염색체 7번 장완의 부분적 역위 중복 1례

김현지,이소영,김미영,백청순,김원덕,이동석,김두권,최성민,Kim, Hyun Ji,Lee, So Young,Kim, Mi Young,Baek, Chung Sun,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long arm of chromosome 7 is characterized by growth and developmental retardation, muscular hypotonia, distinct craniofacial dysmorphic features, a short neck and skeletal abnormalities. A 3 month-old male was referred to our department of Pediatrics because of dyspnea, hypotonia and delayed development. He shows growth and developmental delay, hypertelorism, a depressed nasal bridge, low set ears, a short neck and muscular hypotonia. Karyotype revealed 46, XY, dup(7)(q36q33) by GTC-banding. We report a case of a partial inverted duplication of chromosome 7q. 저자들은 호흡곤란, 근력저하, 발달지체로 병원에 온 3 개윌된 남아의 염색체 핵형분석에서 46, XY, dup(7)(q36q33)으로 진단된 1례를 경험하였기에 보고하는 바이다.

대학생들의 탄산수 효능에 대한 인식과 지식이 섭취 행태 및 만족도에 미치는 효과

김현지,장재선,홍명선,서화정,Kim, Hyun Ji,Jang, Jae Seon,Hong, Myung Sun,Seo, Hwa Jeong 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

The purpose of this study was to determine the effects of awareness and knowledge of the efficacy of carbonated water on consumption patterns and satisfaction for college students, who are the principal consumers of carbonated water. A survey was conducted with 502 college students in the Metropolitan area from May 13 to 18, 2015 and 455 questionnaires were analyzed. As for the differences in awareness and knowledge of the efficacy of carbonated water according to gender, females (14.60 and 0.76) had better awareness and knowledge than males (13.40 and 0.58) (p=0.000 and p=0.036). The more positive the awareness of carbonated water, the greater the knowledge (p=0.000); the greater the knowledge of carbonated water, the higher level of consumption satisfaction (p=0.006). The odds ratio of awareness for carbonated water was 11.98; that is, positive awareness led to higher levels of satisfaction than negative awareness (p=0.003). Since awareness of the efficacy of carbonated water was found to affect carbonated water drinking and satisfaction, it is necessary to provide correct information about the efficacy of carbonated water.

수질(水蛭)이 THP-1세포의 사이토카인 유전자 발현에 미치는 영향

김현지,김경준,Kim, Hyun-Ji,Kim, Gyung-Jun 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1

Objective : This study was performed to evaluate the effect of immune reaction inductive substances such as PMA, LPS, DPE, DNCB and WP, the whitman pigra extracting substance at simultaneously on the translocation of $NF{\kappa}B$ towards to the nucleus and the mRNA expression patterns of various cytokine genes in THP-1 cells, monocytes of human. Methods : To analyze the cytokine genes expressions, the RT-PCR method was used, and measuring TNF-${\alpha}$ that had been secreted during cell culture by the ELISA method. The morphological changes were observed during THP-1 cell by a scanning electron microscope and the quantitative distribution of $NF{\kappa}B$ in the cell that was analyzed through immunocytochemistry and a confocal microscopy. Results : WP showed different influences onto the mRNA expression patterns of cytokine genes with PMA, LPS. DPE and DNCB according to the types of immune inductive substances in the THP-1 cells. Upon treating PMA and DPE on the THP-1 cells at the same time or either additionally treating WP thereon, the movement of $NF{\kappa}B$ increase towards the nucleus from cell cytoplasm was able to be observed. The expressions of IL-$1{\alpha}$ and IFN-${\gamma}$ induced by PMA and PMA+DNCB were suppressed by WP while the expression of TGF-${\beta}$ was promoted. Regarding the secretion pattern of TNF-${\alpha}$ according to the treatment of PMA, its secretion amount was incredibly increased by concurrent treatment of WP, however, in case of co-treatment of WP with PMA and DNCB, it was found that the secretion amount of TNF-${\alpha}$ decreased. Conclusions : In this study, the WP extracting substance was confirmed that it had an influence on expression patterns of cytokine genes according to the actions of a variety kinds of immune reaction inductive substances treated on the THP-1 cells. Especially, WP co-treatment with PMA and DNCB was suppressed the expression of inflammatory cytokines, such as IL-$1{\alpha}$, IFN-${\gamma}$ and TNF-${\alpha}$.

