Ghosh와 Kim 모수 δ의 영향함수 유도 및 확인

김민정,김홍기,Kim, Minjeong,Kim, Honggie 한국통계학회 2017 응용통계연구 Vol.30 No.4

Ghosh와 Kim에 의해 소개된 영 변환 모형은 0이 많거나 적을 때 계수형 자료(count data)를 분석하는 모형이다. 이 모형의 산포형태모수는 평균과 분산, 0 확률로 구성되며 ${\mu}$와 ${\sigma}^2$의 관계에 따라 2가지 형태를 가진다. 본 논문에서는 ${\sigma}^2{\geq}{\mu}$일 때, Ghosh와 Kim 영 변환확률 모형의 모수 ${\delta}$에 대한 영향함수를 도출하였다. 도출한 영향함수의 타당성을 검증하기 위해서 인구주택총조사 자료를 이용해 관측치가 제거된 경우에서 영향함수로 도출한 ${\delta}$ 추정치 변화값과 직접 계산한 ${\delta}$ 추정치 변화값을 비교하였다. 그 결과 영향함수는 ${\delta}$의 변화를 매우 정확히 추정하였다. The Ghosh and Kim zero-altered distribution model is used to analyze count data that have too many or too few zeros. The dispersion type parameter ${\delta}$ in the zero-altered distribution model consists of mean, variance and zero probability and has two forms depending on the relation between ${\mu}$ and ${\sigma}^2$. We derived the influence function on ${\delta}$ when ${\sigma}^2{\geq}{\mu}$. To show the validity of the influence function, we used the Census data on the number of births of married women in Korea to compare the estimated changes in ${\delta}$ using this function with those obtained using the direct deletion method. The result proved that the obtained influence function is very accurate in estimating changes in ${\delta}$ when an observation is deleted.

가임 여성에서 제왕절개술 동안 Deciduosis의 유병율과 자궁내막증과의 관계

김민정,김현정,송재연,김수연,정재은,조현희,김진홍,김장흡,유영옥,권동진,김미란,임용택,Kim, Min-Joung,Kim, Hyun-Jung,Song, Jae-Yen,Kim, Sue-Yeon,Chung, Jae-Eun,Jo, Hyun-Hee,Kim, Jin-Hong,Kim, Jang-Heub,Lew, Young-Ok,Kwon, Dong-Jin,Kim, Mee 대한생식의학회 2009 Clinical and Experimental Reproductive Medicine Vol.36 No.2

Objective: To investigate the prevalence, the distribution of deciduosis, and the relationship with endometriosis in fertile women during Cesarean delivery. Methods: In this study, pelvic tissues suspicious for ectopic deciduas were taken for biopsy during Cesarean section from 154 parturients of full term pregnancy from January 1990 to December 2003. And then those patients were followed up till April 2008. Results: Tissues from 94 parturients (94/154, 61%) were evaluated histopathologically, and ectopic decidua was observed in 70.2% (66/94). Ectopic sites were ovaries only (65/94, 69.1%), ovaries and uterine serosa (12/94, 12.8%), uterine serosa only (9/94, 9.6%), and pelvic serosa. Twenty seven (27/66, 40.9%) parturients had past history of diagnosis and treatments for endometriosis. We have tried to connect 39 (39/66, 59.1%) patients who had never been diagnosed for endometriosis but pathologically confirmed for deciduosis, and 18 patients were able to contact by phone. Twelve patients (12/18, 66.6%) showed no symptoms of endometriosis and had not received any treatments for endometriosis. Conclusion: We can conclude that most of incidental cases confirmed pathologically for deciduosis during pregnancy do not symptomatically progress. 목 적: 임신 능이 확인된 가임 여성에서 다능성 세포가 화생되거나 이전에 존재하던 골반 내 자궁내막증으로부터 발생하는 deciduosis의 발생빈도와 분포, 자궁내막증과의 관계를 알아보고자 하였다. 연구방법: 1990년 1월부터 2003년 12월까지 만삭임신에 이른 154명에서 제왕절개술시 의심되는 병변에서 조직검사를 시행하여 deciduosis의 빈도를 조사하였다. 결 과: 여러 다른 장기의 ectopic decidua는 94명 (94/154, 61%)에서 조사되었고, 이 중 66명 (66/94, 70.2%)에서 조직 검사상 deciduosis로 진단되었다. 발생빈도는 난소 (65/94, 69.1%), 난소와 자궁장막 (12/94, 12.8%), 자궁장막 (9/94, 9.6%), 복막 (2/94, 2.1%) 순이었다. 이 중 27예 (27/66, 40.9%)는 임신 전에 이미 자궁내막증으로 진단받아 다른 치료를 받았던 경력이 있던 여성이었고, 39예 (39/66, 59.1%)는 임신 전 자궁내막증으로 진단받지 않았던 경우였다. 임신 중에 deciduosis로 조직학적 확진을 받았지만 자궁내막증의 기왕력이 없었던 38명을 대상으로 2008년 4월 전화연락을 시도한 결과 통화 가능했던 18명 중 12명 (66.6%)이 다른 증상이 없어 특별한 치료 없이 지내고 있었다. 결 론: 본 연구에서 임신 시 조직학적으로 deciduosis가 확인된 대부분의 경우 자궁내막증으로의 진행은 없었다.

