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Aldose reductase inhibitory activity of the methanol extracts from Korean folk plants
김혜민,한샘,최경,구자정,박광우,조은주,이상현,Kim, Hye-Min,Han, Saem,Choi, Kyung,Ku, Ja-Jung,Park, Kwang-Woo,Cho, Eun-Ju,Lee, Sang-Hyun Institute of Agricultural Science 2012 Korean Journal of Agricultural Science Vol.39 No.2
To search for the aldose reductase (AR) inhibitors from Korean folk plants, the inhibition of rat lens AR in vitro using the methanol (MeOH) extracts from Korean folk plants was investigated. Among fifty four Korean folk plants tested, the MeOH extract of Cedrela sinensis showed highest inhibition of AR ($IC_{50}$ value, 2.52 ${\mu}g/ml$). The plant C. sinensis has a possibility of new natural resources for the development of AR inhibitor for the prevention of diabetic complications.
Lignan contents in Acanthopanax senticosus by HPLC
김혜민,조선행,국순자,이상현,Kim, Hye-Min,Cho, Seon-Haeng,Kook, Soon-Ja,Lee, Sang-Hyun Institute of Agricultural Science 2011 Korean Journal of Agricultural Science Vol.38 No.3
A reverse-phase system of HPLC using a linear gradient of acetonitrile and deionized water was developed for the quantification lignans, eleutherosides B and E, in Acanthopanax senticosus. The HPLC system consisted of linear gradient of acetonitrile and deionized water, and UV/VIS detection was set at 210 nm. Both eleutherosides B and E contents in different parts of A. senticosus were determined. As a result, the contents of eleutherosides B and E were measured in the leaves (trace amounts and 0.029 mg/g, respectively), stems (0.107 and 1.015 mg/g, respectively), roots (0.026 and 0.390 mg/g, respectively), and fruits (0.022 and 0.043 mg/g, respectively). Moreover, eleutherosides B and E in the water extract were found 0.011 and 0.171 mg/g, respectively.
불안장애의 치료추구시간에 대한 공존 정신질환의 영향 : 사회불안장애와 공황장애 간 비교
김혜민,하주원,임세원,오강섭,Kim, Hye-Min,Ha, Juwon,Lim, Se-Won,Oh, Kang-Seob 대한불안의학회 2012 대한불안의학회지 Vol.8 No.2
Objective : Individuals with anxiety disorders experience a wide range of time to seeking treatment (TST) as well as various comorbid mental disorders. The present study examined the TST in social anxiety disorder (SAD) and panic disorder. This study aimed to find out the influence of comorbid mental disorder on TST of anxiety disorder through the comparison of SAD and panic disorder. Methods : This study included 311 SAD and 378 panic disorder patients at the initial visit of psychiatric clinic. Contribution of clinical (number of comorbidity, comorbid type and onset age) and demographic (current age) factors to TST were investigated by multivariate analysis. Results : The median length of TST was 14.03 years in SAD and 2.26 years in panic disorder. In social anxiety disorder, fewer comorbidity, younger onset age, and older age were factors associated with delayed TST. In panic disorder, only younger onset age was associated with delayed TST. In both disorders, comorbid depressive disorder was associated with shorter TST. Conclusion : Our data provided the differences in illness behavior needing help based on comorbid mental disorders between SAD and panic disorder. In addition to comorbid disorder, factors affecting TST of anxiety disorder requires future investigation.