성대 부전 마비의 진단에서 후두 근전도 검사의 유용성

김현지,박혜상,김한수,박기덕,정성민,Kim, Hyun-Ji,Park, Hae-Sang,Kim, Han-Su,Park, Kee-Duk,Chung, Sung-Min 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.2

Background and Objectives : Vocal fold paresis is a clinical condition and considered as a continuum of neurologic dysfunction encompassing partial denervation and variable degrees and patterns of reinnervation. Its incidence, clinical presentation, significance are incompletely understood and still debated. This study describes the clinical, electromyographic findings in patients who presented with complaints of dysphonia and whose laryngoscopic finding revealed vocal fold paresis. Materials and Method : 47 patients (male : 25, female : 22) who referred to Ewha Womans University Medical Center Voice clinic for evaluation of vocal complaints were enrolled in this study. All patients had undergone a through history and physical examination including strobovideoscopic and laryngoscopic examination. Patients with in the history and/or laryngoscopic examination suggestive of vocal fold paresis were evaluated by laryngeal electromyography (LEMG). Results : Of these patients, 23 (48.9%) were found to have evidence of neuropathy on LEMG. There was no significant difference in voice symptoms and laryngoscopic findings between two groups of patients with evidence of neuropathy and who show normal findings on LEMG. Conclusion : LEMG can clinically help to guide the evaluation and management of vocal fold paresis. Due to some limitations of LEMG, laryngoscopic findings and clinical correlations should also be considered when diagnosing the vocal fold paresis.

학생기자의 건축뉴스 - 02 10살된 서울국제건축영화제, 올해는 어땠을까?

김현지,김혜민,박수진,박우승,임보미,허민,Kim, Hyunji,Kim, Hyemin,Park, Sujin,Park, Wooseung,Im, Bomi,Heo, Min 대한건축사협회 2018 建築士 Vol.595 No.-

계획행동이론을 적용한 하동지역 농업유산관광객의 행동의도 - 농업유산에 대한 지각된 가치와 사전적 지식의 역할을 중심으로 -

김현지,황길식,Kim, Hyun-Ji,Hwang, Kil-Sik 한국농촌계획학회 2018 농촌계획 Vol.24 No.2

The study aims to predict the behavior of tourists in Hadong County, which is registered as KIAHS. Based on the theory of planning behavior, we intend to verify the theory of planned behaviour, which adds descriptive parameters of the perceived value and prior knowledge of an agricultural heritage. In detail, first, the perceived value and prior knowledge of tourists about an agricultural heritage understand the influence of tourists' Attitude. Second, we could see the role of the behavioral factors in the causal relationship of the planned behavioral theory. We have identified the planned behavioral theory that attitudes, subjective norms, and perceptual behavior controls affect the intention of the revisit. Hadong should remember that by sending and providing various information about Hadong Green Tea and World Agricultural Heritage sites, it is possible to elicit changes in visitor attitudes and revisit visits.

단독주택 공부방의 조명환경 실태조사

김현지,안옥희,Kim, Hyun-Ji,An, Ok-Hee 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.7

본 연구에서는 단독주택 공부방을 대상으로 조명환경 실태조사를 실시하였다. 그 결과, 공부방은 주로 형광등을 사용하였으며 배광방식은 직접조명 방식을 사용하고 있었다. 또한 국부조명을 사용하는 비율은 48.2[%]로 시작업이 효과적이지 못하였다. 내부공간 조도는 평균 131.41[lx]이며, 책상면 조도는 322.57[lx]로 최저허용조도의 54[%]에 해당하는 열악한 실정이었다. 또한 사용자의 조명환경에 비해 만족도는 높아 조명에 대한 인식이 매우 부족한 것으로 사료된다. In this study, we investigated the actual conditions of illumination environment of study rooms in detached houses. From the results, fluorescent lamp as a lighting source and direct lighting method were mainly used. The additional use of local lighting was 48.2[%], and it was not efficient for detailed work. The average illuminance of general lighting and local lighting were 131.41[lx] and 322.57[lx], respectively, and these level were only 54[%] of the lowest illumination standard. This indicates that the lighting levels and the environment are so poor. The satisfaction level of users, however, was relatively high, suggesting insufficient recognition of importancy of lighting for efficient work.

