논문 : 아유르베다(Ayurveda)의 과학적 근거에 대한 고찰

김해남 ( Hae Nam Kim ) 국제통합대체의학협회 2005 국제통합대체의학회지 Vol.1 No.2

Ayurveda, the traditional natural healing system of India, is quickly gainig popularity in the Western world. Ayurveda has a many thousand year-old clinical tradition and a comprehensive natural method of treatment from diet, herbs, and massage to life-style counseling and meditation. The world "Ayurveda" is composed of two Sanskrit terms, ``ayus`` meaning ``life`` and ``veda`` meaning the ``knowledge`` and taken together, it means the ``Science of Life``. Contrary to the present trend of specialisation for the treatment of diseases in different parts of the body in isolation, Ayurveda belives in the functional unity of the body as a whole. There are two objects of Ayurveda - one preservation of health in the healthy and the other, cure of illness in the diseased. Equilibrium of psycho - somatic elements is health and dis - equilibrium is disease. Ether, air, fire, water and earth are the five elements having lightness. roughness, hotness, coldness and heaviness as specitic qualities respectively. When parna enters into the material body, the three doshas-vata, pitta and kapha emerge to take up the physiological function vata consists of air and ether. pitta of fire and kapha of water in combination with earth. Because the disharmony of menatal dosha and body doshas are major cause of illness the goal of illness manegement in Ayurveda is to bring back harmony among the doshas. Ayurvedic therapy includes clinical examination diagnosis and dietary and lifestyle, excercise, massage and treatment. There are massage-, oil-, formentation- and cleansing therapy in Ayurvedic system. Massage has a greater use than these two areas, yet massage is extermly important in lifestyle treatments and in preparing for pancha karma. The treatment consists of cleansing therapy(pancha karma), palliation(improve digestion, remove toxic waste, fasting, observe thirst, exercise, sunbathing and meditation), mental numuring and spiritual healing depending on the disturbed doshas and the patients constitution. This review suggests a great potential for integration of Ayurvedic therpies into the health care system in the korea.

에센셜 오일의 항균효과 관한 연구

김해남 ( Hae Nam Kim ),김봉남 ( Bong Nam Kim ) 한국미용학회 2003 한국미용학회지 Vol.9 No.2

원심형 수직펌퍼의 흡입성능 향상 연구

정경남(Kyung-Nam Chung),박종후(Jong-Hwoo Park),김용균(Yong-Kyun Kim),김해천(Hae-Cheon Kim) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5

In this paper, a study of performance improvement for a centrifugal vertical pump having specific speed of 330 is introduced. The existing model has high efficiency but needs better NPSH required performance. Such that new pump model is designed to obtain larger suction specific speed. 6 design parameters considered to affect pump performance are selected for impeller design. Key design parameters are investigated using by design of experiments and CFD, and impeller inlet diameter is increased to get better suction performance, Pump efficiency and NPSH required value are analyzed by using CFD. The results show that new design model has higher efficiency and better NPSH required performance.

산업용 수직펌프의 흡입성능 향상 연구

정경남(Kyung-Nam Chung),박종후(Jong-Hwoo Park),김용균(Yong-Kyun Kim),김해천(Hae-Cheon Kim) 대한기계학회 2009 大韓機械學會論文集B Vol.33 No.11

In this paper, a study of performance improvement for a centrifugal vertical pump having specific speed of 330 is introduced. The existing model has high efficiency but needs better NPSH required performance. Such that new pump model is designed to obtain larger suction specific speed. 6 design parameters considered to affect pump performance are selected for impeller design. Key design parameters are investigated using by design of experiments and CFD, and impeller inlet diameter is increased to get better suction performance. The amount of inlet diameter increase is determined by using cavitation analysis. The results show that new design model has higher efficiency and better NPSH required performance than the existing model.

