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        중이 및 유양동 수술 후 발생한 지연성 안면신경 마비

        김중강,이상윤,남성일,신승진,최종원,김동은,박연호,안병훈 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.3

        Background and Objectives:The purpose of this study was to provide posible causes and post-treatment prognosis of delayed facial nerve palsy (DFP) following middle ear and mastoid surgery. Subjects and Method:The medical records of 3787 cases of middle ear and mastoid surgery from June, 1980 to August, 2003 were retrospectively reviewed. Nine cases developed ipsilateral facial nerve palsy after 72 hours of surgery. Their age ranged from 20 to 67 years (the mean of 40 years old and the male:female ratio of 1:1.25). For the review of the chart, we checked preoperative midle ear and mastoid state, intraoperative findings, clinical features of development and recovery of facial nerve palsy. To evaluate the degre and the possibility of recovery of facial nerve palsy, the House-Blackman grading system was used and electrophysiologic studies (Maximal stimulation test, Nerve excitability test and Nerve conduction velocity test) were performed. The steroid and vasodilator drugs were prescribed for the treatment. Results:All of the nine patients had preoperative diagnosis of chronic otitis media and five of them also had choles-teatoma. Radical mastoidectomy was done in two cases, open cavity techniques in two cases and closed cavity techniques in five cases. There were postoperative wound infections in five cases. Facial palsy was developed betwen 5th and 16th postoperative day (mean 9th day) and the initial House-Blackman grade was II or III. The time for complete recovery ranged from 1 month to 6 months, with the fastest recovery time being 9 days after DFP. Conclusion:DFP following middle ear and mastoid surgery is an unpredictable complication. Postoperative wound infection may have been related to it and should be regarded as a risk factor of DFP.

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        Cisplatin에 의해 유도된 이독성에 대한 Melatonin의 효과

        김중강,박선호,남성일,장은주,문교철,김상표 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.10

        Background and Objectives:Cisplatin (CP), an antitumor agent widely used in the treatment of head and neck cancers, has side effects such as ototoxicity and nephrotoxicity. These side effects are closely related to oxidative stress. In the present study, we attempted to suppress CP-induced ototoxicity in rats by administering melatonin, an antioxidant. Materials and Method: Male Sprague-Dawley rats were divided into different groups and were treated as follows:1) saline control, 2) CP (16 mg/kg, i.p.), 3) CP plus melatonin (10 mg/kg, i.p.). The rats were sacrificed at the 6th day after CP treatment. Results:CP-treated rats showed increase in cochlear malondialdehyde, hydrogen peroxide, glutathione peroxidase and glutathione reductase levels, and the decrease in cochlear superoxide dismutase (SOD) and catalase levels. CP-treated rats showed markedly decreased in the number of stereocilia on the inner hair cells and mildly decreased in the number of outer hair cells in organ of Corti under the light and scanning electron microscopic examination. Light and electron microscopic findings, and cochlear hydrogen peroxide, malondialdehyde, SOD, catalase, glutathione peroxidase and glutathione reductase levels were restored in the rats injected with CP plus melatonin than those with CP alone. Conclusion:These results suggest that melatonin suppresses CP-induced ototoxicity via the suppression of the increased production of reactive oxygen species. (Korean J Otolaryngol 2003;46:808-14)

