정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

OCCLUSAL SPRINT가 저작운동에 미치는 영향

김선영,김영수,김창회,Kim, Sun-Yung,Kim, Yung-Soo,Kim, Chang-Whe 대한치과보철학회 1985 대한치과보철학회지 Vol.23 No.1

Occlusal splints have been widely used in dentistry for treatment and diagnosis of signs and symptoms related to dental occlusion. The autor studyed the effect of occlusal splint on masticatory movement of young adult men (mean age 23.8 yrs.). Who had worn. occlusal splint for 1 week. The result were as follows: 1. Lateral movement of the mandible during mastication could be increased after wearing occlusal splint for 1 week. 2. Vertical movement of the mandible during mastication was increased after wearing occlusal splint for 1 week. 3. Maximum opening velocity of the mandible during mastication was increased after wearing occlusal splint for 1 week. 4. Mandibular movement during mastication was more affected by chewing of hard foods than of soft foods following occlusal changes. 5. Steepness of the anterior guidance affected several aspects of masticatory movement. 6. Masticatory movement of the mandible became more regular after wearing occlusal splint for 1 week.

고립성 골 전이를 동반한 식도편평세포암에서 동시 항암화학방사선 요법 후 완전관해를 보인 1례

김선영,서민호,최혁순,김은선,금보라,진윤태,이홍식,엄순호,김창덕,류호상,이우진,전훈재,김예지,Sun Young Kim,Min Ho Seo,Hyuk Soon Choi,Eun Sun Kim,Bora Keum,Yoon Tae Jeen,Hong Sik Lee,Soon Ho Um,Chang Duck Kim,Ho Sang Ryu,Woo Jin Lee,Hoon Jai 대한소화기암연구학회 2013 Journal of digestive cancer reports Vol.1 No.1

There is no established treatment for esophageal carcinoma with metastasis. For the metastatic esophageal squamous cell carcinoma, chemotherapy or best supportive care according to patient's performance status are accepted as an available treatment. We report a case of complete remission after concurrent chemoradiotherapy for esophageal squamous cell carcinoma with metastatic lesion in 5th thoracic vertebrae. A 57-year-old man with ongoing dysphagia and weight loss was admitted to our hospital. On the endoscopic and radiologic imaging evaluation,the patient was diagnosed as a squamous cell carcinoma of esophagus with solitary metastatic lesion in 5th thoracic vertebrae. The patient was treated with combination chemotherapy (5-fluorouracil (5-FU) and cisplatin) and concurrent radiotherapy for two months to relieve dysphagia. Because metastatic lesion in thoracic vertebrae was located near the primary esophageal tumor, the metastatic lesion could be included within the radiation field. After concurrent chemoradiotherapy, consecutive 4 cycles of chemotherapy had been carried out. Primary esophageal tumor with metastatic lymph nodes and metastatic lesion in 5th thoracic vertebrae disappeared on follow up computed tomography (CT) and positron emission tomography-CT (PET-CT). Follow up endoscopic biopsy revealed no remnant malignant cells at previous primary cancer lesion.

TNT(2,4,6-trinitrotoluene)와 카드뮴의 복합오염이 어저귀의 TNT흡수 및 생물학적 전환에 미치는 영향

김선영,배범한,장윤영,이인숙,Kim, Sun-Young,Bae, Bum-Han,Chang, Yoon-Young,Lee, In-Sook 한국생태학회 2002 Journal of Ecology and Environment Vol.25 No.3

군사지역은 TNT와 같은 화약물질이 중금속과 복합으로 오염되어 있다. 따라서 TNT에 대해 식물상 복원공법을 적용할 때 중금속이 식물체의 오염물 제거, 변환, 축적 능력에 영향을 줄 것으로 예상된다. 본 연구에서는 토착 야초류인 어저귀(Abutilion avicennae)를 TNT와 Cd으로 복합 오염된 배지에 서 수경재배하여 카드뮴이 식물에 의한 TNT 제거 및 변환에 미치는 영향을 조사하였다. 그 결과, 20 mgTNT/L와 1.3 mgCd/L이 복합으로 존재할 때 잎의 탄력 감소, 말림 현상, 황백화 현상, 낙엽형성, 생체량 감소 등과 같은 식물 독성효과가 상승하였다. 그러나, 어저귀는 소량의 카드뮴만을 흡수하는 종으로 배지내 카드뮴이 1.3 mg/L 존재하더라도 TNT제거, 변환, 이동 및 니트로기의 환원위치에 유의적인 영향을 받지 않는다. 따라서 카드뮴과 TNT로 복합오염된 지역에 어저귀를 식재하면 TNT를 효과적으로 제거하리라 사료된다. Most of army depots contaminated with co-contaminants, 2,4,6-trinitrotoluene(TNT) and heavy metals. In phytoremediation for the TNT, heavy metals may inhibit mineralization, transformation and sequestration of TNT by the plant. We studied effect of cadmium on TNT degradation and transformation by Abutilion avicennae in hydroponic cultures. When cultured in 20 mgTNT/L and 1.3 mgCd/L, the plant displayed phytotoxicities; reduction of leaf fresh, leaf roil, chlorosis, leaf loss and fresh weight loss. Phytotoxicity was severer in the combined contaminants than in single contaminant. Because A. avicennae uptake just a little cadmium, 1.3 mgCd/L included in the TNT medium did not influece significantly TNT transformation, translocation and distribution by A. avicennae. Therefore, the soil solution containing cadmium would not affect TNT degradation by Abutilion avicennae in Army depots polluted with TNT.

