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쥐(rats)의 full-thickness skin grafts에 대한 hyperbaric oxygen과 α-tocopherol의 효과
김종수,김충희,김곤섭,하대식,박성근,김양미,Kim, Jong-shu,Kim, Chung-hul,Kim, Gon-sup,Hah, Dae-sik,Park, Sun-gun,Kim, Yang-mi 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.3
To document that effects of hyperbaric oxygen(HBO) and ${\alpha}-tocopherol$ on full-thickness skin grafts in rat, we performed full-thickness skin grafts bilaterally on each rats. The HBO-treated rats were received HBO twice daily for 90 minutes at 2 ATA. Surgical control rats were not treated with HBO. ${\alpha}-tocopherol$ treated rats were received the agent via oral gastric tube daily for 3 days preoperative and a fourth dose 1 to 2 hours postoperative. HBO plus ${\alpha}-tocopherol$ treated rats were received HBO and ${\alpha}-tocopherol$ as mentioned above. Biopsy specimens were taken from each rat at the time of grafting and on days 2, 4, 7, 10, 14, 21, and 28, then were processed for tissue-concentration of total glutathione(GSHt), oxidized/reduced glutathione level, and thiobarbituric acid-reactive substance(TBARS) levels. The percentage of viable graft on day 10 ranged from 67 to 93%, and was not significantly different among the each other groups. The percentage of viable graft were, however, higher in HBO plus ${\alpha}-tocopherol$ treated rats(78.6%) than in HBO alone treated rats(59.1%), ${\alpha}-tocopherol$ alone treated rats(66.7%) and surgical control rats(58.2%). TBARS concentration had a significant increase from preoperative concentration at day 2, and peak concentration at day 4(p<0.01). Concentration then decreased to preoperative concentration at day 28. GSHt concentration of free skin graft had a similar patteren of change in four groups and decreased significantly from preoperative concentration at day 2, returning to preoperative concentration by day 7(surgical control, HBO-treated, and ${\alpha}-tocopherol-treated$, alone) and 28(HBO plus ${\alpha}-tocopherol-treated$). Percentage of the concentration of reduced glutathione decreased in surgical control, HBO-treated and, ${\alpha}-tocopherol-treated$(p<0.05), and HBO plus ${\alpha}-tocopherol-treared$(p<0.01) on day 7 after surgery, whereas the concentration of oxidized increased significantly in HBO-treated(p<0.05), ${\alpha}-tocopherol-treated$(p<0.05), and HBO plus ${\alpha}-tocopherol-treated$(p<0.01).
내측광근 강화운동을 이용한 슬개-대퇴 동통 증후군 치험 2례
김종수,김진수,김세준,정승현,김효섭,윤문식,조태영,Kim, Jong-Su,Kim, Jin-Soo,Kim, Se-Jun,Jeong, Seong-Hyun,Kim, Hyo-Sub,Yoon, Moon-Sik,Cho, Tae-Young 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.1
슬개-대퇴 통증 증후군 환자 2례에 내측광근 강화 운동을 이용하여 치료한 결과, Knee X-ray(Skyline view) 상의 일치각 및 NRS, WOMAC Index의 호전을 확인하였다. 이에 저자는 본 증례를 보고하는 바이다. Objectives: The purpose of this case report is to investigate the effect of exercise for vastus medialis to knee pain patients with patello-femoral pain syndrome. Methods: Two patients with patello-femoral pain syndrome were treated by exercise for vastus medialis. To measure the outcome of the patients' improvement, we observed the X-ray of both knee sky-line view, Numerical Rating Scale(NRS), and Western Ontario and McMaster Universities(WOMAC) index. Results: After being treated by exercise for vastus medialis, the patients' X-ray of both knee sky-line view, Numerical Rating Scale(NRS), and Western Ontario and McMaster Universities(WOMAC) index were significantly improved. Conclusions: These results suggest that exercise for vastus medialis is effective treatment to patients with patello-femoral pain syndrome.