MBT-01108 물질에 의한 일반 소독제 및 항생물질 내성균주의 생육억제

김해남,박진영,김삼웅,전홍기,Kim, Hae-Nam,Park, Jin-Young,Kim, Sam-Woong,Jun, Hong-Ki 한국생명과학회 2007 생명과학회지 Vol.17 No.9

The 30% resistant frequencies of pathogenic bacteria were identified against generally utilizing disinfectants. Among the used disinfectants, foodsef, Taego, and Iodo 175 were dictated by lower sensitivities against pathogenic bacteria, as well as higher resistant frequencies when compared with other disinfectants. The resistant frequencies against antibiotics were also dictated by 30% through MIC (minimal inhibitory concentration) and paper disc methods. Especially, the used bacteria exhibited resistances against gentamycin, kanamycin, and streptomycin, which included in all aminoglycoside group. The MBT-01108 material, which extracted and purified from a powder obtained by processing of Opunita ficus-indica var. saboten Makino trunk, did not develop or grow resistant bacteria. Interestingly, the multi-drug resistant bacteria such as MRSA, resistant Pseudomonas aeruginosa, VRE, and E. coli 0157 did not resistant against MBT-01108 material. These results suggest that MBT-01108 material uses as an anti-microbial agent.

Identification of Anti-Microbial Material Originated from Opuntia ficus-indica var. saboten Makino

김해남,조대원,윤웅찬,전홍기,Kim, Hae-Nam,Cho, Dae-Won,Yoon, Ung-Chan,Jun, Hong-Ki Korean Society of Life Science 2007 생명과학회지 Vol.17 No.7

본 연구자들은 동${\cdot}$서양에서 오랫동안 민간요법으로 사용되어져 왔고, 문헌에도 약리적인 작용이 기록되어 있는 Opuntia ficus-indica var. Saboten Makino (손바닥 선인장, 백년초) 줄기 분말을 사용하여 항균생리활성 물질을 규명하고자 하였다. 줄기 분말을 황산으로 가수분해 처리한 후 메탄올, 메틸클로라이드, 에탄올 등의 용매로 추출하였다. 용매추출물 가운데 methylene chloride 추출물의 경우 가장 탁월한 항균활성을 나타내었다. 항균활성을 나타내는 생리활성 물질을 분리 분석하기 위하여 조제용 TLC를 이용하여 산 가수분해 추출물로부터 7개의 분획물을 분리하였다. 7개 분획물 가운데 가장 광범위한 항균활성을 나타내는 유효 분획물로 분리된 것을 MBT-01108이라 명명하였다. 산가수분해로 추출된 분획물 MBT-01108을 구조 분석한 결과 항균 활성을 나타내는 화합물이 levulinic acid임을 밝혀냈다. Opuntia ficus-indica var. Saboten Makino로부터 분리된 levulinic acid는 식품 또는 화장품의 천연 보존제로써 사용가능하리라 판단되며, 또한, 세균성 질병예방, 여드름, 노화 예방, 미백 화장품 성분, 그리고 항생제로도 사용 가능한 물질임을 밝혀냈다.

공기열 히트펌프(Air to Water Heatpump)를 활용한 중앙난방 공동주택 전력화 타당성 검토 사례

남일근(Nam Il Keun),김해봉(Kim Hae Bong),김종학(Kim Jong Hak),김근수(Kim Keun Soo),한성훈(Han Seong Hoon),권민호(Kwon Min Ho) 대한설비공학회 2024 대한설비공학회 학술발표대회논문집 Vol.2024 No.6

원유비축기지용 유중펌프의 형상설계

정경남(Kyung-Nam Chung),김진영(Jin-Young Kim),박종후(Jong-Hwoo Park),김용균(Yong-Kyun Kim),김해천(Hae-Cheon Kim) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

This study deals with hydraulic design of a submergible pump which is installed near the bottom of Ulsan oil stockpiling site. It is used to unload crude oil to a tanker and is run by a 2,800 ㎾ electric motor. This pump has the largest size in the world so far and is a vertical pump with diffuser. Pump design has been carried out by using the analyzed results obtained from the numerical calculations for the effects of several design parameters such as impeller diameter, exit breadth, impeller leading-edge profile, diffuser inlet blade angle, etc. Pump efficiency has been improved by getting rid of flow separation which is generated on the impeller blade due to high pump head and limitation of pump size. NPSH required performance has been improved by applying the above mentioned numerical studies. It has been confirmed from full-scale tests that the pump design is performed satisfactorily.