Herpes Simplex Virus thymidine Kinase/Ganciclovir 유전자 치료에서 새로운 간격결합분자 Connexin 37에 의한 방관자 효과의 증가

김선영,이호근,이정창,황동진,황평한,이대열,조수철,Kim, Sun Young,Yi, Ho Keun,Lee, Jung Chang,Hwang, Dong Jin,Hwang, Pyoung Han,Lee, Dae Yeol,Cho, Soo Chul 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.6

목 적 : HSVtk 유전자를 암세포에 도입하여 GCV에 대해 선택적으로 감수성을 증가시키는 HSVtk/GCV 유전자 치료에서 방관자 효과는 모든 암세포에 유전자를 도입하지 않고도 치료효과를 얻을 수 있으므로 방관자 효과를 증강시킬 수만 있다면 HSVtk/GCV 유전자 치료의 효과를 극대화시킬 수 있다. HSVtk의 방관자 효과에 관한 기전으로는 간격결합분자들이 주요 역할을 하리라고 알려져 있다. 간격결합분자들은 세포간의 통신을 담당하는 connexin family이며, 주로 Cx43에 관해서는 많이 알려져 왔다. Cx37을 암의 유전자 치료에 이용 가능한 유전자로서의 가능성을 타진하기 위하여 HSVtk/GCV 유전자 치료에 Cx37 유전자를 직접 세포에 발현을 시켜 방관자 효과를 증가시킬 수 있는 새로운 방법의 가능성을 검토하였다. 방 법 : 효과의 검증을 위한 세포주로는 NIH3T3를 사용하였다. HSVtk가 형질도입된 NIH3T3 세포에 GCV의 농도별로 세포사를 관찰하였다. 또한 Cx37의 발현 여부에 따른 세포사멸의 효과를 검토하기 위하여 Cx37 발현 세포주와 비발현 세포주를 서로 다른 비율로 혼합 배양후 나타나는 세포사를 관찰하였다. 최종적으로 Cx37이 세포사멸을 직접적으로 매개하고 있음을 규명하기 위하여 Cx37 발현 표적세포를 크로미움으로 표지화한 후 Cx37 발현 세포주와 비발현 작동세포와 혼합 배양 시 사멸되는 세포로부터 유리되는 크로미움의 양을 측정하였다. 결 과: HSVtk 발현 세포는 GCV 농도에 비례하여 세포가 사멸되었으며 HSVtk/Cx37 동시 발현 세포는 HSVtk만 발현된 세포에 비해 2배 이상의 사멸 효과가 나타났다. 아울러 Cx37에 의해 유도되는 방관자 효과는 표적세포와 작동세포 모두에 Cx37이 발현되는 경우는 세포의 혼합배양 비율에 상관없이 80%에 이르는 세포가 사멸되었다. 특히 작동세포에 Cx37이 없더라도 표적세포에 Cx37이 발현하면 세포사멸은 Cx37이 매개되지 않는 경우에 비교하여 2배 이상의 증가를 보였다. 이러한 결과는 크로미움 유리 실험에서도 동일한 결과가 유도되어 Cx37은 세포사멸을 직접적으로 매개하고 있음이 나타났다. 결 론 : 이상의 결과로부터 HSVtk/GCV 유전자 치료에서 방관자효과를 나타내는 분자의 하나로 Cx37의 기능을 확인하였으며, Cx37은 방관자 효과를 증가시켜 유전자치료의 낮은 유전자 전이율을 극복하고 암의 자살 유전자 치료의 효과를 극대화할 수 있는 분자로 예측된다. Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium phosphate method, and we detected their expression from these cells by RT-PCR. GCV-mediated cytotoxicity and the bystander effect of each transfectant was then assessed and compared. Results : Cells transfected with HSVtk became sensitive to low concentration of GCV. We found significantly increased cytotoxicity in HSVtk/GCV gene therapy after introduction of the HSVtk and Cx37 genes together compared with the cytotoxicity seen after introduction of the HSVtk gene in vitro. Co-expression of the HSVtk and Cx37 genes potentiates HSVtk/GCV gene therapy through the bystander effect. Conclusion : These results indicated that the increase of GJIC using Cx37 have potentiated the bystander effect of HSVtk/GCV therapy, and may be a new approach to improve response in suicidal cancer gene therapy.