보건계열의 학생과 일반대학생의 이성 친구 여부에 따른 외모관심도와 행복지수

김민정,최민화,김세은,정연선,김한비,장영주,정호진,김혜진,이민경,윤현서,이정화,Kim, Min-jeong,Choi, Min-hwa,Kim, Se-eun,Jeong, Yeon-seon,Kim, Han-bi,Jang, Young-joo,Jeong, Ho-jin,Kim, Hye-jin,Lee, Min-kyung,Yoon, Hyun-seo,Lee, Jung-hwa 한국임상보건과학회 2018 한국임상보건과학회지 Vol.6 No.1

Purpose. In this study, we aim to clarify the correlation between happiness, appearance, and happiness index among many happiness factors based on the influence of quality of life on the quality of life and the affect of appearance on the happiness index. Methods. We conducted a self - filling questionnaire survey for college students in Busan from March 30 to May 10, 2017, and analyzed 392 copies of the 412 questionnaires, excluding 20 inappropriate copies. In the questionnaire, categorical data were analyzed by frequency and percentage (%) using the SPSS program (ver. 23.0, Chicago, Illinois, USA) by examining 11 items of general characteristics, successive data are presented as mean standard deviation. Results. The higher the grades, the better the dating. Women(3.32) are more likely than men(2.74) at the appearance interest(p>0.001) and the higher the grades, the better. If it's dating someone else, higher than not to do at the appearance interest and all of the questions showed higher interest in appearance. Also there was a high percentage of thought'My life is ideal in all aspects'If it's dating someone else, higher than not to do (p=0.007) Conclusion. At present, There is a high interest in the appearance of dating. In addition, the happiness index according to the current resentment status was higher in both the single item happiness index and the 5 item happiness index, and was significant in the item "My life is ideal in all aspects". Therefore, it is related to the happiness index as well as the appearance interest. Finally, whether or not dating and appearance interest play a role in raising the happiness of the individual.

Surveillance of Acanthamoeba spp. and Naegleria fowleri in environmental water by using the duplex real-time PCR

김민정,이규철,김건우,이현지,김민영,서대근,이정엽,조영철,Kim, Min-jeong,Lee, Gyu-Cheol,Kim, Kunwoo,Lee, Hyunji,Kim, Min Young,Seo, Dae Keun,Lee, Jeong Yeob,Cho, Young-Cheol The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.2

