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RISS 인기검색어
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- 저자 : 김인성(Jeong A Kim) (검색결과 38 건)
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상자성 복합체의 분자량에 따른 T1 및 T2 자기이완시간에 관한 연구
김인성,이영주,김주현,김숙경,김태정,강덕식,장용민,Kim In-Sung,Lee Young-Ju,Kim Ju-Hyun,Sujit Dutta,Kim Suk-Kyung,Kim Tae-Jeong,Kang Duk-Sik,Chang Yong-Min 한국의학물리학회 2006 의학물리 Vol.17 No.2
To evaluate the T1, T2 magnetic relaxation properties of water molecule according to molecular weight of paramagnetic complex. 4-aminomethyicyclohexane carboxylic acid (0.63 g, 4 mmol) was mixed with the suspension solution of DMF (15 ml) and DTPA-bis-anhydride (0.71 g, 2 mmol) to synthesize the ligand. The ligand was then mixed with $Gd_2O_3$ (0.18 g, 0.5 mmol) to synthesize Gd-chelate. For the measurement of magnetic relaxivity of paramagnetic compounds, the compounds were diluted to 1 mM and then the relaxation times were measured at 1.57 (64 MHz). Inversion-recovery pulse sequence was employed for T1 relaxation measurement and CPMG (Carr-Purcell-Meiboon-Gill) pulse sequence was employed for T2 relaxation measurement. In case of inversion recovery sequence, total 35 images with different inversion time(T1)s ranging from 50 msec to 1,750 msec. To estimate the relaxation times, the signal intensity of each sample was measured using region of Interest (ROI) and then fitted by non-linear least square method to yield T1, T2 relaxation times and also R1 and R2. Compared to T1=($205.1{\pm}2.57$) msec and T2=($209.4{\pm}4.28$) msec of Omniscan (Gadodiamide), which is commercially available paramagnetic MR agent, T1 and T2 values of new paramagnetic complexes were reduced along with their molecular weight. That is, T1 value was ranged from $(96.35{\pm}2.04)\;to\;(79.38{\pm}1.55)$ msec and T2 value was ranged from $(91.02{\pm}2.08)\;to\;(76.66{\pm}1.84)$ msec. Among new paramagnetic complexes, there is a tendency that the R1 and R2 increase as the molecular weight is increases. As molecular weight of paramagnetic complex increases, T1 and T2 relaxation times reduce and thus the increase of relaxivity (R1 and R2) Is proportional to molecular weight.
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너도밤나무 크레오소트가 흰 쥐의 장내 미생물 변화에 미치는 영향
김정아(Jeong A Kim),유다윤(Da Yoon Yu),김인성(Jeong A Kim),이철영(Chul Young Lee),정동기(Dong Kee Jeong),이상석(Dong Kee Jeong),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.7
설사는 경제동물의 이유시기 폐사율을 일으키는 가장 높은 요인이다. 크레오소트는 전통 의약품으로 오랜 세월동안 지사제로 사용되어 왔다. 본 연구는 흰 쥐 모델에서 크레오소트 급여가 동물의 성장 효율 및 장내 미생물에 미치는 영향을 구명할 목적으로 수행되었다. 4주령의 수컷 흰쥐 24마리를 임의로 대조구, 항생제 그룹, 크레오소트 0.4% 그룹, 크레오소트 0.8% 그룹으로 배치하였다. 대조구는 기초사료, 항생제 그룹은 apramycin 0.5%, 크레오소트 그룹은 크레오소트 0.4%와 0.8% 수준으로 하여 예비시험 기간 1주일, 본시험 기간 4주일 동안 급여하였다. 일당증체량은 실험구간 차이가 없었으나, 사료 섭취량은 Creo 0.8 그룹에서 유의적으로 증가하였다(p<0.05). 장내 미생물에 대한 문(phylum) 수준 분석 결과 Creo 0.8 그룹에서 Firmicutes가 감소하고 Bacteroidetes가 증가하여 F/B 비율을 감소시키는 것으로 나타났다(p<0.05). 과(family) 수준에서는 Lachnospiraceae가 크레오소트 0.8% 수준에서 증가되었으며(p<0.01), 속(genus) 수준에서는 Turicibacter가 감소되었다(p<0.01). 종(species) 수준에서는 Clostridium disporicum이 감소되었다(p<0.01). 이상의 결과는 쥐에 크레오소트 급여는 사료 섭취량을 증가시키고 장내 미생물의 변화에 영향을 미칠 수 있다는 것을 시사한다. Diarrhea is one of the main disorders which cause the highest level mortality of the post-weaning economic animal. Beech-wood creosote has been used as a traditional anti-diarrheic medicament for a long time. The present study was conducted to investigate the effects of dietary supplementation of Beech-wood on growth performance and intestinal microbiota in rats. Twelve 4-week-old rats were randomly assigned to one of four dietary groups and fed a basal diet supplemented with none (CON), 0.5% apramycin (ANTI), 0.4% creosote (Creo 0.4), or 0.8% creosote (Creo 0.8) for 4 weeks following 1 week of adaptation period to the respective diet. Average daily gain was not influenced by the dietary treatment whereas average daily feed intake was greatest for the Creo 0.8 group. In the intestinal microbiota at the level of the phylum, the percentage of Firmicutes bacteria decreased but Bacteroidetes increased in the Creo 0.8 group vs. Control, which resulted in a decreased F/B ratio for the former (p<0.05). Moreover, the percentage of Lachnospiraceae was greater at the level of the family for the Creo 0.8 group than for Control, but the percentages of Turicibacter and Clostridium disporicum were less in the former (p<0.01) at the genus and species levels, respectively. Collectively, the present results indicate that dietary supplementation of creosote increases the feed intake and also influence the intestinal microbiota in rats.
