연 폭로시 성별에 따른 혈중 Zinc Protoporphyrin의 양-반응 관계

김용배,리갑수,황규윤,이성수,안규동,이병국,안현철,Kim, Yong-Bae,Lee, Gap-Soo,Hwang, Kyu-Yoon,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook,Ahn, Hyun-Cheol 대한예방의학회 1999 Journal of Preventive Medicine and Public Health Vol.32 No.4

Objectives : To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. Methods : A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. Results : $Mean{\pm}SD$ of blood lead and ZPP level was different between male$(27.7{\pm}10{\mu}g/dl\;and\;51.3{\pm}23.4{\mu}g/dl)$ and female subjects$(22.5{\pm}9.2{\mu}g/dl\;and\;78.7{\pm}38.6{\mu}g/dl)$. After adjusting for possible confounders, the effect modification by gender was significant in linear$(\beta=1.119,\;p<0.001)$, exponential$(\beta=Exp(0.008),\;p<0.05)$, and quadratic model$(\beta=1.388,\;p<0.001)$. In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers$(\beta=0.036,\;p<0.001)$, but an exponential relation in female lead workers$(\beta=Exp(0.029), p<0.001)$. Conclusion : Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males.

가토 대동맥 평활근에서 인삼 알콜 추출물에 의한 Calcium 동원에 관한 연구

김용배,이영호,강복순,강두희,Kim, Yong-Bae,Lee, Young-Ho,Kang, Bok-Soon,Kang, Doo-Hee 대한생리학회 1990 대한생리학회지 Vol.24 No.1

There have been conflicting reports concerning the effect of Panax ginseng on the contractility of vascular smooth muscle, i.e., Panax ginseng extract has been reported to cause relaxation, contraction or to have no effect on the tension of vascular smooth muscle. A further investigation of $Ca^{++}$ stores which supply $Ca^{++}$ for contraction of vascular smooth muscle is needed to understand the underlying mechanisms of this conflicting effect of ginseng alcohol extract (GAE). The present study was intended to examine the sources of calcium mobilized for contraction of vascular smooth muscle by GAE. Aortic ring preparations were made from the rabbit thoracic aorta and endothelial cells were removed from the ring. The contractility of the aortic ring was measured under various experimental conditions and $Ca^{++}$ flux across the membrane of aortic ring and the sarcoplasmic reticulum and mitochondria were measured with a calcium selective electrode. The result were summarized as follows; 1) At low concentration of extracellular $Ca^{++}$, GAE increased the contractility of vascular smooth muscle in dose-dependent fashion except high concentration $Ca^{++}$ (1 mM). 2) In the presence of ryanodine, GAE still increased contractility of vascular smooth muscle as much as control group, but in the presence of caffeine, GAE increased it significantly. i.e. Their effects seemed to be additive. 3) In the presence of verapamil+lanthanum, and verapamil+lanthanum+ryanodine, the contractility of the vascular smooth muscle was decreased, but a dose dependent increase in vascular tension was still demonstrated by GAE although total tension was low. 4) GAE increased $Ca^{++}$ efflux from vascular smooth muscle cells, but have no effect on $Ca^{++}$ influx. 5) GAE increased $Ca^{++}$ efflux from sarcoplasmic reticulum and mitochondria vesicles. From the above results, it may be concluded that GAE increased the release of $Ca^{++}$ from sarcoplasmic reticulum, mitochondria or other intracellular $Ca^{++}$ stores of vascular smooth muscle, but it does not increase $Ca^{++}$ influx across the plasma membrane.

