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Aspergillus oryzae를 이용한 수삼으로부터 compound K로의 생물전환
김보혜,강주형,이선이,조효진,김영진,김윤진,안순철,Kim Bo-Hye,Kang Ju-Hyung,Lee Sun-Yi,Cho Hyo-Jin,Kim Yeong-Jin,Kim Yun Jin,Ahn Soon-Cheol 한국생명과학회 2006 생명과학회지 Vol.16 No.1
Ginseng was fermented by Aspergillus oryzae to search metabolites on the basis of increased biological activity and modified structure. From this research, two biotransformed compounds (WC2-2-1 and WC2-2-2) were detected and isolated through several chromatographic techniques. WC2-2-2 was confirmed to biologically active compound K by TLC, HPLC, and mass spectroscopy, while WC2-2-1 was going to be identified until now. In biological activity, both WG2-2-1 and WG2-2-2 exhibit the cytotoxicity on PC-3 cells, but WG2-2-2 was more active than WG2-2-1. It is supposed that WG2-2-1 is an intermediate metabolite transforming to final WG2-2-2, compound K.
지역사회 거주 노인의 성별에 따른 요통 및 좌골신경통 관련 요인
김보혜(Kim, Bo Hye),김옥수(Kim, Oksoo),김아린(Kim, Ahrin) 한국보건간호학회 2012 韓國保健看護學會誌 Vol.26 No.3
Purpose: The aim of this study was to investigate gender differences in risk factors and sleep, depression, and mobility of Korean elderly with and without low back pain and sciatica. Methods: Data were derived from the 2011 Korean National Survey on Older Adults. Participants included 10,674 community-dwelling elderly. The group of elderly subjects with low back pain and sciatica and the group of elderly subjects without low back pain and sciatica were compared according to gender. Result: Age, monthly income, exercise, arthritis, osteoporosis, and providing caring support were significant risk factors for low back pain and sciatica in elderly male subjects. On the other hand, monthly income, living arrangement, arthritis, osteoporosis, providing caring support, and television watching time were significant risk factors in elderly female subjects. Significant differences in depression and mobility according to low back pain and sciatica were observed in both genders. Conclusion: Risk factors for low back pain and sciatica in elderly differed according to gender. Low back pain and sciatica showed an association with depression and mobility. These findings should be considered in planning for nursing intervention for low back pain and sciatica.
창업자기효능감과 창업의지간의 관계연구 : 문제해결능력의 매개 효과를 중심으로
김보혜(Bo-Hye Kim),김창완(Changone Kim) 한국창업학회 2021 한국창업학회지 Vol.16 No.4
본 연구는 창업자기효능감이 창업의지에 미치는 영향과 문제해결능력이 두 변수간의 매개효과를 가지는지에 대한 영향을 검증하였다. 이를 위해 문제해결능력 기반의 디자인씽킹 교과목을 수강한 대학생을 대상으로 회귀분석을 진행하였다. 연구결과로 창업자기효능감의 하위변수인 자신감, 자기조절효능감, 과업도전감은 문제해결능력에 유의한 영향을 미치는 것으로 나타났다. 또한 자신감, 자기조절효능감, 과업도전감이 창업의지에 미치는 영향을 문제해결능력이 완전 매개하는 것으로 확인되었다. 본 연구결과는 실무적으로는 창업교육이 실제 창업으로 전환되기 위해서는 개인적인 특성인 창업자기효능감과 문제해결능력을 강화할 수 있는 교과목의 편성이 요구되며 창업교육 실태조사의 방식을 문제해결능력, 창업자기효능감 등의 역량 중심으로 전환하고 대학에서 콘텐츠 개발을 지원할 수 있는 지원정책이 필요함을 제시한다. In this study, the effect of entrepreneurial self-efficacy on entrepreneurial intention and problem-solving ability has a mediating effect between two variables was verified. We conducted a regression analysis on university students who took the design thinking course based on problem-solving ability. This study found that self-confidence, self-regulating efficacy, and task challenge, sub-variables of entrepreneurial self-efficacy, significantly affected problem-solving skills. Additionally, problem-solving skills mediate the effect of entrepreneurial self-efficacy on entrepreneurial intention entirely. The results of this study show that, in practice, in order for entrepreneurship education to be converted into actual entrepreneurship, it is required to organize courses that can strengthen individual characteristics of entrepreneurship self-efficacy and problem-solving ability. Furthermore, it suggests a need for a support policy that can shift to competency-centered and support content development in universities.
