한국의 학교 검도의 도입 및 전개에 관한 연구 - 중,고등학교를 중심으로 -

김진휘,박귀순 한국체육학회 2015 전국체전기념 한국체육학회 학술발표회 Vol.2015 No.-

Adjuvant therapy in high-risk early endometrial carcinoma: a retrospective analysis of 46 cases

김진휘,이성종,배정훈,이성하,배석년,남궁성은,박종섭 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.4

Objective: We assessed the prognostic factors and the efficacy of adjuvant therapy and reviewed randomized studies carried out on patients receiving adjuvant therapy with early endometrial carcinoma. Methods: One hundred and five patients that received primary surgical treatment for stage IB, IC and II endometrial cancer were enrolled in this study. The clinical outcomes were compared among the patients with variable prognostic factors and adjuvant treatments. Results: One hundred and five patients fulfilled the eligibility criteria and 46 patients (43.8%) underwent adjuvant therapy. Disease recurrence occurred in nine patients within a median time of 24 months. Cervical involvement was an independent prognostic factor for the disease-free survival rates. Eight of 16 patients with FIGO stage II disease received adjuvant chemotherapy consisting of cisplatin and etoposide (or cyclophosphamide) or combined chemoradiation. The 5-year disease-free survival rate for these patients was 87.5%, a value significantly higher than for patients that received radiation therapy alone (30%). Conclusion: Adjuvant chemotherapy or combination chemo-radiotherapy might be superior to radiation therapy alone in high-risk early endometrial cancer patients. Objective: We assessed the prognostic factors and the efficacy of adjuvant therapy and reviewed randomized studies carried out on patients receiving adjuvant therapy with early endometrial carcinoma. Methods: One hundred and five patients that received primary surgical treatment for stage IB, IC and II endometrial cancer were enrolled in this study. The clinical outcomes were compared among the patients with variable prognostic factors and adjuvant treatments. Results: One hundred and five patients fulfilled the eligibility criteria and 46 patients (43.8%) underwent adjuvant therapy. Disease recurrence occurred in nine patients within a median time of 24 months. Cervical involvement was an independent prognostic factor for the disease-free survival rates. Eight of 16 patients with FIGO stage II disease received adjuvant chemotherapy consisting of cisplatin and etoposide (or cyclophosphamide) or combined chemoradiation. The 5-year disease-free survival rate for these patients was 87.5%, a value significantly higher than for patients that received radiation therapy alone (30%). Conclusion: Adjuvant chemotherapy or combination chemo-radiotherapy might be superior to radiation therapy alone in high-risk early endometrial cancer patients.

자궁내막암 수술시 임파절 전이의 예측인자로서 CA 125의 임상적 유용성

김진휘,이성종,임채춘,남궁성은 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4

목적 : 자궁내막암 환자에 있어서 골반 임파절 전이의 예측인자로 수술 전 CA 125 값의 유용성을 알아보고자 하였다. 연구 방법 : 1992년 10월부터 2002년 10월까지 가톨릭대학교 의과대학 강남성모병원에서 자궁내막암 진단하에 수술받은 환자 100명을 대상으로 의무기록을 토대로 수술전 CA 125와 임파절 전이유무의 관계를 살펴보았다. 통계적 방법으로는 만-휘트니 유 테스트와 카이 제곱 피셔 테스트를 사용하였다. 결과 : 수술 전 CA 125 값은 병기가 증가함에 따라, 자궁근층을 1/2 이상 침범한 경우, 자궁경부나 부속기를 침범한 경우, 골반 임파절 전이가 있는 경우 유의하게 높게 측정되었다(p<0.05). 결론 : 수술 전 CA 125의 증가는 자궁내막암의 골반 임파절 전이를 예측하는데 있어 유용하다고 할 수 있다. Objective : The aim of this study is to evaluate the clinical usefulness of preoperative CA 125 levels in determining the need for lymphadenectomy in patients with endometrial carcinoma. Methods : CA 125 levels were measured in 100 patients diagnosed with endometrial carcinoma who underwent surgery at Kangnam St. Mary's Hospital between October 1992 and October 2002. Statistical analysis was performed using the Mann-whitney U test and x-Fisher's exact test. Results : Univariate analyses showed that elevated CA 125 levels were significantly correlated with an advanced stage, increasing depth of myometrial invasion, cervical invasion, adnexal involvement, high grade hystology and lymph node metastases (p<0.05). Conclusion : Our data provide an evidence that the elevation of preoperative CA 125 levels can be considered as a predictor for full pelvic lymphadenectomy in the surgical staging of endometrial cancer.

Can human papillomavirus testing predict residual/recurrent disease in patients with positive margins after LEEP?

김진휘,박태철 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: The purpose of this study was to evaluate the efficacy of human papillomavirus (HPV) testing during follow-up of patients with positive margins after loop electrosurgical excision procedure (LEEP) as a predictive factor for residual/recurrent disease. 방법: We retrospectively analyzed the medical data of patients who were treated using LEEP between January 1, 2000 and December 30, 2015. Post-LEEP follow-up was performed by liquid base Pap smear and HPV genotyping real-time PCR or DNA chip test. Residual/recurrent disease was defined as cytology of atypical squamous cells of unknown origin (ASC-US) or worse without a histology, or low grade squamous intraepithelial lesion (LSIL) histology or worse, at 4months or 12months after LEEP was performed. 결과: A total of 1,509 LEEPs were performed during the study period, and of these 1,263 patients with LSIL histology or negative surgical margin were excluded. Among the remaining 246 patients, 191 (77.6%) did not require any additional treatment (observation group) and 55 (22.4%) received re-operation. During follow-up, 59 patients (31%) had residual/recurrent disease in the observation group. Positive high-risk HPV testing at 4months after LEEP was significantly associated with residual/recurrent disease (relative risk 2.25; 95% confidence interval 1.55–3.80; p<0.05). 결론: HPV genotyping real-time PCR at 4months after LEEP might be a useful tool in the selection of patients requiring closer surveillance and in reducing the number of reoperation in patients with positive margins after LEEP.