김혜민,김재령,최은주,박은주,홍서유,이진용,박원일,Kim, Hye-Min,Kim, Jae-Ryoung,Choi, Eun-Joo,Park, Eun-Joo,Hong, Seo-Yu,Lee, Jin-Yong,Park, Won-Il 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.3
Objective: Significant portion of premature ovarian failure patients ovulate intermittently and even can achieve pregnancy. The clinical features and reproductive potentials of Korean women with premature ovarian failure have never been elucidated. The purpose of this study is to assess ovarian follicular growth and ovulatory potential. Methods: Complete medical records of fifteen women with idiopathic premature ovarian failure were reviewed retrospectively. Subjects with more than 6 ultrasonographic scans and 36 months of follow-up period were included. Once the ovarian follicle was found by ultrasonography, the follicular growth was serially monitored. The result of ovulation induction of 6 cycles in 4 patients were also evaluated. Rate of positive ovarian follicle by ultrasound, rate of natural follicular growth and response of ovulation induction were assessed. Results: Among the 15 patients, 6 women (40%) had ovarian follicle in random ultrasonography. But the chance of positive follicle per ultrasonography scan was 7% (8 out of 115 scans). One out of 6 women eventually ovulated during the follow-up scan. In remaining 5 subjects, size of follicles remained unchanged. None of 6 ovulation induction cycles resulted successful ovulation. Conclusion: Incidence of positive ovarian follicle in Korean premature ovarian failure patients is lower than that of Western counterpart. This result, however, could not be directly compared because of the differences of study design. The ovulation rate by medical ovulation induction in this group is 0%, which is worse than the reported success rate of Western studies. 목 적: 조기난소부전 환자의 10$\sim$20%에서 난소기능이 회복될 수 있다고 하며 간헐적으로 배란이 되고 심지어는 임신이 가능할 수 있다는 보고가 있다. 그러나 한국의 조기난소부전 여성의 임상적 특징과 배란가능성은 논의된 적이 없다. 이 연구의 목적은 한국인 조기난소부전 환자에서 자연 난포의 발생 빈도와 배란유도의 가능성을 평가하는 것이다. 연구방법: 특발성 조기난소부전으로 진단된 15명 여성의 전체 진료기록을 후향적으로 연구하였다. 환자별로 6번 이상의 초음파 검사를 시행하였고 36개월 이상의 기간 동안 추적관찰을 하였다. 또한 4명의 환자에서 6주기의 배란유도시도를 하였다. 조사항목은 초음파 검사에서 난포의 발견율, 자연 난포 성장률과 배란유도를 시행한 경우에 그 반응을 평가하여 결과를 분석하였다. 결 과: 15명 중 6명은 초음파상 난포가 발견되었나 (40%) 초음파 검사 당 난포 발견 빈도는 7%였다 (115회 중 8회). 6명 중 한 명은 초음파 추적관찰 상 배란이 확인되었고 나머지 5명은 크기에 변화가 없었다. 배란유도를 시도한 6명 중 성공적인 난포 성장이 관찰된 예는 없었다. 결 론: 한국인 조기난소부전 환자에서 난포의 발견율은 이전 서양 연구에 비하여 낮다고 생각되지만 관찰 방법에 차이가 있어 직접비교는 불가능하다. 배란유도의 성공율은 0%로서 이전 연구에서 발표된 수준보다 낮았다.
분자동역학법에 의한 기액계면 분자의 운동특성에 관한 고찰
김혜민,박권하,최현규,최순호,Kim Hye-Min,Park Kweon-Ha,Choi Hyun-Kue,Choi Soon-Ho 한국마린엔지니어링학회 2005 한국마린엔지니어링학회지 Vol.29 No.1
An experimental study of molecular motions on a liquid-vapor interface is limited due to micro-scale characteristics of a system with an angstrom or a nanometer size Therefore, in recent, many studies for micro-scale systems have been conducted by a computer simulation because it is free from experimental limitations. In this study, through the molecular dynamic (MD) method. molecular behavior was clarified on a liquid-vapor interface and a criterion to distinguish between liquid and vapor was suggested by a potential energy and the number of neighboring molecules. At an interface. the potential energy of a molecule was increased but the number of neighboring molecules was decreased when the molecule moved into a vapor region from a liquid region, and vice versa.
