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김진철,Juyong Kim,Sangwoo Seo,Jung Han Yoon Park,Ki Won Lee,Jiyoung Kim 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.5
Transient receptor potential vanilloid 1 (TRPV1) protein is a Ca2+-permeable non-selective cation channel known for its pain modulation pathway. In a previous study, it was discovered that a triple-transgenic Alzheimer’s disease (AD) mouse model (3xTg-AD+/+) has anti-AD effects. The expression of proteins in the brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB) pathway in a 3xTg-AD/TRPV1 transgenic mice model was investigated to better understand the AD regulatory effect of TRPV1 deficiency. The results show that TRPV1 deficiency leads to CREB activation by increasing BDNF levels and promoting phosphorylation of tyrosine receptor kinase B (TrkB), extracellular signal-regulated kinase (ERK), protein kinase B (Akt), and CREB in the hippocampus. Additionally, TRPV1 deficiency-induced CREB activation increases the antiapoptotic factor B-cell lymphoma 2 (Bcl-2) gene, which consequently downregulates Bcl-2-associated X (Bax) expression and decreases cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), which leads to the prevention of hippocampal apoptosis. In conclusion, TRPV1 deficiency exhibits neuroprotective effects by preventing apoptosis through the BDNF/CREB signal transduction pathway in the hippocampus of 3xTg-AD mice.
김진철,김창길,Kim, Jin-Cheol,Kim, Chang-Gil 대한산업경영학회 2021 산업융합연구 Vol.19 No.4
본 연구는 일반고 학생들의 희망, 그릿, 학교행복의 관계를 알아보고자 희망과 그릿의 군집별 학교행복 차이를 알아보았다. 세종시 ㅂ고 2, 3학년 282명 자료를 상관분석과 군집분석(cluster analysis)을 했다. 연구결과, 희망과 그릿 및 학교행복 간에 긍정적인 상관관계가 있고 희망 주도사고와 그릿 노력지속성 간 상관관계가 높았다. 다음으로, 희망과 그릿의 하위변인은 4개 군집으로 나타났다. 학교행복은 '높은 심리자본' 집단이 가장 높고, '높은 주도사고'와, '높은 경로사고'는 차이가 없으며, '낮은 심리자본' 이 가장 낮았다. 연구결과, 일반고 교육과정에 주도사고와 노력지속성이 반영되어야 함을 확인할 수 있었다. 또한, 앞으로 실제적 측정을 위한 설문지 개발 등을 제안하였다. The purpose of the study is to find out the difference between high school students' hopes and the school happiness of each cluster of grits. Method: 282 high students' responses were analyzed through correlation analysis and cluster analysis. Results: First, There is a positive correlation between hope and grit and school happiness. Second, Hope and Grit appeared in four clusters. School happiness had the highest "high psychological capital" group and the lowest "low psychological capital. Conclusion: It was discussed that the agency thinking and effort perseverance of grit should be reflected in the curriculum of general high schools. In addition, we propose to develop questionnaires for practical measurements.
라식 수술 후 압평안압계와 비접촉성 안압계 측정치간 큰 차이를 보인 1예
김진철,정태영,기창원.Jin Chul Kim. M.D.. Tae Young Chung. M.D.. Chang Won Kee. M.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.6
Purpose: To report the case of a glaucoma patient with a history of LASIK surgery who presented with a wide discrepancy in intraocular pressure between the Goldmann applanation tonometry and non-contact tonometry. Methods: A 20-year-old male glaucoma patient was referred to our clinic with a chief complaint of blurred vision in his right eye. The patient had a history of uneventful bilateral LASIK surgery. Upon our initial examination, his best-corrected visual acuity in the right eye was 0.04 and his right eye IOP was 14 mmHg by Goldmann applanation tonometry and 40 mmHg by non-contact tonometry. A slit lamp examination showed corneal epithelial edema with diffuse interface opacities. The central corneal thickness in the right eye was 587 ?m. An ultrabiomicroscopy demonstrated an interface fluid accumulation between the LASIK flap and the stromal bed. The patient was diagnosed with juvenile open-angle glaucoma and was scheduled for a trabeculectomy. Results: Seven days after trabeculectomy, the patient`s vision in the right eye improved to 0.7 and his IOP was 12 mmHg by Goldmann applanation tonometry and 14 mmHg by non-contact tonometry. In addition, the corneal epithelial edema, interface opacities, and fluids had all resolved and the central corneal thickness was reduced to 489 ?m. Conclusions: In eyes that have undergone LASIK surgery, the IOP measured by Goldmann applanation tonometry may underestimate the true pressure due to fluid accumulation under the LASIK flap. In such cases, non-contact tonometry can be a convenient and a reliable method for determining treatment plan.
