비즈니스 프로세스 기반의 협업혀브 2.0

김보현,정소영,김현우,이석우,Kim, Bo-Hyeon,Jeong, So-Yeong,Kim, Hyeon-U,Lee, Seok-U 한국생산제조학회 2010 한국생산제조학회지 Vol.10 No.6

신경 및 위장관 증세를 동반한 Erythropoietic Protoporphyria 환아 1예

김보현,박영년,정기섭,Kim, Bo Hyun,Park, Young Nyun,Chung, Ki Sup 대한소아소화기영양학회 2005 Pediatric gastroenterology, hepatology & nutrition Vol.8 No.2

본 저자들은 심한 간 부전과 함께 복통, 구토, 의식 변화, 사지 마비, 배뇨 장애 및 호흡부전을 동반한 EPP 예를 경험하였기에 보고하는 바이다. Erythropoietic protoporphyria is a genetic disorder due to a deficiency of ferrochelatase resulting in excessive accumulation and excretion of protoporphyrin. The predominant clinical feature is photosensitivity. Severe hepatic failure occurs in a small percentage of patients, and neurological symptoms are very rare. We report a case of erythropoietic protoporphyria associated with severe hepatic dysfunction and neurological symptoms. A 9-year-old girl presented with severe abdominal pain, nausea, weakness and pain of extremities, and urinary retention. Ultrasonogram and abdominal CT scanning revealed a diffuse infiltrated and enlarged liver. Liver biopsy showed deposition of dense dark brown pigment within the bile, hepatocytes and Kupffer cells. Plus, dense dark brown deposits gave a red birefringent under polarize light. Porphyrin studies demonstrated markedly elevated serum free erythrocyte protoporphyrin. This girl was diagnosed as erythropoietic protoporphyria with severe liver dysfunction and neurological symptoms.

반월상연골 파열에 대한 관절경적 inside to out 봉합술의 결과

김보현,황인성,윤태봉,변재용,Kim, Bo-Hyun,Hwang, In-Sung,Yun, Tae-Bong,Byun, Jae-Yong 대한관절경학회 2004 대한관절경학회지 Vol.8 No.1

목적: 반월상 연골 파열에 대한 비흡수성 봉합사를 이용한 관절경적 inside to out봉합술후 임상적 치유와 환자의 만족도를 결과에 영향을 주는 인자에 따라 분석하였다. 대상 및 방법: 1999년 8월부터 2002년 6월까지 반월상 연골 파열에 대한 관절경적 Inside to out 봉합술을 비흡수성 봉합사를 이용하여 시행 후 12개월이상 추시가 가능하였던 95명 110례를 대상으로 하였다. 결과는 임상적 치유와 주관적 만족도로 평가 하였으며 이들 결과에 대한 나이, 수상 후 수술까지의 기간, 파열의 부위, 파열 길이, 파열의 종류, 관절 연골의 손상 정도, 동반된 전방 십자인대 수술이 미치는 영향을 분석하였다. 결과: 임상적 치유는 84례(76%)이었으며, 환자의 주관적 만족도는 98례(89%)이었다. 전방십자인대 파열을 동반한 경우에, 파열 길이가 2cm이하인 경우가 2cm이상인 경우보다. 관절 연골의 퇴행성 정도가 심하지 않은 경우가 심한 경우보다 임상적 치유율과 환자의 만족도가 유의하게 높았다. 내측 반월상 연골 파열의 경우에, 수상후 수술까지의 기간이 짧을수록, 파열의 종류가 종 파열인 경우 임상적 치유율이 높았다. 복잡 또는 퇴행성 파열의 경우 낮은 임상적 치유율에 비해 환자의 만족도는 높았다. 결론: 비흡수성 봉합사를 이용한 관절경적 반월상 연골 Inside to out 봉합술은 다양한 봉합이 가능하고 사용이 쉬운 술식이다. 반월상 연골의 봉합 여부 결정에 있어 환자의 연령은 절대적인 고려 대상이 아니며, 퇴행성 또는 복잡파열, 관절연골의 손상이 동반된 파열의 경우 환자선택과 수술에 신중을 기해야 할 것으로 사료 된다.증을 줄일수 있으며, PASTA 병변을 포함해서 후상방 파열과 동반되지 않은 견갑하건의 부분 파열은 매우 적합한 관절경하복원술의 적응증이 될 수 있다고 사료된다. Purpose: This study examined clinical cure and patients' satisfaction degrees by factors influencing surgical operation results, after arthroscopic inside to out repair as a nonabsorbable suture material, in case of meniscal rupture. Materials and Methods: Materials were 110 cases of 95 patients who could make paces for over 12 months from August 1999 to June 2002. Results were evaluated by clinical cure and subjective satisfaction degrees. This study, concerning those results, analyzed age, term from taking pictures to taking surgical operation, rupture section, rupture length, rupture types, lesion of articular-cartilage, and effects of anterior cruciate ligament operation accompanied. Results: 84 cases(76%) were clinically cured, 98 cases(89%) were subjectively satisfied. In case of accompanying anterior cruciate ligament rupture, and in case that rupture length was below 2 cm, rates of clinical cure and patients subjective satisfaction were significantly high. In case of complex or degenerative rupture, patients satisfaction rates were higher when comparing with clinical cure rates. Conclusion: Various sutures are possible as well as available in case of arthroscopic meniscal inside to out repair using nonabsorbable suture material. It can be concluded that patients age is not absolte consideration in determining the suture of meniscus. In cases of complex rupture, degenerative rupture, ruptures companied by joint-cartilage injuries, considerate consideratin need be paid to choose patients and operations.