김혜민(Hye Min Kim),황승재(Seung Jae Hwang) (사)한국생물환경조절학회 2015 생물환경조절학회지 Vol.24 No.2
전통적인 접목은 노동 집약적인 작업이며, 접사의 실수에 의한 불량 접목묘가 쉽게 발생할 수 있다. 접목로봇의 개발은 전통적인 접목방법의 대안책으로써 주목받고 있다. 본 연구에서는 상업적으로 생산된 자동 접목로봇과 공정육묘장에서 전통적으로 행해지는 접목방법에서의 접목 효율성을 구명하기 위해 수행되었다. 고추(Capsicum annuum L.) ‘부촌’과 ‘안성맞춤’ 품종이 각각 접수와 대목으로 2013년 3월 29일에 파종되었으며, 접목로봇과 초보자, 접목 전문가에 의해 2013년 5월 31일에 접목되었다. 접목 후 접목 효율성과 접목 특성을 초장, 시간당 접목 성공률과 실패율로 비교하였다. 초장은 전문가에 의한 접목묘의 초장의 차이가 최대 0.6cm로 가장 균일하게 나타났으나 초보자에 의한 접목묘의 초장 차이는 최대 2.1cm로 가장 불균일하였다. 접목로봇에 의한 접목묘의 최대 초장 차이는 최대 1cm로 균일하였다. 시간당 접목묘의 개수에서 접목로봇에 의해서 접목된 묘의 수는 접목로봇(667주)에서 전문가(466주)에 의한 접목에 비하여 가장 많게 나타났다. 그러나 접목로봇에 의한 접목 실패율은 21.7%로 가장 높게 나타났다. 본 연구 결과는 접목로봇 기술이 농업에서 현장 적용 가치가 있으며, 상업적 공정육묘장에서 사용될 수 있고 전통적인 접목의 단점을 보완할 수 있다는 것을 증명하였다. Manual grafting is a labor-intensive operation and highly susceptible to human error. Development of grafting robot has been considered as an effective alternative to manual grafting. The study was conducted to investigate the grafting efficiency between the domestically produced automated grafting robot and traditional manual grafting performed in a commercial plug seedling greenhouse. Plug seedlings of pepper (Capsicum annuum L.) ‘Buchon’ and ‘Anseongmatchum’ were sown as scions and rootstocks, respectively on March 29, 2013. The grafting was performed by a grafting robot, amateur grafters, and professional grafters on May 31, 2013. After grafting, the seedling efficiencies and seedling characteristics were compared in terms of plant height, the number of success as well as failure of seedling grafts produced in an hour. The results showed that plant heights were most uniform in the grafts performed by the professionals that had a 0.6 cm difference whereas an uneven difference of 2.1 cm difference was observed in plug seedling grafted by an amateur. However, plug seedlings grafted by the grafting robot were found to be uniform with 1 cm plant height difference. Moreover, the maximum number of grafting processed plug seedlings per hour (667 plants) was achieved by the grafting robot on compared with the seedlings grafted (466 plants) by the professionals. Furthermore, the least failure rate of 21.7% was noted upon the usage of grafting robot than the manual grafters. Thus, the results demonstrate that the technology of automated grafting robots is the most appealing and can be employed in commercial plug seedling greenhouses to overcome the drawbacks of manual grafting.
동절기 수박 접목묘의 안정적 생산을 위한 나노탄소섬유적외선 램프의 난방효과에 대한 적정 설치간격
김혜민(Hye Min Kim),정현우(Hyeon Woo Jeong),황희성(Hee Sung Hwang),황승재(Seung Jae Hwang) (사)한국생물환경조절학회 2022 생물환경조절학회지 Vol.31 No.1
본 연구는 동절기 공정육묘장의 수박 플러그 묘 생산 시, 난방 에너지 절감에 유리한 난방장치인 나노탄소섬유 적외선 난방등의 효율적인 사용을 위한 적정 전력과 설치 간격을 구명하기 위해 수행되었다. 유리온실 내 소형 베드 6개를 플라스틱 필름으로 구획을 나누었으며, 100cm 높이에 700W와 900W 난방등을 설치하였다. 난방등은 설치 간격을 각각 중앙 1개(Control), 60cm 간격(2개), 40cm 간격(3개)으로 설치하였다. 나노탄소섬유 적외선 난방등을 점등한 후 대조구를 제외한 모든 처리에서 설정한 야간 기온(20℃)을 유지하였다. 엽온은 난방등 설치 간격이 좁을수록 빨리 상승하는 경향을 보였다. 나노탄소섬유 적외선 난방등을 사용함에 따른 처리구간 수박 접목묘의 생육에는 뚜렷한 차이가 없었으나, 엽장과 엽폭은 700W 난방등에서 설치 간격이 짧을수록 길어지는 경향을 보였으며, 700W 난방등을 40cm 간격으로 설치하였을 때 묘의 충실도가 높은 값을 나타내는 것을 확인할 수 있었다. 따라서 야간 기온 유지와 묘의 충실도를 고려하였을 때, 700W 난방등을 40cm 간격으로 설치하는 것이 수박 접목묘를 생산하는데 경제성을 고려하여 효율적인 나노탄소섬유 적외선 난방등의 전력과 설치 간격으로 판단된다. This study was carried out to investigate the proper wattage and installation distance for the efficient use of nano-carbon fiber infrared heating lamp (NCFIHL), a heating device advantageous for heating energy saving, when the production of watermelon plug seedlings in the plug seedling nursery in winter season. Six small beds were divided into plastic film, and 700 W and 900 W nano-carbon fiber infrared heating lamps were installed at 100 cm above the bed. 1 lamp at central (control), 60 cm interval (2 lamps), and 40 cm interval (3 lamps) heating lamps were installed in each bed inside the greenhouse. All treatments, except the control, were set to keep the night air temperature at 20℃ after lighting the NCFIHL. The leaf temperature showed a tendency to increase fast as the install distance was narrow. The leaf length and leaf width tended to increase as the installation distance of the 700 W heating lamp was narrow. The compactness was high in 700 W heating lamp with 40 cm of installation distance. Therefore, in consideration of maintaining the set temperature at night, installing 700 W electric lamps at 40 cm was an efficient power and installation distance for watermelon grafted seedlings considering economic feasibility.
