백색광 LED를 사용한 독서등의 최적 색온도에 따른 사람의 시력 변화 연구

김주현,장원범,이석환,정광교,김동현,김정미,류재준,문성득,이승현,고영수,허산,장미나,정창호,장지호,Kim, Juhyun,Chang, Wonbeom,Lee, Seokhwan,Jung, Kwangkyo,Kim, Donghyun,Kim, Jeongmi,Ryu, Jaejun,Moon, Seongdeuk,Lee, Seunghyun,Ko, Youngsu,Huh, Sa 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.1

White light emitting diode (LED) determined the most appropriate color temperature in reading lighting evaluated fatigue degree of eye according to color temperature. The eye fatigue degrees are determined by brightness and color temperature. Therefore, we measured the results of eyes test according to the change of color temperature and brightness. Experiments except for astigmatic corrected visual acuity of 0.8 more and age 20 to 25 years old, male and female college students was conducted in 100 patients. And constant illumination conditions, visual acuity was measured by varying the color temperature. The optometry at 10 minutes in the darkroom adapted eye. And then the temperature of $25{\pm}3$ degrees, the humidity was carried out at $50{\pm}5%$. As a result of typical color temperature of white light (5,600 K) has identification of the readability.

타이탄의 고분산 스펙트럼

김주현,김상준,김강민,심채경,손동훈,KIM JOO HYEON,KIM SANG JOON,KIM KANG-MIN,SIM CHAE KYUNG,SON DONG HOON 한국천문학회 2004 天文學論叢 Vol.19 No.1

We have carried out the high-resolution spectroscopic observations of Titan using BOES (Bohyunsan Echelle Spectrometer) to establish a standard spectral atlas of Titan. The observations were made on November 3, 4, 16 and 17, 2003 using a 300 11m fiber optics with a spectral resolving power of 30,000. The spectral atlas will be served as a reference for the future spectroscopic researches of Titan and other planetary objects. We were able to confirm $CH_4$ absorption lines of the Kuiper bands, and find unidentified lines near $7500{\AA}$.

Complete genome sequence of Lactobacillus koreensis 26-25, a ginsenoside converting bacterium, isolated from Korean kimchi

김주현,류청매,스리니바산 사티야라지,김명겸,김상용,위지향,임완택,Kim, Ju-Hyeon,Liu, Qing-Mei,Srinivasan, Sathiyaraj,Kim, Myung Kyum,Kim, Sang Yong,Wee, Ji-Hyang,Im, Wan-Taek The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.4

A Gram-positive, rod-shaped, ivory colored, and motile, Lactobacillus koreensis 26-25 was isolated from Korean kimchi. Strain 26-25 showed the ability of conversion from major ginsenosides into minor ginsenosides for which whole genome was sequenced. The whole genome sequence of Lactobacillus koreensis 26-25 consisted of one circular chromosome comprised of 3,006,812 bp, with a DNA G + C content of 49.23%. The whole genome analysis of strain 26-25 showed many glycosides hydrolase genes, which may contribute to identify the genes responsible for transformation of major ginsenosides into minor ginsenosides for its high pharmacological effects. 김치로부터 분리한 Lactobacillus koreensis 26-25 균주의 유전체서열을 분석하였다. 균주 26-25의 유전체는 G + C 비율이 49.23%이며, 2,720개의 유전자와 2,556개의 단백질 코딩 유전자, 85개의 위유전자 그리고 78개의 RNA 유전자를 포함한 단일 원형 염색체로 구성되었으면 그 크기는 3,006,812 bp였다. 균주 26-25는 인삼사포닌의 당 분해에 관여하는 여러 타입의 글라이코시다제 유전자를 가지고 있었다. 이러한 지놈 분석은 주요 진세노사이드가 우수한 약리학적 활성의 미량 진세노사이드로 전환하는데 관여하는 유전자 특징을 이해하는데 큰 기여가 되었다.

