소아의 일측 음낭수종 교정술 후 반대측 발생의 치험 1례

김은진,민상연,김장현,Kim, Eun Jin,Min, Sang Yeon,Kim, Jang Hyun 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.1

Objectives Hydrocele is a common disease found in pediatrics and is usually treated by hydrocelectomy, and even after the unilateral repair of hydrocele, it has been reported that the contralateral hydrocele still occurs in 5.4-12.5%. Therefore, the purpose of this study is to conduct a case study of contralateral hydrocele treated by Oryeong-san and Bangkeehwangkee-tang (五?散 合 防己黃?湯). Methods A patient diagnosed with San Syndrome (Su-San) (水疝) was administered Oryeong-san and Bangkeehwangkee-tang (五?散 合 防己黃?湯). Results The sizes of hydrocele and symptoms were reduced. Conclusions In the case of contralateral occurrence after unilateral repair of hydrocele in children, it is better to select a safer treatment than operation considering other possible complications. In this report, we have proven that Oryeong-san and Bangkeehwangkee-tang (五?散 合 防己黃?湯) can be very effective in reducing the size of hydrocele, improving symptoms and preventing recurrence.

GMO 도입과 우리의 자세

김은진,Kim, Eun-Jin 한국단미사료협회 2003 사료산업 Vol.2 No.-

생쥐에 있어 Enalapril 및 Ginkgo biloba Extract(EGb 761) 복합체의 경구 아급성 독성실험

김은진,김진이,이영미,안형수,신완균,Kim, Eun-Jin,Kim, Lin-Lee,Lee, Young-Mi,Ann, Hyung-Soo,Shin, Wan-Kyun 한국독성학회 1998 Toxicological Research Vol.14 No.3

Group of 40 male and 40 female ICR mice was given daily per oral treatment with the combination of enalapril plus Ginkgo biloba extract (EGb 761), 3+9mg/kg/day(low dosage group), 10+30mg/kg/day (middle dosage group), 30+90mg/kg/day (high dosage group) for 3 months in drinking water according to Established Regulation of Korean National Institute of Safety Research (1994. 4.14). Appearance, behavior, mortality, and food consumption of mouse of treated groups were not affected during the experimental periods. No significant the combination of enalapril plus Ginkgo biloba extract (EGb 761)-related changes were found in urinalysis, hematology, serum chemistry, and organ weight, Lung edema were observed and the weight of lung were increased in low dosage treated group of the male mice, which be associated with enalapril treatment, but these changes were not found in middle and high dosage group. Our results suggest that to toxic changes were found in rat treated orally with the combination of enalapril plus Ginko biloba extract (EGb 761) for 3 months.

청소년에서 우울 및 불안 증상과 수면 곤란의 성별에 따른 차별적 관련성

김은진,강수경,문명성,임세원,오강섭,Kim, Eun-Jin,Kang, Su-Gyeong,Moon, Myeong-Sung,Lim, Se-Won,Oh, Kang-Seob 한국정신신체의학회 2010 정신신체의학 Vol.18 No.2

