히드록시프로필 키틴의 합성과 액정형성

김선정,이영무 ( Seon Jeong Kim,Young Moo Lee ) 한국공업화학회 1992 공업화학 Vol.3 No.3

키틴에 산화프로필렌을 반응시켜 키틴의 수산기에 히드록시프로필기가 치환된 히드록시프로필 키틴(HPCH)을 합성하였다. 여러가지 유기 용매중에서 키틴과 그 유도체의 용해성 시험에서 HPCH가 키틴보다 용해성이 향상되었으며 포름산에서 가장 좋은 용해성을 나타내었다. 포름산을 용매로 HPCH용액을 제조하여 농도를 변화시키면서 편광현미경으로 관찰한 결과 30 wt% 이상의 농도에서 지문형태의 복굴절 현상이 나타났으며, 열분석기(DSC)의 분석에서 열적 특성피크는 관찰되지 않아서 HPCH는 콜레스테릭 구조를 갖는 유방성 액정임을 확인할 수 있었다. Hydroxypropyl chitin (HPCH) was prepared by reacting chitin with propylene oxide. HPCH showed the improved solubility in several organic solvents compared with chitin. It showed the remarkable solubility in formic acid. Form the results of polarized microscopic observatoin of HPCH solution in formic acid, finger-print pattern was observed in concentrations over 30 wt% solution. Since no typical thermogram was observed in DSC scan, the HPCH showed a lyotropic cholestric liquid crystallinity.

환경정보 검색 시스템의 활용에 관한 연구 : 대기오염 물질의 위험성 확인을 중심으로

김선정,신동천,정용,구자건,Kim, Sun-Jeong,Shin, Dong-Chun,Chung, Yong,Koo, Ja-Kon 한국환경영향평가학회 1996 환경영향평가 Vol.5 No.1

The objective of this study is to establish the application method of environmental information system which is related to hazard identification for Health Risk Assessment. For establishing the environmental information system, fourteen hazardous chemicals were chosen and applicated to the database network such as RTKNET(Right Know Net), MSDS(Material Safety Data Sheets), TRI(Toxic Release Inventory), IRIS, AIRS, etc. The searching method of environmental information is classified to three sections such as the domestic commercial information company, international database agencies, and internet. Recently the importance of environmental information is being emphasized because it is essential 10 use database system in the field of environmental studies. Most of the foreign research organizations are communicating actively for information exchange, and the improvement of the quality of research. It is required to accumulate the data and develop them to database for future research.

HEC-HMS/RAS와 HEC-GeoRAS 모형을 이용한 홍수범람 시나리오 수립 및 분석

김선정,김건태,정종혁,한상옥,Kim. Seon Jeong,Kim. Geon Tea,Jeong. Jong Hyeok,Han. Sang Ok 한국방재학회 2013 한국방재학회논문집 Vol.13 No.4

최근 우리나라의 기상재해는 이상 기후변화로 인한 태풍 및 국지성 호우에 의한 피해가 대부분을 차지한다. 이러한 피해를 줄이기 위하여 홍수위험지도 및 재해지도 제작이 필수적이며, 이에 시나리오별 홍수범람 해석은 중요한 부분을 차지한다. 본 연구는 강릉시 사천천에서 홍수범람 시나리오를 수립하고 HEC-GeoRAS 모형을 이용하여 분석을 실시하였다. 확률강우량은 강릉지상관측소의 1961년~2010년(50년) 강우자료를 사용하였고 시나리오는 100년, 200년 빈도 및 가능최대홍수량(PMF)으로 태풍루사 사례를 가정하여 분석하였다. 그 결과 100년 빈도 강우량을 초과할 경우 홍수범람이 예측되며, 200년 빈도와 PMF빈도의 경우 범람면적이 64.3 ha, 135.9 ha, 최대 침수심은 4.1 m, 5.7 m로 각각 모의되었다. 이러한 결과는 실시간 기상자료와 모델수치해석 자료 합성을 활용하여 지속시간에 대한 강우량으로 홍수범람 구역을 예측하는데 도움이 될 것으로 기대한다. Damages by hurricanes and regional torrential rains due to anomaly climate changes take up the most of recent meteorological disasters in Korea. To reduce these damages, producing flood hazard maps and disaster maps is essential, and accordingly, the interpretation of flood inundation by scenario accounts for an important part. This study established a flood inundation scenario at Sacheon River in Gangneung-si and carried out an analysis using the HEC-GeoRAS model. The rainfall data at the Gangneung General Observation Post from 1961 to 2010(50 years) were used for probable rainfall, and the scenario was analyzed by assuming the case of Typhoon Rusa with 100-year and 200-year frequencies and Probable Maximum Flood (PMF). As a result, flood inundation is predicted if it exceeded the 100-year frequency rainfall while for the 200-year frequency and PMF frequency, flooded areas were simulated at 64.3 ha and 135.9 ha, respectively and maximum flooded depths in 4.1 m and 5.7 m, respectively. It is expected that these results will help predict flood inundation area with rainfall in the duration using the synthetic data of the real-time weather data and the model numerical analysis.

