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마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과
김용준,이정치,김홍용,설광화,윤용갑,장선일,Kim Young Jun,Lee Jeong Chi,Kim Hong Yong,Xie Guanghua,Yun Yong Gab,Jang Seon Il 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6, IL-10 and $IFN-\gamma$ on DNFB-induced Th1 and Th2 cytokines in a concentration-dependent manner. Interestingly, this compound increased the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner The above results reveal that wogonin possesses anti-inflammatory, humoral and cellular immunomodulatory, and stress reducing activities on the DNFB-induced DTH in mice and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.
$CD4^+$ Jurkat T 세포주에서 Th1과 Th2 사이토가인 조절에 미치는 황금 유래 Baicalin, Baicalein 및 Wogonin의 효과
김용준,이정치,김홍용,설광화,윤용갑,장선일,Kim Young Jun,Lee Jeong Chi,Kim Hong Yong,Xie Guanghua,Yun Yong Gab,Jang Seon Il 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
In the present study, baicalin, baicalein, and wogonin, a major flavone isolated from Scutellaria Radix were examined for their effects on PMA-induced Interlukin-6 (IL-6), $interferon-\gamma(IFN-\gamma)$, tumor necrosis factor $(TNF)-\alpha$, IL-4, IL-10, and IL-13 productions in the PMA-stimulated $CD4^+$ Jurkat T cells. These three compounds inhibited PMA-induced Th1 cytokine $(IL-6,\;IFN-\gamma,\;TNF-\alpha)$ and Th2 cytokine (IL-4 and IL-13) productions in a concentration-dependent manner. But wogonin, but not baicalin baicalein, increased PMA-induced IL-10 production. These results suggest that baicalin, baicalein, and wogonin, a major flavone modulate Th1 and Th2 cytokine productions in $CD4^+$ Jurkat T cells and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.
디지털 임플란트 시스템을 전용한 "All-on-4" 개념의 임플란트 보철 증례
김용준,정승미,김경희,방정환,김대환,최병호,Kim, Yong-Jun,Jeong, Seung-Mi,Kim, Kyeong-Hee,Fang, Jeong-Whan,Kim, Dae-Hwan,Choi, Byung-Ho 대한치과보철학회 2018 대한치과보철학회지 Vol.56 No.1
최근 치과치료의 영역에서 디지털 임플란트 시스템은 그 영역을 넓혀 나가고 있다. 디지털 장비들의 기술적 발전에 힘입어 한계점들이 하나 둘씩 극복되었다. 초기 단일치아 수복 정도에나 사용되었던 디지털 임플란트 시스템은 임플란트 수술에서부터 보철물 제작까지 무치악의 영역에서도 사용되고 있다. 본 증례에서는 50세의 하악 무치악 환자가 임플란트를 이용한 교합 재건을 원하였다. 하악의 임플란트 수복을 위해서 "All-on-4" 개념의 디지털 임플란트 시스템 사용을 계획하였고, 무절개 수술을 위한 가이드 장치를 제작하여 수술을 시행하였다. 수술 후, 전악 보철을 디지털 장비를 이용하여 제작하였다. 전체 치료 과정에서 기존의 아날로그 방식(인상채득, 납형 제작, 주조 등)을 가능한 배제하고 디지털 시스템을 이용하여 기공과정 및 임상과정을 최소화하기로 계획하였고 만족할만한 결과를 얻었기에 보고하는 바이다. Recently, digital implant systems are expanding its influence in dental area. Due to technical improvement, they jumped over their limits nowadays. We can use these newest systems to treat edentulous patient, from implant surgery to fabrication of prosthesis. In this case, The patient was a fifty years old female. She had a full edentulous ridge on mandible and wanted to reconstruct occlusion with using implants. We planned to use digital implant system with "all-on-4" concept on mandible and produced surgical guide for flapless implant surgery. After the surgery, we tried to fabricate full arch prosthesis just using a digital devices and confirmed satisfying result.
