage analysis into two ways; large structural rearrangements were screened by genomic Southern blotting or long-PCR technique, and small structural rearrangements were screened by PCR of each exon followed by SSCP analysis. The exact mutation sites were confirmed by sequencing. Result : 1) Large mutation : Three different large deletions(FH110, FH29, FH32) were found in 7(11.5%) among 61 families screened. FH110 was a deletion of 5.7kb from intron 8 to 12, which was found in 5 unrelated families. FH29 was a deletion of 3.8kb from intron 6 to 8, and FH32 was a deletion of 2kb from intron 6 to 7. These three deletions have not been reported previously. The mechanism of deletion was unequal crossover from mispairing Alu-sequences. 2) Small or point mutations : Nineteen different small mutations were found in 19(31.4%) among 86 families screened . These mutations comprised 9 missense, 3 nonsense, 2 splicing mutations, 3 small deletions, and 2 small insertions. One missense mutation (Pro664Leu) was found in 6 unrelated families. Among these mutations, 12 have not been reported previously.Conclusions : LDL receptor gene mutations are heterogeneous in Korean FH patients. We could not observe founder mutation but detect common mutations.(Korean. J. Med 57:881-895, 1999)
김효수(Hyo Soo Kim),진영아(Young A Jin),유은경(Eun Gyong Yoo),채규영(Kyu Young Chae) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.2
저자들은 간질 지속상태를 주소로 내원한 환아에서 좌측 뇌반구 위축을 동반한 Angelman 증후군 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Angelman syndrome is a neurogenetic disorder which results from the loss of expression of a maternal imprinted gene, UBE3A, mapped within 15q11-q13 presenting with various neurodevelopmental problems. We report a 3 year-old-girl who had severe developmental delay, speech impairment, ataxic gait, jerky movement and recurrent seizures with abnormal EEG, characteristic pattern with high amplitude slow spike-and-wave discharge on the bifrontal region. The patient was genetically confirmed Angelman syndrome who had two episode of status epilepticus with cortical atrophic changes on her left hemisphere. Angelman syndrome should be suspected in differential diagnosis in infant who has severe speech and developmental delay, tremulous movement accompanied by cryptogenic seizure disorders including characteristic EEG features.