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김효송(Hyo Song Kim),라선영(Sun Young Rha) 대한정형외과학회 2015 대한정형외과학회지 Vol.50 No.6
원발성 골종양은 비교적 드문 질환이지만 골육종과 유잉육종은 소아청소년기에서 가장 흔히 발생하는 종양이다. 복합 항암요법을 이용한 수술 전, 후의 항암치료를 도입함으로써 매우 큰 생존율 향상을 이루었으며, 대부분의 환자가 현재 사지 구제 수술이 가능하게 되었다. 그러나 이러한 생존율 향상은 최근 답보상태로 denosumab과 같이 분자유전학적 메커니즘 기반 약제를 이용한 새로운 약제 기반 임상연구가 절실한 실정이다. 따라서 본 저자들은 원발성 골종양의 다양한 분류와 항암치료의 최신 지견을 리뷰하고자 한다. Despite the rarity of primary bone tumors, osteosarcoma and Ewing sarcoma are the most common primary malignant bone tumors in children and adolescents. Multiagent chemotherapy regimens for neoadjuvant and adjuvant treatment remarkably improved the survival outcome for patients with osteosarcoma and Ewing sarcoma, therefore, most patients are now limb-salvage candidates. However, survival rate reached a plateau for last decades and is still unsatisfactory in the metastatic and relapse setting. Therefore, as seen in denosumab in giant cell tumor, further clinical trials based on molecular mechanism are warranted. This article reviews the current state of the art of systemic chemotherapy by focusing on the clinical heterogeneity of each subtype.
증례 : 심장자가이식술로 치료한 좌심방의 원발성 악성섬유조직구종 1예
장혜원 ( Hye Won Jang ),김효송 ( Hyo Song Kim ),최효경 ( Hyo Kyung Choi ),한아름 ( A Reum Han ),박계현 ( Kay Hyun Park ),안긍환 ( Geung Hwan Ahn ),박준오 ( Joon Oh Park ) 대한내과학회 2007 대한내과학회지 Vol.73 No.2
원발성 악성 심장 종양은 매우 드물며 완치를 위해서는 무엇보다 종양의 완전절제가 중요하다. 악성 섬유조직구종은 악성 심장 종양 가운데에서도 드문 종양으로서, 저자 등은 국내에서는 처음 시도된 것으로 파악된 심장자가이식술을 시행하여 종양을 완전절제하고 보조항암치료를 시행한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary cardiac tumors are rare findings and they are mostly benign. Malignant primary cardiac tumors make up 25% of the primary cardiac tumors and most of them are sarcomas. Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adulthood, and it is an extremely rare sub-type of cardiac sarcoma. It is known that MFH displays a poor clinical course with complete resection being the most important prognostic factor for survival. We described here the case of a malignant fibrous histiocytoma of the heart in a 54-year-old woman who presented with dyspnea. The tumor was treated by mass excision via cardiac explantation and autotransplantation followed by adjuvant chemotherapy. This is the first report of cardiac autotransplantation in Korea.(Korean J Med 73:223-227, 2007)
강버들,임아영,김영재,황의동,김선욱,김효송 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S
Radiation recall dermatitis refers to an acute inflammatory reaction in a previously irradiated field triggered by the administration of certain drugs days to years after the exposure to radiation. Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor and is an effective treatment for patients with advanced stage of non small cell lung cancer (NSCLC). Here, we report a rare case of gefitinib induced radiation recall dermatitis. A 52-year-old woman with a metastatic NSCLC had received a palliative radiation therapy of 20 cGy on spine metastasis area (C6-T6). After 24 days of receiving radiation therapy, she had started to take gefitinib. Eight months after taking drug, pain, swelling and erythema of skin were occurred on previously irradiated field. These symptoms were resolved after the cessation of gefitinib for 6 days and the topical use of steroid.