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We aimed to study about the effect of acute hyper-gravity (HG) on the allergic immune response in a murine model of allergic asthma. Thirty-two BALB/c mice were used. In Group A (control group, n=8), mice were sensitized and challenged with saline. Group B (HG control group, n=8) were exposed to HG (10 Gz, 1 hour) after intraperitoneal and intranasal saline challenge. Group C (asthma group, n=8) received intraperitoneal and intranasal ovalbumin (OVA) challenge. Group D (HG asthma group, n=8) were exposed to HG after intraperitoneal and intranasal OVA challenge. We evaluated serum total and OVA-specific IgE; serum titers of cytokines; and histopathologic examination of lung. As a result, titers of Serum total and OVA-specific IgE were not significantly different between groups. Compared to Group C, mice in Group D showed significant increase of Th2 cytokines (IL-4, IL-13), cytokines involved in eosinophilia (IL-3, IL-5, GM-CSF) and those involved in cell-medicated immunity (IFN-γ). In histopathologic examination, lungs of Group D showed significantly more infiltration of inflammatory cells compared to Group C. However, these differences were not so significant between Groups A and B. In conclusion, acute HG could exacerbate allergic asthma in experimental animals.
Several ground-based facilities have been developed for the study of hyper-gravity on Earth. Gravitational accelerator uses centrifugal force to make hyper-gravity condition. This machinery could be used not only for humans (for training of pilots), but also for experimental animals (basic research about its effect in vivo). In order to study the effect of long-term as well as short-term hyper-gravity on experimental animals, we developed Gravitational accelerator using rotatory centrifugal force. With 1 meter-long arms on both sides and with the rotational speed of 120 rpm, we could reproduce 15 Gz of hyper-gravity. We assured its stability and safety by operating it during 7 continuous days. After we made it certain that our Gravitational accelerator was well operated during that period, we performed additional study about the effect of hyper-gravity on the immune status of experimental animals.