Subcutaneous Interleukin-2 Monotherapy for Metastatic Renal Cell Carcinoma in Korean Patients

Jeong Ho Kim(김정호),Ki Soo Lee(이기수),Choung-Soo Kim(김청수),Young Deuk Choi(최영득),Tae Hyo Kim(김태효) 대한비뇨기종양학회 2021 대한비뇨기종양학회지 Vol.19 No.4

Purpose: This study was a prospective single-arm clinical trial aimed at assessing the efficacy and toxicity of subcutaneous interleukin (IL)-2 monotherapy in patients with metastatic renal cell carcinoma (RCC). Materials and Methods: We enrolled 26 patients with metastatic RCC in this multicenter controlled trial. The patients received subcutaneous injections of recombinant IL-2 (BMI-rh-IL2, an aldesleukin biosimilar, BMIKOREA Co., Ltd.) in 5-week cycles. In the first week, the patients received a subcutaneous IL-2 loading dose of 18×10<SUP>6</SUP> IU once on treatment days 1–5, followed by 2 days of rest. In the following 3 weeks, they received a dose of 18×10<SUP>6</SUP> IU via subcutaneous injection once on treatment days 1 and 2. Then, the patients received a dose of 9×10<SUP>6</SUP> IU via subcutaneous injection once on treatment days 3, 4, and 5, followed by 2 days of rest. The primary end point was the objective response rate; the secondary end points were progression-free survival (PFS) and safety. Results: Overall, 22 patients were included in the final per-protocol analysis. The objective response and the disease control rates were 13.64% (3 of 22), and 90.9% (20 of 22), respectively. The mean PFS was 5.55 months (95% confidence interval, 2.71–8.4). The proportion of patients who experienced a treatment-related grade 3 or 4 adverse event was 3.85% (1 of 26). There were no treatment-related deaths. Conclusions: In this study, the subcutaneous IL-2 monotherapy regimen demonstrated efficacy and safety comparable to those reported in previous studies of subcutaneous IL-2 monotherapy and was effective in Korean patients with metastatic RCC.

전립선암 환자에서 Leuprolide Acetate Depot (루피어<SUP>Ⓡ</SUP> 데포주 3.75mg)의 유효성과 안전성 평가를 위한 다기관 임상시험

김형진(Hyung-Jin Kim),유정현(Chong-Hyon Ryu),이영구(Yong-Goo Lee),김청수(Choung-Soo Kim),류수방(Soo-Bang Ryu),김법완(Bup-Wan Kim),장성구(Sung-Goo Chang),김세중(Se-Joong Kim),이현무(Hyun-Moo Lee),최한용(Han-Yong Choi),홍성준(Sung-Joon 대한비뇨기종양학회 2009 대한비뇨기종양학회지 Vol.7 No.1

정계정맥류로 인한 불임증에 대한 췌장성 Kallikrein의 효능

이희영,이상곤,김청수,이성원,Lee, Hee-Yong,Lee, Sang-Kon,Kim, Choung-Soo,Lee, Seung-Won 대한생식의학회 1986 Clinical and Experimental Reproductive Medicine Vol.13 No.2

It has been reported that oral kallikrein therapy exerts a favourable effect on sperm motility in asthenozoospermic patients. In order to evaluate the efficacy of kallikrein on asthenozoospermia, a total of 20 subfertile male patients with varicocele, whose sperm counts were less than $40{\times}10^6/ml$ and sperm motility was less than 30%, was subjected to this clinical study (Table 1). They were divided into 2 study groups: 1) Varicocelectomy group consisted of 10 patients with varicocele (grade II-III) who underwent varicocelectomy. 2) Kallikrein group was composed of 10 patients with varicocele (grade I) who were given kallikrein orally 600 KU (kallikrein unit) daily divided 3 times after meal for 3 to 9 months. Semen analyses were repeated twice before the study, once a month during the study and twice after the study. Effective results designate that sperm parameters improved more than 30% from the basical levels after varicocelectomy or kallikrein exposure. Sperm counts increased from $32.5{\times}10^5/ml$ to $45.5{\times}10^6/ml$ after varicocelectomy in 3 patients and sperm motility increased from 25% to 38.5% after varicocelectomy in 3 patients. Pregnancy occurred in 2 patients of 3 responders and 1 patient of 7 non-responders 3 to 6 months after varicocelectomy in Varicocelectomy group. Sperm motility increased from 28% to 40.2% after kallikrein treatment in 3 patients. Pregnancy occurred in 2 patients of the 3 responders in Kallikrein group (Tables 2-3). There were no significant changes in volume and morphology in Varicocelectomy group before after varicocelectomy and no significant changes in volume, counts, and morphology before and after kallikrein exposure. No remarkable side effects were noted with kallikrein treatment.