커튼월 관련 자재에서 RFID 적용을 위한 인식 성능 테스트

김용배,송제홍,윤수원,진상윤,권순욱,김예상,Kim, Yong-Bae,Song, Jae-Hong,Yoon, Soo-Won,Chin, Sang-Yoon,Kwon, Soon-Wook,Kim, Yea-Sang 한국건설관리학회 2008 건설관리 : 한국건설관리학회 학회지 Vol.9 No.1

최근 RFID기술은 산업 전반에서 다양한 형태로 적용되고 있으며, 국내 건설 산업 분야에서도 현장 노무관리 및 레미콘, 철골, 커튼월 등의 물류관리를 위한 적용 기술 개발 및 연구가 활발히 수행되고 있다. 그러나 RFID 기술은 주변 환경 및 자재의 특성에 따라 인식성능의 차이를 보임에도 불구하고, RFID 기술 활용은 이론적인 인식 성능에 근거한 적용방안을 제시하고 있다. 본 연구는 이론적 인식거리, 무반사실 테스트, 현장 테스트를 통해 RFID 기술별 인식 성능 테스트를 하였으며, 일반적으로 현장에서의 인식거리는 감소하는 것으로 나타났다. 또한 커튼월의 주요 자재인 알루미늄과 유리를 대상으로 정확한 인식 성능 테스트를 실시 비교하였으며, 유리면이나 금속면에 일반 라벨 태그를 부착하였을 경우 유리 전용 태그나 금속 태그를 부착하였을 때에 비해서 인식이 불가능하거나 인식 거리 감소가 큰 것으로 나타났다. 따라서 본 연구에서는 위와 같은 테스트를 통해 커튼월에 RFID 기술 적용 시 인식 성능을 최적화하기 위한 고려 요소를 제시하고자 한다. The radio frequency identification (RFID) technology allows various forms of applications in many industries including construction. and in Korea, RFID has already been adopted for the use in daily labor control, logistics monitoring of ready-mix concrete, supply chain management of long-lead items, such as structural steel members and curtain walls. Even though RFID tags have varied reading performances depending on various factors including material of tracking target and surrounding environment, there is no information on how much the reading performance of an RFID tag can be achieved against a specific construction components or materials. Therefore, the objective of this research is to identify the actual reading performance of various RFID technologies and to derive a method to maximize the reading performance for the use in the supply chain management process of curtain wall components.

소화효소정제(消化酵素錠劑)의 제조(製造)에 관(關)한 연구(硏究) (제3보)(第3報)

김용배,이병국,민신홍,신현종,Kim, Yong-Bae,Yi, Pyong-Kuk,Min, Shin-Hong,Shin, Hyun-Jong 한국약제학회 1976 Journal of Pharmaceutical Investigation Vol.6 No.2

Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen, $Avicel{\circledR}$ and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then $Avicel{\circledR}$ and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.

절제 불가능한 췌장암의 동시항암화학방사선요법

김용배,성진실,송시영,박승우,서창옥,Kim, Yong-Bae,Seong, Jin-Sil,Song, Si-Young,Park, Seung-Woo,Suh, Chang-Ok 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.4