frailtyHL 통계패키지를 이용한 프레일티 모형의 변수선택: 유방암 생존자료

김보현,하일도,노맹석,나명환,송호천,김자혜,Kim, Bohyeon,Ha, Il Do,Noh, Maengseok,Na, Myung Hwan,Song, Ho-Chun,Kim, Jahae 한국통계학회 2015 응용통계연구 Vol.28 No.5

통계적 모형에서 적절한 변수를 선택하는 것은 회귀분석에서 매우 중요하다. 최근 벌점 함수(예: LASSO 및 SCAD)와 함께 벌점화 가능도를 사용하는 변수 선택 방법들이 선형모형 및 일반화 선형모형과 같은 단순한 통계 모형에서 널리 연구되고 있다. 이러한 방법들의 주요 장점은 중요한 변수를 선택하고 동시에 회귀계수를 추정하는 것이다. 그러므로 이 방법들은 0으로 회귀계수를 추정함으로써 중요하지 않은 변수를 삭제한다. 이 논문에서는 콕스 비례 위험 모형의 한 확장인 준 모수적 프레일티 모형에서 벌점화된 다단계 가능도(h-likelihood; HL)를 기반으로 적절한 변수를 선택하는 방법을 연구한다. 이를 위해 세 가지 벌점 함수 LASSO, SCAD 및 HL을 사용한다. 본 논문에서는 변수선택을 효율적으로 하기 위해 "frailtyHL" R 패키지 (Ha 등, 2012)를 기반으로 하여 새로운 함수를 개발하였다. 개발된 방법의 예증을 위해 전남대 의과대학 병원에서 수집된 유방암 생존자료를 이용하여 세 가지 변수 선택 방법의 결과를 비교하고, 이 변수선택방법들의 상대적 장 단점에 대해 토론한다. Determining relevant variables for a regression model is important in regression analysis. Recently, a variable selection methods using a penalized likelihood with various penalty functions (e.g. LASSO and SCAD) have been widely studied in simple statistical models such as linear models and generalized linear models. The advantage of these methods is that they select important variables and estimate regression coefficients, simultaneously; therefore, they delete insignificant variables by estimating their coefficients as zero. We study how to select proper variables based on penalized hierarchical likelihood (HL) in semi-parametric frailty models that allow three penalty functions, LASSO, SCAD and HL. For the variable selection we develop a new function in the "frailtyHL" R package. Our methods are illustrated with breast cancer survival data from the Medical Center at Chonnam National University in Korea. We compare the results from three variable-selection methods and discuss advantages and disadvantages.

초음파 PACS의 개념과 소개

김보현,Kim, Bo-Hyeon 대한디지털의료영상학회 1998 대한디지털의료영상학회논문지 Vol.4 No.1

족관절에 발생한 미만성 색소 융모 결절성 활액막염의 개방적 절제술(1예 보고)

김보현,권순억,강신택,박세욱,Kim, Bo-Hyeon,Kwon, Soon-Eok,Kang, Shin-Taek,Park, Se-Wook 대한족부족관절학회 2009 대한족부족관절학회지 Vol.13 No.2

Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder that affects synovium, tendon sheath and bursa. Although the condition can present in any joint, knee joint is the most commonly affected site and only 2.5% of cases occur in foot and ankle joint. PVNS occurs in two types: localized and diffuse. Localized type is characterized by focal involvement of the synovium with either nodular or pedunculated masses, Diffuse type affects virtually the entire synovium. Diffuse type has reported more recurrence rate. We have experienced a patient who has diffuse type PVNS of ankle joint and report an optimal method of surgical treatment.