COVID-19 팬데믹이 대학생의 신체적 활동과 정신적 건강에 미치는 영향
김보혜 ( Bo-Hye Kim ),이보영 ( Bo-young Lee ),이예영 ( Ye-Young Lee ),황수진 ( Su-jin Hwang ) 대한통합의학회 2021 대한통합의학회지 Vol.9 No.3
Purpose : The purpose of this study was to investigate the lecture method and physical activity level of Korean university students during the COVID-19 pandemic to determine their effect on the students’ mental health, self-efficacy, and learning motivation. Methods : A total of 203 participants (53 male, 150 female) completed the study. An online survey was distributed through a social media platform between March 24 and April 7, 2021. Participants completed the international physical activity questionnaire-short form (IPAQ-SF), COVID-19 stress scale for Korean people (CSSK), the Korean version of the general health questionnaire (KGHQ-30), and self-efficacy and learning motivation scales. Results : Among the general characteristics of the study subjects, there were statistically significant differences in the IPAQ-SF, CSSK, KGHQ, self-efficacy, and learning motivation measures by sex. There were no significant differences in the degree of IPAQ-SF, CSSK, KGHQ, self-efficacy, and learning motivation among any of the lecture method and university area groups. The level of physical activity corresponded with significant differences in KGHQ, self-efficacy, and learning motivation, excluding CSSK. There was a statistically significant positive correlation between IPAQ and self-efficacy (r=.273, p<.001), IPAQ-SF and learning motivation (r=.201, p<.01), CSSK and KGHQ (r=.271, p<.001), self-efficacy and learning motivation measures (r=.506, p<.001). There was a statistically significant negative correlation between IPAQ-SF and KGHQ (r=-.203, p<.01) and between KGHQ and self-efficacy (r=-.558, p<.001). Conclusion : CSSK and KGHQ measures were significantly higher in female students than in male students. Therefore, it is important to consider sex as a protective factor in the mental health management of university students in the context of an infectious disease pandemic. The results of this study suggest that university students should continue to engage in physical activities, even during a pandemic, and that it is necessary to prepare health management to improve mental health in such situations.
김보혜(Kim, Bohye),김옥수(Kim, Oksoo) 한국간호과학회 2020 Journal of Korean Academy of Nursing Vol.50 No.5
Purpose: The aim of this study was to develop a situation-specific theory to explain the disease management experience of patients with asthma. Methods: Twenty participants with asthma were selected using the theoretical sampling method. The data were acquired through in-depth interviews conducted from June to October 2018 and analyzed using the grounded theory approach of Strauss and Corbin. Results: In total, 69 concepts, 30 subcategories, and 13 categories were generated to explain the disease management experience of patients with asthma. The core category of the disease management experience of patients with asthma was ‘management of the disease to prevent aggravation of symptoms over the lifetime’. The disease management process of asthma patients included three steps: the ‘cognition phase’, the ‘adjustment phase’, and the ‘maintenance phase’. However, some patients remained in the ‘stagnation phase’ of disease management, which represents the result of the continual pursuit of risky health behavior. There were three types of disease management experiences among patients with asthma: ‘self-managing’, ‘partially self-managing’, and ‘avoidant’. Conclusion: This study shows that patients with asthma must lead their disease management process to prevent exacerbation of their symptoms. It is imperative to develop nursing strategies and establish policies for effective disease management of patients with asthma based on their individual disease management processes and types.