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두 가지 유전적 변이가 동반된 선천성 적혈구조혈성 포르피린증 1예
김성은,이형근,Sung Eun Kim,Hyung Keun Lee 대한안과학회 2009 대한안과학회지 Vol.50 No.3
Purpose: Congenital erythropoietic porphyria (CEP) is a rare disorder inherited as an autosomal recessive trait, which is characterized by almost complete reduction of uroporphyrinogen III synthase (UROS) activity. The authors of the present study report a case of congenital erythropoietic porphyria with severe ocular involvement. Case summary: A 27-year-old male patient diagnosed with congenital erythropoietic porphyria was referred to our clinic with a history of ocular pain, and foreign body sensation in both eyes. Visual acuity was light perception in both eyes. Severe scarring of eyelids, corneal leukoma with neovascularization, total limbal deficiency and scleromalacia were observed in both eyes. Identification of the uroporphyrinogen III synthase (UROS) gene mutation revealed the patient had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10. Conclusions: CEP is clinically characterized by severe cutaneous photosensitivity, hemolytic anemia and porphyriuria. In addition to these manifestations, the authors report a severe ocular involvement in a patient with CEP who had a compound heterozygote mutation at p.Q249X (c.745C>T) and p.L237P (c.710T>C) in exon 10.
김성은,Sung Eun Kim 대한소화기암연구학회 2016 Journal of digestive cancer reports Vol.4 No.2
Gastric cancer is the fifth most common malignancy in the world and still remains the third and fifth leading cause of cancer death in male and female, respectively. In terms of the cancer survival, the survival of gastric cancer is low in the West with showed 5-year survival rates of 10-30%, whereas the survival rates in Asia is more than 50%. The reason of the higher survival rate from gastric cancer in Asia partially related with the availability of gastric cancer screening programs, however, the population-based screening for gastric cancer has been conducted just in Korea and Japan. Therefore, more effective method for detecting the gastric cancer is needed for countries without a population-based gastric cancer screening. Endoscopy is the most effective method for diagnosis of gastric cancer however, it requires a large infrastructure including a large number of endoscopic equipment and well-trained endoscopists. To overcome these problems, several noninvasive methods (such as serologic markers, biomarkers, cancer autoantibodies, and exhaled breath analysis) for diagnosis of gastric cancer screening are suggested. This review addresses the conventional methods and the emerging methods for gastric cancer screening.
H.264에서 다중참조 프레임을 이용한 효율적인 움직임 예측
김성은,한종기,Kim Sung-Eun,Han Jong-Ki 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.9C
H.264에서 다중참조 프레임을 사용한 움직임 예측 방법은 단일 참조프레임을 이용한 움직임 예측보다 더 많은 시간적 중복성을 제거하여 부호화 효율을 높이거나 채널에러에 강인하게 부호화하기 위해 사용된다. 하지만 다중 참조 프레임을 이용하여 움직임 예측을 하는 것은 단일의 참조 프레임을 이용하는 것보다 많은 계산량을 요구하기 때문에 비디오 인코더의 복잡도를 증가시키게 된다. 본 논문에서는 다중참조 프레임을 사용한 움직임 예측을 화질 열화 없이 적은 복잡도로서 가능하게 하는 알고리즘을 제안한다. 움직임 예측 절차의 복잡도를 줄이기 위해, 제안한 알고리즘에서는 연속되는 프레임 사이에 구성된 움직임 벡터맵을 이용하여 움직임벡터를 추정한다. 제안한 방식은 추정된 움직임벡터를 작은 탐색영역에서 보정하는 방식을 적용하기 때문에 기존의 방식들에 비해 적은 복잡도가 요구된다. 제안된 방법으로 추정된 움직임벡터는 각 참조프레임들에 대해 최적의 움직임 벡터를 효과적으로 추적하기 때문에 부호화 된 영상의 화질은 전 탐색영역 움직임 예측 알고리즘을 이용한 결과와 매우 비슷하다. 제안된 방식은 세가지 단계로 구성된다. (a) 연속되는 두 개의 프레임 사이에 벡터맵을 구성한다. (b) 벡터맵에 있는 요소벡터를 이용하여 시간적 움직임 벡터를 구성한다. (c) 마지막으로, 임시 움직임 벡터를 좁은 탐색영역에서 보정한다. 컴퓨터 실험을 통해 제안된 방식의 효율성을 입증하였다. 제안된 방식과 기존의 방식들과의 비교를 위해 H.264 부호화기에서 움직임 예측 모듈에 의해 소비된 CPU 시간을 측정하였다. 컴퓨터 실험을 통해 알 수 있듯이 제안된 방식에 의해 부호화된 영상의 화질은 기존 방식과 을 통해 얻은 영상화질과 거의 같으면서 알고리즘 복잡도는 크게 줄어드는 것을 볼 수 있다.