연구목적 청소년에서 성별에 따른 불안, 우울과 수면 장애의 유병율을 조사하고 우울, 불안과 수면 곤란의 관련성을 성별에 따라 분석하고자 한다. 방 법 서울시 마포구 내 7개 중학교의 1학년 학생 1,422명을 대상으로 자가 보고 질문지인 Children's Depression Inventory(CDI), Beck Anxiety Inventory(BAI), Pittsburgh Sleep Quality Index(PSQI)를 실시하였다. CDI, BAI, 그리고 PSQI는 각각 다음과 같이 분류되었다 : $\leq$21, 22-25, 26-28, 그리고 $\geq$29 ; $\leq$21, 22-26, 27-31, 그리고 $\geq$32 ; $\geq$5, <5. 각각의 cut-off 점수는 CDI 22, BAI 22 그리고 PSQI는 5점 이었다. 두 군간 연속 변수 비교에는 독립 t-검정, 비 연속변수 비교에는 $\chi^2$-검정, 불안과 우울 증상이 수면 곤란에 미치는 영향은 로지스틱 회귀분석을 이용하였다. 결 과 여학생에서 평균 CDI 점수($12.52{\pm}8.32$ vs. $10.39{\pm}7.52$ ; p=0.003), BAI($7.77{\pm}7.9$ vs. $9.84{\pm}9.044$ ; p<0.001) 그리고 PSQI($4.57{\pm}2.67$ vs. $3.64{\pm}2.30$ ; p=0.013)는 남학생보다 유의하게 높았다. 그러나 성별, 과거 정신과 치료력을 통제한 후, 매우 높은 수준의 우울과 불안 상태에서 남학생이 수면 곤란을 경험할 위험도가 여학생에 비해 현저히 높았다(CDI aOR, 14.66 ; 95% CI, 4.17-51.53, BAI aOR, 32.99 ; 95% CI, 4.26-255.39). 결 론 이 연구 결과는 여학생에 비해 남학생에서 우울과 불안의 정도가 심각할 때 수면 곤란을 경험할 위험이 더욱 높다는 것을 시사한다. Objectives : The aim of the study was to investigate the prevalence by gender and to evaluate associations of depression, anxiety and sleep disturbances in a large sample of adolescents from the general population. Methods : 1422 subjects, aged 14 years students were recruited in the seven middle-school of the local community. The self-report questionnaire(Children's Depression Inventory : CDI, Beck Anxiety Inventory : BAI and Pittsburgh Sleep Quality Index : PSQI) was used for screening depression, anxiety and sleep disturbances in adolescent. CDI, BAI, and PSQI score was categorized into the following quartiles : $\leq$21, 22-25, 26-28, and $\geq$29 ; $\leq$21, 22-26, 27-31, and $\geq$32 ; $\geq$5, <5. The cut-off score is that CDI is 22, BAI is 22 and PSQI is 5. The result was analyzed using the independent t-test, the chi-square test and logistic regression analyses. Results : The mean CDI score($12.52{\pm}8.32$ vs. $10.39{\pm}7.52$ ; p=0.003), BAI($7.77{\pm}7.93$ vs. $9.84{\pm}9.04$ ; p<0.001) and PSQI($4.57{\pm}2.67$ vs. $3.64{\pm}2.30$ ; p=0.013) of girls were significantly higher than for boys. But, boys in the fourth quartile of CDI(CDI$\geq$29) and BAI(BAI$\geq$32) were at significantly elevated risk for sleep disturbances more than for girls after adjustment for sex, history of psychiatric treatment(CDI odd ratio, 14.66 ; 95% CI, 4.17-51.53, BAI odd ratio, 32.99 ; 95% CI, 4.26-255.39). Conclusion : The results suggest that high CDI, BAI score appears to increase the risk for developing sleep disturbances in boys more than girls.

Organic matrix-free imaging mass spectrometry

김은진,Jisu Kim,Inseong Choi,Jeongwook Lee,여운석 생화학분자생물학회 2020 BMB Reports Vol.53 No.7

Mass spectrometry (MS) is an ideal tool for analyzing multiple types of (bio)molecular information simultaneously in complex biological systems. In addition, MS provides structural information on targets, and can easily discriminate between true analytes and background. Therefore, imaging mass spectrometry (IMS) enables not only visualization of tissues to give positional information on targets but also allows for molecular analysis of targets by affording the molecular weights. Matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) MS is particularly effective and is generally used for IMS. However, the requirement for an organic matrix raises several limitations that get in the way of accurate and reliable images and hampers imaging of small molecules such as drugs and their metabolites. To overcome these problems, various organic matrix-free LDI IMS systems have been developed, mostly utilizing nanostructured surfaces and inorganic nanoparticles as an alternative to the organic matrix. This minireview highlights and focuses on the progress in organic matrix-free LDI IMS and briefly discusses the use of other IMS techniques such as desorption electrospray ionization, laser ablation electrospray ionization, and secondary ion mass spectrometry.