교수학습방법 개관

김보현,Kim, Bo-Hyeon 연세대학교 의과대학 2008 의학교육논단 Vol.10 No.1

의학교육에의 교육순환모델(Learning Cycle)의 적용과 쟁점

김보현,김상현,Kim, Bo-Hyun,Kim, Sang-Hyun 연세대학교 의과대학 2008 의학교육논단 Vol.10 No.2

Purpose: The 'learning cycle' proposed by Guilbert in 1981 has been accredited as an effective and useful model for curriculum design. Three components of learning cycle, learning objective, instructional method, and assessment are connected organically and form basic structure of curriculum. In this study, we intend to analyze how the learning cycle and its three components are applied to present medical curriculum and examine the points at issue of the learning cycle in medical education. Also, we try to identify the educational significance of the leaning cycle in medical education. Results: First, concerning the learning objective, it was identified that impractical and abstract expressions are major controversial points. Also, there is a need to make learning objectives covering entire medical curriculum. Second, because of various structural problems, it is hard to practice new and various instructional methods. Third, even though there is a growing need for medical curriculum to develop and utilize more various and detailed assessment and evaluation, it was revealed that only are standardized and traditional assessments mainly used. Conclusion: Synthetically, we have some suggestions as follows. First, it is necessary to specify and actualize the learning objectives. Also, instructional methods and assessments should be diversified. And finally, there is a need to build organic and delicate medical curriculum by applying the learning cycle to medical education more actively.

방위사업에 적용 가능한 시스템 엔지니어링 표준에 대한 고찰

김보현,허장욱,Kim, Bo Hyeon,Hur, Jang Wook 한국시스템엔지니어링학회 2016 시스템엔지니어링학술지 Vol.12 No.2

The system engineering should be actively applied to successfully develop a complex and advanced weapon system, because the system engineering uses a multidisciplinary approach. Therefore, this study proposed a system engineering process for a successful weapon system development. According to the national standard policy, an IPT aspect system engineering standard must adapt the ISO/IEC/IEEE 15288. It also asks for tailoring with considering the IPT characteristics as a weapon system acquisition institution. The IPT aspect system engineering process to acquire a weapon system can be expressed with 3 process groups (Agreement, Technical Management, Technical) and 20 processes. There was a need for an institutional framework to hire retired experts from related organizations as consultants to apply the low-cost and high efficiency system engineering in the weapon system acquisition field.

플라즈마 산화방법을 이용한 질소가 첨가된 실리콘 산화막의 제조와 산화막 내의 질소가 박막트랜지스터의 특성에 미치는 영향

김보현,이승렬,안경민,강승모,양용호,안병태,Kim, Bo-Hyun,Lee, Seung-Ryul,Ahn, Kyung-Min,Kang, Seung-Mo,Yang, Yong-Ho,Ahn, Byung-Tae 한국재료학회 2009 한국재료학회지 Vol.19 No.1

Silicon dioxide as gate dielectrics was grown at $400^{\circ}C$ on a polycrystalline Si substrate by inductively coupled plasma oxidation using a mixture of $O_2$ and $N_2O$ to improve the performance of polycrystalline Si thin film transistors. In conventional high-temperature $N_2O$ annealing, nitrogen can be supplied to the $Si/SiO_2$ interface because a NO molecule can diffuse through the oxide. However, it was found that nitrogen cannot be supplied to the Si/$SiO_2$ interface by plasma oxidation as the $N_2O$ molecule is broken in the plasma and because a dense Si-N bond is formed at the $SiO_2$ surface, preventing further diffusion of nitrogen into the oxide. Nitrogen was added to the $Si/SiO_2$ interface by the plasma oxidation of mixtures of $O_2/N_2O$ gas, leading to an enhancement of the field effect mobility of polycrystalline Si TFTs due to the reduction in the number of trap densities at the interface and at the Si grain boundaries due to nitrogen passivation.