목적 : 절제 불가능한 췌장암은 예후가 불량하여 효과적인 치료법의 개발이 요망되고 있다. 본 연구에서는 Gemcitabine 또는 Paclitaxel과 5-Fluorouracil (5-FU)을 이용한 동시항암화학방사선요법을 시행하여 치료효과를 분석하고자 하였다. 대상 및 방법: 임상적으로 혹은 개복수술 소견 상 절제 불가능한 췌장암으로 진단받은 환자를 대상으로 Gemcitabine 또는 Paclitaxel과 5-FU을 이용한 동시항암화학방사선요법을 시행하였다. 방사선 치료는 원발병소와 주위 림프절을 포함하여 5주 동안 45 Gy를 조사하였다. 이 기간동안 Gemcitabine $1,000\;mg/m^2$ 또는 Paclitaxel $50\;mg/m^2$의 매주 1회 주사 및 5-FU의 매일 경구 투여를 시행하였다. 추적관찰기간은 6개월에서 36개월이었으며, 생존율은 Kaplan-Meier법을 이용하여 분석하였다. 결과 : 1999년 1월부터 2001년 11월까지 본 치료법이 시행된 경우는 54예였으며, 이중 계획된 치료를 종료한 42예를 분석하였다. 남녀 비는 30 : 12였고 중앙 연령은 60세였다. 총 54예 중 치료 중 원격전이나 암종증(carcinomatosis) 등으로의 진행 6명$(50\%)$, 시작시 불량한 전신수행 상태 4명$(33.3\%)$, 병변과 무관한 병발질환 1명$(8.3\%)$, 치료 거부 1명$(8.3\%)$ 등으로 총 12예에서 치료가 중단되었다. 42명의 환자 중 40예에서 반응 평가가 가능하였으며 완전 관해 1예, 부분 관해 24예로 관해율은 $59\%$로 나타났다. 중앙 생존값은 12개월, 1년 생존율은 $46.7\%$, 2년 생존율은 $17.0\%$였다. Grade III 이상의 치료독성으로는 혈액학적 독성이 8예$(19\%)$, 오심, 구토 등의 비혈액학적 독성이 9예$(20\%)$이었다. 이중 2명은 치료독성에 의한 상부 소화기 출혈로 사망하였다. 결론 : 절제 불가능한 췌장암에서 Gemcitabine 또는 Paclitaxel를 이용한 동시항암화학방사선요법은 관해율과 생존율에 있어서 효과적인 치료로 생각된다. 그러나 독성감소를 위한 연구가 또한 병행되어야 할 것으로 생각된다. Purpose : To analyze the treatment results of concurrent chemoradiation with oral 5-FU plus Gemcitabine or Paclitaxel for unresectable pancreatic cancer. Materials & Methods : The patients, who were diagnosed by imaging modalities or by explo-laparotomy, were treated with concurrent chemoradiation. Radiotherapy was delivered to primary tumor and regional lymph nodes, and the total dose was 45 Gy. Patients received Gemcitabine $1,000\;mg/m^2$ or Paclitaxel $50\;mg/m^2$ weekly and oral 5-FU daily The total number of cycles of chemotherapy ranged from 1 to 39 (median, 11 cycles). The follow-up period ranged from 6 to 36 months, Survival was analyzed using the Kaplan-Meier method. Results : Fifty-four patients between Jan. 1999 to Nov. 2001 were included in this study. Forty-two patients who completed the planned treatment were included in this analysis. The patients' age ranged from 37 to 73 years (median, 50 years) and the male to female ratio was 30:12. Treatment was interrupted for 12 patients due to: disease progression for 6 $(50\%)$, poor performance status for 4 $(33.3\%)$, intercurrent disease for 1 $(8.3\%)$, and refusal for 1 $(8.3\%)$. Response evaluation was possible for 40 patients. One patient gained complete remission and 24 patients gained partial remission, hence the response rate was $59\%$. The survival rates were $46.7\%\;and\;17.0\%$ at 1 year and 2 years, respectively with a median survival time of 12 months. Patients treated with Paclitaxel showed superior outcomes compared to those patients treated with Gemcitabine, in terms of both response rate and survival rate although this difference was not statistically significant. Grade III or IV hematologic toxicity was shown in 8 patients $(19\%)$, while grade III or IV non-hematologic toxicity was shown in 5 patients $(12\%)$. Conclusion : Concurrent chemoradiation with oral 5-FU and Gemcitabine or Paclitaxel improves both the response rate and survival rate in patients with unresectable pancreatic cancer. A prospective study should be investigated in order to improve both the patient selection and the treatment outcome as well as to reduce the toxicity.