김혜민(Hye Min Kim),김병수(Byoungsoo Kim) 성신여자대학교 경영연구소 2011 경영관리연구 Vol.4 No.2
최근 증권 시장에서 온라인이나 모바일 단말을 이용해 주식 투자를 하는 비중이 점차 늘어나고 있다.온라인이나 모바일 환경에서는 투자자들이 손쉽게 증권사의 투자 정보나 애널리스트의 분석 정보를 받아볼 수 있다는 장점이 있다.본 연구에서는 투자자들이 증권사나 애널리스트들이 제공하는 투자 정보를 활용하여 주식 투자 의지를 형성하는 의사 결정 과정을 살펴보았다. 기술 수용 모형에 정보에 대한 평판과 친밀성을 접목하여 연구 모형을 제안하였다. 그리고,기술 수용 모형에서 고려되고 있는 변수인 인지된 유용성과 인지된 사용 용이성에 영향을 미치는 요인으로 자기 효능감을 고려하였다. 제안한 연구 모형 검증을 위해 설문을 실시하였고, 160부의 데이터가 분석에 사용되었다. 분석 결과로 정보에 대한 인지된 유용성과 친밀감이 주식 투자 의지 형성에 유의한 영향을 미침을 알 수 있었고, 자기 효능감은 인지된 유용성과 인지된 사용 용이성을 제고하는데 필수적인 요소임을 알 수 있었다. 본 연구 결과를 통해 투자자들의 주식 정보를 활용한 주식 투자 행태에 대한 이해를 제고할 수 있을 것으로 기대된다. Given the rapid growth of use of online and mobile devices in the stock market, it is important to understand investors’ decision-making processes to decide to invest stock based on investment information. In online and mobile environments, users can easily received investment information of analysts. This study develops the theoretical model by incorporating reputation and familiarity into a technology acceptance model. Moreover, this study investigates the effects of self-efficacy on perceived usefulness and perceived ease of use. To verify the proposed research model, the survey was conducted and 160 respondents were used for data analysis. Analysis results show that perceived usefulness and familiarity with investment information significantly affects intention to invest stock by using investment information. The findings reveal that self-efficacy plays an informant role to enhance perceived usefulness and ease of use. The results provide an in-depth understanding of investors’ decision making processes in a stock market.
두침을 중심으로 시행한 외사시 환자 한의복합치료 치험 1례
김혜민 ( Hye Min Kim ),윤영훈 ( Young Hoon Youn ),김재수 ( Jae Soo Kim ),이현종 ( Hyun Jong Lee ),임성철 ( Sung Chul Lim ),이윤규 ( Yun Kyu Lee ) 경락경혈학회 2023 Korean Journal of Acupuncture Vol.40 No.1
Strabismus is a vision disorder in which the eyes do not properly align with each other when looking at an object and it can negatively affect the quality of life. This case is a report on a strabismus patient who received Korean medicine treatment including scalp acupuncture. Scalp acupuncture, body acupuncture, and herbal medicine were performed on a patient diagnosed with strabismus and diplopia. The improvement of symptoms was evaluated by the Numeric Rating Scale (NRS), Scott and Kraft Score (SK score), and change of symptoms and progress of diplopia. NRS decreased by more than 85%, and the SK score gradually changed from -4 to 0, which means strabismus mostly recovered, and the symptom and progress of diplopia were reduced. In this study, it is considered that Korean medical treatment including scalp acupuncture is useful for strabismus patients.