용혈검체가 핵의학 검체검사 결과에 미치는 영향

김진태,이종필,이수빈,김동민,Kim, Jin-Tae,Lee, Jong-Pil,Lee, Soo-Bin,Kim, Dong-Min 대한핵의학기술학회 2021 핵의학 기술 Vol.25 No.1

용혈 검체는 혈액검사 결과에 영향을 미치는 요인 중 하나이다. 핵의학 분야 또한 용혈 검체를 부적합검체를 분류하고 채혈실에 재 채혈을 요구하기도 한다. 이는 신속한 검사를 진행해야 하는 검사실 입장에선 장애 요소이기도 하다. 그러나 진단검사의학에서는 용혈이 각 검사 종목에 미치는 영향이 많이 알려진 반면, 핵의학에서는 용혈이 얼마나 검사 결과에 영향을 미치는지 실험을 통해 알려진 바가 없어 알아보고자 한다. 먼저, 19명의 환자에서 한 명당 각2개의 검체를 획득하고, 하나는 정상적인 혈청을 얻고, 다른 하나는 인위적으로 용혈 혈청을 획득했다. 그리고 각 종목별(AFP, CEA, PSA, CA-125, CA19-9, Thyroglobulin, Prolactin, E2, Insulin, T3, T4, TSH, FT4, TG-Ab, Anti-TPO, TBII, LH, FSH, Testosterone, PTH, DHEA-s, Cortisol, C-peptide)로 검사를 실시 한 후, 용혈검체와 정상 검체간의 결과값을 t-test를 통하여 통계적으로 유의성을 확인해 보았다. 실험 결과 키트 내 매뉴얼에 용혈검체를 사용하지 않도록 한 검사 종목 뿐만 아니라 대부분의 종목에서 용혈이 핵의학 검사결과에 영향을 미치지 않음을 알 수 있었다. 그러나, 인슐린과 C-peptide의 경우에는 용혈검체가 정상검체에 비해 통계적으로 유의하게 나타났다(P<0.05). 검체의 수가 적어 모든 검사 결과에 일반화 시킬 수는 없으나, 모든 용혈 검체를 부적합 검체로 간주하여 재채혈을 요구할 필요가 없음 또한 확인되었다. 그러므로 복잡한 핵의학 검사실의 접수 업무 개선에 도움이 될 것이라 생각된다. Purpose In nuclear medicine blood tests, hemolysis samples are considered as inappropriate sample and are recommended not to be used for blood test. So, the lab are required to collect the blood again in the blood collection room However, The effect of hemolyzed samples on radioimmunoassay has not studied yet. This study was designed to evaluate effects of hemolysis on radioimmunoassay. Materials and Methods The kit manuals of 23 test items were reviewed to confirm whether hemolyzed samples were used. The subjects were 19 general applicants(male : 9, female : 13) and the samples were collected by each two SST tubes, one tube was obtained by centrifugation normally, and the other was obtained hemolyzed sample by centrifugation after external shock. It has been known that highly hemolyzed samples can affect the test results, so the test was performed using the severe hemolyzed sample. The test was performed for each test item using 23 normal serum and hemolysis serum, and SPSS19 program was used for statistical comparison of the test result. Results There was no significant difference between normal serum and hemolysis serum in 21 of 23 test items, but the results of insulin and C-peptide were significantly different(P<0.05). Conclusion It has been known that hemolysis in blood samples can affect the results of biochemical and hematological test, However, hemolysis effect is relatively low. Similarly, this study showed that hemolysis had not much effect on most of immunological radioimmunoassay except for some tests. Therefore, it is thought that the demand for re-collection due to hemolysis will be reduced in the laboratory, which will improve the work process of the laboratory.