골연령 측정을 통한 한방 성장 치료의 임상적 연구

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.3

Objectives : The object of this study was to evaluate the effect of oriental medical treatment to the growth of children using bone age as measurer. Methods : This clinical study has been carried out with 32 cases(male 15, female 17 of children) aging from 7 to 15 years old, who visited to the Department of Pediatrics growth clinic, ○○ medical center from January 2004 to August 2006 and were treated for more than 12 months. Their height, body weight, body mass index(BMI) and bone age were estimated at two points: Before and after oriental medical treatment was applied. Bone age is measured by X-ray image of growth plate in inferior radiocarpal joint. Results : Bone age correlated with choronological age, height, weight. Difference between bone and choronological age was correlated with percentile of height and weight. The mean growth of children showed 4.03 percentile upwardly(p=.046), and difference between bone and choronological age was reduced from $0.23{\pm}1.62$ to $-0.026{\pm}1.64(p=.040)$ after treatment. Conclusions : This study shows that oriental medical treatment helped growth of children using bone age as measurer.

보육교사의 자아탄력성, 낙관성 및 직무스트레스의 영향요인

김현지,구상미,김연수,Kim, Hyun-Ji,Koo, Sang-Mee,Kim, Yeon-Soo 중소기업융합학회 2021 융합정보논문지 Vol.11 No.8

본 연구는 보육교사의 자아탄력성, 낙관성, 직무스트레스 정도와 이들 변수간의 관계를 파악하고 직무스트레스의 영향 요인을 규명하기 위한 서술적 조사연구이다. 연구방법은 2021년 3월부터 4월까지 D광역시에서 일하고 있는 보육교사 191명을 대상으로 하였다. 보육교사의 자아탄련성, 낙관성 및 직무스트레스를 검사도구를 통해 설문 조사하였다. 자료분석은 SPSS WIN 20.0 프로그램을 이용하여 빈도, 백분율, 신뢰도분석, t-test, ANOVA, correlation, multiple regression을 실시하였다. 본 연구의 결과 첫쨰, 자아탄력성과 낙관성은 정적 상관관계, 자아탄력성과 직무스트레스는 부적 상관관계, 낙관성과 직무스트레스는 부적 상관관계를 보였다. 둘째, 보육교사의 직무스트레스의 영향요인을 분석한 결과 자아탄력성이 영향을 미치는 것으로 나타났다. 이러한 결과에 따라 보육교사의 직무스트레를 낮추기 위해서는 자아탄력성을 향상시키고, 직무스트레스를 낮출 수 있는 프로그램이 개발 및 제공되어야 할 것이다. This study is a descriptive research study to understand the relationship between childcare teachers' ego-resilience, optimism, and job stress and the relationship between these variables and to identify factors affecting job stress. The study method was targeted to 191 childcare teachers working in D Metropolitan City from March to April 2021. The self-reliance, optimism, and job stress of childcare teachers were surveyed using a survey instrument. For data analysis, frequency, percentage, reliability analysis, t-test, ANOVA, correlation, and multiple regression were performed using SPSS WIN 20.0 program. As a result of this study, first, ego resilience and optimism showed a positive correlation, ego resilience and job stress had a negative correlation, and optimism and job stress had a negative correlation. Second, as a result of analyzing the factors affecting the job stress of childcare teachers, it was found that ego resilience had an effect. According to these results, in order to lower the job stress of childcare teachers, a program that can improve self-resilience and lower job stress should be developed and provided.