김성은,조준휘,천승환,이승용,최기훈,배지훈,서정열,안희철,안무업,옥택근,박찬우,Kim, Sung-Eun,Cho, Jun-Hwi,Cheon, Seung-Whan,Lee, Seung-Young,Choi, Ki-Hoon,Bae, Ji-Hoon,Seo, Jeong-Yeul,Ahn, Hee-Cheol,Ahn, Moo-Eob,Ok, Taek-Gun,Park, Chan 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
Paraquat, is a widely used for its great effect as a herbicide. But the mortality rate by paraquat intoxication is known to be very high. It is thought to act by changing form to superoxide and peroxide free radical. Almost paraquat intoxication is through ingestion. A few intoxication of paraquat is through skin absorption. But there was no known death case through skin absorption. We experienced a case of a expired patient by paraquat intoxication through skin abrasion and scratching wound. A 75-year-old man was visited emergency room after motorcycle accident during transporting paraquat. He has multiple abrasion and scratching wound on extremities, and pelvic bone fracture. There was no evidence of ingestion of paraquat. But serum/urine gramoxone level was all positive. In spite of wound irrigation and hemoperfusion, his condition was been gone form bed to worse. 2 days after, multiple organ failure and the respiratory arrest were developed and he was expired. Paraquat intoxication through skin wound is extremely dangerous and death by that could possibly happen
Stage 3 플러스 징후를 동반한 미숙아 망막병증에서 일차 유리체강내 베바시주맙 주입술의 효과
김성은,임형택,이승규,Sung Eun Kim,Tyler Hyung Taek Rim,Christopher Seungkyu Lee 대한안과학회 2015 대한안과학회지 Vol.56 No.1
Purpose: To evaluate the efficacy and safety of primary intravitreal bevacizumab injection in stage 3 retinopathy of prematurity with plus signs. Methods: We reviewed retrospectively the medical records of 30 eyes of 16 patients diagnosed with stage 3 retinopathy of prematurity with plus signs treated with primary intravitreal bevacizumab injection between March 1, 2011 and February 28, 2013 and followed up for at least 9 months. Results: Mean gestational age was 26 + 4 weeks ± 11 days and mean birth weight was 822 ± 251.4 g. The locations of disease were zone II in 24 eyes and zone III in 6 eyes. Intravitreal bevacizumab injection was performed after the mean 1.3 ± 1 day after plus signs were detected. Mean postconceptional age at treatment was 38 + 2 weeks ± 16 days. Mean follow-up period was 16.6 ± 6.9 months. Plus signs started to regress after the mean 4.6 ± 2.3 days after injection and completely regressed after the mean 24.3 ± 12.4 days. Cataract extraction was performed in 1 eye due to a cataract that appeared not associated with the injection procedure, but was regarded as a treatment failure. There were no local or systemic complications. Conclusions: Primary intravitreal bevacizumab injection in stage 3 retinopathy of prematurity with plus signs demonstrated excellent short-term efficacy and safety. J Korean Ophthalmol Soc 2015;56(1):62-69
대학생의 정보활용능력 교수학습모형 개발에 관한 기초연구
김성은,이명희,Kim, Sung-Eun,Lee, Myeong-Hee 한국비블리아학회 2006 한국비블리아학회지 Vol.17 No.2
This research has been done to develope a curricular model for the Information Literacy Course as one of liberal arts courses in Korean universities. This curricular model had resulted from investigating the standards and models for Information Literacy at the 4 standards(ACRL in USA, CAUL in Australia ANZILL in Australia and New Zealand, and SCONUL in the United Kingdom), 5 syllabi for Information Literacy used by 5 American universities and 33 syllabi by 23 Korean universities. On the basis of these educational results of the Information Literacy syllabi, a learning-instruction model has come into being for the Information Literacy Course that includes 7 core areas : information sources, information need, information access. information analysis, information management, information transfer and communication, and information ethics.
김성은,김재덕,Kim Sung-Eun,Kim Jae-Duk 대한영상치의학회 2002 Imaging Science in Dentistry Vol.32 No.1
Osteochondroma is a benign lesion of osseous and cartilagenous origin. It is a relatively common benign tumor of the skeleton, occurring most often in the metaphyseal region of long bone. However, it is rare in the facial bones. Reported foci in the mandible were the condyle, coronoid process, and symphysis region. Synovial chondromatosis is an uncommon benign condition of unknown etiology which affects the articular joints. Foci of cartilage develop through metaplasia in the underlying connective tissue of the synovial membrane. These cartilagenous foci and fragments may undergo calcification and ossification. We experienced 4 patients with abnormal appearance of mandibular condyle. This report describes 3 cases of osteocondroma and 1 case of synovial chondromatosis of the mandibular condyle with review of the literature.
