經營者開發의 理論과 展開方向에 관한 考察 : 大田地方의 企業體를 中心으로 Based on the enterprise firms in Daejon area

김선돈 충남대학교 경영대학원 1978 經營學論文集 Vol.5 No.-

The contemporary business administration is characterized by the fact that it is divided into three parts the capital provider who is in charge of financial resources, the working rank who provides management and labor, and the administrator who is in charge of executive funciton. From the administrator's point of view, the owner manager of the earlier capitalistic economy has been replaced by the "employed manager". And in addition to the factors mentioned above, other factors such as ever-changing situations from outside of the business and the tendency toward the division and specialization of task have forced the "professional manager" to come into existence. Korea, for one thing, has seen its industrial structure under way to rapid change and expansion with remakable rapidity as the result of the four Five-Year Economic Development Plans. However, the training of qualified business administrators is still short of fulfilling the task of producing enlightened man-power for business administration. This task is urgent since the modernization of the administration is essential to effective business management. This treatise conists of five chapters and eight sub-chapters, in which the writer tried to propose a principle of Business Administrative Development and its progressive course. I . Preface. Emphasis was laid on the necessity of training specialized business administrators who can cope with the rapidly changing situation both from outside and within the business firms themselves and on the need for establishment of preparedness for the international competition. Ⅱ. On Theoretical Disclosure of Business Administrative Development. In this chapter, the writer attempted to describe theoretically the importance of Business Administrative Development and its procedures in terms of technical aspect. Ⅲ. A Pragmatic Study of Business Administrative Development. In this chapter, the writer disclosed the results of his survey on the current trends of business administrative development in the manufacturing firms in Daejon Area. He also tried to analyze the outcome of the research survey. The problems found through the research-survey are as follow. The first is that the business administrative development is not realized as a way of coping with the depressive economy. The second is that the program for Business Administrative Development is not as effective as it should be. The third is that Business Administrators find too little time for participating in Educational Projects for Business Administration. Ⅳ. The procedure of Business Administrative Development. This chapter is devoted to the remedial ways found in the research-survey mentioned in the chapter Ⅲ, in order to propose effective procedural development programs which correspond to the enterprise environment. Ⅴ. Conculsions: This is a condensed summary of the treatise. Eight points for the improvement of the Business Administrative Development are provided in this chapter. The first is that the opportunity of participating in the administrative education program should be opened to all in management. The second is that a long-term man-power promotion program should be maintained in order to meet future demands. Thirdly, it is required that activities of an organization in charge of Administrative Education Program be strengthened. The forth is that The Education Program should be improved by means of case-study rather than class room lectures. The fifth is that specialized educators are required in the field of education mentioned above. The sixth is that a complementary measure should be also used to promote the participation by every member of the firm in management with a systematic purposes presented. The seventh points to the fact that desire for self-development on the part of the administrator himself is indispensable to the Administrative Education Program. And finally, there should be the Reviewing Program regularly into the results of the education. The education should be continuous and be repeated on regular intervals.

유전자 재조합 사람형 erythropoietin, GC-rhEPO의 약물동태 및 조직분포

김선돈 ( Sun Don Kim ),한성규 ( Seong Kyu Han ),이호성 ( Ho Sung Lee ),김성남 ( Seong Nam Kim ),정원휘 ( Wo Nee Chong ),백대현 ( Dae Hyun Baek ),조은성 ( Eun Sung Cho ),허재욱 ( Jae Wook Huh ),류판동 ( Pan Dong Ryu ) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.2

알츠하이머질환에서 LRP의 역할

안상미,김선돈 한국뇌학회 2001 한국뇌학회지 Vol.1 No.2

아밀로이드전구단백질(amyloid precursor protein; APP)의 대사산물인 베타아밀로이드 침착이 알츠하이머질환의 중요한 병리학적 특징이다. 최근에 발표된 여러 논문에 의하면, 베타아밀로이드의 침착은 베타아밀로이드단백의 생성과 제거의 불균형에 기인한다. 베타아밀로이드의 대사에 관여하거나 알츠하이머질환과 관련이 있는 것으로 보고된 여러 유전자 산물들은 하나의 수용체물질인 low density lipoprotein receptor-related protein(LRP)에 수렴된다. 즉, LRP는 아밀로이드전구단백질, apolipoprotein E(apoE), α₂-macroglobulin(α₂M)의 수용체이다. 이외에도 LRP는 심혈관질환과 뇌신경질환과 관련이 있는 적어도 20개 이상의 리간드와 결합하는 다양한 기능을 지녔는데, 주 기능으로서는 이들 리간드의 재흡수를 매개한다. 다양한 세포에서 LRP의 기능은 LRP의 발현과 그 조절에 의해서 이해될 수 있다. 본 논문에서는 LRP의 구조, 기능과 조절에 대해서 논의하며, LRP와 알츠하이머질환과의 관계을 설명하고자 한다. Deposition of beta-amyloid(Aβ), a metabolite of amyloid precursor protein(APP), is a critical pathological feature in Alzheimer’s disease. Aβ deposition reflects an imbalance of Aβ synthesis and/or clearance. Several pathways that impact Aβ metabolism converge on a single receptor molecule, the low density lipoprotein receptor-related protein(LRP). LRP is a multifunctional cell surface receptor which mediates the endocytic uptake of ligands implicated in cardiovascular and neuronal pathophysiology and which is the major neuronal receptor both for apolipoprotein E(apoE), APP and α₂-macroglobulin(α₂M). The functional roles of LRP in a variety of cells may be partly accounted for by the expression of LRP and its tight regulation. In this paper, we will discuss structure, funnction and regulation of LRP. In addition, the relationship of LRP with Alzheimer’s disease will be discussed based on the recent research data.