가시아메바(Acanthamoeba spp.)와 파울러자유아메바(Naegleria fowleri)는 자유생활아메바로 자연계에 널리 분포하며 사람과 동물에게 치명적인 질병을 일으킨다. 본 연구에서는 가사아메바와 파울러자유아메바를 물 환경에서 조사하기 위해 기존에 보고된 네 종류의 분자생물학적 방법과 상용 real-time PCR 키트의 분석 민감도를 비교하였다. 그 결과 duplex real-time PCR 방법이 민감도가 가장 좋았으며, 동시에 두 종류의 자유생활아메바를 검출할 수 있었다. 따라서 이 방법을 사용하여 한국의 대전시에 위치한 3개 하천, 6개 지점을 대상으로 그 분포를 2회 조사하였다. 가시아메바는 12개 시료 중 10개 시료에서 검출되었으며(83.3%), 파울러자유아메바는 2개 시료에서 검출되었다(16.6%). 향후 이러한 유해 아메바로부터 먹는 물의 안전성을 확보하기 위해 지속적인 분포조사가 필요할 것이다. Naegleria fowleri and Acanthamoeba spp. are free-living amoebas that are widely distributed in natural environments. Although uncommon, infection with these protozoans can cause fatal disease in humans and animals. In this study, in order to select the appropriate method to survey Naegleria fowleri and Acanthamoeba spp. in water samples, four molecular biology techniques and one commercially available kit for real-time PCR were compared. The results indicated that the duplex real-time PCR was the most sensitive, and could be used to simultaneously detect two different free-living amoebas. Using the duplex real-time PCR approach, the two free-living amoebas were surveyed in three local streams in Daejeon, Republic of Korea. The concentrated free-living amoebas were inoculated onto non-nutrient agar plates which had been spread with heat-inactivated Escherichia coli and incubated for 5~7 days. After incubation, gDNA was extracted and used as the template for amplification by duplex real-time PCR. Acanthamoeba spp. and N. fowleri was detected from ten (83.3%) and two (16.6%) of the twelve samples, respectively. As these two free-living amoebas can be fatal, continuous surveillance is needed to track their distribution in the aquatic environment for the drinking water safety.

치은부에 이식한 이중인공진피의 조직학적 치유

김민정,정현주,김옥수,김영준,Kim, Min-Jeong,Chung, Hyun-Ju,Kim, Ok-Su,Kim, Young-Joon 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2

The autogenous free gingival graft is the most predictable procedure currently used to increase the width of the attached gingiva in periodontics. But the major disadvantage of the procedure is to create the multiple surgical wounds at both a donor site and a recipient site. The other problem is the limited amount of available graft material in oral cavity. Therefore, recent researches have been focused to develop the biomaterial to substitute the autogenous gingival tissue. The purpose of this study was to evaluate the histologic healing after grafting of bilayer artificial dermis, compared to the free gingival graft. Four non-smoking subjects (mean age, 32.5 years) in systemically healthy state and good oral hygiene were selected according to their particular needs for correction of mucogingival problems as suggested by Nabers(1966). The recipient sites were prepared through the procedure for the free gingival graft and were grouped according to the graft materials: Experimental group(n=5) - bilayer artifcia1 dermis ($Terudermis^{(R)}$; Terumo Co. Japan) and Control group(n=6) - free gingival graft with autogenous palatal mucosa. Biopsies were harvested at 1,2,3 and 6 weeks postsurgery to evaluate histologically. At the third week in the experimental group and at the second week of in the control group, the grafts has been clinically stabilized on the recipient bed and the graft border has been blended into the surrounding tissue. In the experimental group after 1 week of grafting, the epithelial migration from the adjacent tissue to graft material was seen and after 3 weeks of grafting, the : nflmmation decreased, collagen layer of the artificial dermis was lost and the basement membrane of epithelium was formed. After 6 weeks of grafting, both groups demonstrated orthokeratinized epithelium and increased thickness of epithelial tissue and the rete peg formation, similar to the adjacent tissue, Histologic evaluation revealed a biologic acceptance and incorporation of the collagen layers of the graft tissue to the host tissue, without foreign body reaction. In conclusion, a bilayer artificial dermis is essentially similar to autogeneous free gingival graft in the correction of mucogingival problems, and has the advantages of decreased patient morbidity (no donor site) and availability of abundant amounts of graft material when needed.