건물용도별 옥상공간의 이용행태 및 선호도 분석 - 서울특별시의 사례를 중심으로 -

김은진,정태열,Kim, Eun-Jin,Jung, Tae-Yeol 한국조경학회 2014 韓國造景學會誌 Vol.42 No.6

오늘날 옥상공간은 대부분 휴식과 같은 이용을 목적으로 조성되고 있다. 하지만, 이러한 옥상공간의 이용이 적거나, 유지관리가 소홀하게 되면, 옥상공간이 방치되거나, 용도변경 등의 이유로 조성비용의 낭비를 초래할 수 있어, 이용을 활성화하기 위한 설계가 필요할 것으로 판단하였다. 한편, 국내의 경우, 옥상공간은 비교적 획일적이고 단순하게 조성되어 있다. 하지만, 건물용도에 따라 이용자 특성이 다르기 때문에 옥상공간의 이용행태와 선호도도 다를 것이며, 옥상공간의 이용을 활성화하기 위해서 이러한 점을 고려할 필요가 있다고 보았다. 이에 본 연구에서는 4개의 건물용도(공공건물, 교육연구건물, 의료건물, 판매건물)를 선정하여 연구대상지의 이용경험자를 대상으로 설문조사를 실시하였으며, 옥상공간의 이용행태와 선호도를 건물용도별로 비교분석하였다. 이때, 교차분석, 다중응답분석, 신뢰도분석, 일원배치 분산분석을 하였으며, 그 결과는 다음과 같다. 먼저 옥상공간의 이용행태에서 이용목적, 이용동기, 이용빈도, 평균체류시간이 건물용도별로 차이가 있는 것으로 나타났다. 특히, 이용목적의 경우, 모든 건물에서는 휴식을 위해서 옥상공간을 가장 많이 이용하는 것으로 나타났다. 한편, 공공건물에서는 대화와 흡연을, 교육연구건물에서는 흡연, 산책 및 스트레칭, 외부경관감상을, 의료건물에서는 산책 및 스트레칭과 대화를, 판매건물에서는 아이 돌보기와 대화를 목적으로 옥상공간을 많이 이용하는 것으로 나타났다. 또한, 옥상공간의 선호도에서도 식물유형, 포장재, 시설물 선호도가 건물용도별로 차이가 있는 것으로 나타났다. 특히, 식물유형의 경우, 공공건물 이용자들은 초본류와 채소류 및 수생식물을, 의료건물 이용자들은 채소류 및 수생식물을, 판매건물 이용자들은 모든 유형의 식물을 다른 용도의 건물 이용자들보다 더 선호하는 것으로 나타났다. 이러한 건물용도별 옥상공간의 이용행태와 선호도 차이를 고려하여 옥상공간을 조성함으로써 이용 활성화에 기여할 수 있을 것으로 기대한다. Today, most roof spaces are being designed as places for resting. The use of the roof spaces needs to be raised otherwise, budgeting or costs involved can be wasteful. A well-made plan is needed to increase the use of the roof spaces. The behavior of and preference for roof spaces could differ depending on building usage because the users of these roof spaces can be different. Therefore, this study selected 4 building types depending on usage: public buildings, educational and research buildings, medical buildings, and commercial buildings. Two buildings that created roof spaces per building type were selected. A survey was undertaken of the user experience of roof spaces on the buildings. The behavior and preference of roof spaces depending on building types were analyzed and the results are as follows. The behavior of using roof spaces regarding purpose, motivation, frequency, and average length of stay were different depending on the building types. In terms of purpose, over all four building types, taking a rest was the primary reason for using roof spaces. However, talking and smoking in public buildings, smoking, taking a walk or stretching, and viewing the exterior landscape in educational and research buildings, taking a walk or stretching and talking in medical buildings, taking care of children and talking in commercial buildings were also important reasons for using roof spaces. The preference of roof space components such as plants, paving materials, and facilities were different depending on the building types. In terms of plants, the users of public buildings preferred herbaceous plants and vegetables/aquatic plants more than the users of other building types. The users of medical buildings preferred vegetables/aquatic plants, and the users of commercial buildings preferred arbores, herbaceous plants, and vegetables/aquatic plants more than the users of other building types. This study provides empirical data for the behavior and the preference of roof spaces depending on building types. These findings could provide new insights into how to increase the use of roof spaces.