Divinyl Sulfone으로 가교된 히알루론산 마이크로비드의 특성평가

김진태,이득용,장주웅,김태형,장용운,Kim, Jin-Tae,Lee, Deuk Yong,Jang, Ju-Woong,Kim, Tae-Hyung,Jang, Yong-Wun 대한의용생체공학회 2013 의공학회지 Vol.34 No.3

Hyaluronic acid(HA) microbeads were synthesized by dropping the sodium hyaluronate(Streptococcus) solutions in NaOH into a solution mixture of divinyl sulfone(DVS) in 2-methyl-1-propanol, followed by stirring, cleaning and drying process at room temperature. The initial experimental conditions are crosslinking time(CLTi) of 5 h, crosslinking temperature(CLTe) of room temperature, injection air pressure(IAPr) of 5 psi, and DVS concentration( DVSc) of 0.2 vol%, respectively. Then, parametric studies were performed by varying the parameters to investigate the morphology, the porosity, the swelling ratio and the size of the beads. The microbead size pattern was not regular to function of the degree of crosslink. It was observed that the swelling ratio, the degree of crosslink, and the pore size can be controlled by adjusting the CLTi, CLTe and DVSc. Among the parameters investigated, the smallest bead size can be achieved by varying the CLTi parameter. The lowest swelling ratio, as an indication of the highest degree of crosslink, can be obtained by varying CLTe.

ESS 안전성 개선을 위한 결로 운전 조건 고려 고체절연물 연면 절연파괴특성 분석

김진태,이승용,김지영,석복렬,Kim, Jin-Tae,Lee, Seung-Yong,Kim, Ji-young,Seok, Bok Yeol 한국전력공사 2021 KEPCO Journal on electric power and energy Vol.7 No.2

As the large-scale renewable energy power plant increases, the high-capacity and compact Energy Storage System (ESS) is required. However, this trend could reduce the insulation reliability of ESS. In this study, the surface flashover characteristics for four types of solid insulators are investigated in the uniform electric field with AC and Lightning Impulse (LI) voltage waveforms under various contamination levels. In addtion, insulator surfaces are compared based on the contact angle before and after surface flashover. The experimental results show that AC flashover voltage is dependent on the materials and the contamination level, but LI flashover voltage is only associated with the contamination level. Especially, AC flashover voltage of PC (PolyCarbonate) is higher than that of other insulators, which is associated with the unique and sequential creepage discharge propagation pattern of PC. The localized discharges on the surface of PC form corresponding tracking points. Then, the interconnected trackings result in the complete flashover. This flashover patterns degrade the surface of PC much more than that of epoxy and Bulk Molding Compoud (BMC). Thus, the contact angle of PC is significantly reduced compared to that of other insulators. The increased hydrophilicity in the surface of PC enhances the insulator surface conductivity.

인체 삽입용 LC 공진형 혈압 센서 디자인 및 제작

김진태,김성일,정연호,Kim, Jin-Tae,Kim, Sung Il,Joung, Yeun-Ho 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.3

In this paper, we present a MEMS (micro-electro-mechanical system) implantable blood pressure sensor which has designed and fabricated with consideration of size, design flexibility, and wireless detection. Mechanical and electrical characterizations of the sensor were obtained by mathematical analysis and computer aided simulation. The sensor is composed of two coils and a air gap capacitor formed by separation of the coils. Therefore, the sensor produces its resonant frequency which is changed by external pressure variation. This frequency movement is detected by inductive coupling between the sensor and an external antenna coil. Theoretically analyzed resonant frequency of the sensor under 760 mmHg was calculated to 269.556 MHz. Fused silica was selected as sensor material with consideration of chemical and electrical reaction of human body to the material. $2mm{\times}5mm{\times}0.5mm$ pressure sensors fitted to radial artery were fabricated on the substrates by consecutive microfabrication processes: sputtering, etching, photolithography, direct bonding and laser welding. Resonant frequencies of the fabricated sensors were in the range of 269~284 MHz under 760 mmHg pressure.

그래핀 기반 광소자

김진태,최춘기,Kim, Jin-Tae,Choe, Chun-Gi 한국광학회 2012 광학과 기술 Vol.16 No.2

실시간 맥박 및 혈압 측정을 위한 폴리머 기판 압력센서 개발

김진태,김성일,정연호,Kim, Jin-Tae,Kim, Sung Il,Joung, Yeun-Ho 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.9

In this study, we introduce a polymer(polyimide) based pressure sensor to measure real-time heart beat and blood pressure. The sensor have been designed with consideration of skin compatibility of material, cost effectiveness, manufacturability and wireless detection. The designed sensor was composed of inductor coils and an air-gap capacitor which generate self-resonant frequency when electrical source is applied on the system. The sensor was obtained with metalization, etching, photolithography, polymer adhesive bonding and laser cutting. The fabricated sensor was shaped in circular type with 10mm diameter and 0.45 mm thickness to fit radial artery. Resonant frequencies of the fabricated sensors were in the range of 91~96 MHz on 760 mmHg pressurized environment. Also the sensor has good linearity without any pressure-frequency hysteresis. Sensitivity of the sensor was 145.5 kHz/mmHg and accuracy was less than 2 mmHg. Real-time heart beat measurement was executed with a developed hand-held measurement system. Possibility of real-time blood pressure measurement was showed with simulated artery system. After installation of the sensor on skin above radial artery, simple real blood pressure measurement was performed with 64 mmHg blood pressure variation.

