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근치 절제술을 시행한 위암에서 절제림프절 수의 임상적 의의
김세진,장유진,김종한,박성수,박성흠,김승주,목영재,김종석,안형진,Kim, Se-Jin,Jang, You-Jin,Kim, Jong-Han,Park, Sung-Soo,Park, Seong-Heum,Kim, Seung-Ju,Mok, Young-Jae,Kim, Chong-Suk,Ahn, Hyong-Gin 대한위암학회 2009 대한위암학회지 Vol.9 No.4
목적: 위암의 근치 절제술에서 광범위 림프절 절제는 중요한 의미를 가지며 전이 림프절의 수가 종양의 침윤 정도와 함께 병기 결정의 기준이 되고 있다. 이에 저자들은 근치 절제술을 시행 받은 위암 환자에서 절제 림프절 수가 생존율에 미치는 영향을 분석하고 종양의 각 병기에 따라서 생존율 및 병기결정에 영향을 미치는 절제 림프절수의 최소 기준값을 구하고자 하였다. 대상 및 방법: 1992년부터 2002년까지 고려대학교병원에서 근치적 위절제술을 시행 받고 5년 이상 추적 관찰이 가능하였던 949명의 환자들을 대상으로 하였다. 조직검사결과에 따른 종양 침윤 정도에 따라 환자군을 분류하여 절제 림프절의 수를 조사하였다. 절제 림프절 수의 최소 기준값은 생존율에 유의한 차이를 보이는 최소값으로 정하였다. 결과: 종양의 크기, 위치, 림프절 병기, 전이 림프절의 수 및 절제 림프절의 수는 종양의 병기에 따라 유의한 차이를 보였다. Cox 비례위험모형을 통한 분석 결과 절제 림프절 수의 최소 기준값은 전체 환자에서는 14개였으며 각 병기별로 pT1군에서 15개, pT2군에서 28개, pT3군에서 37개의 값을 보였고 기준값 이상으로 절제된 경우 생존율이 유의하게 높았다. 결론: 근치적 위절제술을 받은 환자에서 기준값 이상의 림프절 절제가 생존을 향상시킬 수 있으며 이를 위해 외과의가 근치적 위절제술 시 기준값 이상의 림프절 절제술을 위해 노력해야 하며 병리의는 절제된 조직의 림프절 개수의 정확한 결과를 보고 하기 위해 더욱 노력해야 할 것이다. Purpose: The objectives of this study were to investigate the impact of the number of resected lymph nodes on the survival of gastric cancer patients who underwent curative resection, and to evaluate the cut-off values that can have an influence on survival on the tumor stage-stratified analysis. Materials and Methods: The subjects were 949 gastric cancer patients who underwent curative resection at Korea University Medical Center from 1992 to 2002. They were classified according to the depth of tumor invasion, and the influence of the number of resected lymph nodes on survival was investigated. The cut-off value for the number of resected lymph nodes was determined as the smallest value that showed a significant survival difference. Results: The tumor size, location, lymph node stage, the number of metastatic lymph nodes and the number of resected lymph nodes were significantly different according to the tumor stage. The average number of resected lymph nodes was about 39, and it showed linear correlation with the number of metastatic lymph nodes. On the Cox proportional hazard model, the cut-off values of the number of resected lymph nodes, as corrected by the number of metastatic lymph nodes, was 14 for all the patients, 15 for the pT1 patients, 28 for the pT2 patients and 37 for the pT3 patients, respectively. Conclusion: Retrieving a number of lymph nodes that is more than the cut-off value could improve the survival of gastric cancer patients. Surgeons should also make efforts to perform an exact and thorough D2 lymph node dissection. Therefore, we urge surgeons to perform D2 dissection and pathologists should examine an certain exact number of lymph nodes.
김세진,길경석,김동건,김일권,송동영,Kim, Se-Jin,Kil, Gyung-Suk,Kim, Dong-Geon,Kim, Il-Kwon,Song, Dong-Young 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.10
This paper dealt with the development of a LED floodlight for naval vessels to replace the conventional floodlight using an incandescent and a halogen lamp. We found a technical solution for current problems of conventional lights and also improved optical characteristics by developing a LED floodlight which has a typical long-lived light source with high efficiency. To satisfy the requirements specified in Korea Standard Vessels (KS V), the optical structure was designed with selected LED package and lens. A LED module was composed of 10 LEDs in series for stable luminous output, and an aluminium heat sink was adopted for effective heat-radiation design. The LED floodlight was fabricated as a module type so that it can easily replace the conventional light source. The power consumption of the prototype floodlight was only a tenth of a conventional one with the same optical performance. Also, a test showed the floodlight satisfied the electrical, optical and environmental requirements of the standards.