여가제약에 따른 한강시민공원 여가공간개발에 대한 인식연구

김현지,이용학,강은지,김용근,Kim, Hyeon-Jee,Lee, Yong-Hak,Kang, Eun-Jee,Kim, Yong-Geun 한국조경학회 2014 韓國造景學會誌 Vol.42 No.5

본 연구는 여가제약에 따른 한강시민공원의 여가공간개발 영향에 대한 이용자의 인식차이에 관한 연구로 한강시민공원 이용에 표출되는 여가제약을 파악하고, 한강시민공원의 이용행태 특성 및 여가공간개발에 따른 긍정적 부정적 영향에 대한 인식을 파악하고자 하였다. 여가제약에 따른 한강시민공원 이용자의 여가공간개발에 대한 인식차이를 비교분석 하기 위해 한강시민공원에서의 여가활동에 미치는 정보와 자원, 경제적 여유, 시간적 여유를 영향정도가 높은 집단과 낮은 집단으로 분류하여 심층분석하였다. 그 결과는 다음과 같다. 첫째, 한강시민공원은 산책 및 휴식을 비롯한 조깅 및 마라톤, 자전거 등 여가제약요인에 영향이 적은 근린이용의 성격을 지닌 간단한 운동을 위해 방문하는 공간이었다. 둘째, 한강시민공원의 여가공간개발에 따른 영향에 있어서 저렴한 여가활동 비용, 접근의 용이를 가장 높게 평가하고 있었으며, 이용자 증가로 인한 혼잡 및 운영 관리상 예산과 관리인원의 증가를 가장 많이 우려하고 있었다. 셋째, 한강시민공원에서의 여가제약은 시간적 여유, 경제적 여유, 정보와 자원의 순으로 영향을 미치고 있었으며 여가제약의 영향정도에 따라 다양한 여가기회 및 여가수준의 향상, 한강에 대한 자부심 및 애착심 고취, 저렴한 여가활동 비용을 비롯하여 운영 관리상 예산과 관리인원의 증가, 이용자의 증가로 인한 혼잡에 있어 인식차이를 나타내고 있었다. 따라서 본 연구는 한강시민공원 이용자들에게 영향을 미치는 여가제약과 이에 따른 여가공간개발에 대한 인식을 확인할 수 있었으며, 여가제약의 영향정도가 한강시민공원의 여가공간개발에의 이용행태 및 긍정적 부정적 개발영향의 지각에 차이가 있음을 밝혀냈다는 점에서 연구의 의의가 있다고 할 수 있겠다. 또한 여가제약에 따른 여가불만을 해소하기 위해서 한강시민공원의 여가공간에 대한 홍보 및 정보전달과 함께 여가공간 운영 및 관리체제 수반, 다채로운 맞춤형 프로그램 개발, 사익보단 공익이 우선적인 여가공간 및 시설의 도입 등의 필요성이 고찰되었다. This is the study on users' perception gap about the effects of leisure space development of the Han River Citizen Park according to leisure constraints and was to identify leisure constraints expressed when using Han River Citizen Park and identify perception on positive and negative impacts according to use behavior characteristics of Han River Citizen Park and leisure space development. In order to compare and analyze the perception gap about the leisure space development of Han River Citizen Park users according to leisure constraints, we classified information and resources, economic affordability, free time on leisure activities in Han River Citizen Park into high influence group and low influence group and did an in-depth analysis. The results are as follows. First, Han River Citizen Park has the nature of neighborhood use with little influence on leisure constraints such as jogging and marathon, biking etc. including walking and relaxation and was a place to visit for simple exercises. Second, in the effects according to leisure space development of Han River Citizen Park, affordable leisure activity costs and ease of access were evaluated the most highly and congestion due to increasing users, increase in administrative operating budget and management personnel were concerned the most. Third, the leisure constraints in Han River Citizen Park were affected in the order of free time, economic affordability, information and resources. There were also perception gaps in congestion due to an increase in administrative operating budget and management personnel, increase in users including improvement of various leisure opportunities and leisure levels, encouragement of pride and attachment for Han river, affordable leisure activity costs depending on the degree of the influence of leisure constraints. Therefore, this study can be said to have the meaning in that we could identify leisure constraints affecting Han River Citizen Park users and resulting perception in leisure space development and revealed that the degree of the influence of leisure constraints varies in the use behavior of leisure space development of Han River Citizen Park and perception of positive and negative development impact. In addition, in order to resolve leisure complaints according to leisure constraints, we studied the need of accompaniment of leisure space operation and management system, development of various customized programs, introduction of recreational space and facilities prioritizing public interest rather than private interest with public relations and information delivery about leisure space of Han River Citizen Park.