소화효소제(消化酵素劑)의 제조(製造)에 관(關)한 연구(硏究) 제4보(第4報)

김용배,김완회,이병국,신현종,Kim, Yong-Bae,Kim, Whan-Hoe,Yi, Pyong-Kuk,Shin, Hyun-Jong 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.4

Since the active center of digestive enzymetic preparations, while under storage, lose their activity and potency by the exposure to moisture, colorization, solidifying and other physical changes. It is more important than beautiful package form that protected packaging form from moisture to get a pharmaceutical safety preparations and to maintain a definite potency. Then, in order to get a desirable conditions of storage and packaging, we used shellac and $AEA^{\circledR}$ as a coating base, and blister package, foil and bottle container as a packaging material. Temperature were set on room temperature and $37^{\circ}C$, moisture was adjusted to 40% RH and 80 % RH as a accelerated conditions. Accelerated test was carried out 6 times. The results are as follows: 1) The effect of packaging conditions give great influence on the maintenace of the stable potency. 2) Best result was produced with bottle container package. 3) $AEA^{\circledR}$ is more useful than shellac as a coating base of prevention from moisture. 4) Absorption of moisture gave considerable effects on potency and it has a limited point. 5) Difference in potency between optimal and worst condition is 472 u/2T, and difference in effective period is about 44 months.

연취급 근로자들의 혈중 ZPP 농도 선별기준에 따른 정확도의 변화

김용배,안현철,황보영,리갑수,이성수,안규동,이병국,Kim, Yong-Bae,Ahn, Hyun-Cheol,HwangBo, Young,Lee, Gap-Soo,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook 대한예방의학회 1997 예방의학회지 Vol.30 No.4

Measurement of blood lead (PbB) and blood zinc protoporphyrin (ZPP) are most common biological indices to identify the individual at risk for excess or the health sequences by lead exposure. Because PbB is known most important and reliable index of lead exposure, PbB is often regarded as a gold standard to detect lead exposure. But in Korea PbB is a secondary test item of detailed health check-up with positive finding of screening test in most occasion. Our lead standard requires all lead workers to take annual heath-check twice a year for investigation of their health effect due to lead exposure. Blood ZPP is one of most important index to detect high lead absorption in lead workers as a screening test. Measurement of blood ZPP is known ,well to correlate with PbB in steady state of exposure in most lead workers and is often used as a primary screening test to detect high lead absorption of lead workers with the advantage of simplicity, easiness, portability and low cost. The current cut-off criteria of blood ZPP for further detailed health check-up is $100{\mu}g/d\ell$ which is supposed to match the level of $40{\mu}g/d\ell$ of PbB according to our standard. Authors tried to investigate the validity of current criteria of cut-off level $(100{\mu}g/d\ell)$ of blood ZPP and possible another better cut-off level of it to detect the lead workers whose PbB level over $40{\mu}g/d\ell$. The subjects in our study were 212 male workers in three small scale storage battery industries. Blood ZPP, PbB and hemoglobin (Hb) were selected as the indices of lead exposure. The results were as follows. 1. The mean of blood ZPP, PbB and Hb in lead workers were $79.5{\pm}46.7{\mu}g/d\ell,\;38.7{\pm}15.1{\mu}g/d\ell,\;and\;14.8{\pm}1.2g/d\ell$, respectively. There were significant differences in blood ZPP, PbB and Hb by industry (P<0.01). 2. The percents of lead workers whose blood ZPP were above $100{\mu}g/d\ell$ in the group of work duration below 1, 1-4, 5-9 and above 10 years were 8.6%, 17.2%, 47.6%, and 50.0%, respectively. The percents of lead workers whose PbB were above $40{\mu}g/d\ell$ in those were 31.4%, 40.4%, 71.4%, and 86.4%, respectively. 3. The percents of lead workers whose PbB were below $40{\mu}g/d\ell$, $40-59{\mu}g/d\ell$ and above $60{\mu}g/d\ell$ were 54.7%, 34.9% and 10.4%, respectively. Those of lead workers whose blood ZPP were below $100{\mu}g/d\ell$, $100-149{\mu}g/d\ell$ and above $150{\mu}g/d\ell$ were 79.2%, 13.7% and 7.1%, respectively. 4. Simple linear regression of PbB on blood ZPP was statistically significant (P<0.01) and as PbB was $40{\mu}g/d\ell$, blood ZPP was $82.1{\mu}g/d\ell$. 5. While the highest sensitivity and specificity of blood ZPP test to detect lead workers with PbB eve. $40{\mu}g/d\ell$ were observed in the cut-off level of $50{\mu}g/d\ell$ and $100{\mu}g/d\ell$ of blood ZPP, respectively, the highest validity (sensitivity+specificity) of blood ZPP to detect lead workers with PbB over $40{\mu}g/d\ell$ was observed in the cut-off level of around $70{\mu}g/d\ell$ of blood ZPP. But even with optimal cut-off level of around $70{\mu}g/d\ell$ of blood ZPP, still 25.0% of false negative and 20.7% false positive lead workers were found. As the result of this study, it was suggested that reconsideration of current blood ZPP cut-off of our lead standard from $100{\mu}g/d\ell$ to somewhat lower level such as around $70{\mu}g/d\ell$ and the inclusion of PbB measurement as a primary screening test for lead workers was highly recommended for the effective prevention of lead workers.

