Study on the Integration of Fabric Pilling Generation and Evaluation System

김유림,김성민,Kim, Yurim,Kim, Sungmin The Korean Fiber Society 2016 한국섬유공학회지 Vol.53 No.5

An integrated pilling formation and evaluation system has been developed to evaluate the fabric pilling automatically and objectively. A pilling generation system was made using custom 3-D printed parts to generate pilling under consistent abrasion condition. A CCD camera was used to capture the images of specimen before and during the abrasion to observe the chronological changes that occur during the pilling generation process. Image analysis technique was used to measure and grade the pilling objectively.

한국 고유 담수어종 참갈겨니(Zacco koreanus) 개체군의 계통지리학 및 집단유전학 연구

김유림,장지은,최희규,이혁제,Kim, Yu Rim,Jang, Ji Eun,Choi, Hee-kyu,Lee, Hyuk Je 한국환경생물학회 2020 환경생물 : 환경생물학회지 Vol.38 No.4

본 연구는 동해유입하천(강릉 연곡천, 양양 남대천), 한강수계(섬강, 속사천), 낙동강수계(길안천)에 서식하는 참갈겨니(Zacco koreanus) 개체군을 대상으로 채집된 110개체로부터 미토콘드리아 DNA COI 유전자(mitochondrial DNA cytochrome oxidase I)를 분자마커로 이용하여 계통지리학적 분석을 수행하고, 추가적으로 강릉 연곡천 상·중·하류 개체군을 대상으로 집단유전학적 분석을 수행하였다. 계통지리학 분석 결과, 동해유입하천과 한강수계의 참갈겨니 개체군은 동일한 단일계통을 나타내었고, 낙동강수계의 개체군은 상이한 계통으로 분기됨을 나타내었으며, 다른 수계 계통과의 유전적 거리 수치 범위가 평균 4.0%(3.7~4.2%)로서 동일종 이상 수준을 보여 잠재종 가능성을 시사하였다. 참갈겨니가 서식하는 수계에 따른 형태학적 차이는 연구된 바 있으나 DNA 염기서열의 변이를 이용한 분자유전학적 연구는 부족한 실정이므로 본 연구 결과는 향후 낙동강수계 참갈겨니 개체군의 계통분류학적 연구에 기초자료로 활용될 수 있을 것으로 판단된다. 추후 집단유전체학 및 생태학적 분석을 통하여 관찰된 낙동강수계 계통이 다른 종, 잠재종 혹은 단순히 큰 수준의 종내 변이를 나타내는지에 대한 추가적인 연구가 필요하다. 강릉 연곡천 상·중·하류에 서식하는 개체군의 집단유전학 분석을 통해 중류의 개체군이 상대적으로 높은 다양성을 나타냈으며 상·중·하류 개체군 간의 유전적 차이는 나타나지 않았다. 이는 상·중·하류 개체군 간 유전자 확산이 원활하게 이루어지고 있음을 의미하며 하천의 개체군 간 연결성을 판단할 수 있는 지표로 활용될 수 있다. 하지만 생태학적 시간 스케일의 연구에 더 적합한 분자마커를 이용한 추후 연구가 필요할 것으로 사료된다. We conducted a phylogeographic analysis of Korean endemic Zacco koreanus populations inhabiting the East-flowing river (Gangneung Yeongokcheon; GY, Yangyang Namdaecheon; YN), the Han River (Seomgang; SG, Soksacheon; SS), and the Nakdong River(Gilancheon; GA) using the mitochondrial DNA cytochrome oxidase I (COI) gene (619 bp). Population genetic analysis was further performed to assess the population connectivity for the GY river where there is a large number of human-made artificial weirs with several fishways. The phylogeographic analysis revealed that while the populations of the East-flowing river and those of the Han River formed a monophyletic lineage, the Nakdong River individuals represented a distinct lineage with 3.7-4.2% (mean=4.0%) genetic distance from the other lineages. The population genetic analysis of the GY showed that a mid-stream population harbored relatively higher mitochondrial diversity relative to up- and down-stream populations, and there was no genetic differentiation between these three populations. The latter findings might suggest high genetic connectivity between the populations via genetic flow along the fishways. However, an analysis using faster-evolving genetic markers, such as microsatellites, is needed to confirm the findings of high population connectivity. Our study suggests the possibility of the presence of cryptic species in Z. koreanus in the Nakdong River basin. However, further study with more individual samples as well as additional markers or even more advanced genomic tools is required to test our hypothesis. Ecological or phenotypic analyses should be conducted to test whether the observed Nakdong River lineage represents a different or cryptic species, or simply hidden, but excessive, intraspecific diversity.

