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        • SCOPUSKCI등재후보

          국한성 소세포 폐암에서 항암 화학 및 흉부 방사선치료의 병합요법 적응

          김문경,안용찬,박근칠,임도훈,허승재,대용,신경환,이규찬,권오정,Kim Moon Kyung,Ahn Yong Chan,Park Keunchil,Lim Do Hoon,Huh Seung Jae,Kim Dae Yong,Shin Kyung Hwan,Lee Kyu Chan,Kwon O Jung 대한방사선종양학회 1999 Radiation Oncology Journal Vol.17 No.1

          목적 : 국한성 병기의 소세포 폐암에 대하여 항암 화학 및 흉부 방사선치료의 병합요법을 적용하여 국소 반응율, 급성 부작용의 빈도, 단기 임상 추적 관찰 결과 등을 보고하고자 한다. 대상 및 방법 : 1994년 10월부터 1998년 4월까지 국한성 병기의 소세포 폐암으로 진단되어 VIP 요법(etoposide, ifosfamide, cis-platin) 또는 EP 요법(etoposide, cis-platin)의 복합 항암 화학 및 흉부 방사선치료의 동시 병합요법을 시행받은46명의 환자를 대상으로 하였다. 항암 화학요법은 3주 간격으로 모두 6회의 시행을 목표로 하였고, 흉부 방사선치료는 10MV X-ray를 사용하여 일일선량 2Gy씩 44Gy를 4.5주간에 첫번째 화학요법과 동시에 시행하고자 하였다. 관해율은 예정된 치료가 모두 종료된지 4주만에 판정하였으며, 완전 관해를 얻었던 경우에는 10회에 걸쳐 25Gy의 예방적 전뇌 방사선치료를 예정하였다. 급성 부작용의 빈도와 정도는 SWOG 부작용 판정 등급체계를 적용하였으며, 단기 추적 관찰 결과로서 1년 및 2년 생존율, 무병 생존율 등은 Kaplan-Meter법을 사용하였다. 결과 : 전체 환자에 대한 추적 기간의 중앙값은 16개월이었다(범위 2개월$\~$41개월). 완전 관해는 30명(65$\%$)에서 있었으며, 이 중 22명에서 예방적 전뇌 방사선치료를 시행하였다. 동시 병합요법의 3도 이상의 혈액학적 부작용의 빈도는 각각 백혈구감소증 23명(50$\%$), 적혈구감소증 17명(37$\%$), 혈소판감소증 9명(20$\%$)이었고, 비혈액학적 부작용은 탈모 9명(20$\%$), 오심 및 구토 5명(11$\%$), 그리고 말초신경염 1명(2$\%$)이었으며, 이로 인한 화학요법의 지연은 한명에서, 화학요법제의 용량 감소는 전체 246회의 화학요법 중 58회에서 있었다. 3도 이상의 방사선 식도염은 없었으나 화학요법의 부작용으로 인한 흉부 방사선치료의 일시 중단은 21명에서 평균 8.3일간 필요하였다. 국소 재발은 완전 관해 환자에서 8명, 국소 진행은 부분관해 및 불변 환자에서 6명이 확인되었고, 원격 전이는 17명에서 확인되었으며, 이 중 4명에서 국소 재발과 원격 전이가 함께 확인되었다. 원격 전이의 주요 장기로는 뇌가 10명으로 가장 많았고, 간이 4명으로 다음을 차지하였다. 전체 환자들의 생존기간의 중앙값은 23개월이었으며, 1년, 2년 생존율 및 무재발 생존율은 각각 79%$\%$ 45$\%$ 및 55$\%$, 32$\%$였다. 결론 : 국한성 소세포 폐암환자에서 항암 화학 및 방사선치료의 병합요법을 적용하여 만족할 만한 관해율 및 1년, 2년 생존율을 얻었으며, 대체적인 환자들의 치료 방침에 대한 순응도는 양호한 편으로 판단된다. Purpose : This is a retrospective study to evaluate the response rate, acute toxicity, and survival rate of a combined chemotherapy and radiation therapy in limited disease small cell lung cancer, Materials and Methods : Firty-six patients with limited disease small-cell lung cancer who underwent combined chemotherapy and radiation therapy between October 1994 and April 1998 were evaluated. Six cycles of chemotherapy were planned either using a VIP regimen etoposide, ifosfamide, and cis-platin) or a EP regimen (etoposide and cis-platin). Thoracic radiation therapy was planned to deli- ver 44 Gy using 1 OMV X-ray, starting concurrently with chemotherapy. Response was evaluated 4 weeks after the completion of the planned chemotherapy and radiation therapy, and the prophylaetic cranial irradiation was planned only for the patients with complete responses. Acute toxicity was evaluated using the SWOG toxicity criteria, and the overall survival and disease-free survival were calculated using the Kaplan-Meier Method. Results : The median follow-up period was 16 months (range:2 to 41 months). Complete response was achieved En 30 (65$\%$) patients, of which 22 patients received prophylactic cranial irradiations. Acute toxicities over grade III were granulocytopenia in 23 (50$\%$), anemia in 17 (37$\%$), thrombo- cytopenia in nine (20$\%$), alopecia in nine (20$\%$), nausea/vomiting in five (11$\%$), and peripheral neuropathy in one (2$\%$). Chemotherapy was delayed in one patient, and the chemotherapy doses were reduced in 58 (24$\%$) out of the total 246 cycles. No radiation esophagitis over grade 111 was observed, while interruption during radiation therapy for a mean of 8.3 days occurred in 21 patients. The local recurrences were observed in 8 patients and local progressions were in 6 patients, and the distant metastases in 17 patients. Among these, four patients had both the local relapse and the distant metastasis. Brain was the most common metastatic site (10 patients), followed by the liver as the next common site (4 patients). The overall and progression-free survival rates were 79$\%$ and 55$\%$ in 1 year, and 45'/) and 32% in 2 years, respectively, and the median survival was 23 months. Conclusion : Relatively satisfactory local control and suwival rates were achieved after the combined chemotherapy and radiation therapy with mild to moderate acute morbidities in limited disease small cell lung cancer.

