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인진의 생식 독성에 대한 연구 -수태능 및 초기 배발생을 중심으로-
김치동 ( Kim Chi Dong ),김숭모 ( Kim Sung Mo ),임명현 ( Im Myeong Hyeon ),이준희 ( Lee Jun Hui ),박재현 ( Park Jae Hyeon ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objective : The objective of this study was to access the safety of Artemisia iwaymogi Kitamura extracts that have been used as oriental medicine to the liver disease on the fertility and early embryonic development of male and female Wistar rats when administered by oral gavage with their potential hepatotoxicity. Method : Males were administerd 4 weeks before pairing and 2 weeks after mating including the mating periods up to termination after necropsy of the majority of the females. Females were dosed 2 weeks before pairing, and from Day 0 to Day 7 of gestation. It was conducted in accordance with the recommendations of the KFDA Guideline for Detection of Toxicity to Reproduction for Medicinal Products. Result : No Artemisia iwoyomogi Kitanura extracts treatment-related changes of clinical signs, mortalities, estrous cycle, pre-coital intervals, mating index, conception rate, fertility index, gross findings, histopathological observation, corpora lutea number, implantation site number, live fetus number, number of resorption embryo and gre- and post-implantation loss were demonstrated in all dosed levels in this study. Although the body weight gains, food consumption and absolute organ weights of epididymis, prostate, seminal vesicle, testis, ovary and liver were significantly increased in Mxxlmg/kg -dosing groups, and the relative organ weights were not changed. So it was concluded that this increase was natural according to the growth. And no changes of serum AST, ALT, LDH and ALP levels were demonstrated in all dosed levels in this study. Condustions : it is considered that the NOAEL(No Observed Adverse Effect Level) for fertility and early embryonic development toxicity of Artemisia iwaymogi Kitamura extracts was up to 2000㎎/kg/day because there no changes of other fertility and early embryonic developmental index were demonstrated.
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형방지황탕이 사염화탄소 장기 투여로 유발된 백서 간경변의 예방에 미치는 영향
정성윤 ( Jeong Seong Yun ),김숭모 ( Kim Sung Mo ),임명현 ( Im Myeong Hyeon ),이준희 ( Lee Jun Hui ),박재현 ( Park Jae Hyeon ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objective : In order to determine the prevention effects of oral administration with HyeungBungJiHumflangW3JHT) on the liver cirrhosis of rats induced by long time carbon tetrachloride injection, the changes of body weight and gains, absolute and relative liver weight, biochemistry of blood, histopathological changes, urine specific gravity and urine bilirubin levels were monitored after 10 weeks of concomitantly dosing of HBJHT extract(per os) and CCl₄(i.p). Method : The WBJHT extracts were daily dosed at 50(T1), l00(T2) and 200(T3)ms/kg for 10 weeks. Result : The body weight and gains were significantly and dose dependently increased in HBJHT treated group compared to that of CCl₄treated control group. The absolute and relative liver weight were significantly and dose dependently reduced in HBJHT treated group compared to that of CCl₄treated control group. Severe hepatocellular necrosis and ballooning, hyperplasia of connective tissue and subdue reduction of hepatic lobule, hyperplasia of bile duct in portal triad were dramatically decreased in HBJHT treated group compared to that of CCl₄treated control group in histopathological observation.The diameter of hepatic lobules was significantly enlarged, and in HBJHT treated group compared to that of cc14 treated control group, and the numbers of connective tissue, degenerative cell and bile duct were significantly and dose dependently decreased. The levels of serum AST, ALT, LDH, ALP, GGT and total bilirubin were SignificantJy and dose dependently reduced in HBJHT treated group compared to that of CCl₄treated control group. The urine specific gravities were significantly and dose dependently increased, and the urine bilirubin levels were decreased in HBJHT treated group compared to that of CCl₄treated control group. Conclustions : it is considered that HBJWT extracts have some favorable effect to prevent the induce of hepatic cirrhosis by CCl₄injection.
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