Surveillance of viable Acanthamoeba spp. and Naegleria fowleri in major water sources for tap water in Korea

김민정,이규철,김건우,이현지,김민영,서대근,이정엽,조영철,Kim, Min-jeong,Lee, Gyu-Cheol,Kim, Kunwoo,Lee, Hyunji,Kim, Min Young,Seo, Dae Keun,Lee, Jeong Yeob,Cho, Young-Cheol The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.3

자유생활아메바인 가시아메바(Acanthamoeba spp.)와 파울러자유아메바(Naegleria fowleri)는 아메바성 뇌염 등 치명적인 질병을 일으키며, 물을 포함한 자연 환경에 널리 분포한다. 가시아메바와 파울러자유아메바가 한국의 주요 상수원수에 존재하는지 알아보기 위해 배양법에 기초한 실시간 중합효소연쇄반응법을 이용하여 2017년 7월부터 12월 사이에 한국의 52개 주요 상수원수를 조사하였다. 가시아메바와 파울러자유아메바가 각각 42개 시료(80.8%)와 6개 시료(11.5%)에서 검출되었다. 가시아메바의 경우 계절과 상관없이 고른 검출율을 보였으나, 파울러자유아메바는 주로 여름과 가을에 검출되었으며 겨울에는 검출되지 않았다. 이상의 결과는 이러한 자유생활아메바가 한국의 상수 원수에도 고루 존재한다는 것을 의미한다. The pathogenic free-living amoebas (FLAs), Acanthamoeba spp. and Naegleria fowleri, can cause fatal infections, including amoebic encephalitis. They are ubiquitously distributed in nature, including in diverse bodies of water. In order to survey Acanthamoeba spp. and N. fowleri in source water in Korea, we used culture-based real-time PCR to detect viable FLAs in 52 source water samples collected between July 2017 and December 2017. Acanthamoeba spp. and N. fowleri were detected in 42 samples (80.8%) and 6 samples (11.5%), respectively. Acanthamoeba spp. were detected at approximately the same frequency in all seasons, but N. fowleri was mainly detected in summer and autumn, with no N. fowleri detected in winter. These results demonstrate that these pathogenic FLAs, especially N. fowleri, which has caused deaths in the United States and China, are widely distributed in the Korean aquatic environment.

멘탈헬스 측정 및 멘탈웰빙 관리시스템 기술개발 동향

김민정,박경현,김정숙,김현숙,권오천,윤대섭,Kim, M.J.,Park, K.H.,Kim, J.S.,Kim, H.S.,Kwon, O.C.,Yoon, D.S. 한국전자통신연구원 2021 전자통신동향분석 Vol.36 No.5

As the COVID-19 crisis continues, working environments and lifestyles have been changed unexpectedly, therefore the importance of mental health in the working environments has been highlighted. When the workers' mental health deteriorates, there will be personal losses but also human resources losses caused productivity decrements of the company or the organization. Many researchers have been tried to solve these issues with the help of ICT technologies such as wearable devices. Most wearable healthcare devices have been designed to detect the physiological status of users and collect the physical activities of users, and their applications are gradually expanding. Those devices may be good candidates to prevent loss of human resources from working environments especially under the COVID-19 situation by continuously monitoring mental health status in connection with mobile devices and managing the mental health on their own by combining mental well-being with support solutions. In this paper, the development trend of mental health measurement and mental well-being support technologies is analyzed, and development prospects are examined.

