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암 환자에서 방사선 치료가 염색체에 미치는 영향에 관한 연구
김윤련,서흥석,함창곡,류명수 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.2
We evaluated frequency and types of chromosomal aberrations by ionizing radiation in cancer patients treated in our institution. Twenty-five patients with various types of carcinomas such as lung. uterine cervix. esophagus, head and neck, rectum and pancreatic cancers were studied just before and immediately after external beam radiotherapy. The incidence of aberrant methphases prior to treatment was 4.93%, which was higher than that of control group. In lung cancer the frequency of abrrant methphases was 3 times higher than that of control. A comparision of chromosome abnormalities abserved before and after the radiotherapy demonstrated that proportion of aberrant metabhases was significnatly increased to 22.13%. Major chromosomal aberrations especially structural abnormalities showed remarkable increase from 65.45 to 88.45%. The numbers of chormosomal alteration per cell were increased by a factor of 6.5 after radiotherapy. Structural changes with two ro more breakpoints increased rather than those with single breakpoint and these unbalbanced type more prominent than expected 1:1 ratio. Chromosomal breakpoints were observed more prominent than expected valued expecially in 1,3,8 and 11 chromosomes. However, those were decreased in 13,15,17 and 21 chromosomes. Based on this study, we believe that the distribution of chromosomal breakages is related with gene and chromosomal rearrangement which could result in the development of cancers.
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이용주,이은경,김용주,노경빈,김윤련,최숙자 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.3
Duodenal diaphragm is a rare congenital anomaly among the congenital duodenal obstructions. Its symptom and sign usually appear since birth if obstruction is complete. The clinical manifestations of incompletely obstructive duodenal diaphragm are intermittent vomiting, abdominal pain and poor weight gain. Diagnosis may be delayed in this case. Authors experienced a case of incomplete duodenal diaphragm with a central hole. A 29 months old girl presented failure to thrive, intermittent episodes of bloating, abdominal discomfort and occasional vomiting. The patient vomited every 10-14 days, then the abdominal pain and distention were relieved. She overate for about 10 days until the next projectile vomiting. The vomitus frequently contained food ingested several days previously. Plain x-ray films of abdomen showed marked gastric distention. Upper gastrointestinal series revealed marked distention of the duodenum with windsock configuration and radiolucent line at the third portion of the duodenum. On gastroscopic examination, gastric bezoar impacting the pyloric canal and antrum was noted. At operation, we found mucosal membrane in the third portion of the duodenum and bezoar(Chinese cabbage) above the membrane. Side-to-side duodeno-jejunostomy was performed and bezoar was removed. She was discharged on the 13th postoperative day without any complication.
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