입자 강화 복합재의 연속체 강도 해석을 위한 전위 펀치 영역 모델링 정식화의 타당성 연구

김용배(Yong Bae Kim),서영성(Yeong Sung Suh) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.4

Multiple Myeloma 4예

김용배(Kim Yong Bae),인주철(Ihnn Joo Choul),이수영(Lee Soo Young),김익동(Kim Ik Dong) 대한정형외과학회 1974 대한정형외과학회지 Vol.9 No.4

반도체 레이아웃의 자동이식과 수율 향상을 위한 자동화 시스템의 관한 연구

김용배(Yong-Bae Kim),신만철(Man-Chul Sin),김준영(Jun-Young Kim),이윤식(Yun-Sik Lee) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1A

반도체 설계는 급속한 기능 추가와 기가 헬쯔에 육박하는 고속 동작에 부응하는 제품의 설계와 빠른 출시를 위하여 다방면의 연구를 거듭하고 있다. 하지만, 인터넷과 정보 가전의 모바일 기 기기에서 요구하는 폭발적인 기능의 추가와 가전기기의 최소화를 위하여서는 그 요구를 감당하지 못하고 있다. 이를 위한 방안으로 설계 재활용과 System-On-Chip의 설계가 수년 전부터 대두되었으나 아직 큰 실효를 거두지 못하고 있다. SoC설계는 다기능을 한 칩에 구성하는 방법을 시도하고 있고, 설계 재활용은 기존의 설계(IP)를 다른 것과 혼합하여 필요한 기능을 제공하는 방법이 시도되고 있다. 이 두 가지의 VLSI 설계 방식 흐름을 가능하도록 하기 위한 연구로써, 레이아웃 이식에 관한 연구를 진행하였다. IP 재활용을 위하여서는 다양한 공정변화에 신속히 대응하고, 기존의 설계 설계규칙으로 설계된 도면을 현재의 공정인 0.25um, 0.18um 테크놀러지에 맞도록 변환하는 VLSI 소프트웨어 시스템을 필요로 한다. 레이아웃 설계도면을 분석하여 소자 및 배선을 인식하는 알고리즘을 연구와 개발하고, 도면을 첨단 테크놀러지의 설계 규칙에 부응하도록 타이밍, 소비, 전력, 수율을 고려한 최적의 소자 및 배선의 크기를 조절하는 방법을 고안하며, 칩 면적을 최적화할 수 있는 컴팩션 알고리즘을 개발하여 레이아웃 설계 도면을 이식할 수 있는 자동화소프트웨어 시스템을 연구하였다. 더불어, 현재 반도체 소프트웨어 시스템의 최대 문제점에 해당하는 처리 속도와 도면의 처리 능력을 비교, 검토하여 본 연구가 속도면에서 평균 27배, 효율면에서 3배 이상의 상대우위를 점하였다.