Diazinon이 계배(鷄胚)의 기형 유발에 미치는 효과 I. 계배(鷄胚) 형태와 콜린성 봉쇄약물에 미치는 효과
김종수,김곤섭,김양미,최원영,손성기,허정호,이주홍,Kim, Jong-shu,Kim, Gon-sup,Kim, Yang-mi,Choi, Wong-young,Son, Sung-gi,Heo, Jung-ho,Lee, Ju-hong 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.1
Teratogenic effects of diazinon were assessed on morphology of chick embryos cholinergic blocking agents. Diazinon at doses ranging from 25 to $2000{\mu}g/egg$, was injected on Day 3 of incubation. $TD_{50S}$, were different for the various teratogenic sings such as wry neck, micromelia, abnormal feathering, abnormal beak and curled claws. The threshold dose for wry neck was higher than the threshold dose for other signs; $40{\mu}g/egg$ produced substantial micromelia, abnormal feathering, abnormal beak and curled claws, but gave no sings of wry neck. In contrast to the teratogenic doses, the $LD_{50}$ of diazinon was very high(above $2000{\mu}g/egg$). One of the characteristics of diazinon-induced teratogenesis was reduction of body weight(78.8%) and body length(73.8%). Maximal teratogenic effects, scored as sings of retarded growth, wry neck, micromelia, abnormal feathering, abnormal beak, and curled claws, were produced when the insectcide was administered on the third or fourth day. The threshold dose for type II teratogenic sings including wry neck and short neck was higher than for type I including micromelia and abnormal feathering. Morphorlogical studies, using atropine and gallamine, suggested that nicotinc but not muscarinic receptors may be involved in the mechanism of diazinon-induced type II malformations.
Phytomitogen에 의한 기니픽 임파구의 Blast Transformation: II. 유사분열에 미치는 혈청농도와 배양시간의 효과
김종수,Kim, Jong-shu 대한수의학회 1987 大韓獸醫學會誌 Vol.27 No.1
The present study was carried out to investigate the optimal conditions on blastogenesis of guinea pig lymphocytes. A microculture system in conjuction with a semiautomatic multiple sample harvester was used to study the in vitro optimal condition of guinea pig lymphocytes. Careful analysis of lymphocyte transformation to concanavalin A (Con A) and lipopolysaccharide (LPS) mitogen determined optimal conditions as: (a) 10% fetal bovine serum in RPMI-1640 medium (b) 48-hour culture period.
보조 전원을 이용한 12 펄스 다이오드 정류기를 사용하는 추진시스템의 고조파 및 토크 리플 저감
김종수,서동환,최재혁,Kim, Jong-Su,Seo, Dong-Hoan,Choi, Jae-Hyuk 해양환경안전학회 2013 海洋環境安全學會誌 Vol.19 No.1
The input current of three phase rectifier which is mainly used in the propulsion system of the electric propulsion ship includes a variety of low order harmonics. To reduce these harmonics, the power conversion system, used in the large vessels which high power is required, is currently used the rectifiers of 12-pulse output, but it still has a problem that occurs $12{\pm}1$ harmonics. Also, in the case of the direct torque control technique which is widely used for the speed and torque control, the torque ripple is severe and the input current of motor has greatly included harmonics by the switching of the inverter. In order to reduce harmonics and improve the performance of torque control, this paper presents that the auxiliary supply assisted into the 12-pulse rectifier of the electric propulsion system using direct torque control technique. We confirm the validity of the proposed method through the simulation under the environment of a real vessel system. 전기추진선박의 추진시스템에 주로 사용되는 3상 정류기의 입력전류는 다양한 저차 고조파를 포함하고 있다. 이러한 고조파 저감을 위해서 대전력이 필요한 대형 선박에 사용되는 전력변환장치는 12펄스 출력의 정류기가 현재 사용되고 있지만 여전히 $12{\pm}1$차의 고조파가 발생되는 문제점이 있다. 또한, 속도 및 토크 제어기법으로 널리 사용되고 있는 직접토크제어기법의 경우에는 토크 리플이 심하고 전동기의 입력전류는 인버터의 스위칭에 의해 고조파를 크게 포함하고 있다. 본 연구에서는 직접토크제어기법을 이용하는 전기추진시스템의 12펄스 정류기에 보조 전원을 공급하여 고조파를 저감하고 토크 제어성능을 향상시켰으며 실선시스템 환경에서 시뮬레이션을 통해 그 유효성을 입증하였다.