창업 인터뷰 기사로 살펴본 기업가정신 동향 연구

김창규(Chang-Kyu Kim),이병헌(Byungheon Lee),김선영(Sun-Young Kim) 기업가정신학회 2020 기업가정신연구 Vol.1 No.1

국가의 성장 동력이자 경제성장의 중요한 요소인 기업가정신은 창업환경과 시대 흐름에 따라 변화하며 각기 다른 방식으로 발현됐다. 본 연구는 기업가의 창업 동기 변화를 추적하여 시대별로 기업가정신이 어떻게 변화하며 나타났는지 살펴보았다. 연구 문제 해결을 위해 주요 경제지와 일간지에 키워드 ‘창업 인터뷰’를 검색하여 창업 동기를 포함한 기사를 취합했다. 1980년대 고속 경제성장 시기부터 2019년 현재까지 40년에 걸쳐 총 54개 기사를 선별한 후 주요 핵심어를 도출했다. 워드클라우드라는 시각화 기법을 활용하여 핵심어 분포도를 제시함으로써 시대별 기업가정신의 특성 비교와 동향파악을 도왔다. 분석 결과, 1980년대는 자신이 보유한 기술력을 바탕으로 수입에 의존하던 기계부품의 국산화, 품질 강화, 최고･최초 달성 목적의 창업이 많았고 고학력자의 컴퓨터, 정보통신 분야진출이 시작되었다. 1990년대에 들어서면서 우리나라는 급격한 외부 환경 변화로 큰 부침을 겪었다. 초고속 인터넷망이 구축되자 이를 기반으로 하는 온라인 교육이나 IT 관련 창업이 줄을 이었으며, 코스닥 시장 개장과 IMF 사태로 직장을 떠나 창업에 뛰어든 사례가 늘었다. 한편, 경제성장과 시장개방으로 소비 수준 향상과 소비 트렌드가 변화하면서 패션이나 뷰티 산업의 활성화 조짐이 보였다. 2000년대에는 기술자나 고급 인력에 국한되었던 창업의 원천이 주부, 유학생 등으로 확장되었다. 자신이 좋아하거나 잘할 수 있는 것, DIY처럼 개인 특성을 살릴 수 있는 아이템을 중심으로 창업이 이루어졌으며, 100세 시대를 대비해 은퇴 이후의 삶을 준비하는 창업 분위기가 형성되었다. 2010년대 창업은 커피, 게스트하우스, 가구, 인테리어 등 사업 아이템이 다양해졌다. 개인방송 스트리밍플랫폼의 확산으로 콘텐츠, 크리에이터, MCN(Multi Channel Network), 방송 등의 핵심어가 새롭게 나타났고, 시공간을 뛰어넘는 온라인 쇼핑몰 창업이 활발해지면서 세계가 하나의 시장이 되고, 경쟁이 심화하면서 브랜드의 중요성이 더욱 커지고 있음을 확인할 수 있었다. Entrepreneurship, the nation s growth engine and the key element in economic growth, has been manifested in different ways as it changes with the entrepreneurial environment and the flow of the times. This study traced the changes in motivation for starting a business and looked at how the entrepreneurship changed over time. For the purpose of this study, major economic and daily newspapers were searched for the keyword “start-up interview” and the articles were compiled which included the motivation for starting a business. For over 40 years from the period of rapid economic growth in the 1980s to the present in 2019, a total of 54 articles was selected and the keywords were derived. Using a visualization technique called Word Cloud, keywords distribution was presented to help compare characteristics of entrepreneurship by period and identify trends. Analysis revealed that, in the 1980s, there were many start-ups aimed at localizing mechanical parts that used to relying on imports, improving quality, or securing the best or the first place on record, taking advantage of the technological skills of their own and those who were highly educated began to explore computer as well as information and communication fields. In the 1990s, Korea suffered a great deal from the rapid changes in the external environment. As the high-speed internet network was established, online education or IT-related start-ups increased and, in many cases, start-ups were founded by those who left their job, voluntarily or involuntarily, due to the opening of KOSDAQ market and the IMF crisis. On the other hand, as the consumption grew and the trend of consumption changed due to economic growth and market opening, the fashion and the beauty industries showed the signs of vitalization. In the 2000s, the source of entrepreneurship, which had been limited to the engineers and the highly skilled workers, expanded to housewives or students studying abroad. Start-ups were centered around what entrepreneurs did well or liked to do or DIYs that could make use of personal characteristics. Another trend in entrepreneurship was to prepare for life after retirement in the era of 100-year life. In the 2010s, items for start-up were diversified such as coffee, guesthouses, furniture, and interior design. With the proliferation of the personal broadcasting streaming platform, keywords such as contents, creators, MCN (Multi Channel Network), and broadcasting newly emerged, and more and more online shopping malls were founded that transcended space and time which confirms that the world has become one market and the brand is more important than ever as the competition has intensified.