김성은,이정현,김덕만,박진균,기선완,김지웅,Kim, Sung-Eun,Lee, Jung-Hyun,Kim, Deok-Man,Park, Jin-Kyun,Ki, Seon-Wan,Kim, Ji-Woong 한국정신신체의학회 2006 정신신체의학 Vol.14 No.1
연구목적 : 본 연구는 월경전 불쾌기분장애와 기질 특성과의 관련성을 알아봄으로써 월경전 불쾌기분장애의 병태생리 및 관련된 성격 경향을 이해하며 치료 응용의 가능성을 제시해 보고자 하였다. 방법 : DSM-IV 진단기준에 의해 월경전 불쾌기분장애로 진단된 28명을 대상으로 한국어판 TPQ, 축약형 월경전기평가서 등을 작성케 한 후, 이들 사이의 상관관계를 구하였다. 결과 : 기질의 4가지 차원에 해당하는 점수를 독립 변인으로 하고, 축약형 월경전기평가서 점수를 종속 변인으로 하여 표준 중다회귀분석을 시행하였을 때 월경전 불쾌기분장애 증상은 Cloninger가 제시한 성격의 기질을 구성하는 4가지 요인 중 손해 회피(HA) 요인과 보상 의존(RD) 요인에 대하여 유의하였으며, 특히 손해 회피(HA) 요인에 의해 가장 많이 설명될 수 있는 것으로 나타났다. 결론: 월경전 불쾌기분장애의 증상은 높은 손해 회피(HA) 요인과 낮은 보상 의존(RD) 요인에 의해 잘 설명되었다. 월경전기증상 중 특히 정동 증상이 손해 회피(HA) 요인과 상관관계를 갖고 있는데, 이는 월경전 불쾌기분장애가 기질의 특성에 영향을 받음을 의미한다. 이는 향후 월경전 불쾌기분장애의 병태생리의 이해에 도움이 될 것으로 생각한다. Objectives: The study was intended to explore the relationships between temperament and premenstrual dysphoric disorder, to understand symptomatology of premenstrual dysphoric disorder and associated personality trait and to suggest therapeutic availability. Method : Twenty eight women, diagnosed as premenstrual dysphoric disorder by DSM-IV, were asked to complete the Korean version of Tridimensional Personality Questionnaire, and Shortened Premenstrual Assessment Form. The correlations between the severity of premenstrual symptoms and the scores of Tridimensional Personality Questionnaire were calculated. Results : The severity of symptoms of premenstrual dysphoric disorder was best explained by the harm-avoidance factor of the four dimensions of temperament. Conclusion : The symptoms of premenstrual dysphoric disorder are well explained by the harmavoidance factor and the reward-dependence factor of four dimensions of the temperament.
골격성 III급 부정교합자의 측두하악관절에 관한 방사선학적 연구
김성은,김재덕,Kim Sung-Eun,Kim Jae-Duk 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.2
Purpose : To investigate the differences between the position of the mandibular condyles in temporomandibular joints of patients presenting with normal occlusion and skeletal class III malocclusion. Materials and Methods: Forty-two subjects with normal occlusion and thirty-seven subjects exhibiting skeletal class III malocclusion prior to orthodontic treatment were included in the study. Transcranial radiographs of each subject were taken at centric occlusion and 1 inch mouth opening. The positional relationship between the mandibular condyles with articular fossae and articular eminences at two positional states were evaluated and analyzed statistically. Results: The mandibular condyles of the skeletal class III malocclusion group were found to be located more anteriorly from the center of the articular fossae compared to the normal occlusion group in centric occlusion. The mandibular condyles of the skeletal Class III malocclusion group were located more superiorly from the middle of articular height than those of the normal occlusion group in centric occlusion. However, these differences were not statistically significant. At 1 inch mouth opening, the mandibular condyles of the skeletal class III malocclusion group were placed more posteriorly from the articular eminences than those of the normal occlusion group. The mean angle of the articular eminence posterior slope were 56.51 ° ± 6.29° in the normal occlusion group and 60.37° ± 6.26° in the skeletal Class III malocclusion group. Conclusions: The mandibular condyles of the skeletal Class III malocclusion group were placed more anteriorly at centric occlusion and more posteriorly at 1 inch mouth opening when compared with those of the normal occlusion group.