Phytomitogen에 의한 기니픽 임파구의 Blast Transformation : I. 유사분열에 미치는 배지, 유사분열촉진물질 및 세포농도의 효과
김종수,박응복,Kim, Jong-shu,Bak, Ung-bok 대한수의학회 1986 大韓獸醫學會誌 Vol.26 No.2
The present study has been carried out to investigate the optimal condition on the blastogenesis of guinea pig lymphocytes. A microculture system in conjunction with a semiautomatic multiple sample harvester(SAMSH) was used to study the in vito optimal condition of guinea pig lymphocytes. Data were presented to show many variables that are Involved in studying the responses of guinea pig lymphocyte in a microculture system to the stimulation of Concanavalin A(Con A) and lipopolysaccharide (LPS). Analysis indicated that the conditions for optimal Con A as measured by incorporation of $^3H$-TdR include : (1) use of RPMI-1640 as culture medium, (2) use of $6{\mu}g$ of Con A, per culture, (3) use of $1{\times}10^6$ cells per culture. Conditions for optimal stimulation with LPS mitogen were similar to those used for Con A.
김종수,김용환,Kim, Jong-shu,Kim, Yong-hwan 대한수의학회 1992 大韓獸醫學會誌 Vol.32 No.1
The present study were carried out to investigate the effects of Vomitoxin(Deoxynivalenol, DON) induced dysregulation of IgA synthesis. The data presented here demonstrate that exposure to dietary DON increases serum IgA and concurrently decreases IgG and IgM. Peyer's path(PP) and splenocytes from mice fed dietary DON produced increased IgA in mitogen stimulated and macrophage(MØ) perform essential role for Ig synthesis and was affected by the presence of DON. The synthesis and secretion of IgM and IgG under the presence of DON do not require T cell helper activity, whereas those of IgA do require such activity. These results suggest that dietary DON alters the regulation of IgA production and may act as an immunostimulator.
도어트림 그립핸들 마찰이음 근본개선을 위한 내구 시험법 개발 및 개선연구
김종수,나형현,조영빈,Kim, Jongsoo,Na, Hyunghyun,Cho, Youngbin 한국음향학회 2018 韓國音響學會誌 Vol.37 No.4
In this paper, we develop a durability test method that can verify the noise caused by the repeated load on the door trim grip handle. The test method was developed in consideration of the load mode and durability test cycle applied to the grip handle. In order to verify the validity of the method, we demonstrated the door trim grip handle noise that occurred in the field claim with the product in the early stage of mass production through the developed test method. Finally, It is used to detect and improve the noise of subsequent development products through the currently developed test method. 본 논문에서는 기존에 없었던 도어트림 그립핸들에서 반복된 하중으로 인해 발생하는 소음을 사전에 검증할 수 있는 내구 시험법을 개발하고자 하였다. 시험 방법은 그립 핸들이 받는 하중 모드, 내구 횟수를 고려하여 개발하였으며, 시험 방법의 유효성을 확인하기 위해, 양산 초기 제품에 시험 법을 적용하여 필드클레임에서 발생한 도어트림 그립 핸들 소음을 재현하였다. 최종적으로, 현재 개발된 시험법을 통해서 후속 개발 제품의 소음 검출 및 개선하는 데 활용하고 있다.