이상치 탐색을 위한 통계적 방법

김진휘 건강보험심사평가원 2020 HIRA 정책동향 Vol.14 No.1

자궁내막증식증의 진단과 치료

김진휘 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary

김진휘,김태정,박용규,이성하,이정원,송민종,이근호,허수영,배석년,박종섭 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.3

Objective: We have assessed the accuracy of frozen section diagnosis and the outcomes of misdiagnosis in borderline tumors of the ovary (BTO) according to frozen section. Methods: All pathology reports with BTO in both frozen and permanent section analyses between 1994 and 2008 at Seoul St. Mary’s Hospital were reviewed. Frozen section diagnosis and permanent section histology reports were compared. Logistic regression models were conducted to evaluate the correlation of patient and tumor characteristics with diagnostic accuracy. The clinical outcomes of misdiagnosis were evaluated. Results: Agreement between frozen section diagnosis and permanent histology was observed in 63 of 101 patients (62.4%). Among the 76 patients with frozen section proven BTO, under-diagnosis and over-diagnosis occurred in 8 of 76 (10.5%) and 5 of 76 patients (6.6%), respectively. Mean diameter of under-diagnosed tumor was larger than matched BTO (21.0±11.4 vs. 13.7±7.1; p=0.021). Tumor size 20 cm was determined as the optimal cut-off for under-diagnosis (50% sensitivity, 87.3% specificity). Among 8 under-diagnosed patients, no patient relapsed. Among 5 over-diagnosed patients, 2 patients < 35 years of age had fertility-preserving surgery. Conclusion: Although frozen section diagnosis is an important and reliable tool in the clinical management of patients with ovarian tumors, over-diagnosis and under-diagnosis are relatively frequent in frozen proven BTO. Surgical decision-making for BTO based on frozen section diagnosis should be done carefully, especially in large tumors. Objective: We have assessed the accuracy of frozen section diagnosis and the outcomes of misdiagnosis in borderline tumors of the ovary (BTO) according to frozen section. Methods: All pathology reports with BTO in both frozen and permanent section analyses between 1994 and 2008 at Seoul St. Mary’s Hospital were reviewed. Frozen section diagnosis and permanent section histology reports were compared. Logistic regression models were conducted to evaluate the correlation of patient and tumor characteristics with diagnostic accuracy. The clinical outcomes of misdiagnosis were evaluated. Results: Agreement between frozen section diagnosis and permanent histology was observed in 63 of 101 patients (62.4%). Among the 76 patients with frozen section proven BTO, under-diagnosis and over-diagnosis occurred in 8 of 76 (10.5%) and 5 of 76 patients (6.6%), respectively. Mean diameter of under-diagnosed tumor was larger than matched BTO (21.0±11.4 vs. 13.7±7.1; p=0.021). Tumor size 20 cm was determined as the optimal cut-off for under-diagnosis (50% sensitivity, 87.3% specificity). Among 8 under-diagnosed patients, no patient relapsed. Among 5 over-diagnosed patients, 2 patients < 35 years of age had fertility-preserving surgery. Conclusion: Although frozen section diagnosis is an important and reliable tool in the clinical management of patients with ovarian tumors, over-diagnosis and under-diagnosis are relatively frequent in frozen proven BTO. Surgical decision-making for BTO based on frozen section diagnosis should be done carefully, especially in large tumors.

A case of malignant transformation of mitotically active Leiomyoma after total hysterectomy

김진휘 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

열처리 온도 변화에 따른 Viscose Rayon계 탄소펠트의 전기적 특성 연구

김진휘,안병길,윤호규 한국고분자학회 2004 한국고분자학회 학술대회 연구논문 초록집 Vol.2004 No.04

응급의학과 전공의에 의한 장겹침증 초음파 검사는 가능한가?

김진휘,강보승,강형구,임태호,제상모,최혁중,박세훈 대한응급의학회 2012 大韓應急醫學會誌 Vol.23 No.5

Purpose: The aim of this study was to evaluate the sensitivity and specificity of ultrasonography of suspected ileocolic intussusception performed by emergency medicine (EM)residents who participated in a 2-hour focused ultrasound training program for intussusception. Methods: This was a 16-month retrospective, observational study. Pediatric patients with suspected ileocolic intussusception who underwent ultrasound performed by second or third year EM residents were included in the study. The gold standard was a diagnostic work-up performed by a radiologist or clinical follow-up, compared with the results of ultrasonography performed by EM residents. Results: A total of 38 patients were enrolled. The sensitivity of ultrasound performed by emergency medicine residents for prediction of ileocolic intussusception was 92.86% (66.13% to 99.82%), the specificity was 91.67%(73.00% to 98.97%), the positive likelihood ratio was 11.14(2.93 to 42.34), and the negative likelihood ratio was 0.08(0.01 to 0.52). Conclusion: Emergency residents can identify ileocolic intussusceptions with only minimal training, which could substitute for ultrasonography performed by radiologists when they are not immediately available.