Impact of bronchiectasis on clinical outcome and medical utilization in COPD patients

김유림,( Kyungjoo Kim ),( Seung Won Ra ),( Chin Kook Rhee ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

With use of computed tomography, bronchiectasis(BE) is not uncommon finding in chronic obstructive pulmonary disease (COPD) patients, but there has not fully understood the clinical aspects of COPD with BE. We aimed to investigate the effect of BE on prognosis and medical utilization in patients with COPD. From the Health Insurance Review and Assessment(HIRA) data from 2011 to 2015, we identified COPD patients and checked the co-existence of BE. Exacerbation and medical utilization were compared between COPD with BE (COPD-BE) and COPD without BE group. Of 263,747 COPD patients, 19,285 (7.3%) were classified as COPD-BE and 244,462(92.7%) as COPD without BE. The percentages of hospitalization including emergency room visits and intensive care unit admission were higher in COPD-BE group (36.0%vs.26.1%,p<0.001; 6.3% vs. 5.0%, p <0.001), and the co-existence of BE was found to be a crucial factor for moderate to severe exacerbation in multivariate analysis( incidence rate ratio [IRR] 1.29; 95% CI 1.271-1.319; p<0.001). Exacerbation with the need for antibiotics was significantly higher in COPD-BE group. Days and costs during medical utilization were also higher in patients with COPD-BE, compared to those with COPD without BE(17.43±29.67vs.13.44±24.82 days, p<0.001; 2024.77±4903.85 vs. 1473.45±4346.24 USD, p<0.001). Age, gender, insurance type, co-existence of BE, and medications were found to be important factors for exacerbation and medical costs in multiple linear regression. COPD patients with BE demonstrated worse outcomes and higher medical costs than COPD patients without BE.

교사학습공동체 활동을 한 초임중등과학교사의 과학 탐구 수업에 대한 인식

김유림,최애란,Kim, Yurim,Choi, Aeran 대한화학회 2019 대한화학회지 Vol.63 No.5

본 연구는 교사학습공동체에서 과학 탐구 수업이라는 공동의 목표를 자발적으로 설정하고 1년 이상 탐구 수업 계획, 실행 경험 공유, 반성을 함께 한 5명의 교사를 대상으로 과학 탐구 수업에 대하여 어떠한 인식을 갖고 있는지 개방형 설문과 개별 면담 자료를 통해 알아보는 것을 목적으로 한다. 본 연구 참여 교사들은 과학 수업에서 학생들이 스스로 탐구를 수행함으로써 교육 과정에 제시된 과학 핵심 개념을 형성하는 것이 과학 탐구 수업의 목표라고 인식하는 것으로 나타났다. 또한 본 연구의 참여교사들은 학생들이 과학 수업에서 탐구를 수행하면 '과학 핵심 개념 학습', '과학에 대한 흥미 향상', '과학적 사고력 함양', '과학의 본성 이해' 등의 과학 교육의 목표를 달성할 수 있다고 인식하는 것으로 나타났다. 본 연구의 참여 교사들은 과학 탐구 수업에서 교사의 역할이 중요하다는 것뿐만 아니라 과학 탐구 수업에서 학생들이 탐구를 수행할 수 있도록 하기 위해 교사가 어떠한 역할을 해야 하는지 구체적으로 인식하는 것으로 나타났다. 과학 수업에서 학생들이 능동적으로 탐구를 수행할 수 있도록 교사는 '핵심 개념 설정', '과학 실천 기반 교수-학습 내용 재구성', '학생의 수준 고려', '발문 및 피드백 제공', '과학적 개념 설명', '학생들의 활발한 논의 유도'하는 역할을 해야한다고 강조하였다. The purpose of this study was to investigate beginning science teachers' perceptions of inquiry-based science instruction using open-ended questionnaire and semi-structured interview. Participants of this study voluntarily set up a goal of inquiry-based science instruction, planned inquiry-based science lessons, and shared and reflected their teaching experiences in their professional learning community for more than a year. Participant teachers recognized students' construction of core scientific concepts through performing scientific inquiry as a goal of science inquiry instruction. Participant teachers indicated that goals of science education such as 'learning scientific core concepts', 'improving students' interest of science', 'improving scientific thinking', and 'understanding the nature of science' can be achieved through students' active engagement in scientific inquiry. Participant teachers recognized not only the importance of teachers' role, but also what roles science teachers should play in order to enable students to perform scientific inquiry. Participant teachers emphasized teachers' roles such as 'identifying core concepts', 'reorganizing science curriculum', 'considering student ability', 'asking questions and providing feedbacks to students', 'explaining scientific concepts', and 'leading students' argumentation.'