장기간의 스테로이드 치료를 받고 있는 신병증 환아에서 Recombinant Human Growth Hormone의 효과
김세진,김선경,김성도,조병수,Kim, Se-Jin,Kim, Sun-Kyoung,Kim, Sung-Do,Cho, Byoung-Soo 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2
Purpose : Growth retardation is one of the serious problems in children with nephropathy requiring long-term steroid therapy. We observed the efficacy and safety of recombinant human growth hormone(rhGH) on the growth in children with long-term steroid therapy. Methods : We studied 60 children(male 47, female 13) with nephropathy who received rhGH(1 U/kg/week) for more than 0.5 years($1.39{\pm}1.12$). Their mean age was 11.0 years($11.17{\pm}2.62$). They received steroid therapy from January 1987 through July 2005, and the mean duration of steroid therapy was $4.32{\pm}2.97$ years. Among the patients, there were 32 nephrotic syndrome, 9 IgA nephropathy, 4 mesangial proliferative glomerulonephritis, 4 focal segmental glomerulosclerosis, 2 Henoch $Sch\ddot{o}nlein$ nephritis, 2 Alport syndrome and 7 other cases. Data were gathered on the growth parameters, such as growth velocity, height standard deviation score(SDS), IGF-1, IGFBP-3, bone mass density(BMD) and general chemistry changes. Results : Height velocity increased significantly with rhGH therapy from $3.29{\pm}1.95$ to $8.66{\pm}3.75$(cm/yr) and height SDS decreased from $-0.72{\pm}0.93$ to $-1.04{\pm}0.86$ at one year after steroid therapy but increased to $-0.55{\pm}0.96$ at one year after rhGH administration(P<0.05). BMD improved from $0.71{\pm}0.14$ to $0.79{\pm}0.15g/cm^2$(P<0.05). IGF-1 increased from $445.09{\pm}138.01$ to $506.62{\pm}181.31ng/mL$(P<0.05). IGFBP-3 decreased from $4073.75{\pm}700.78$ to $3933.61{\pm}789.25ug/L$ numerically, but there was no statistically significant difference(P=0.533). Conclusion : The administration of rhGH in the short stature patients who received long-term steroid therapy showed improvement in growth parameters such as SDS, growth velocity, and BMD without significant side-effects or changes in the biochemical parameters.
초고밀도 네트워크에서 상향링크 성능향상을 위한 유동적 채널할당 연구
김세진,Kim, Se-Jin 한국인터넷정보학회 2022 인터넷정보학회논문지 Vol.23 No.5
In ultra dense networks (UDNs), macro user equipments (MUEs) have significant interference from small-cell access points (SAPs) since a number of SAPs are deployed in the coverage of macro base stations of 5G mobile communication systems. In this paper, we propose a dynamic channel assignment scheme to increase the performance of MUEs for the uplink of UDNs even though the number of SAPs is increased. The target of the proposed dynamic channel assignment scheme is that the signal-to-interference and noise ratio (SINR) of MUEs is above a given SINR threshold assigning different subchannels to SUEs from those of MUEs. Simulation results show that the proposed dynamic channel assignment scheme outperforms others in terms of the mean MUE capacity even though the mean SUE capacity is decreased a little lower.
문제기반학습 교육과정 개편에 따른 과정 만족도 및 학생평가 결과 비교 분석 연구
김세진,김민정,공섬김,정호중,Kim, Sejin,Kim, Minjeong,Kong, Seom Gim,Jeong, Ho Joong 연세대학교 의과대학 2022 의학교육논단 Vol.24 No.2
The purpose of this study was to redesign a problem-based learning (PBL) curriculum and compare the differences between the previous and redesigned PBL based on the results of course satisfaction and student assessments. The PBL was redesigned using curriculum design guidelines (including revisions of curriculum objectives, learning components, learning environments, and assessment methods) that were developed based on previous studies and evaluation results. A comparative study was employed using course satisfaction surveys from the previous and redesigned curricula, and a total of 45 students participated. We also compared student assessment results from concept mapping, learning issue reports, modified essay questions, and reflection journals. We identified four key findings. First, we explored the possibility that the redesigned PBL could be implemented by student facilitators without professors as tutors. Second, the redesigned PBL fostered group dynamics that facilitated developing communication skills and collaborative learning through small-group discussions. Third, the new learning elements added in the redesigned PBL made a meaningful contribution to enhancing students' clinical reasoning based on hypothetico-deductive reasoning. Fourth, concept maps in redesigned PBL contained more complex and various nodes and connections, and the levels of the nodes were more appropriate. The implications of this study can provide meaningful preliminary information for redesigning PBL curricula for medical students to develop their essential competencies through PBL.
OFDMA-TDD 시스템에서 채널상태 예측을 이용한 효율적인 하향링크 스케줄링 기법
김세진,원정재,이형우,조충호,Kim Se-Jin,Won Jeong-Jae,Lee Hyong-Woo,Cho Choong-Ho 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.5a
본 논문에서는 Orthogonal Frequency Division Multiple Access/Time Division Duplex 시스템에서 한정된 하향링크 무선 자원을 효율적으로 이용하고, 시스템 성능을 높이는 스케줄링 기법을 제안하였다. 시계열 예측 알고리즘을 이용하여 향후 변화될 기지국과 단말들 사이의 채널상태를 예측하고, 이 예측된 정보를 무선 자원 할당의 우선순위를 결정하는데 이용하였다. 시뮬레이션을 통해 제안하는 알고리즘의 성능을 분석하였고, 시스템 처리율과 지연시간에서 Proportional Fairness, 그리고 Maximum Carrier to Interference Ratio 알고리즘과 비교 평가하였다. In this paper, we propose a novel scheduling algorithm for downlink transmission which utilizes scarce wireless resource efficiently in an Orthogonal Frequency Division Multiple Access/Time Division Duplex system. Scheduling schemes which exploit channel information between a Base Station and terminals have been proposed recently for improved performance. Time series analysis is used to estimate the channel state of mobile terminals. The predicted information is then used for prioritized scheduling of downlink transmissions for improved throughput, delay and jitter performance. Through simulation, we show that the total throughput and mean delay of the proposed scheduling algorithm are improved compared with those of the Proportional Fairness and Maximum Carrier to Interference Ratio schemes.