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초기 비외상성 대퇴골두 무혈성 괴사의 골 이식에 대한 임상적 고찰
최원식 ( Won Sik Choy ),김환정 ( Whan Jeong Kim ),이광원 ( Kwang Woo Lee ),유천환 ( Chun Hwan Yoo ),송대화 ( Dae Hwa Song ),김규현 ( Kyou Hyun Kim ),옹상석 ( Sang Suk Ong ) 대한고관절학회 1996 Hip and Pelvis Vol.8 No.2
The authors retrospectively reviewed 21 patients who underwent 22 bone grafting procedures for early atraumatic avascular necrosis of femoral head to evaluate effectiveness of the procedure. The minimum follow up period was 2 years and evaluation included clinical results using Merle d'Aubigne-Postel scale as modified by Charnely and radiographs using Ficats staging system. The result were as follows. l. All case". were males and 20 patients have bilateral involvement. The ages ranged from 26 to 67 years and mean age was 46.1 years. 2. According to the Ficat stage, Stage I was 8 cases (36%), Stage II were 14 cases (64%). At last follow up, Stage I were 1 case (5%), Stage II were 4 cases (18%), Stage III were 8 cases (36%) and Stage IV were 9 cases (41%). 3. The successful results in clinical and roentgenological evaluations were obtained in 5 cases (23%). Progressive collapse was not prevented in 17 cases (77%). 4. The role of core decompression with bone grafting in precollapse stage of avascular necrosis of femoral head is uncertain.
유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의
문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.
이준규,안재성,권순태,김환정,정제택 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
This study was compared pre-operative MRI finding with operative finding on 36 cases with the failed back surgery syndrome (FBSS) retrospectively. The purpose of this study was to determine the accuracy of the MRI on the FBSS including early complications such as hematoma of infection. Of the 51 patients with FBSS, we analyzed pre-operative MRI finding compared with operative finding on 36 cases excluding nonunion, instability, metal failure and pseudoarthrosis who underwent an operation for the FBSS from December 1994 to June 1997. There were 25 men (69.4%) and 11 women (30.6%), aged from 16 to 68 years (average 43.6 years). These were divided into 5 sub-groups and calculated sensitivity, specificity and positive predictability. MRI accuracy in recurred disc was 84%, scar adhesion, recurred or developed stenosis, infection and hematoma 100% each and all, overall accuracy of the MRI 93%, respectively. Average interval of re-operation in FBSS WAS 4.3 years. In the 18 cases (50%), symptoms persist without pain-free interval after first operation. Early complications including hematoma and infection are easily detected with MRI. Especially if patient complains of severe leg pain or neurologic deficit, it is a good diagnostic procedure to check the MRI. The MRI is a useful method for evaluation of most cases of the FBSS, but it has limitations to evaluate recurred disc or scar adhesion only in T1, T2 weighted image. Therefore Gd-DTPA enhancement is necessary for the accurate diagnosis.
LCS System 을 사용한 슬관절 전치환술의 임상적 고찰
신현대,이광원,박현종,강종원,최원식,김환정 대한슬관절학회 1996 대한슬관절학회지 Vol.8 No.1
A metal backed, interchangeable, meniscal bearing knee replacement system has been designed to combine low constrained fe ces with low contact stresses(LCS) to allow nearly nomsal joint articulation and loading as well as long terrn wear resistance of the implants. We performed 14 total knee arthroplasty using LCS system(meniscal bearing type) in 11 patients. The average follow-up period was 2 year and 6 months(2 years -3 year and 10 months). In our series, there were 9 fetnales and 2 males with 3 bilateral cases, their mean age was 62.2 years(45-71 years). The results were as follows. 1. Knee joint function by HSS(Hospital for Special Surgery) knee rating score was increased from 47 points preoperatively to 88.7 points postoperatively with all cases rated as excellent or good. 2. The average range of motion was increased from 97.2 degrees preoperatively to 124.3 clegrees postoperatively. The average degree of flexion contracture was improved from 9.3 degrees preoperatively to 1.8 degrees postoperatively. 3. According to the Knee Society Roentgenographic Evaluation and Scoring System, the radiolucent lines were found in zone 1(8 knee), zone 2(4 knees), zone 3(1 knee) and zone 4(2 knees) on the anteroposterior radiographs of the tibia. But total widths of the radioiucency were less than 4.