COVID-19 대유행 시기 전후 국내 감염관련 환자안전 사고 보고 현황 분석

김은진,박연환,Eun-Jin Kim,Yeon-Hwan Park 한국기초간호학회 2023 Journal of korean biological nursing science Vol.25 No.2

Purpose: The purpose of this study was to analyze the trends and characteristics of infection-related patient safety incident reporting before and during the coronavirus disease 2019 (COVID-19) pandemic in Korea, and to provide basic data for preventing infection-related patient safety incidents and improving their management. Methods: A cross-sectional analysis of secondary national data (Patient Safety Reporting Data) was conducted. In total, 517 infection-related patient safety incidents reported from 2018 to 2021 were analyzed. Changes in the number of reports before and during the COVID-19 pandemic and differences in variables related to infection-related patient safety incidents were analyzed using the chi-square test and independent t-test in SPSS 29.0. Results: This study found that infection-related patient safety incidents decreased during the COVID-19 pandemic compared to before the pandemic. Furthermore, incident-related characteristics, such as the type of healthcare organization, severity of harm, and post-incident actions, changed during the COVID-19 pandemic. Conclusion: The many changes in the infection control system and practices during the COVID-19 pandemic may have contributed to a decrease in the reporting of infection-related patient safety incidents. It is hoped that longitudinal studies on patient safety incidents related to the pandemic and analytical studies on factors influencing patient safety incidents will continue to be conducted to prevent and improve patient safety incidents.

삼출건비탕가미방(蔘出健脾湯加味方)을 이용한 식간(食癎) 환아 치험 2례에 대한 증례보고

김은진,민상연,김장현,Kim, Eun Jin,Min, Sang Yoen,Kim, Jang Hyun 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.4

Objectives The purpose of this study is to report the cases of two pediatric patients diagnosed as Sik-gan (食癎), a kind of epileptic seizure thought to be caused by uncontrolled consumption of food, treated by formula variation of Samchulkunbi-tang (蔘朮健脾湯). Methods Two pediatric patients diagnosed as Sik-gan (食癎) according to traditional Korean medical terms were administered by variety of Samchulkunbi-tangs (蔘朮健脾湯) while correcting unhealthy eating habit. To measure the degree of the patients' process, the number and exact symptoms of seizure events, and gastrointestinal symptoms were recorded. Results The treatment of various Samchulkunbi-tang (蔘朮健脾湯) was not only extended remission period of seizure, but also improved gastrointestinal symptoms on both of the patients. Conclusions Pediatric patients who have past medical conditions for epileptic seizure as well as unhealthy eating habits or gastrointestinal malfunctions are prone to have a specific form of seizure called the Sik-gan (食癎). In this report, we have proven that variety of Samchulkunbi-tang (蔘朮健脾湯) can considerably be effective in improving the patients' gastrointestinal symptoms and preventing recurring seizure events.

금수육군전(金水六君煎)이 이산화황으로 유발된 흰쥐의 호흡기 점액 및 뮤신생성에 미치는 영향

김은진,민상연,김장현,Kim, Eun Jin,Min, Sang Yeon,Kim, Jang Hyun 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.2

Objectives In this study, effect of Geumsuyukgunjeon (GYJ) on the increase in airway epithelial mucosubstances of rats with acute bronchitis and EGF-induced MUC5AC mucin production from human airway epithelial cells were investigated. Materials and Methods Hypersecretion of airway mucus was induced by exposure of rats to SO2 during 3 weeks. Effect of orally-administered GYJ during 2 weeks on increase in airway epithelial mucosubstances from tracheal goblet cells of rats was assesed using histopathological analysis after staining the epithelial tissue with PAS-alcian blue. Possible cytotoxicity of GYJ was assessed by examining the potential damage of kidney and liver functions by measuring serum GOT/GPT activities and serum BUN and creatinine concentrations of rats and the body weight gain during experiment, after administering GYJ orally. Effect of GYJ on EGF-induced MUC5AC mucin production from human airway epithelial cells (A549) was investigated. Confluent A549 cells were pretreated for 30 min in the presence of GYJ and treated with EGF (25 ng/ml) for 24 hrs, to assess the effect of GYJ on EGF-induced MUC5AC mucin production using enzyme-linked immunosorbent assay (ELISA). Results (1) GYJ decreased the amount of intraepithelial mucosubstances of trachea of rats. (2) GYJ did not show kidney and liver toxicities and did not affect body weight gain of rats during experiment. (3) GYJ significantly inhibited EGF-induced MUC5AC mucin production from A549 cells. Conclusions The result from the present study suggests that GYJ might control both the mucus hypersecretion in vivo and do not show in vivo toxicity to liver and kidney functions after oral administration and the production of pulmonary mucin.

2016년을 전망하다 - 2016년, 석유화학 산업 구조개선 통해 위험 대비할 때

김은진,Kim, Eun-Jin 대한석유협회 2015 석유와 에너지 Vol.298 No.-