림프절의 전이성 소세포암종의 세침흡인 세포학적 소견 - 악성 림프종과의 감별을 중심으로 5예 분석 -

김연미,조혜제,고일향,Kim, Yeon-Mee,Cho, Hye-Je,Ko, Ill-Hyang 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

Small cell carcinoma of the lung is characterized by cells with finely stippled chromatin and scanty cytoplasm as well as a particularly aggressive clinical course and favorable response to the chemotherapy. Recently percutaneous fine needle aspiration (FNA) biopsy has become both widely established and highly respected for the diagnosis of lung cancer. However metastatic small cell carcinoma of lymph node should be cytologically differentiated from the small round cell tumor of particular sites, especially malignant lymphoma, because small ceil carcinoma of classic oat cell type nay simulate small cell non-Hodgkin's lymphoma. We report five cases of metastatic small cell carcinoma of in-termediate cell type diagnosed by FNA of the enlarged lymph nodes of the neck and axilla. The cytologic smears contained diffuse small neoplastic cells larger than lymphocytes with dense, pyknotic nuclei and extremely scanty cytoplasm. Apparently viable large tumor cells have vesicular nuclei with granular, sometimes very coarse chromatin. The characteristic cytologic features of small cell carcinoma as compared to malignant lymphoma were as follows.: 1) small cells with dense pyknotic nuclei are evenly distributed in the background of apparently viable larger tumor cells, admixed with mature lymphocytes and phagocytic macrophages. 2) small loose aggregates of cells with nuclear melding are indicative of small cell carcinoma rather than non-Hodgkin's lymphoma. 3) the cytoplasmic and nuclear fragments of tumor necrosis are more dominant in the smears of small cell carcinoma. 4) nuclear membrane and nucleoli are generally indistinct in small cell carcinoma due to condensation of chromatin.

이행세포암종의 요 세포학적 소견 - 83예 분석 -

김연미,조혜제,Kim, Yeon-Mee,Cho, Hye-Je 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

Urinary cytology has become an essential element in the diagnosis and management of transitional ceil carcinoma(TCC) of the urinary tract. It has the advantage of being noninvasive, inexpensive, and easily accessible. Besides that it can even detect malignancy when unsuspected at cystoscopy. We report a retrospective review of urine cytology un the diagnosis of 83 TCC cases that underwent 295 cytologic evaluation. All patients had biopsy-proven TCC of the bladder, ureter and renal pelvis, The overall incidence of the positive cytology cases was 66.2%. To define the cytologic features of tumor cells, we tried to use three cytologic gradings such as "grade 1", "grade 2", and "grade 3" according to the cytologic degree of anaplastic neoplastic cells. These cytologic gades of TCC were relatively well correlated with the histologic grade and tumor invasiveness. This result suggests that the recognition of characteristic cellular features of TCC can suspect the histologic grade and tumor stage. The false negative TCC cases were 78.9%. They showed severe inflammatory or bloody background and a few neoplastic cells. Therefore, a cautious approach for accurate interpretation, personal experience, and proper fixation and processing could expand the role of urinary cytology.

비오톱 지도와 항공라이다 자료를 이용한 바람통로 분석 및 기후평가

김연미,안승만,문수영,김현수,장대희,Kim, Yeon-Mee,An, Seung-Man,Moon, Soo-Young,Kim, Hyeon-Soo,Jang, Dae-Hee 한국조경학회 2012 韓國造景學會誌 Vol.40 No.6