A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hürthle Cell Thyroid Cancer and Meningioma

김유림,Young Woo Jang,Jin Taek Kim,성수아,Tae Seok Lee,Won Mi Lee,Hyo Jeong Kim 대한의학회 2012 Journal of Korean medical science Vol.27 No.5

Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hürthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.

뇌성마비 아동의 한방 및 보완대체의료 이용 실태

김유림,구현경,윤영주,Kim, Yurim,Gu, Hyungyung,Yun, Youngju 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.2

Objective : The aim of this study was to review the use of Korean medicine (KM) or Complementary and Alternative Medicine (CAM) therapies among children with cerebral palsy (CP). Method : Literature searches were performed using Pudmed, CNKI, J-STAGE and four Korean databases. We investigated the frequency, types, predictors of the use of KM or CAM therapies used in children with CP. Results : Thirteen survey studies including use of KM or CAM among children with CP were selected - six Korean studies and seven overseas studies. The utilization rate of CAM among children with CP varied 26.8~56.0% according to the studies. CP children used KM or CAM more than other children with chronic disease. Acupuncture and Korean herbal medicine was the major treatment used in Korea, however physical manipulations such as massage, osteopathy and chiropractic were in high demand in western country. Disease severity of CP, use of CAM in the past by the parent or family member and high education of parent are the factors that significantly affect CAM utilization. Conclusion : Further studies on effectiveness and safety of KM therapies combined with conventional rehabilitation treatment would be required to expand the implementation of KM treatment for CP children.

Rebamipide Protects Colonic Damage Induced by Trinitrobenzene Sulfonic Acid (TNBS) via Down-Regulation of TNF-α, IL-1β‚ and ICAM-1

김연하(Yeun-Ha Kim),김성중(Sung-Jung Kim),황호근(Ho-Geun Hwang),최석채(Suk-Chei Choi),김유림(Yu-Rim Kim),김경숙(Kyung-Suk Kim),김철(Chul Kim),최덕화(Deok-Hwa Choi),오정택(Jung-Taek Oh),김강득(Gang-Deuk Kim),김혜원(Hye-Won Kim),전창덕(C 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.2