유전자 재조합 사람 erythropoietin, GC-rhEPO의 일반약리작용

한성규 ( Seong Kyu Han ),김선돈 ( Sun Don Kim ),정원휘 ( Wo Nee Chong ),이호성 ( Ho Sung Lee ),김성남 ( Seong Nam Kim ),백대현 ( Dae Hyun Baek ),허재욱 ( Jae Wook Huh ),성연희 ( Yeon Hee Seong ),류판동 ( Pan Dong Ryu ) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.2

새로운 항암제 AG 60 의 일반약리작용

성연희(Yeon Hee Seong),강종구(Jong Koo Kang),안희열(Hee Yul Ahn),김선돈(Sun Don KIm),이선애(Sun Ae Lee),조순옥(Soon Ok Jo),유보림(Bo Rim Yoo),정영신(Young Shin Jung),홍은경(Eun Kyung Hong),한영복(Young Bok Han) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.4

General pharmacological properties of AG 60 (mixture of acriflavine and guanosine (1:1, w/w)), which has anticancer effect, following intramuscular administration were examined in terms of effects on central nervous system, gastrointestinal system, cardiovascular system, respiratory system and autonomic nervous system in mice, rats, guinea-pigs and rabbits. AG 60 at the dose of 15 mg/kg had no influences on pentobarbital sleeping time, spontaneous motor activity, chemoshock produced by pentylenetetrazole solution, writhing syndromes induced by 0.8% acetic acid solution, and motor coordination of mice. However, AG 60 at the dose of 7.5 and 15 mg/kg caused significant decrease of normal body temperature 1 and/or 2 h after the administration. No influence on body temperature was observed at 3.75 mg/kg in mice. Gastric secretion of rat and intestinal motility of mice were not influenced by the dose of 15 mg/kg. In terms of autonomic nervous system, AG 60 did not show direct effect and inhibitory or augmentative action of histamine- or acetylcholine-induced contractions at the concentration of 5 mg/L in the isolated ileum of guinea-pig. The administration of 15 mg/kg of AG 60 did not affect mean arterial blood pressure and heart rate in rat. AG 60 (15 mg/kg) given to anesthetized rabbits showed no effect on respiratory rate.

새로운 식품원료인 아메리카왕거저리 유충 탈지분말의 In Vivo 독성시험

김선영(Sun Young Kim),곽규원(Kyu-Won Kwak),강건(Gun Kang),오윤식(Yun-Shik Oh),윤형주(Hyung Joo Yoon),김용순(Yong-Soon Kim),박관호(Kwanho Park),김은선(Eunsun Kim),김선돈(Sun-Don Kim) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.5

딱정벌레목 거저리과 곤충으로 국내외에서 식용 또는 동물사료용으로 이용되고 있는 슈퍼 밀웜(super mealworm) 탈지분말에 대한 설치류 및 비설치류를 이용한 경구독성시험에서 시험물질 frpfdZAL에 의한 독성학적 변화를 관찰하지 못했다. 특히, Hartley계 기니피그를 이용한 피부감작성 시험에서 피부를 통한 생체 내 흡수에 따른 면역기계의 이상을 확인하지 못했다. 따라서 아메리카왕거저리 유충 탈지분말은 동물을 이용한 비임상시험에서 독성학적 변화가 없는 안전한 시험물질로 판단되며 본 연구 결과는 다른 식품원료 등에 적용 및 응용 가능한 자료로 활용될 수 있을 것으로 판단된다. Zophobas atratus (Coleoptera: Tenebrionidae), the giant mealworm beetle, has been recognized as an edible insect with a high protein content for new human food source and animal feed. On the other hand, the potential toxicity and food safety of Z. atratus is not well understood. Therefore, this study evaluated the toxicity of freeze-dried skimmed powder of Z. atratus larvae (frpfdZAL), known as the super mealworm, using different model approaches, including acute oral toxicity studies in SD rats and Beagle dogs and skin sensitization in Hartley guinea pigs (Buehler’s method) in accordance with the OECD guidelines and the principles of Good Laboratory Practice. No toxicological changes were observed in the clinical signs, body weights, and gross findings in acute single-dose administration in SD rats and Beagle dogs. In addition, skin sensitization rate was 0%, and its sensitization potential was classified as grade I (very weak) using Buehler’s method. In conclusion, frpfdZAL is safe with no adverse effects and can be applied as an edible ingredient for animal feed or used for other biological purposes.