김진철,최성봉,김정훈,Kim, Jin-Cheol,Choe, Seong-Bong,Kim, Jeong-Hun 통신위성우주산업연구회 2003 Joint Conference on Satellite Communications Vol.2003 No.-
2008 년에 발사예정인 국내최초 정지궤도 복합위성인 통신해양기상위성은 한국항공우주연구원에서 시스템 및 본체, 기상/해양탑재체, 지상국 개발을 담당하고 있다. 통신해양기상위성에 대한 시스템 및 본체의 개념설계와 기술요구사항을 수립하였다. 수립된 시스템요구사항(안)은 통신/해양/기상의 다목적임무를 수행하는 통신해양기상위성 설계의 초안을 제공하였다. 위성버스서브시스템 및 지상국에 대하여 개념설계 및 기술요구사항에 관한 분석을 수행하였다. 본 선행연구의 결과는 향후 통신해양기상위성의 시스템 초기 설계에 중요한 기초자료가 될 것이다. The first multi-functional geosynchronous satellite in Korea, COMS(Communication, Ocean and Meteorological Satellite), is planned to launch in 2008. KARI, the leading organization of COMS program, is charged with the satellite systems, bus, meteorological/ocean sensor, and ground station development. In the initial phase of the COMS program, a conceptual design of the satellite system and bus is achieved as well as the establishment of technical requirements. The set-up of the system requirements(draft) of the COMS is outlined the realize the multi-missions of communication, ocean and meteorology. Such as satellite bus subsystems and ground station systems, the conceptual design and technical requirement analysis are performed for those space and ground segments, the conceptual design and technical requirement analysis are performed for those space and ground segments, Results obtained from these preliminary studies of the COMS program play an important role in the initial system design of the COMS.
김진철,함돈일,Jin Chul Kim,Don Il Ham 대한안과학회 2009 대한안과학회지 Vol.50 No.1
Purpose: To investigate the clinical characteristics and treatment of intermediate uveitis under new diagnostic standards. Methods: Medical records of patients diagnosed with pars planitis or intermediate uveitis were followed for more than 6 months, and retrospectively reviewed. Results: A total of 90 patients and 117 eyes were enrolled in the study. The mean age was 40.1 years, and the mean follow-up period was 43.0 months. Thirty percent of cases were bilateral. The most common initial symptom was decreased visual acuity. Snowbank was detected in 39.3%, snowballs in 15.4%, vitritis in 96.6%, and vasculitis in 56.4%. Common complications includedcystoid macular edema (57.3%), cataracts (43.6%), and epiretinal membrane (36.8%). Therapies included topical steroids (82.9% of cases), posterior sub-Tenon steroid injection (45.3% of cases), systemic steroid administration (67.8% of cases), and immunosuppressants (28.7% of cases). Vitrectomy was performed in 11.1% of patients due to complications such as epiretinal membrane and traction retinal detachment. The mean initial and final visual acuities were 0.67 and 0.74, respectively. Conclusions: The patients in this study experienced various courses of symptoms that required different treatment plans. Future investigations may corroborate these results.