사람의 혈관간세포에서 고농도의 당에 의한 Monocyte Chemoattractant Protein-1(MCP-1) 의 발현 및 신호 전달 체계에 관한 연구

장상필(Sang Pil Chang),김청수(Choung Soo Kim),김명재(Myung Jae Kim),김순배(Soon Bae Kim),이상구(Sang Koo Lee),박정식(Jung Sik Park) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4

Infiltration of circulating monocytes into glomeruli has been implicated in the pathogenesis of glomerular injury in many human and experimental forms of glomerulonephritis. Monocyte chemoattractant pro- tein-l(MCP-l), a potent chemokine with considerable specificity for monocytes, can be up-regulated by various cytokines and growth factors in mesangial cells. Glomerular infiltration of monocytes has been reported in diabetic nephropathy as well. However, effect of high glucose on MCP-1 expression in hu- man mesangial cells has not been known well. We investigated the effect of high glucose on MCP-1 expression and its signal transduction pathway. Human mesangial cells were conditioned with glucose(5-60 mM) or mannitol chronically for up to 5 days. Expression of MCP-1 mRNA and protein was measured by Northern blot analysis and ELISA respectively. To examine the role of transcription factor AP- 1 or NF-κB, electrophoretic mobility shift assay(EMSA) was performed. Glucose induced MCP-1 mRNA expression in a time and dose dependent manner. MCP-1 protein in cell culture supemant was also increased. Equivalent concentrations of mannitol had no significant effect. EMSA revealed that glucose increased the AP-1 binding activity in a time and dose dependent manner but not NF-B. Inhibitor of AP-1, curcumin(7.5- 15 pM) dose dependently suppressed the induction of MCP-1 mRNA by high glucose. Tyrosine kinase inhibitors such as genistein(12.5-50 μM) and herbimycin A(0.1-1 μM) inhibited the high glucose-induced IvlCP-1 mRNA expression in a dose dependent manner and also suppressed the high glucose-induced AP-1 binding activity. In summary, high glucose induces mesangial MCP-1 expression partly via tyrosine kinase-AP-1 pathway.

부신 종양의 실제 크기와 전산단층촬영에서의 크기 비교분석

김한권(Han Kwon Kim),박창후(Chang Hoo Park),김성진(Sung Jin Kim),박창면(Chang Myeon Park),송기현(Ki Hyun Song),김청수(Choung Soo Kim),안한종(Han Jong Ahn),정현철(Hyun Chul Chung),송재만(Jae Mann Song),박종연(Jong Yeon Park) 대한비뇨기종양학회 2008 대한비뇨기종양학회지 Vol.6 No.3

침윤성 방광암의 예후인자

김우건(Woo Kun Kim),박영환(Young Hwan Park),이규형(Kyoo Hyung Lee),이정신(Jung Shin Lee),박태한(Tae Han Park),안한종(Han Jong Ahn),홍준혁(Jun Hyuk Hong),김청수(Choung Soo Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3

N/A Transitional cell carcinoma(TCC) of the bladder is confined to mucosa or submucosa on initial presentation. However, high grade superficial tumors tend to recur and progress to muscle invasive or metastatic diseases. Regardless of radical cystectomy in invasive bladder cancer, a poor prognosis was noted due to local recurrence and distant metastasis in recent studies. In this study, the clinical and pathological factors affecting survival of patients with muscle invasive bladder cancer were analyzed. Methods : A total of 105 patients with histopathologically verified muscle invasive bladder cancer who were admitted to Asan Medical Center between August 1989 and August 1998 were reviewed retrospectively. The clinical manifestations, laboratory findings, and histopathological findings at initial diagnosis were evaluated. Overall survival, disease free survival, and disease specific survival according to many prognostic factors were also analyzed. Results : The factors affecting overall survival of muscle invasive bladder cancer were age, sex, TNM stage, performance status, tumor size, invasion of deep bladder muscle, tumor grade, lymphovascular invasion, and complete resection of tumors. In patients with completely resected bladder cancer by radical cystectomy, tumor size, deep bladder muscle invasion, stage, and lymph node involvement were significant prognostic factors. In patients who had either incomplete resection of bladder cancer or in whom no operation was performed, the survival rate was lower in cases with lymph node involvement or hemoglobin level of less than 10 g/dl. Conclusion : After radical cystectomy, the recurrence rate appeared to be higher in solid tumors with deep bladder muscle invasion and lymphovascular invasion on cystoscopic findings. Overall survival was higher in patients with lower tumor stage, no lymph node involvement, and completely resected bladder cancer. Age and sex had no significant correlation with overall survival. No apparent survival advantage was noted in those patients who received post-operative chemotherapy. However, prospective randomized controlled studies are necessary to evaluate the benefit of adjuvant chemotherapy in muscle invasive bladder cancer. (Korean J Med 57:333-347, 1999)