본 연구는 비오톱 지도와 항공 라이다 자료만을 이용해 GIS 분석기법을 적용하여 개개의 비오톱에 대한 기후분석 및 평가정보를 제공함을 목적으로 하고 있다. 1차 분석단계에서 비오톱 지도로부터 면적, 경사, 경사길이, 표면특성, 바람통로 기능, 바람통로 폭, 바람통로 장애물 요소를 각각 구하여 냉기/신선기 생성 및 바람통로 기능을 평가하였으며 2차 분석단계에서는 이들 요소를 종합하여 기후평가를 수행하여 비오톱 단위 별로 기후평가 자료를 생성하였다. 항공라이다 자료는 비오톱을 이용한 바람통로 분석에 유효하였다. 평가인자와 평가 등급 간의 상관성을 그래프 및 상관계수를 통해 확인한 결과 냉기/신선기 생성 등급과 Surface_GRD 평균값과의 상관계수가 (-)0.967로 높게 나타났으며 바람통로 기능에서는 등급별 Function_GRD 평균값과의 상관계수가 (-)0.884, Obstacle_GRD 평균값과의 상관계수는 (-)0.834로 나타났다. 기후평가 등급과 WindCorridor_GRD 상관계수는 0.928, 기후평가 등급과 ColdAir_GRD 상관계수는 0.855로 나타나 비오톱의 WindCorridor_GRD가 ColdAir_GRD에 비해 상관성이 높게 나타났으며 항공사진 정사영상을 이용한 육안 검수에서도 기후평가 및 등급화 결과가 잘 반영된 것으로 나타났다. 결과적으로, 비오톱 지도와 항공라이다 자료를 이용해 기후 분석 및 평가 방법을 적용한 결과 광명-시흥시 보금자리 주택개발 예정지의 기후평가등급에 따른 면적분포 비율은 1등급 18.5%, 2등급 18.2%, 3등급 30.7%, 4등급 25.2%, 5등급 7.4% 순으로 나타났으며 본 연구방법을 통해 기후평가 정보를 각각의 비오톱 단위별로 통계적 정보와 함께 제시할 수 있었다. The main purpose of this paper is to deliver a climate analysis and evaluation method based on GIS by using airborne LiDAR data and Biotop type map and to provide spatial information of climate analysis and evaluation based on Biotop type Map. At first stage, the area, slope, slope length, surface, wind corridor function and width, and obstacle factors were analyzed to obtain cold/fresh air production and wind corridor evaluation. In addition, climate evaluation was derived from those two results in the second stage. Airborne LiDAR data are useful in wind corridor analysis during the study. Correlation analysis results show that ColdAir_GRD grade was highly correlated with Surface_GRD (-0.967461139) and WindCorridor_ GRD was highly correlated with Function_GRD (-0.883883476) and Obstacle_GRD (-0.834057656). Climate Evaluation GRID was highly correlated with WindCorridor_GRD (0.927554516) than ColdAir_GRD (0.855051646). Visual validations of climate analysis and evaluation results were performed by using aerial ortho-photo image, which shows that the climate evaluation results were well related with in-situ condition. At the end, we applied climate analysis and evaluation by using Biotop map and airborne LiDAR data in Gwangmyung-Shiheung City, candidate for the Bogeumjari Housing District. The results show that the aerial percentile of the 1st Grade is 18.5%, 2nd Grade is 18.2%, 3rd Grade is 30.7%, 4th Grade is 25.2%, and 5th Grade is 7.4%. This study process provided both the spatial analysis and evaluation of climate information and statistics on behalf of each Biotop type.

뇌척수액내 종양세포의 원발부위 분석 및 세포학적 특징 - 총 1,438예 분석 -

김연미,전미영,지제근,Kim, Yeon-Mee,Jeon, Mi-Yeong,Chi, Je-Geun 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.2

Cytologlc evaluation of cerebrospinal fluid(CSF) is an effective mean for diagnosing many disorders involving the central nervous systems(CNS). One of the most important reasons for cytologic examination of CSF is to detect metastatic or primary neoplasms of the CNS. We did a retrospective study of 1,438 CSF specimens obtained between 1992 and 1996. A total of 1,205 adult and 233 pediatric CSF specimens from 947 patients were accessed at the Department of Pathology of Seoul National University Hospital and Children's Hospital, respectively. Among 1,438 CSF cytology specimens, 169 cases(11.8%, 77 patients) including 135 adult cases(59 patients) and 34 pediatric cases(18 patients) were positive for malignant cells. Diagnoses included 50 metastatic carcinomas(adult, 60; pediatric, 0); 46 malignant lymphomas(adult, 44; pediatric, 2); 21 leukemias(adult, 20; pediatric, 1); 4 retinoblastomas(adult, 0; pediatric 4); 2 rhabdomyosarcomas(adult, 0; pediatric, 2); 1 multiple myeloma(adult, 1; pediatric, 0), and 35 primary CNS neoplasms(adult, 10; pediatric, 25). The most commonly identified metastatic carcinomas in adults were adenocarcinoma. Their primary sites were the lung, gastrointestinal tract, and breast in order of frequency. The most common primary CNS neoplasm in children was medulloblastoma.

특징적인 Warthin-Finkeldey형의 다유핵 거대세포 소견을 보인 기무라 림프절염의 세침흡인 생검소견 - 1예 보고 -

김연미,조혜제,Kim, Yeon-Mee,Cho, Hye-Je 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1

Kimura's disease is a chronic Inflammatory disorder of unknown etiology, presenting usually as a painless subcutaneous swelling in the head and neck region or in the lymph nodes. We experienced a case of Kimura's lymphadenitis with characteristic Warthin-Finkeldey type polykaryocytes by fine needle aspiration cytology. The patient was a 10-year old male with two enlarged lymph nodes in the postauricular area. Fine needle aspiration cytology from the lymph nodes disclosed hypercellular smears with some scattered eosinophils and polykaryocytes in a polymorphous lymphoid background. There were also fragmented vessel wails and activated endothelial cell clusters in the slightly necrotic background. The Warthin-Finkeldey type polykaryocytes had three to thirty nuclei and prominent nucleoli with cytoplasmic borders. Their nuclei were arranged in grapevine or ring shaped clusters. As these polykaryocytes could also be found in lymph nodes and extranodal tissues of both reactive and neoplastic lymphoid disorders, polykaryocytes themselves are clinically nonspecific. However, the morphologic features of the Warthin-Finkeldey type giant cells are quite different from the foreign body type or Langhans' type giant cells. When the characteristic cytologic features of Kimura's disease such as significant number of eosinophils in a background of lymphoid cells asd proliferation of vessels and endothelial cells are also observed in the smear, it is possible to suggest this diagnosis in the appropriate clinical setting.