염증성 장 질환의 병리기전에는 tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) 및 intracellular adhesion molecule-1 (ICAM-1)의 발현 등 수많은 염증반응의 매개 물질들이 관여하고 있다. Rebamipide는 위염과 위궤양 치료제로 개발된 약제로 아직까지 염증성 장 질환의 치료효과를 검증한 연구는 거의 없다. 따라서 본 연구에서는 Rebamipide의 염증성 장 질환에 대한 치료효과를 검증하고 그 기전을 분석하고자 Rebamipide의 TNF-α와 IL-1β, 그리고 세포의 부착에 중요한 역할을 하는 ICAM-1의 발현의 조절에 대한 효과를 조사하였다. 5%의 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)를 실험 첫째날과 7일째에 직장 내로 넣어줌으로써 염증성 장질환의 동물모델을 제작하였고 2mM의 Rebamipide를 실험 0일, 3일, 6일째에 역시 직장 내로 투여하여 염증 억제 효과를 분석하였다. Rebamipide는 TNBS에 의하여 유도되는 체중감소를 현저히 억제하였으며 대장의 충혈과 부종역시 억제하였다. 조직소견에서도 Rebamipide 는 TNBS에 의해 유도되는 염증세포의 침착을 현저히 억제하였다. 또한 Rebamipide에 의해 TNF-α, IL-1β 및 ICAM-1의 발현 역시 현저히 억제되는 것을 면역 조직 화학 염색법을 통하여 확인하였다. 결론적으로 Rebamipide는 TNF-α, IL-1β와, ICAM-1의 발현을 조절함으로써 TNBS에 의해 유도되는 대장의 손상을 억제하리라고 생각되며 염증성 장 질환의 치료에도 좋은 효과가 있을 것으로 생각한다. During inflammation of the colon, cells of the gut mucosa produce or express numerous inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and intercellular adhesion molecule 1 (ICAM-1). These mediators have been implicated as contributory factors to the inflammatory process, which results in colitis during inflammatory bowel disease (IBD). Rebamipide is an anti-gastric ulcer drug with anti-inflammatory properties in vivo and in vitro. The effects of Rebamipide on IBD have not been largely evaluated. Therefore, this study investigated the potential of Rebamipide to regulate the production of inflammatory mediators such as TNF-α, IL-1β, and ICAM-1. Mice with trinitrobenzene sulfonic acid (TNBS)-induced colitis (IBD animal model), were treated intrarectally with 2 mM Rebamipide. Body weight, macro- and micro-histological scores, and activity were evaluated. As an index of tissue edema, the thickness of the colonic wall was measured between the serosal surface and the luminal surface of the mucosa. TNF-α, IL-1β, and ICAM-1 were detected by immunohistochemical staining. Rebamipide treatment of mice exhibiting TNBS-induced colitis dramatically improved the clinical and histopathological findings of inflammation. In addition, Rebamipide suppressed TNF-α, IL-1β, and ICAM-1 expression in TNBS-treated animals. Taken together, these findings suggest that Rebamipide is a potential therapeutic agent for treating patients with IBD.

스팀 절감량 예측을 위한 흑액 다중 효용 증발 공정 모델 개발

김유림 ( Yurim Kim ),임종훈 ( Jonghun Lim ),최영렬 ( Yeongryeol Choi ),김태복 ( Taebok Kim ),박한신 ( Hansin Park ),조형태 ( Hyungtae Cho ),김정환 ( Junghwan Kim ) 한국화학공학회 2022 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.60 No.1

본 연구에서는 흑액 증발공정에 소비되는 스팀의 절감량을 예측하기 위해 증발기 수에 따른 다중 효용 증발공정 모델을 개발하였다. 개발한 공정 모델은 흑액의 예열 및 증발 과정으로 구성되어 있고, 스팀 사용량을 예측하기 위해 가상의 재비기가 추가되었다. 시뮬레이션 결과, 2중 효용 증발기에서 스팀 사용량은 48.9% 감소하였고, 증발기 수가 증가함에 따라 스팀 사용량이 감소하여 8중 효용 증발기에서 최대 76.5% 감소함을 확인하였다. 시뮬레이션 결과를 증발기 수에 따른 포화증기의 잠열 회수량, 스팀 사용량, 각 증발기의 포화증기 생산량으로 분석하여 최적의 증발기 수 도출을 위한 방안을 제시하였다. This study developed the black liquor evaporation process models using the multiple-effect-evaporator according to the number of effects to predict steam consumption. The developed models were divided into the black liquor preheating and evaporation processes, and a virtual reboiler was added to predict steam consumption. In simulation results, the steam consumption in the double-effect-evaporator was decreased by 48.9 %, and as the number of effects increased, the steam consumption was decreased. Finally, the steam consumption in the octuple-effectevaporator was decreased by 61.2 %. Also, this study suggests a strategy for deriving the optimal number of effects in the process by analyzing the latent heat recovered from the saturated vapor produced in the multiple-effect-evaporator and the amount of saturated vapor produced by each effect.

초기 하중을 갖는 고압 실린더의 압축 성능 예측

김유림(Yu Lim Kim),김성훈(Sung Hoon Kim),조창주(Chang Joo Cho),김성백(Sung Baek Kim),최병준(Byoung Jun Choi),임형진(Hyung Jin Im) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.4

독립형 마이크로그리드 시스템에서 마스터 인버터의 양방향 운전특성에 관한 연구

김승호(Seung-Ho Kim),김병목(Byung-Mok Kim),김유림(Yoo-Rim Kim),김승종(Seung-Jong Kim),안종보(Jong-Bo Ahn),노대석(Dae-Seok Rho) 대한전기학회 2016 대한전기학회 학술대회 논문집 Vol.2016 No.7