옥천지향사대(沃川地向斜帶) 동남대(東南帶)에서의 화성활동(火成活動)(III)(나주(羅州)-남창지역(南倉地域)을 중심(中心)으로)
김용준,박영석,주승환,오민수,박재봉,Kim, Yong-Jun,Park, Young-Seog,Choo, Seung-Hwan,Oh, Min-Soo,Park, Jay-Bong 대한자원환경지질학회 1991 자원환경지질 Vol.24 No.3
The main aspect of this study are to clarify igneous activity of igneous rocks, which is a member of various intrusives and volcanics exposed in Naju-Namchang area of southern central zone of Ogcheon Geosynclinal Belt, southern part of Youngdong-Kwangju depression zone of tectonic provinces in Korea. Naju-Namchang area are subdivided into three rock belts based on occuring of Cretaceous granites. Three rock belts consist of foliated granites, Jurassic granites and Cretaceous granites in central granitic rock belt (C-C), and acidic tuff and lavas in northwest volcanic rock belt(C-NW) and southeast volcanic rock belt(C-SE). Chemical composition of these igneous rocks show mostly similar trend to the Daly's values on Harker diagram and correspond to VAG + Syn-COLG region on Pearce's discrimination diagram. These igneous rocks vary wide range in total REE amount(37.4-221.3ppm) characterized by enriched LREE content and steep negative slope in Eu(-) anomaly. It is concluded each synchronous granites which composed of serveral rock facies is considered to formed by differentiation of co-magma at continental margin, and igneous activity of study area are two more Pre-Cambrian Orogenies, Songrim Disturbance, Daebo Orogeny and Bulkuksa Disturbance.
옥천지향사대(沃川地向斜帶) 동남대(東南帶)에서의 화성활동(火成活動)(I): 남원(南原)-거창(居昌)-상주(尙州) 지역(地域)을 중심(中心)으로
김용준,박영석,주승환,오민수,Kim, Yong Jun,Park, Yong Seog,Choo, Seung Hwan,Oh, Mihn Soo 대한자원환경지질학회 1989 자원환경지질 Vol.22 No.4
Igneous rocks of study area consist of Pre-Cambrian orthogneiss, Devonian granite, Triassic foliated granites and Jurassic granites distributed along the southeast margin of Ogcheon Geosynclinal belt(SE-zone), and irregular shaped granitic stocks in the central part of the belt(C-zone). Anorthosite and gaabbro are also present in southern part of the SE-zone in the belt and intruded into gneiss complex of Ryongnam massif. Distribuition of foliated granites shows three linear arrangements which are composed of hornblende-biotite foliated granodiorite, porphyritic foliated granodiorite, biotite foliated granodiorite, leuco foliated granite and two mica foliated granite. Foliated granites generated by dextral strike slip movement at deep level. Jurassic granites composed of several rock facies are considered to be formed by differentiation of magma during Daebo Orogeny. A general trend of the chemical composition of these igneous rocks in study area suggests that most of them corresponding to calc-alkaline rock series was affected under orogeny and I-type granite except for two mica foliated granite. In chondrite normalised REE pattern of these igneous rocks, LREE shows more variable range and strong (-)Eu anomaly than HREE. Geochronological episodes of igneous activity from early Proterozoic to Cretaceous in SE-zone of Ogcheon Geosynclinal belt are two more Pre-Cambrian Orogeny, Devonian Orogeny(Variscan), Songrim Disturbance, Daebo Orogeny and Bulkuksa Disturbance.
영남육괴(嶺南陸塊)에 분포(分布)하는 고기화강암질암(古期花崗巖質岩)의 지질연대(地質年代)와 성인(成因)에 대(對)한 연구(硏究)
김용준,Kim, Yong Jun 대한자원환경지질학회 1986 자원환경지질 Vol.19 No.no.spc
The older granitic rocks of the study area are composed of mainly orthogneiss and foliated granite. These rocks shows mostly mortar or fiaser structure by strong mylonitization and thermal metamorphism during several orogenies. $^{40}Ar-^{39}Ar$ incremental·release ages of these rocks have been determined for 6 hornblende. 7 muscovite and 4 biotite concentrates separated from rocks collected across the Ryeongnam massif. Most $^{40}Ar-^{39}Ar$ age are discordant with Rb-Sr whole rock age of the same area. These ages range from 1998 to 172Ma. This discordant age is interpreted to indicate that samples were in contact with Daebo granite body that was characterized by large and variable $^{40}Ar-^{39}Ar$ ratios. Such ratios most likely resulted from widespread diffusion of the argon liberated from older granitic rocks during several metamorphic overprint. The general trend of the chemical composition of these rocks suggest that most of them are some series of differentiated products by fractional crystallization.
김용준,조충호,Kim Yong-Jun,Jo Choong-Ho 한국임상수의학회 1990 한국임상수의학회지 Vol.7 No.1
To investigate the changes of adrenal gland associated with follicular cyst in Korean native cattle, adrenals ans ovaries were collected from 54 Korean native cattle at abbatoir. Adrenals were stained by H-E stain and they were examined under light microscope. Enlargement of adrenal cortex affecting fascicular and reticular zone appeared in cows associated with follicular cyst.