손바닥선인장 줄기 methanol 추출물의 항균활성

김해남,권도훈,김해윤,전홍기,Kim Hae-Nam,Kwon Do-Hoon,Kim Hae-Yun,Jun Hong-Ki 한국생명과학회 2005 생명과학회지 Vol.15 No.2

The Opuntia ficus-indica var. saboten Makino (Cactus) is a tropical or subtropical plant, which is cultivated or grows naturally in Jeju island. It has been widely used as folk medicine for burned wound, edema and indigestion. In addition, its extract has been claimed to have several biological activities including anti-inflammation in oriental medicine. In this study, we examined the antimicrobial activities of the methanol extract of Opuntia ficus-indica var. saboten Makino. The extract showed a broad spectrum of antimicrobial activity against pathogenic bacteria, including antibiotics resistant bacteria (MRSA, R-P. aeruginosa, VRE) and Propionibacterium acnes, yeast, and fungi. The extract retained the activity after heat treatment for 15 min at $100^{\circ}C$ and $121^{\circ}C$ and after extended storage, up to 10 weeks storage period at $4^{\circ}C$ and $25^{\circ}C$, also stably retained its activity. It showed a better inhibitoring effect to the growth of E. coli than sodium benzoate did it at the same concentration. Addition of various salts or metal ions did not affect on its antimicrobial activity. Therefore, the antimicrobial characteristics of the extract can be applicable as a natural preservative and an antimicrobial agent for bacterial disease.

피부에서 분리한 Staphylococcus aureus JJ-11이 생산하는 collagenase의 정제 및 특성

이진경,김해남,강호영,전홍기,Lee Jin-Kyoung,Kim Hae-Nam,Kang Ho-Young,Jun Hong-Ki 한국생명과학회 2006 생명과학회지 Vol.16 No.2

피부 트러블을 가진 남,여 40명의 피부에서 분리한 collagenase를 생산하는 균주를 분리, 동정한 결과 Staphylococcus aureus로 판명되었으며 이를 S. aureus JJ-11이라 명명하였다. S. aurells JJ-11 균주의 collagenase의 최적 생산 조건은 1.5%(w/v) gelatin, 1%(w/v) yeast extract, 0.4% (w/v) $K_2HPO_4$, 0.005%(w/v) $NiSO_4{\cdot}6H_2O$를 함유한 배지 (pH 7.0)에서 $37^{\circ}C$, 200 rpm으로 18시간 동안 배양하는 것이다. 분리 균주가 생산하는 collagenase를 정제하기 위해서 amberlite IRA-900과 sephacryl S-300 HR columns를 이용하였고, 6.66-folds로 정제되었다. S. allreus JJ-11 균주가 생산하는 collagenase를 정제한 결과 분자량은 약 62 kDa이었으며, pH 7.0과 $37^{\circ}C$에서 각각 최대의 활성을 가졌고, pH와 온도에 대한 안정성은 pH 4.0-8.0, $40^{\circ}C$까지 100%의 활성이 있었다. 금속이온에 대해서는 $Fe^{2+},\;Co^{2+},\;Ba^{2+}$ 존재 하에서는 5 mM 농도에서도 활성을 유지하였다. $Sr^{2+},\;Hg^{2+}$에서는 30% 이상이 저해를 받는 것으로 확인되었다. 또한 EDTA와 O-phenanthroline에 의해 65% 이상이 저해되는 일 반적인 collagenase의 특정인 metalloproteinase의 특정을 보였으며, 그리고, 여러 가지 기절에 대해 효소활성을 비교한 결과, insoluble collagen (type I)에 대해 효소 활성이 가장 높았다.