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사람 치은 섬유아세포에서의 Tannerella forsythia 전세균, 막단백질, 당지질에 의한 염증성 사이토카인 발현
김정은,이성훈,최봉규,구기태,김태일,이용무,구영,정종평,류인철,Kim, Jung-Eun,Lee, Sung-Hoon,Choi, Bong-Kyu,Koo, Ki-Tae,Kim, Tae-Il,Lee, Yong-Moo,Ku, Young,Chung, Chong-Pyoung,Rhyu, In-Chul 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.3
Purpose: The purpose of this study was to investigate induction of cytokine expression in human gingival fibroblasts (HGFs) by whole cell and the components of T. forsythia. Material and Methods: After HGFs were treated with lipopolysaccharide (LPS), membrane protein isolated from T. forsythia or culture media of T. forsythia, the induction of interleukin (IL)-1, IL-6 and IL-8 was examined with real-time PCR and ELISA. Their induction ability of cytokines was compared with whole bacteria. Result: The expression of IL-6 and IL-8 was significantly induced in HGFs by whole bacteria and membrane protein. The expression of IL-$1{\beta}$ was induced by membrane protein of T. forsythia, not by whole bacteria. LPS and condition media of T. forsythia slightly activated HGFs. Conclusion: The membrane protein of T. forsythia could be one of virulence factors.
철도 차량용 배터리 충전을 위한 LLC 공진형 컨버터의 SiC FET와 Si FET의 병렬 연결에 관한 연구
김정은(Chong-Eun Kim),류상균(Sang-Gyun Ryu),이재범(Jae-Bum Lee) 대한전기학회 2021 전기학회논문지 Vol.70 No.12
Wide-Band-Gap (WBG) switching semiconductor has been improved for higher efficiency and higher power density. Especially, SiC FET is the most attractive switching semiconductor for mid-voltage and high power applications, such as, railway transportation. Its desired features for high power converter are low on-state resistance, thermal stability, no reverse recovery, high switching speed, and so on. However, faster switching speed derives higher dv/dt of drain-source voltage, then this result in larger voltage ringing and worse switching noise. In this paper, parallel configuration of SiC FET and Si FET is proposed to suppress voltage ringing and minimize switching noise. Based on the characteristics of output capacitances of both SiC and Si FETs, the switching performances of single SiC FET and parallel connection of SiC/Si FETs are compared of voltage ringing and switching noise in LLC resonant converter for 10kW battery charging module of railway transportation.
고효율 더블 엔디드 능동 클램프 영전압 스위칭 포워드 컨버터
김정은(Chong-Eun Kim),강정일(Jeong-il Kang),한상규(Sang-Kyoo Han),문건우(Gun-Woo Moon) 전력전자학회 2001 전력전자학술대회 논문집 Vol.2001 No.-
In this paper, a high-efficiency double-ended active clamp ZVS forward converter is proposed This converter can be used in compact size AC/DC converter applications such as a notebook adapter The principles of operation are described and the zero voltage switching characteristics are analyzed. High efficiency of this converter is verified by the experimental results.<br/> <br/>
혈소판유래 성장인자 함유 흡수성 차폐막이 치주조직의 재생에 미치는 영향
구영,김정은,한수부,정종평,박윤정,이승진,권영혁,Ku, Young,Kim, Jeong-Eun,Han, Soo-Boo,Chung, Chong-Pyoung,Park, Yoon-Jeong,Lee, Seung-Jin,Kwon, Youg-Hyuk 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.1
PDGF-BB has been recognized as a highly potential growth factor for guided tissue regeneration in periodontal defect. This study carried out histologic and histometric evaluation of $200ng/cm^2$ PDGF-BB loaded bioresorbable membrane made from polyglycolic and polylactic acid. It was tested for its biocompatibility, ability to prevent epithelial downgrowth and amount of periodontal regeneration. Without membrane and PDGF-BB unloaded bioresorbable membrane were used as control. Healthy six beagle dogs were used. Each dog was anesthetized and buccal flaps were reflected in the mandibular and maxillary premolar areas. Buccal alveolar bone between the mesiobuccal and distobuccal line angles was surgically removed on the lower 2nd and 4th premolar in mandible, 2nd premolar in maxilla, to a level 4mm apical to the cementoenamel junction with creating a Class II buccal furcation defect for available space. Care was taken not to remove the root cementum layer and rubber impression materials were placed over each surgically created defect. Flaps were repositioned and sutured. Reconstructive surgery was performed 1 month after defect preparation. PDGF-BB loaded membranes and controls were randomly placed on maxillary 2nd premolars and mandibular 2nd and 4th premolars. Plaque control regimen was instituted with daily brushing with a 0.1% chlorhexidine digluconate during experimental periods. The animals were sacrificed 2 and 5 weeks after surgery and undecalcified specimens were prepared for histologic evaluation. The degree of coronal regrowth of new bone, new cementum and the amonut of new bone areas formed on the defected area of the PDGF-BB loaded membrnae turned superior to without membrane and drug unloaded membrane. Experimental membrane could prevent the epithelial downgrowth irrespective of drug loaded or not and showed good biocompatiblity, These results implicated that PDGF-BB loaded bioresorbable membrane could be highly useful tool for guided tissue regeneration of periodontal defects.
넓은 영전압 스위칭 범위를 갖는 새로운 고효율 DC/DC 컨버터
박기범(Ki-Bum Park),김정은(Chong-Eun Kim),문건우(Gun-Woo Moon),윤명중(Myung-Joong Yoon) 전력전자학회 2004 전력전자학술대회 논문집 Vol.- No.-
A new high efficiency DC/DC converter is proposed, which is derived from the conventional half-bridge converter. The proposed converter has good ZVS condition compared with the conventional half-bridge converter, and shows a high efficiency by solving the unbalance voltage stress and current stress problem of secondary rectifier diode of the conventional half-bridge converter. In this paper, the basic operations of the proposed converter is analyzed compared with that of the conventional half-bridge converter, and the excellent performance of the proposed converter is verified by the experimental results with the 425W prototype of the power supply for PDP Sustain Driver.
Isotretinoin와 Pulsed Dye Laser로 치료한 Rosai-Dorfman병
한지수 ( Ji Su Han ),김정은 ( Jeong Eun Kim ),박경훈 ( Gyeong Hoon Park ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.6
Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SMHL) is a benign histiocytic proliferative disorder of unknown etiology. The disease is usually accompanied by massive bilateral lymphadenopathy, fever, elevated erythrocyte sedimentation rate, leukocytosis with neutrophilia, and polyclonal hypergammaglobulinemia. Histopathologic examinations showed characteristically large histiocytes exhibiting emperipolesis. On immunohistochemical stains, histiocytes are positive for CD68 and S-100 protein, but negative for CD1a. The lymph node involvement is typical, but it may also involve other systemic organs in one third of the cases such as skin, upper respiratory tract, bones and so on. Patients with purely cutaneous Rosai-Dorfman diseases are of older age at onset of the disease with a reversed male/female ratio, thus, cutaneous Rosai-Dorfman disease is recognized as a distinct entity from the Rosai-Dorfman disease. Herein, we present a 50-year-old man with erythematous papules and indurated plaques on both cheeks, diagnosed as cutaneous Rosai-Dorfman disease. The lesions were treated with isotretinoin 10 mg bid for 9 months with pulsed dye laser.