신세포암 환자에서 수상돌기세포의 배양 및 신세포암 세포주에 대한 항암면역효과

정한(Han Chung),지영환(Young Hwan Ji),김청수(Choung-Soo Kim) 대한비뇨기종양학회 2003 대한비뇨기종양학회지 Vol.1 No.4

배양한 사람 사구체 내피세포의 Cytokine자극에 따른 접착 분자 및 HLA-DR 발현의 연구

박수길(Su Kil Park),양원석(Won Seok Yang),안한종(Han Jong Ahn),김청수(Choung Soo Kim),이종수(Jong Soo Lee),이재담(Jae Dam Lee) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.2

N/A Background: Glomerular endothelial cells should participate in the process of glomerular disease by expressions of HLA antigens and adhesion molecules. However, few have been known about the regulation of the expression of these molecules in human glomerular endothelial cells(HGEC). The aim of this study was to evaluate the expressions of VCAM-1, ICAM-1 and HLA-DR to see if there are any cytokine-dependent or time-dependent differences. Methods: HGEC were isolated and cultured from the normal portion of the kidneys removed due to renal cell carcinoma, which was confirmed by factor VIII and fluorescent-labeled acetylated LDL. The effects of cytokine on the cell surface expression of VCAM-1, ICAM-1 and HLA-DR were measured by ELISA. Results : ICAM-1 was increased by IL-1 α, TNF- β and IFN- γ. VCAM-1 was increased by IL-1 α and TNF- β, not by IFN- γ. IFN- γ only increased expression of HLA-DR. Basal expression of ICAM-1 was higher than VCAM-1 and HLA-DR. The time course of expression was different according to adhesion molecule. Conclusions : These data showed that the expression of adhesion molecules and HLA-DR in HGEC were regulated differentially by inflammatory and immune-regulatory cytokines.

방광전이를 보인 위암의 임상적 고찰

정성희(Sung Hee Jung),정훈용(Hwoon Yong Jung),김태원(Tae Won Kim),김청수(Choung Soo Kim),강경훈(Gyeong Hoon Kang),형철호(Chul Ho Hyung),명승재(Seung Jae Myung),양석균(Suk Kyun Yang),홍원선(Weon Seon Hong),김진호(Jin Ho Kim),민영일(Yo 대한소화기학회 2002 대한소화기학회지 Vol.39 No.3

Background/Aims: Metastatic urinary bladder cancer from a distant organ is unusual. The aim of this study was to analyze clinical characteristics of bladder metastases from stomach cancer. Methods: We reviewed the medical records of 14 patients with metastatic bladder cancer from stomach cancer who admitted at Asan Medical Center between June 1989 and April 2001. Results: The mean age was 47.8 (31-61) years. Nine patients were male and 5 patients female. Mean duration between diagnosis of metastatic bladder cancer and the onset of stomach cancer was 19.7 months (0-40). The most common symptom was hematuria (9 cases), followed by dysuria, frequency, and flank pain. Patients underwent CT scan, urine cytology, IVP, and cystoscopy to evaluate metastasis of the urinary bladder. The locations of metastatic urinary bladder cancer were lateral wall (n=4), dome (n=3), posterior wall (n=3), trigone and dome (n=1), uretero-vesical junction (n=1), and entire bladder (n=2). Three patients underwent transurethral resection and one patient took radical cystectomy. Mean survival duration was 5 months (2-11 months). Conclusions: When urologic symptoms newly develop in patients with stomach cancer, metastasis to the urogenital organs should be considered. (Korean J Gastroenterol 2002;39:173-178)

다기관 한국 전립샘 암 등록(KPCR) 데이터베이스를 이용한 근치적 전립샘 절제술의 수술 결과 비교

유성혜 ( Sung Hye Yu ),최문주 ( Mun Joo Choi ),김청수 ( Choung-soo Kim ),서성일 ( Seong Il Seo ),정창욱 ( Chang Wook Jeong ),변석수 ( Seok-soo Byun ),이지열 ( Ji Youl Lee ),홍준혁 ( Jun Hyuk Hong ),최인영 ( In Young Choi ) 한국보건정보통계학회(구 한국보건통계학회) 2018 보건정보통계학회지 Vol.43 No.3