뇌종양 확산강조영상에서 High B-value의 유용성 평가

김진태,변재후,박용성,이래곤,황선광,Kim, Jin-tae,Byun, Jae-Hu,Park, Yong-Seong,Lee, Rae-Gon,Hwang, Seon-Kwang 대한디지털의료영상학회 2015 대한디지털의료영상학회논문지 Vol.17 No.1

This study attempts to examine the clinical usefulness of High b-value DWI (diffusion weighted imaging) for brain tumors with an edema. Subjects were seven patients selected from 65 patients who received an MRI scan for suspected encephalopathy and confirmed diagnosis at our hospital from February to July 2015 (male: 7, average age : 66 years old). As test equipment, 3.0T MR System (ACHIEVA Release, Philips, Best, The Netherlands) and 8Channel SENSE Head Coill were used. DWI checks on the use of the variable TR 5460ms, TE 132ms, Slice Thickness 4mm, gap 1mm, Slice number 29 is, 3D T1WI is TR 8.4ms, TE 3.9ms, matrix size $240{\times}240$, Slice can set 180 piecesIt was. b value of 0, 1,000, 2,000 s/mm2 with DWI acquisition and 3D T1WI enhancement five minutes after the Slice Thickness 3mm, gap 0mm to reconstruct the upper face axis (MPR TRA CE) was. As for the experiment, in b-value 1,000 and 2,000 images, SNR and the lesion at the lesion site and CNR in the normal site opposite to the lesion are measured. WW(window width) and WL(window level) are made equal in MRICro software, and the volume of the lesion is measured from each of b-value and MPR TRA CE image. Using SPSS ver. 1.8.0.0 Mann Whitney-test was analyzed for SNR and CNR, while Kruskal-Wallis test was analyzed for volume.

낭성 변화없이 하악과두로 이동한 하악 제3대구치

김진태,조명철,전국진,박광호,허종기,Kim, Jin-Tae,Cho, Myung-Chul,Jeon, Kug-Jin,Park, Kwang-Ho,Huh, Jong-Ki 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2

Impacted third molars of the mandible are generally found at or close to the second molar. If the third molar is impacted far distant from its original site, it may be affected by cysts or tumors. Ectopic impaction of third molar in the condyle area is very rare. Furthermore, impaction without cystic lesion is even less common. The etiology of migration of the mandibular third molar without cystic lesion is unknown. So periodical X-ray taking is essential.

우리나라 사색신호등 문제점 및 방향별 삼색전용신호등으로 전환 (교통운영체계선진화 일환으로)

김진태,황창선,김영한,나성수,이재준,Kim, Jin-Tae,Hwang, Chang-Sun,Kim, Young-Han,Na, Sung-Soo,Lee, Jae-Joon 대한교통학회 2010 교통 기술과 정책 Vol.7 No.2

유치(乳齒) 치근(齒根) 흡수(吸收)에 관(關)한 연구(硏究)

김진태,Kim, Jin-Tae 대한소아치과학회 1977 大韓小兒齒科學會誌 Vol.4 No.1

178 naturally exfoliated maxillary deciduous central incisors, 149 deciduous lateral incisors of children at exfoliation stage were studied on the degree and the tendency of the root resorption, and the age of exfoliation of the deciduous central and lateral incisors. The results were as follows; 1. The root of maxillary deciduous central and lateral incisors tended to be resorbed disto-lingually. 2. The age of exfoliation of maxillary deciduous central incisor was 7.27 year in male, 7.01 year in female, and the age of exfoliation of maxillary deciduous lateral incisor was 8.22 year in male, 7.77 year in female. 3. The exfoliation age of maxillary deciduous central and lateral incisors was earlier in female than in male.