      • 一部 農村主民들의 高血壓症에 관한 疫學的 硏究

        金重剛 慶北大學校 醫科大學 1979 慶北醫大誌 Vol.20 No.2

        農村住民들의 高血壓 有病率과 高血壓에 影響을 미치는 諸要因과의 相關關係를 究明하기 위하여 1978年 3月부터 12月 까지 10個月間 慶北 慶山郡의 30歲이상 住民 1,505名을 對象으로 調査하였다. 本 調査에서는 年齡, 生活程度, 體重, 喫煙, 飮酒, 調味料 攝取程度, 尿蛋白 및 家族歷등의 因子를 設定하여 各各의 高血糖 有病率을 調査比較하였다. 그 成績을 要約하면 다음과 같다. 1. 總對象者 1, 505名中 收縮期 高血壓者는 150mmHg를 기준했을 때 16.5%(249名)였고 160mmHg인 경우 10.2%(145名)였다. 擴張期 高血壓者는 90mmHg를 기준 했을 때 30.1%(452名)였고 100mmHg인 경우 12.1%(181名)였다. 收縮期 및 擴張期 血壓을 綜合한 高血壓者는 150/90mmHg를 기준 했을 때 12.7%(190名) 였고 160/95mmHg인 경우 7.0%(105名)였다. 2. 年齡의 增加에 따라 高血壓 有病率은 增加하는 경향을 나타내었다. 3. 生活程度와의 關係에서 男子는 生活水準이 낮은 群에서 高血壓 發生頻度가 높았으나 女子는 生活水準에 比例해서 높은 경향이었다. 4. 體重과의 관계에서 男子는 關連性을 인정할 수 없었으나 女子는 體重에 比例해서 有病率이 높았다. 5. 喫煙群이 非喫煙群보다, 飮酒群이 非飮酒群보다 高血壓有病率이 높았다. 6. 짜게 먹는다는 群은 싱겁게 먹는다는 群보다 擴張期 血壓 100mmHg를 기준으로 했을 때 高血壓 有病率이 높았으며 맵게 먹는다는 군은 맵지 않게 먹는는 群보다 그 率이 낮았다. The present study was conducted to investigate the prevalence of hypertension and the relationship between hypertension and several related factors; age, body weight, habits of smoking and drinking, intake amount of salt and pepper, proteinuria, family history and socio-economic status. The subjects were 1,505 of rural residents over the age of 30 years in Kyungsan Gun, Kyungsang Pook Do. And it was performed through ten months from March to December, 1978. The results obtained are summarized as follows. In considering systolic blood pressure only, the prevalence rate of hypertention was 16.5% (249 cases) in the level of 150mmHg or more and 10.2% (145 cases) in the level of 160mmHg or more. And the diastolic only, the rate was 30.1% (452 cases) in 90mmHg or more, and 12.1% (181 cases) in 100mmHg or more, In considering both systolic and diasolic blood pressures, the rate was 12.7% (190 cases) in the level of 150/90mmHg or more, and 7.0% (105 cases) in 160/95mmHg or more. The prevalence was gradually increased by aging and increasing amount of alcohol, pepper and salt-intake. It was significant to weight gain in female but not in male. And it was prevalent in lower economic class in male but in upper economic class in female, and also prevalent in those who had family history of hypertensive diseases. Among the proteinuria cases, hypertension was revealed higher in rate compared with normal group.

      • 肝吸蟲被囊幼蟲에 對한 1,4-bic-trichloromethylenbenzol의 豫防的 效果

        金重剛,李性寬 慶北大學校 醫科大學 1978 慶北醫大誌 Vol.19 No.2

        간흠충증의 예방적 화학요법을 실험하기 위하여 아직 완전 성충이 도지 않은 간흡충피낭유충에 감염된 토끼를 대상으로 감염 직후, 1주일 후 그리고 2주일 후에 각각 체중 1kg당 100mg의 Hetol을 5일간 계속하여 투여한 결과 충란검사(EPG)상 모든 실험군에서 대조군과 별 차이가 없었으며 따라서 Hetol이 간흡충증의 예방적 약제로서는 효과가 없음을 확인하였다. Rabbits experimetally infaected with metacercaria of Clonorchis sinesis were treated with a dose of 100mg per kg body weight of 1, 4, -bis-trichloromethylenbenzol (Hotol) for five consecutive days at various periods after infection, and the curative effect of the drug was studied comparatively. The number of eggs per gram of feces(EPG) was observed in the treated rabbits and control rabbits. There was no difference in the number of eggs discharged in the foollowing three experimedtal groups of rabbits compared with that of the control group; the group in which the drug was administered simultaneously with the infection, the group in which the drug was administered one week later and the group in which the drug administered two weeks later.

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