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피부 섬유아세포에서 진달래 추출물의 항산화 및 항노화 효능
최선일 ( Choi S. I. ),이사라 ( S. Lee ),이혜진 ( H. J. Lee ),김병직 ( B. J. Kim ),여주홍 ( J. Yeo ),정태동 ( T. D. Jung ),조봉연 ( B. Y. Cho ),최승현 ( S. H. Choi ),한웅호 ( X. Han ),심완섭 ( W. S. Sim ),이진하 ( J. H. Lee ),이옥환 ( O. 강원대학교 농업생명과학연구원 2017 농업생명환경연구 Vol.29 No.3
Skin aging is associated with increased reactive oxygen species (ROS) production by human cells, which is characterized by wrinkles and atypical pigmentation. Use of antioxidants is an effective approach to prevent symptoms associated with ROS-induced skin aging. Although synthetic antioxidants have been used to remove free radicals, several studies have reported that the synthetic antioxidants have side effects that cause long-term edema, which subsequently results in cancer and intracellular toxicity. Therefore, the study of safe and functional antioxidants derived from natural products is necessary for replacement of synthetic antioxidants. In this study, the antioxidant and anti-aging effect of Rhododendron mucronulatum Turcz. extracts (RTE) on human dermal fibroblasts (HDFs) were investigated. We confirmed that RTE markedly reduced hydrogen peroxide-induced cell damage, intracellular ROS, and oxidative stress-induced senescence in HDFs. These results suggest that RTE is potential natural source of antioxidant and anti-aging compounds.