Pseudomonas aeruginosa AJ1에 의한 Microcystis aeruginosa의 성장제어

김선정,이상섭,Kim, Sun-Jung,Lee, Sang-Seob 한국미생물학회 2009 미생물학회지 Vol.45 No.4

대청호의 한 지류인 소옥천으로부터 고효율 조류억제 세균을 분리하기 위하여 176균주를 분리 스크린하였으며, 이 중 AJ1이 가장 높은 조류성장억제능을 나타내었다(지름 50.0 mm 성장억제환). 조류성장억제능이 높았던 AJ1 균주 동정을 위하여 형태학적, 생리 생화학적, 16S rRNA gene sequence 분석, 지방산 분석을 수행하였으며 그 결과, Pseudomonas aeruginosa 로 판별되었다. AJ1 배양액을 원심분리한 후 상등액을 조류배양액에 첨가 시, 상등액에 의한 조류성장억제능이 나타남에 따라 세포 외 물질 분비에 의한 것을 확인할 수 있었다. 가장 높은 조류성장억 제능[60.2(${\pm}$1.3)%]은 탄소원으로 mannitol을 사용하고, 온도 $30^{\circ}C$, pH 8에서 배양할 때 보였다. 또한, AJ1 균주의 배양기간 및 투여시기에 따른 조류성장억제능 평가 결과, 조류 성장 초기 단계에 조류성장억제균을 투여하였을 때 조류성장억제능이 높게 나타났고, 균주의 배양기간에 따른 조류성장억제능은 연관성이 나타나지 않았다. 상등액 접종량에 따른 조류성장억제능은 상등액의 접종량이 높아질수록 M. aeruginosa의 제거량은 증가하였으며, 고농도(40ml/L)로 적용하였을 때 80.3(${\pm}$8.6)%의 가장 높은 M. aeruginosa 제거효율을 보여주었다. 제거 속도의 경우 상등액 접종량이 낮아질수록 M. aeruginosa 제거율이 높아지는 경향을 확인하였으며, 저농도(10 ml/L)로 적용시 $8.2{\mu}g$ chl-a/supernatant ml/day로 가장 높게 나타났다. 본 연구 결과, AJ1 균주의 현장 적용 시 M. aeruginosa의 제어에 효율적일 것으로 사료된다. Among total 176 strains with antialgal effects isolated from So-ok stream in Korea, Pseudomonas aeruginosa AJ1 showed the highest removal efficiency for an algal species Microcystis aeruginosa (clear zone of diameter 50.0 mm on algal lawn after 20 days). The algal growth was suppressed even when the supernatant of AJ1 culture was applied, suggesting that extracellular substances are responsible for its antialgal activity. The removal activity of AJ1 was optimal under the following condition: pH 8, $30^{\circ}C$, and mannitol as a carbon source. The antialgal activity of AJ1 appeared to be dependent of the growth phase of M. aeruginosa, i.e., the highest at the early phase, but not its own phase. As expected, the algicidal effect was improved as the amount of the treated supernatant was increased; the highest removal efficiency (80.3%) was achieved when 40 ml/L of the supernatant was used. Interestingly, however, the removal rate was opposite. The highest removal rate ($8.2{\mu}g$ chl-a/ml supernatant/day) was achieved when low concentration (10 ml/L) was applied. These results suggest that P. aeruginosa AJ1 is a promising biological agent to control the problematic algal bloom.