한국인에서의 사이트린 결핍증의 경험

김주현,김구환,유한욱,Kim, Ju-Hyun,Kim, Gu-Hwan,Yoo, Han-Wook 대한유전성대사질환학회 2006 대한유전성대사질환학회지 Vol.6 No.1

Citrin deficiency resulting from mutations of SLC25A13is associated with two major clinical phenotypes; neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and adult-onset type 2 citrullinemia (CTLN2). In Korea, 7 cases of citrin deficiency have been diagnosed based on biochemical and molecular findings. Four NICCD cases were identified by newborn screening using MS/MS or presenting symptoms like cholestatic jaundice. They are all males, presenting with conjugated hyperbilirubinemia, elevated liver enzymes, hypoalbuminemia, mild hyperammonemia, elevated citrullin, methionine and threonine. All of them have been spontaneously recovered from hepatic manifestation by the age of 6-8 months. Mutation analysis has been performed using their genomic & cDNAs obtained from skin fibroblasts. They turned out to be compound heterozygotes carrying each of 851del4, IVS11+1G>A, and IVS13+1G>A. Three CTLN2 patients were identified. Two adult male patients presented with a sudden loss of consciousness, seizure, vomiting, hyperammonemia and citrullinemia in their twenties. They carried an IVS13+1G>A, 851del4, and IVS11+1G>A mutant alleles. The other CTLN2 patient was 52 year old female patient, manifesting lethargy, altered consciousness, irritability and hyperammonemia. Similar clinical symptoms had recurred at the delivery of first and second babies in her past medical history. She was managed by hemodialysis and survived with neurological sequellae. Also, we screened the presence of 9 common mutations in 500 Korean newborns using dried blood spot of filter papers. Only a allele carried 854del4 mutation. In conclusion, the entire picture of citrin deficiency in Korea including incidence, genotype, clinical features and natural courses, is still vague at the present time.

분무열분해공정에 의한 메조기공 알루미나 제조에 있어 Al 전구체 영향

김주현,정경열,박균영,Kim, Joo-Hyun,Jung, Kyeong-Youl,Park, Kyun-Young 한국분말야금학회 2010 한국분말재료학회지 (KPMI) Vol.17 No.3

Mesoporous alumina particles were prepared by spray pyrolysis using cetyltrimethyl-ammonium bromide (CTAB) as a structure directing agent and the effect of Al precursor types on the texture properties was studied using $N_2$ adsorption isotherms, small-angle X-ray scattering (SAXS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The surface area and the microstructure of alumina particles were significantly influenced by the Al precursor type. The largest BET surface area was obtained when Al chloride was used, whereas alumina particles prepared from Al acetate had the largest pore volume. According to small-angle X-ray scattering (SAXS) analysis, the alumina powders prepared using nitrate and acetate precursors had a clear single SAXS peak around $2{\theta}=1.0{\sim}1.5^{\circ}$, indicating that regular mesopores with sponge-like structure were produced. On the basis of TEM, SAXS, and $N_2$ isotherm results, the chloride precursor was most profitable to obtain the largest surface area ($265\;m^2/g$), whereas, the nitrate precursor is useful for the preparation of non-hollow mesoporous alumina with regular pore size, maintaining high surface area (${\sim}233\;m^2/g$).

식도 자연천공 치험 1례

김주현,김영태,Kim, Ju-Hyeon,Kim , Yeong-Tae 대한흉부심장혈관외과학회 1978 Journal of Chest Surgery (J Chest Surg) Vol.11 No.2

Twenty-two years old male was operated for spontaneous rupture of the esophagus. In the event of perforation, there is nothing to prevent wide spread dissemination, and a devastating necrotizing chemical insult occurrs which is rapidly complicated by anaerobic and aerobic infection which quickly jeopardizes the patient`s life, often with a fatal result. For these reasons and despite modern diagnostic aids, anesthetic and operative technics, and antibiotics, perforation of the esophagus is still an alarming accident. In this case, thoracotomy and surgical closure of the perforation resulted in satisfactory outcome except postoperative fistula, which healed spontaneously.