림프절에 발생한 랑게르한스 세포 조직구증의 세침흡인 세포소견 -1예 보고-

김민정,김교영,조현이,정동해,김나래,하승연,Kim, Min-Jung,Kim, Gou-Young,Cho, Hyun-Yee,Chung, Dong-Hae,Kim, Na-Rae,Ha, Seung-Yeon 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1

Langerhans cell histiocytosis (LCH) is a pleomorphic disease entity characterized by local or disseminated atypical Langerhans cells (LCs) found most commonly in bone, lungs, mucocutaneous structures and endocrine organs. Among different sites, unifocal disease confined to a lymph node (LN) is rare. We report a case of LCH confined to a LN in a 38-year-old male who presented with a 2 cm-sized cervical mass. The fine needle aspiration (FNA) smears of cervical LN showed high cellularity having isolated LCs with contorted nuclei and nuclear grooves mixed in multinucleated giant cells, small lymphocytes and eosinophils. Charcot-Leyden crystals were also seen, as were a few dendritic-like cells and intranuclear inclusions. Confirmation of LCH was made by histopathologic studies, positive reactions for S-100 protein and CD1a immunohistochemical staining and by the demonstration of Birbeck granules on electron microscopy. The differentials to be considered include dermatopathic lymphadenitis, sinus histiocytosis with massive lymphadenopathy, Hodgkin's lymphoma and malignant histiocytosis. The characteristic cytomorphologic pattern of LCH in a LN FNA smear plays an important role in suggesting the diagnosis of LCH.

유기농업 생태계로부터 담수 녹조류 분리 및 형태적 동정

김민정,심창기,김용기,홍성준,박종호,한은정,지형진,윤종철,김석철,Kim, Min-Jeong,Shim, Chang-Ki,Kim, Yong-Ki,Hong, Sung-Jun,Park, Jong-Ho,Han, Eun-Jung,Jee, Hyeong-Jin,Yun, Jong-Chul,Kim, Suk-Chul 한국유기농업학회 2014 韓國有機農業學會誌 Vol.22 No.4

본 연구는 유기농업에서 생물자원으로서 담수 클로렐라의 활용 가능성을 연구하고자 유기농 생태계로부터 담수 녹조류를 분리, 동정하고, 생물학적인 특성을 조사하였다. 조사 지역의 수온은 $12.4{\sim}28.2^{\circ}C$, pH는 6.1~8.5이었다. 담수 녹조류를 분리할 때 고체배양법이 액체배양법보다 오염도가 낮고 분리 빈도가 높았다. 전국 9개 지역, 6개 담수 녹조류 서식처로 부터 총 115개의 균주를 분리하였다. 담수 녹조류의 분리 및 배양을 위해 질소원으로는 $NaNO_3$과 $KNO_3$, 탄소원으로 $Na_2CO_3$를 사용하였고, macro media의 구성 성분 중 $MgSO_4{\cdot}7H_2O$과 $CaCl_2{\cdot}2H_2O$를 분리하여 제조한 BGMM(BG11 Modified Medium)배지를 고안하였다. 담수녹조류는 배양 후 4일째부터 급격히 흡광도가 증가하였고 8일째부터 흡광도가 감소하였다. 공시한 7개의 균주 중 CHK008 균주가 배양 7일째에 가장 높은 흡광도를 보였다. 담수 녹조류 배양에 적합한 BGMM 배지의 pH는 6~7이었고 조사되는 빛이 강할수록 생육이 증가하였으며 5종류 당류 중에서 Glucose와 Galactose를 첨가하였을 때 클로랄라의 생육이 좋았다. 순수 분리한 16개 녹조류 균주의 균총색은 녹색, 진녹색, 연녹색을 나타내었고, 11개의 균주가 형광현미경하에서 강한 형광 빛을 나타내었다. 녹조류 16개 균주의 형태적인 특징을 조사한 결과 C. vulgalis, C. sorokiniana, C. pyrenoidosa, C. kessleri, C. emersonii, and Chlamydomonas sp.의 2개 속 6개종으로 동정되었다. 담수 녹조류의 세포 크기는 종마다 다양한 변이를 보였다. 대부분의 담수 녹조류의 세포형태는 구형이었다. Chlamydomonas sp.는 타원형이었고 Chlorella sorokiniana는 구형과 타원형이 섞여 있었다. 6개 녹조류 종류 중 Chlamydomonas sp.를 제외한 모든 균주는 편모가 없었다. Chlamydomonas sp. 1개 균주와 C. sorokiniana 5개 균주는 세포에서 점질물을 분비하였다. This study aimed to isolate and identify freshwater algae from the organic agricultural ecosystems and investigate its biological characteristics to study the possibility of utilizing a biomass freshwater algae in organic farming. In the survey area, average water temperature was $12.4{\sim}28.2^{\circ}C$ and the pH ranges were from 6.1 to 8.5. The solid culture method is more suitable than liquid culture method for isolation of freshwater algae with lower contamination level and higher isolation frequency. A total of 115 strains were isolated from six freshwater algae habitats in nine regions in Korea. BGMM (BG11 Modified Medium) amended with NaNO3 and $KNO_3$ as a nitrogen, and $Na_2CO_3$ as carbon source was designed to isolate and culture freshwater algae. Absorbance of freshwater algae culture has increased dramatically to four days and decreased after eight days after inoculation. CHK008 of the seven isolates showed the highest absorbance in seven days after culturing in BGMM. The optimal pH of BGMM for culturing freshwater algae was pH 6-7. As light intensity increased, growth of freshwater algae increased. Among the five kinds of carbon sources, glucose and galactose promoted good growth of freshwater algae in BGMM. The colony color of purified 16 green algae isolates showed a separation of green, dark and light green, and of them, eleven algae strains showed a strong fluorescent light under fluorescence microscopy. Cell size of the green algae showed a wide range of variation depending on the species. General morphology of the green algae strains was spherical. Chlamydomonas sp. was elliptical, and Chlorella sorokiniana was ellipsoidal and cylindrical. All strains of the green algae except for Chlamydomonas sp. did not have flagella. One isolate of Chlamydomonas sp. and five isolates of C. sorokiniana secreted mucus. Sixteen isolates of 16 green algae were identified as two family and six species, Chlorella vulgalis, C. sorokiniana, C. pyrenoidosa, C. kessleri, C. emersonii, and Chlamydomonas sp. based on their morphological characteristics.