레이더 반사면적 데이터 기반 목표물 탐지 성능에 영향을 미치는 파라미터 분석

김선영(Sun Young Kim),최승엽(Seung Yeab Choi),김하선(Ha Seon Kim),강창호(Chang Ho Kang) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4

국내 다제내성 및 광범위내성결핵의 최근 현황

김선영 ( Sun Young Kim ),김희진 ( Hee Jin Kim ),김창기 ( Chang Ki Kim ),윤혜령 ( Hye Ryung Yoon ),배혜경 ( Hye Gyung Bae ),이선화 ( Sun Hwa Lee ),성낙문 ( Nack Moon Sung ),김대연 ( Dae Yeon Kim ),이강영 ( Gang Young Lee ),조영수 ( 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.3

Background: The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has become a serious worldwide problem. However, there is insufficient data regarding the current status of MDR-TB and XDR-TB in Korea. This study examined the recent status of MDR- and XDR-TB using the data from 7 laboratories, in which almost all drug susceptibility tests (DST) for Mycobacterium tuberculosis were performed. Methods: The patients` identification data and DST results were collected from all 7 laboratories from 2001 to 2006 and the number of patients with MDR-TB and XDR-TB were calculated. Results: The number of DSTs was 140,638 for 6 years with an increasing incidence each year (p<0.001). The number of DST with MDR results was 18,510 and personal identifying information was obtained in 16,640 (89.9%) tests. The number of MDR-TB patients from 2001 to 2006 was 2,329, 2,496, 2,374, 2,300, 2,354, and 2,178, respectively, when counting the duplications in a year as one patient. The number of MDR-TB patients when counting the duplications in 6 years as one patient was 2,281, 1,977, 1,620, 1,446, 1,512, and 1,373, respectively. When the same method was adopted, the number of XDR-TB patients was 191, 238, 282, 260, 272, and 264, respectively, and 189, 150, 130, 90, 122, and 110 patients, respectively. Conclusion: Despite the national efforts to control TB, there are still a large number of MDR- and XDR-TB patients in Korea.

패턴 매칭 기법을 적용한 DDoS 공격 탐지

김선영(Kim Sun-Young),오창석(Oh Chang-Suk) 한국콘텐츠학회 2005 한국콘텐츠학회 종합학술대회 논문집 Vol.3 No.2

현재의 해킹 기술은 네트워크상에 과도한 트래픽을 유발하여 단일 호스트 혹은 해당 네트워크 전체를 마비시키는 분산 서비스 거부 공격으로 변모하고 있다. 본 논문에서는 각 프로토콜별 평균 편차와 각 필드별 평균 편차에 이동성을 부여하고 패턴 매칭 기법을 적용하여 보다 정확하고 오탐율이 적은 DDoS 공격 탐지 기법을 제안하였다. Present hacking technology is undergone a change on the distributed DoS Attack which cause a lot of traffic to the network or single host. In this paper, with giving mobility to the mean deviation per protocol and it's field, and with adapting pattern matching approach to DDoS attack detection technique, we propose a method to detect the DDoS attack, to have less misdetection and to detect these attacks correctly.

적응 페이딩 칼만 필터를 이용한 기준국 기반의 램프 형태 GNSS 기만신호 검출 알고리즘

김선영(Sun Young Kim),강창호(Chang Ho Kang),박찬국(Chan Gook Park) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.3

In this paper, a GNSS interference detection algorithm based on an adaptive fading Kalman filter is proposed to detect a spoofing signal which is one of the threatening GNSS intentional interferences. To detect and mitigate the spoofing signal, the fading factor of the filter is used as a detection parameter. For simulation, the effect of the spoofing signal is modeled by the ramp type bias error of the pseudorange to emulate a smart spoofer and the change of the fading factor value according to ramp type bias error is quantitatively analyzed. In addition, the detection threshold is established to detect the spoofing signal by analyzing the change of the error covariance and the effect of spoofing is mitigated by controlling the Kalman gain of the filter. To verify the performance analysis of the proposed algorithm, various simulations are implemented. Through the results of simulations, we confirmed that the proposed algorithm works well.