동맥류성 골낭종 1예 보고

김주현,홍기우,김영태,Kim, Joo-Hyun,Hong, Gi-U,Kim, Yeong-Tae 대한흉부심장혈관외과학회 1977 Journal of Chest Surgery (J Chest Surg) Vol.10 No.2

Here represents a case of aneurysmal bone cyst which is very rare non neoplastic bone tumor especially in rib. The aneurysmal bone cyst usually arises from long bones of the upper and lower extemities and tt-e spine, which together account for 60 to 70 per cent of cases. In this case the tumor is found in right ninth rib on routine chest X-ray. It is resected successfully and the result is excellent.

사례기반학습을 이용한 주식 데이터 예측 방법

김주현,전민수,정용규,Kim, Ju-Hyun,Jeon, Min-Soo,Jung, Yong-Gyu 서비스사이언스학회 2011 서비스연구 Vol.1 No.1

현재 국내에선 많은 수의 사람들이 주식관련업계에 종사하고 있으며 주식관련 정보와 관련 산업은 점점 발전해 가고 있다. 따라서, 주식을 예측하는 프로그램이 많이 나왔으며, 또한 정확한 수치화를 통해 주식을 예측하고자 하는 노력들이 더해지고 있다. 그러나 주식예측 결과는 아직 불안정하고, 근거가 없는 것이 현실이다. 본 논문에서는 방대한 량의 주식 데이터를 가지고, 주식의 변동 폭에 많은 영향을 끼치는 항목들을 조사하고, 가중치를 구하고자 한다. 이는 기존에 주식에 관련된 수치와 종목별의 분류와 다른 방법이다. 실험결과에 따른 체계적인 주식 데이터의 객관성 있는 분류를 제시하고자 한다. In recent years, a number of people are going more and more to develope and engage in stock and equity-related information and related industry. a lot of stock expection programs came out, but they are still unstable, especially predictions methods and reality is unfounded. In this paper, we have vast amounts of stock data, shares many of the changes affecting the width of the survey items, and should seek the weights. This is related to existing stock levels and categories and is another way. Results based on a systematic classification of the stock data that would like to introduce objectivity

입자론의 관점에서 본 확산과 용해 개념에 관련된 과학 교과서 및 인터넷 자료 분석과 컴퓨터 수업 보조자료의 개발

김주현,이동준,김선경,강성주,백성혜,Kim, Ju Hyun,Lee, Dong Jun,Kim, Sun Kyoung,Kang, Seong Joo,Paik, Seong Hey 대한화학회 2000 대한화학회지 Vol.44 No.6

이 연구에서는 확산과 용해에 관련된 3~12학년의 과학교과서와 여러 문헌 자료들, 인터넷 사이트들을 분석하였다. 이 자료들로부터, 교과서에 제시된 확산과 관련된 설명들이 용해, 상태변화, 분출과 혼동되어 사용되고 있었으며 매질과의 충돌 또한 고려되고 있지 않았다는 것을 알았다. 그리고 용해와 관련된 거의 모든 자료도 용해의 원리를 인력에 의한 영향으로 설명하지 못하고 있었으며, 거의 대부분 용해에 관한 설명이 개념의 이해보다는 계산 문제 풀이에 초점이 맞추어져 있었다. 또한, 각종 인터넷 사이트들도 단편적인 교과서의 나열 수준에서 벗어나지 못하였고 단지 시청각적인 효과에 치중하고 있었다. 화학이 입자론적 관점에서 자연현상을 이해해야 함에도 불구하고 대부분의 교과서와 인터넷 사이트들은 그것을 충분히 반영하지 못하고 있었다. 이에 이 연구에서는 올바른 과학적 개념을 형성하고 입자론적인 관점에서 미시세계를 거시적 자연현상과 연결시키고자 했다. 그 방법으로 움직이는 물체를 표현할 수 있는 컴퓨터의 장점을 최대한 활용하여 입자이동의 관점으로 확산과 용해와 관련된 수업보조자료를 개발하였다. In this study we analysed 3-12 grade science textbooks, many literatures and internet sites related to diffusion and dissolution concepts. From these data, we discovered that the explanations of diffusion that used in textbooks are not considered the site of collision with mediums, and confused with dissolution, state transition and effusion. In the case of dissolution, almost analysis data were short of the explanations of interaction effect. Most of all, the focus of dissolution explanations was to solve the calculation problems rather than to understand the concept. Every internet site was poor, just as the level of showing textbook contents with computer, so the only effect of using computer was the sense of sight and hearing. Chemistry must be understood nature phenomena with a view point of particle theory, but many textbooks and Internet sites didn't represent it sufficiently. We set up the correct scientific concept and linked micro world of particle theory with macro world of nature phenomena. With a use of computer which have the advantage of representing moving things, we developed the computer-assisted instruction programs related to diffusion and dissolution with the viewpoint of particle movement.