동신대 목동한방병원 안이비인후피부과 내원환자의 성향에 관한 설문조사

김민정,김종한,박수연,최정화,박용호,김대수,정민영,Kim, Min-Jeong,Kim, Jong-Han,Park, Soo-Yeon,Choi, Jeong-Hwa,Park, Yong-Ho,Kim, Dae-Su,Jung, Min-Young 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3

Objective : The purpose of this study is to understand preferences of patients who had visited the Dept. of Ophthalmology Otolaryngology & Dermatology Method : We conducted questionnaire survey on the patients who had visited the Dept. of Ophthalmology, Otolaryngology & Dermatology Hospital of Dong Shin University from March to September, 2007. Result : The result were as follows. 1. Distribution of sex: male 41 % female 59% 2. The age distribution of patients showed highest in 30-39 years(23%), followed by 20-29 years, 40-49 years in order. 3. The classification of patients according to disease: Skin disease (38%), Nose (23%), Face (10%), Eye (9%), Throat (8%), Ear (7%) 4. Other offices patients visited before coming to this clinic: Local clinic (41%). Hospital (18%), Oriental clinic or hospital (5%), None (22%) 5. The length of time the patient has had the disease: 2years (26%), more than 3years (15%), 2-4weeks (13%), 6months (11%), 1year (10%) in order 6. The expected length of treatment: 1week (21%), 2week (12%), 1month (21%) 7. 26% expected about 100,000 won as medical expenses. 8. 88% of the patients are willing to have a check-up when it needed and 40% expected about 50,000 won as check-up expenses. 9. 52% of the patients are not willing to withstand pain, and would rather heal slowly. 10. 69% of the patients said that treatment would be affected by company(44%), school(19%) and business(16%). 11. 73% of the respondants are positive about night-time treatment and 92% is positeve about making an appointment for the treatment. Conclusion : Through the research, we could understand preferences of patients who had visited Dept. of Ophthalmology, Otolaryngology & Dermatology