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아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과
김인성(In Sung Kim),김성학(Sung Hak Kim),김정아(Jeong A Kim),유다윤(Da Yoon Yu),김광일(Gwang Il Kim),박동찬(Dong-Chan Park),임종민(Jong Min Lim),이상석(Sang Suk Lee),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.1
본 연구에서는 아토피 피부염 동물 모델에 대한 β-1,3/1,6-glucan과 L. plantarum LM1004의 면역조절 효과를 확인하고자 하였다. 가려움증의 횟수와 유출된 evans blue, 그리고 혈청 IgE와 histamine의 농도는 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹에서 아토피 피부염 유발그룹에 비해 유의적으로 감소하는 결과를 나타내었다. 아토피 피부염이 유발되면 전사 수준에서 Th2 및 Th17 세포의 전사인자 및 cytokine은 과발현되며, β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취하였을 때 이를 유의적으로 감소되었다. 또한 β-1,3/1,6-glucan과 L. plantarum LM1004는 Th1 및 Treg 세포의 전사인자(T-bet, GATA-3, RORγT, Foxp3) 및 cytokine (INF-γ, IL-4, IL-17, TGF-β)의 발현을 증가시킴으로써 면역 균형을 조절하는 것으로 나타났다. Galectin-9과 filaggrin은 아토피 피부염 유발 처리군에서 유의적으로 가장 낮았으며, β-1,3/1,6-glucan 처리군에서 유의적으로 가장 높게 나타났다. 이와 반대로 TSLP는 아토피 피부염 유발그룹에서 유의적으로 가장 높았으며 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹은 대조군과 유사한 수준이었다. 이러한 결과를 통해 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염 동물 모델에서 면역조절 작용 및 아토피 피부염의 개선 효과를 가짐을 알 수 있었다. 따라서 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염에 유용한 천연소재로서 사용될 것으로 기대된다. In this study, we examined the efficacy of the immune regulation of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of β-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis–induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor γ T [RORγT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of β-1,3/1,6-glucan and L. plantarum LM1004. In addition, β-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-γ [IFN-γ], transforming growth factor-β [TGF-β]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis–induced group and significantly higher in the β-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis–induced group, while mice that were orally administered β-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that β-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that β-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.
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옻에 의한 급성 전신성 발진성 농포증이 Anti-TNFα로 호전된 2예
김인성 ( In Sung Kim ),김주희 ( Joo Hee Kim ),강은정 ( Eun Jung Kang ),장은정 ( Eun Jung Jang ),진현정 ( Hyeon Jeong Jin ),박해심 ( Hae Sim Park ),예영민 ( Young Min Ye ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
Acute generalized exanthematous pustulosis (AGEP) is characterized by the rapid occurrence of many sterile, nonfollicular pustules on an edematous erythema accompanied by leucocytosis and fever. It is usually attributed to drugs, including herbal medications such as rhus in Korea. We report two cases of AGEP due to rhus hypersensitivity treated with anti-tumor necrosis factor (TNF)-α. The patients developed a generalized erythematous rash and edema, particularly on the face, with high fever and leukocytosis several days after ingesting rhus chicken or contacting rhus extract. Following treatment with a systemic steroid, the skin rash spread to the entire body and pustules arose on an edematous erythema. After stopping the systemic steroid and administering a subcutaneous injection of Etanercept, the pustular rashes, fever, and edema improved within 4 days. These results suggest that anti-TNF-α treatment may be effective for rapidly improving AGEP. (Korean J Med 2011;81:537-542)
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3-1 타입 트리모프 캔틸레버의 마이크로발전 응용기술 개발
김인성(Insung Kim),주현규(Hyeonkyu Joo),정순종(Soonjong Jeong),김민수(Minsoo Kim),송재성(Jaesung Song),전소현(Sohyeon Jeon) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
With recent advanced in portable electric devices, wireless sensor, MEMS and bio-Mechanics device, the new typed power supply, not conventional battery but self-powered energy source is needed. Particularly, the system that harvests from their environments are interests for use in self powered devices. For very low powered devices, environmental energy may be enough to use power source. Therefore, in other to made piezoelectric energy harvesting device. The made 31type triple-morph cantilever was resulted from the conditions of 100㏀, 0.25g, 154㎐ respectively. The thick film was prepared at the condition of 6.57Vrms, and its power was 432.31㎼ and its thickness was 50㎛. And than, the fabricated piezoelectric cantilever was packaged for application.
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