혼합 현실

김선정,송창근,이정,Kim, Seon-Jeong,Song, Chang-Geun,Lee, Jeong 한국정보처리학회 2018 정보처리학회지 Vol.25 No.2

환경정보 검색 시스템의 활용에 관한 연구 대기오염 물질의 위험성 확인을 중심으로

김선정,신동천,정용,구자건 ( Sun Jeong Kim,Dong Chun Shin,Yong Chung,Ja Kon Koo ) 한국환경영향평가학회 1996 환경영향평가 Vol.5 No.1

The objective of this study is to establish the application method of environmental information system which is related to hazard identification for Health Risk Assessment. For establishing the environmental information system, fourteen hazardous chemicals were chosen and applicated to the database network such as RTKNET(Right Know Net), MSDS(Material Safety Data Sheets), TRI(Toxic Release Inventory), IRIS, AIRS, etc. The searching method of environmental information is classified to three sections such as the domestic commercial information company, international database agencies, and internet. Recently the importance of environmental information is being emphasized because it is essential to use database system in the field of environmental studies. Most of the foreign research organizations are communicating actively for information exchange, and the improvement of the quality of research. It is required to accumulate the data and develop them to database for future research.

Life-Sustaining Procedures, Palliative Care, and Cost Trends in Dying COPD Patients in U.S. Hospitals: 2005~2014

김선정,Ji Won Yoo,Jay Shen,Eunjeong Ko,Pearl Kim,Yong-Jae Lee,Jae Hoon Lee,Xibei Liu,Johnson Ukken,Mutsumi Kioka 한국호스피스완화의료학회 2018 한국호스피스.완화의료학회지 Vol.21 No.1

Purpose: Little is known regarding the extent to which dying patients with chronic obstructive pulmonary disease (COPD) receive life-sustaining procedures and palliative care in U.S. hospitals. We examine hospital cost trends and the impact of palliative care utilization on the use of life-sustaining procedures in this population. Methods: Retrospective nationwide cohort analysis was performed using National Inpatient Sample (NIS) data from 2005 and 2014. We examined the receipt of both palliative care and intensive medical procedures, defined as systemic procedures, pulmonary procedures, or surgeries using the International Classification of Diseases, 9th revision (ICD-9-CM). Results: We used compound annual growth rates (CAGR) to determine temporal trends and multilevel multivariate regressions to identify factors associated with hospital cost. Among 77,394,755 hospitalizations, 79,314 patients were examined. The CAGR of hospital cost was 5.83% (P<0.001). The CAGRs of systemic procedures and palliative care were 5.98% and 19.89% respectively (each P<0.001). Systemic procedures, pulmonary procedures, and surgeries were associated with increased hospital cost by 59.04%, 72.00%, 55.26%, respectively (each P<0.001). Palliative care was associated with decreased hospital cost by 28.71% (P<0.001). Conclusion: The volume of systemic procedures is the biggest driver of cost increase although there is a cost-saving effect from greater palliative care utilization.

의과대학의 의사소통기술 교수전략

김선정,Kim, Seon-Jeong 연세대학교 의과대학 2007 의학교육논단 Vol.9 No.2

국내 특허 찾기

김선정,Kim, Seon-Jeong 한국데이터베이스진흥원 1998 디지털콘텐츠 Vol.4 No.-

지난호에 이어 국내의 특허 검색에 관해 알아보도록 하겠다. 이제 국내에서도 특허의 데이터량이 방대하여 수작업으로 특허 조사를 실시하는 것은 거의 불가능한 상태이며 특허 자료의 대부분이 온라인으로 되어 그 검색이 용이해졌다.

Polypeptide계 인공 피부의 합성과 특성

김선정,민동선,김계용,Kim, Seon-Jeong,Min, Dong-Seon,Kim, Gye-Yong 대한의용생체공학회 1987 의공학회지 Vol.8 No.1

In order to evaluate the artificial skin for burn would covering materials, copoly(N. carbobenzoxy-L-Iysine-L-leucine)s were prepared by Ipolymerization of N - carbobenzoxy-L- I sine anhydride and L-leucine anhydride in homogeneous solvents using triethylamine as an initiator. The synthetic polypeptides and the oxter type polyurethane(PV)of medical grade were used as the sheet type membranes were prepared ; monolayer membrances were composed of only the polypeptides, bilayer membranes and blend membranes were controlled by composition of the polypeptides and PU. Test of the swelling degree, mechanical tensile strength, elongation, oxygen permeability, water-vapor loss and In vitro degradation treated by pretense TV of samples of artificial skin were measured by adequate methods so as to mechanical, physincal characterization and biodegradation. As a result, all the values of samples were found to be similar to desired value of skin which was nature. The Artificial skin based on polypeptides can be considered as ideal burn wound covering materials.