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시호(柴胡)가 총담관결찰 및 taurocholate 부하(負荷) 흰쥐 간의 MAO 활성에 미치는 영향
김승모,왕오호,박재현,Kim, Seong-Mo,Wang, Wu-Hao,Park, Jae-Hyun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2
Object : This study was carried out to examine the effect of Bupleuri Radix on experimental cholestasis, and make clear apart of this mechanism. Methods : Two models of common bile duct ligation group and taurocholate load group after common bile duct ligation were induced, and Bupleuri Radix extract was taken orally for 14 days. In the 1, 2, 4, 7 and 14 days after treatment, the mitochondrial and microsomal monoamine oxidase(MAO) A and B activities in liver were measured. Results : The mitochondrial MAO A and B activities increased in both Blupleuri Radix treated group after common bile duct ligation and Blupleuri Radix treated group after taurocholate load and common bile duct ligation. MAO A increased in Blupleuri Radix treated group after taurocholate load and common bile duct ligation, and MAO B increased in Blupleuri Radix treated group after common bile duct ligation. The microsomal MAO A activities increased in both Blupleuri Radix treated group after common bile duct ligation and Blupleuri Radix treated group after taurocholate load and common bile duct ligation. Conclusion : According to the result, it is consider that Blupleuri Radix not only improves cholestatis in liver, but also decreases a genetic synthesis of taurocholic acid.
사염화탄소의 장기(長期) 투여(投與)로 유발된 백서(白鼠) 간경변(肝硬變)에 대한 형방지황탕(荊防地黃湯)의 조직병리학적 영향
김승모,Kim, Seong-Mo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2
Objective : This study was carried out to investigate the effects of oral administration of Hyeungbangjihwang-tang (HBJHT) on the liver cirrhosis of rats induced by Carbon tetrachloride for 10 weeks. Method : The histopathological changes were observed. The HBJHT extracts were daily dosed at 50, 100 and 200mg/kg for 12 weeks. Results : Severe hepatocellular necrosis and ballooning, hyperplasia of connective tissue, subdued reduction of hepatic lobule, and hyperplasia of bile duct in portal triad were dramatically decreased in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group in histopathological observation. The diameter of hepatic lobules was significantly enlarged in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group, and the amounts of connective tissue, degenerative cells and bile ducts were significantly and dose-dependently decreased. Conclusion : It is concluded that HBJHT has a significant recovering effect on the liver of rats induced by carbon tetrachloride.
종설(綜說) : 랑탕근(랑탕根)의 독성(毒性)에 관한 문헌적 고찰
김승모 ( Seong Mo Kim ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.1
Hyoscyami Radix is in use in Korean medicine. Korean medical doctors use Hyoscyami Radix for killing insects(殺蟲) and eliminating toxic material(攻毒), etc. We investigated toxicity, poisoning symptoms, poisoning treatment and prevention against poisoning of Hyoscyami Radix. The results were summarized as follows: 1. The main ingredients of poisoning are atropine, hyoscyamine, etc. The ingredients of poisoning from Hyoscyami Radix mainly cause mental symptoms, etc. 2. The representative methods of poisoning treatment in western medicine are promotion of vomiting, washing out the stomach, causing diarrhea, supplies of grape sugar, administering toxicide and symptomatic treatment, etc. 3. The representative methods of poisoning treatment in Korean medicine take advantage of herbs, such as Nokdugamchotang, watermelon, Glycyrrhizae Radix(甘草), Cimicifugae Rhizoma(生麻), Bubali Bubalis Cornu(水牛角), etc. 4. In order to prevent against poisoning of Hyoscyami Radix, the patients should keep usage, dosage and notes.