목적: 전립샘암은 한국 남성에서 발병률이 급격히 증가하는 추세이다. 국소 전립샘암의 표준 치료로 근치적 전립샘 절제술이 시행되고 있으며 수술 기법은 개복, 복강경 그리고 로봇 수술로 나뉜다. 여러가지 수술 기법은 삶의 질, 경제적 측면, 수술 및 예후의 결과에서 차이가 있다. 이에 저자는 다기관 한국 전립샘 암 등록(KPCR) 데이터베이스를 이용하여 국소 전립샘 암 수술을 시행한 환자들의 결과와 예후에 대한 결과를 비교하고자 한다. 방법: KPCR 데이터베이스에는 5개 의료기관에서 수집한 6,032명의 데이터가 수집되어 있고 데이터의 무결성 보장을 위해 데이터 표준화 및 품질 관리를 시행하였다. KPCR 데이터베이스로부터 분석에 필요한 데이터를 추출하였다. 추출된 데이터는 2006년 1월부터 2011 년 12월까지 수집된 3,262명으로 최종 분석을 시행하였다. 이 데이터를 이용하여 수술 기법에 따른 국소 전립샘 암 환자의 인구학적 특성, 수술 결과 및 예후에 대해 분석하였다. 통계 분석방법은 one-way ANOVA, chi-square test, post-hoc 분석을 실시하였다. 무재발 생존율 분석을 위해 Kaplan-Meier와 multivariable Cox proportional hazard regression model을 통해 분석을 실시하였다. 결과: 분석 결과, 초기 전립샘 특이 항원치의 평균 값은 10.30 ng/mL이었다. 총 환자의 56.7%는 임상 병기 T2를, 43.3%는 병기 T1을 가지고 있었고 환자의 64.4%는 글리슨 스코어가 7 이상이었다. 절제면 양성률의 결과는 개복수술이 33.6%, 복강경 수술이 27.0%, 로봇수술이 28.8%로 나타났다(p <0.001). 로봇수술은 수술 후 합병증 및 예상 출혈량 결과에서 우수한 결과를 나타냈다. 5년 생화학 무 재발 생존율은 전체 환자에서 77.0%의 결과를 보였고 세 수술 기법은 임상 결과에 있어서 차이가 없었다. 또한 Cox 회귀분석 결과 세 수술기법은 생존율에 영향을 미치지 않았다. 결론: 본 연구결과는 국소 전립샘 암 환자의 예후와 특성을 설명한다. KPCR 데이터베이스를 통한 본 결과는 환자와 의료진의 올바른 의사 결정에 도움을 줄 것이라는 것을 보여준다. Objectives: Prostate cancer, commonly is rapidly increasing the incidence of prostate cancer among Korean men. Primary treatment of localized prostate cancer involves radical prostatectomy, and surgery techniques are divided into the abdominal, laparoscopic, and robotic surgery. Different surgical techniques differ in quality of life, economic aspect, and outcome of surgery and prognosis. Therefore we compared the outcomes and prognosis of patients who underwent surgery for localized prostate cancer using the multicenter Korean Prostate Cancer Registry (KPCR) database. Methods: The KPCR database collected data of 6,032 patients from five medical institutions, and data standardization and quality management were performed to ensure data integrity. We extracted data necessary for analysis from the KPCR database. We analyzed data for 3,262 patients during the period from January 2006 to December 2011. The demographic characteristics, surgical outcomes, and prognosis of patients with localized prostate cancer were analyzed. All statistical analyses were performed using one-way ANOVA, chi-square test, and post-hoc analysis. We used the Kaplan-Meier method and multivariable Cox proportional hazard regression model for biochemical recurrence-free survival rate (BCR-FS) analysis. Results: The analysis results showed that the average initial prostate specific antigen value was 10.30 ng/mL. A total of 56.7% of the patients had clinical stage T2, 43.3% had stage T1, and 64.4% of the patients had a Gleason score of more than 7. The rate of positive surgical margin was radical retropubic prostatectomy, laparoscopic radical prostatectomy, robotic-assisted laparoscopic radical prostatectomy (RALP) as 33.6%, 27% and 28.8%, respectively (p<0.001). The RALP gave excellent results for postoperative complication, and estimated blood loss (EBL). The 5-year overall BCR-FS was 77.0%, and the three surgical techniques did not differ in clinical outcomes. Cox regression analysis showed that the surgical technique did not affect the biochemical recurrence rate. Conclusions: Our study describes the characteristics of patients with localized prostate cancer and their prognosis. These results indicate that patients and medical staff can rely on information from the KPCR database for decision-making.