C형 간염바이러스(HCV) 유전체를 특이적으로 변형할 수 있는 Trans-Splicing Aptazyme 발굴

김주현,이창호,장선영,이성욱,Kim, Ju-Hyun,Lee, Chang-Ho,Jang, Sun-Young,Lee, Seong-Wook 한국미생물학회 2008 미생물학회지 Vol.44 No.3

C형 간염바이러스(hepatitis C virus; HCV) 복제를 효과적이며 특이적으로 제어할 수 있는 유전산물을 개발하기 위하여 특정 리간드 존재에 의해 allosteric하게 그 활성이 조절될 수 있는 HCV 유전체 표적 trans-splicing 리보자임(trans-splicing aptazyme)을 발굴하였다. 이러한 trans-splicing aptazyme은 특정 리간드와 특이적으로 결합하는 RNA aptamer 부위, aptamer와 리간드와의 결합에 의해 리보자임 활성을 유도할 수 있도록 구조적 변이를 전달할 수 있는 communication module부위 및 HCV IRES의 +199 nt를 인지하는trans-splicing리보자임 등으로 구성되도록 설계하였다. 특히 trans-splicing 리보자임의 catalytic core의 P6과 P8 부위에 aptamer와 communication module을 삽입하였을 때 가장 allosteric하게 리보자임 활성이 유도되었다. 이러한 리보자임은 리간드가 없거나 대조 리간드가 존재할 때에는 trans-splicing 반응을 유도하지 못하였으나 특정 리간드가 존재할 때에만 효과적이며 특이적으로 trans-splicing 반응을 유도하여 표적 RNA를 변형시킬 수 있음을 관찰하였다. 이러한 aptazyme은 HCV 증식에 대해 특이적이며 효과적인 억제를 위한 선도물질로 이용 가능할 뿐 아니라 HCV 치료선도 물질의 스크리닝용 도구로서도 활용될 수 있을 것이다. For the development of specific and effective basic genetic materials to inhibit replication of hepatitis C virus (HCV), HCV genome-targeting trans-splicing aptazyme, which activity is allosterically regulated by a specific ligand, was developed. The aptazyme was designed to be comprised of sequence of RNA aptamer to the ligand, communication module sequence which can transfer structural transition for inducing ribozyme activity upon binding the ligand to the aptamer, and trans-splicing ribozyme targeting +199 nt of HCV IRES. Especially, when the aptamer and the communication module was inserted at both P6 and P8 catalytic domain of the specific ribozyme, allosteric activity of the aptazyme was the most induced. The aptazyme was shown to induce activity of trans-splicing reaction specifically and efficiently only in the presence of the specific ligand, but neither in the absence of any ligand nor in the presence of control ligand. This aptazyme can be used as a specific and effective genetic agent against HCV, and a tool for the isolation of anti-HCV lead compounds.