인삼이 PTU (6-n-propyl-2-thiouracil)로 유발된 Rat 갑상선 기능저하증에 미치는 영향
김승모 ( Seong Mo Kim ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.3
Object: This study was to evaluate the effect of Ginseng Radix, aqueous extracts of the root part of Panax ginseng on the 6-n-propyl-2-thiouracil(PTU)-induced rat hypothyroidism. Methods: Aqueous extracts of Ginseng Radix(GR; yield=11.70%) were administered, once day for 42 days from 2 weeks before start of PTU treatment as an oral dose of 300 and 150㎎/㎏(body weight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10㎎/㎏ for 28 days. The changes in the body weight, thyroid gland weights, serum levels of thyroid hormone-thyroid stimulating hormone(TSH), tri-iodothyronine(T3) and thyroxine(T4), total cholesterol, low density lipoprotein(LDL), high density lipoprotein(HDL) and triglyceride, liver antioxidant defense system-lipid peroxidation, H2O2, superoxide dismutase(SOD) and catalase(CAT) were observed with histopathology of thyroid glands. Results: Results were compared with LevoT4 0.5㎎/㎏ treated rats. GR extracts suppressed the decreases in the body weight, thyroid gland weights, T3 and T4, TG, liver H2O2 and SOD activities as results of PTU treatment. And GR extracts suppressed the increases of HDL contents, liver CAT activities, thyroid gland weight as results of PTU treatment. In addition, marked hyperplasia of follicular cells with decreases of follicular colloid contentsand sizes were demonstrated at histopathological inspections. However, these PTU-induced histopathological changes related to hypothyroidism were dramatically decreased by treatment of both different dosages of GR extract, respectively Conclusions: This study suggest that GR extracts have favorable effects on the thyroid hormone productions with beneficial effects on the hypothyroidism mediated by the modulatory effects on the antioxidant defense system.
황련해독탕(黃連解毒湯)의 전투여(前投與)가 $CCL_4$와 ethanol 중독(中毒) 흰쥐의 간장(肝臟) 및 신장(腎臟)에 미치는 조직병리학적(組織病理學的) 연구(硏究)
윤주현,김승모,임명현,박재현,Yoon, Ju-Hyun,Kim, Seong-Mo,Leem, Myung-Hyun,Park, Jae-Hyun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1
Object : This study was carried out to examine the effect of Hwangryunhaedoktang on the liver and kidney of rats induced by carbon tetrachloride and ethanol. Methods : The histopathological changes were examined after preadministration of 100 and 200mg/100g Hwangryunhaedoktang. Results : The perivenular ballooning degeneration and infiltration of basophilic inflammatory cells were decreased in the experimental group when compared with the control group. No abnormalities were observed in the kidneys of both groups. But, interstitial nephritis was observed only in the experimental group. Conclusion : This study suggests that Hwangryunhaedoktang may be of benefit to the prevention of hepatotoxicity induced by carbon tetrachloride and ethanol, and it is more effective in high dosages.
번조증환자(煩躁證患者)의 중풍이후(中風以後) 악화(惡化)된 번조증(煩躁證)에 소양인(少陽人) 양격산화탕(凉膈散火湯)을 통한 증례(證例)
박미연,김승모,곽민아,김종대,최해윤,김대준,Park, Mee-Yeon,Kim, Seong-Mo,Kwak, Min-Ah,Kim, Jong-Dae,Choi, Hae-Youn,Kim, Dae-Jun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4
In oriental medicine, Byun-jo(煩躁) is including in insomnia, restless, uneasiness, chest discomfort, irritation et all. Byun-jo is one of symptom in Soyangin(少陽人)(one of human type in Sasang constitutional medicine(四象醫學) the lower chest-overheated disease(胸膈熱證). In the book 'dongyi soose bowon(東醫壽世保元)', Soyangin Yanggueksanwha-tang(凉膈散火湯) is used at Soyangin the lower chest-overheated disease. One patient usually who had suffered from chest discomfort, insomnia of Byun-jo, after cerebral infarction the symptom of Byun-jo had grown worse, the patient was classified as Soyangin by somatotype, personality, therefore the patient treated with Soyangin Yanggueksanwha-tang for 10days, and the patient improved in clinical symptoms. so we report it for the better treatment.