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Naesohwangryeon-tang Induced Apoptosis and Autophagy in A549 Human Lung Cancer Cells
김홍재,정진우,박철,최영현,홍수현 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.4
Objectives: Naesohwangryeon-tang (NHT) is a type of traditional herbal formula, however, little is known about its antitumor activity. In this study, the antitumor properties of NHT was evaluated in human lung adenocarcinoma cells. Methods: To check the inhibitory effect of NHT, MTT assay was performed. Cell cycle analysis and detection of ROS production were conducted by flow cytometry. To evaluate the signaling pathway, Western blotting was conducted. Results: Our results showed that the decrease of cell proliferation by NHT stimulation occurred more significantly in A549 cells than in NCI-H460 cells. In addition, NHT-induced apoptosis was associated with the activation of caspases and production of reactive oxygen species (ROS). NHT-induced apoptosis was attenuated after pretreatments with z-VAD-fmk or N-acetylcysteine, suggesting that NHT-induced apoptosis was caspaseand ROS-dependent. Interestingly, NHT treatment led to the development of autophagic vesicular organelles and upregulation of several autophagy-related genes. The pretreatment of bafilomycin A1 decreased apoptosis slightly but increased cell viability in the presence of NHT. Conclusion: These findings indicated that NHT induces both apoptosis and cell-protective autophagy in human lung cancer cells. This data suggests that NHT might be a novel herbal drug for lung cancer.
김홍재,강창민,오준성,황민진 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
In order to prevent harmful effects on humans and environment, carwash wastewaters have to treat before discharging into the surface water bodies because they contain various pollutants such as detergents, oil, grease, chemicals and road grime, and heavy metals, etc. In this study, the microbubbles were employed to separate for suspended particles include the oils, dusts, and detergents without any coagulants. During the flotation process, the small amounts of oxidation agent such as ozone gas was introduced with air for facilitate of pollutants disintegration. The disintegrated pollutants from oils and detergents were used as biodegradable carbon sources in soil covered oxidation process (SCOP). The experimental results demonstrated the efficiency of the flotation, ozonation, and SCOP in removing suspended solids and chemical contaminants from real carwash wastewater.
Integration Architecture for Virtualized Naval Shipboard Computing Systems
김홍재,오상윤 한국엔터프라이즈아키텍처학회 2013 정보기술아키텍처연구 Vol.10 No.1
Various computing systems are used in naval ships. Since each system has a single purpose and its applications are tightly coupled with the physical machine, applications cannot share physical resources with each other. It is hard to utilize resources efficiently in conventional naval shipboard computing environment. In this paper, we present an integration architecture for virtualized naval shipboard computing systems based on open architecture. Our proposed architecture integrates individual computing resources into one single integrated hardware pool so that the OS and applications are encapsulated as a VM. We consider the issue of varying needs of all applications in a naval ship that have different purposes, priorities and requirements. We also present parallel VM migration algorithm that improves the process time of resource reallocation of given architecture. The evaluation results with the prototype system show that our algorithm performs better than conventional resource reallocation algorithm in process time.
해군 함정 컴퓨팅 체계 정보교환을 위한 Publish Subscribe 모델 기반 아키텍처 및 매칭 알고리즘
김홍재,오상윤,Kim, Hong-Jae,Oh, Sang-Yoon 한국정보처리학회 2011 정보처리학회논문지 A Vol.18 No.5
정보우위는 현대전에 있어 승패를 결정할 수 있는 요소로써 효과적인 정보교환을 통해 달성이 가능하다. 현재 해군함정에는 다양한 체계가 탑재되어 운용 중이나 체계 들이 군 독자표준(MIL-STD)과 상용(COTS) 장비들이 혼재 되어 구성이 되어 상호운용성이 제한되고 체계들 간의 정보교환이 어렵다. 이에 본 논문에서는 Publish Subscribe 모델 기반의 함정 체계 간 정보교환 아키텍처를 제안한다. 제안 아키텍처는 Publish Subscribe 모델을 통신 미들웨어로 적용하여 서로 다른 체계들 간의 상호운용성을 향상시키고 정보교환이 가능하도록 하였으며 확장성을 가질 수 있도록 하였다. 그리고 Publish Subscribe Broker의 부하 경감을 위해 개선된 트리 기반의 매칭 알고리즘을 제안하였다. 제안하는 트리 매칭 알고리즘은 트리를 구성하는 각 노드에서 Subscription의 Predicate 정보를 포함하여 이벤트 매칭 시간을 단축할 수 있다. 그리고 본 논문의 성능평가를 통해 제안한 트리매칭 알고리즘이 비교대상 알고리즘에 비해 이벤트 매칭시간을 절감 할 수 있는 것을 확인하였다. Information superiority is an essential factor in modern warfare and it can be archived by efficient information exchange between systems. Various computing systems are installed on the today's navy vessels. However, it is hard to improve interoperability and efficiency of information exchange since the configurations of installed systems are varying. The military standard and commercial standard are mix-used between systems. In this paper, we propose an information exchange architecture based on Pub/Sub model as a communication middleware to improve interoperability as well as enhancing scalability. We also propose a novel tree matching algorithm to improve a performance of PubSub broker. In the proposed algorithm, each tree nodes have information about predicates of subscription that can reduce event matching time. The performance evaluation results show our proposed algorithm reduces time for matching predicates compare with other algorithms.