Reduction Potential for Thermal Load by Extensive Green Roofs

Kim, Yeon Mee(김연미),Nam, Mi A(남미아),Jang, Dae Hee(장대희),Kim, Hyeon Soo(김현수),Kim, Hyun Ok(김현옥) 한국생태환경건축학회 2013 한국생태환경건축학회 논문집 Vol.13 No.5

재발성 서혜부 탈장으로 오인된 지방모세포종

남소현,임윤정,김연미,Nam, So Hyun,Lim, Yun-Jung,Kim, Yeon Mee 대한소아외과학회 2014 소아외과 Vol.20 No.2

Palpable inguinal mass in children should be differentiated from inguinal hernia, hydrocele, lymph node, and tumor. Though using ultrasonography, fatty tumor would be misdiagnosed as incarcerated inguinal hernia containing fatty component. We experienced the huge inguinal lipoblastoma in 5-year-old girl mimicking recurrent incarcerated hernia. Laparoscopic exploration revealed it was not incarcerated hernia but well demarcated bulging mass from abdominal wall. Mass was about $10{\times}4{\times}3cm$ and extended from internal inguinal ring to saphenous opening. It was near total excised because of right external iliac vein injury. Pathologically, it was proven as lipoblastoma containing mature adipocyte with lipoblast and fibrous septa. Postoperatively, we noticed a segmental thrombotic occlusion of external iliac vein. After 1 year, she has no symptom related to occluded vessel. The remained lipoblastoma showed no interval change. Even lipoblastoma has a good prognosis with low recurrence rate, we need careful follow-up.

다른 기형을 동반한 완전 기도 폐쇄에 의한 선천성 상기도 폐쇄증후군 증례

조현진 ( Hyun Jin Cho ),김연미 ( Yeon Mee Kim ),이희영 ( Hee Young Lee ),원혜성 ( Hye Sung Won ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2

Congenital high airway obstruction syndrome (CHAOS) is caused when the upper airway is obstructed or severely narrowed. The prenatal ultrasound findings of CHAOS include large echogenic lungs, inverted diaphragms, dilated airways, and fetal ascites and/or hydrops. Recently, exutero intrapartum treatment (EXIT) procedure or fetoscopic tracheostomy are being widely used for the treatment of CHAOS. However, CHAOS with early presentation of hydrops confers ominous sign even with EXIT procedure. We report a case of CHAOS with hydrops and associated anomalies that was confirmed by autopsy.

Klippel-Trenaunay 증후군 여성에서의 임신

전균호 ( Gyun Ho Jeon ),김연미 ( Yeon Mee Kim ),전성욱 ( Sung Wook Chun ),조현진 ( Hyun Jin Cho ),지용일 ( Yong Il Ji ),정철회 ( Chul Hoi Jeong ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2

The Klippel-Trenaunay syndrome is rare congenital disease characterized by a triad of cutaneous vascular malformations, varicose veins, and hypertrophy of bone and soft tissue. Although several cases of pregnancy in women with Klippel-Trenaunay syndrome were reported as there may be increased risk of pregnancy- and/or delivery-associated complications such as varicosities, thromboembolism and hemorrhage, there is little general information regarding how to deal with pregnancy in patients with Klippel-Trenaunay syndrome and their obstetric outcome. We describe the case of a woman suffering from Klippel-Trenaunay syndrome delivering a healthy child with a brief review of concerned literature.

임신 초기 3차원 초음파로 양막대를 확인한 뇌없음증이 동반된 양막대 증후군 증례

조현진 ( Hyun Jin Cho ),김연미 ( Yeon Mee Kim ),전균호 ( Gyun Ho Jeon ),전성욱 ( Sung Wook Chun ),정철회 ( Chul Hoi Jeong ),지용일 ( Yong Il Ji ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.3

Amniotic band syndrome (ABS) is entrapment of fetal parts by disrupted amnion and formation of fibrous amniotic band. As results, it causes a variety of fetal malformation involving the limbs, the craniofacial region and trunk. A visualization of free floating amniotic band is appropriate diagnostic method for ABS. Three dimensional (3D) and four dimensional (4D) ultrasounds are useful to diagnosis ABS. However prenatal diagnosis is difficult especially when they do not circulate a limb or cause single abnormality. In the cases of anencephaly, a differentiation between ABS and primary neural tube defect is important because the recurrence rate is significantly different. We reported a case that a fetal anencephaly with hydrops was diagnosed using prenatal 3D and 4D ultrasound then confirmed as amniotic band syndrome by autopsy at 12 weeks of gestation. After autopsy, we demonstrated amniotic band through 3D ultrasound review.