        • SCOPUSKCI등재

          냉각압연 가공용 자동 형상제어장치의 특성에 관한 연구

          김문경,전언찬,순경,Kim, Moon-Kyung,Jeon, Eon-Chan,Kim, Soon-Kyung 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.9

          Flatness of cold rolled strip is vital to the quality of the product and productivity of the mill. Therefore, in recent year requirement for flatness control in strip rolling have become increasingly severe. The necessity for more accurate automatic gauge control and automatic flatness control(AFC) has increased by customer's requirement for cold rolled steel sheets with thinner gauge and better flatness quality. In this paper, the performance and functions of AFC system installed on the 4 hi-reversing mill has been investigated under actual conditions. The test results are as follows : The more strip thickness is thick, the smaller the I-value. The I-value is a strain measured by stressometer. Complex distributions of strip tension are controlled to remove not only a quarter buckle but also a simple center wave and edge wave. The defects caused by poor flatness have been drastically decreased. And a proper coolant temperature for work roll cooling system on the AFC system is about $50~55^{\circ}C$.

        • KCI등재

          중금속 오염 준설토의 토양으로서의 유효활용을 위한 선별수준 생태위해도평가

          김문경(Moon Kyung Kim),기범(Ki Beum Kim),최용주(Yong Ju Choi),남경필(Kyoung Phile Nam) 大韓環境工學會 2016 대한환경공학회지 Vol.38 No.5

          본 연구에서는 중금속의 생태독성자료를 통해 준설토의 육상 재활용을 위한 screening-level 생태위해도 평가를 수행하였다. 대상 중금속 6종(Cu, Zn, Cd, Pb, Cr, Ni)의 독성자료는 USEPA의 ECOTOX를 통해 수집하였으며, 선별과정을 거쳐 생태위해도 평가에 사용하였다. 각 중금속의 예측무영향농도는 독성자료의 획득이 가능한 육상 수용체의 종 수에 따라 확률론적 방법(Cu, Zn, Cd)과 결정론적 방법(Pb, Cr, Ni)을 통해 도출하였다. 현장 채취 준설토에서 발견되는 중금속 실제오염농도와 예측무영향농도와의 비교를 통해 생태위해도를 계산하였으며 Cu, Zn, Cr, Pb, Ni의 위해도가 1을 초과하여 생태독성학적 위해도가 존재할 수 있는 가능성을 확인하였다. 따라서 재활용 부지의 생태위해도를 고려하였을 때 해당 중금속 오염 준설토를 활용하기 위해서는 중금속 정화 또는 보다 높은 수준의 생태 위해도평가가 선행되어야 할 것으로 판단된다. This study conducted a screening-level ecological risk assessment for heavy metals in dredged sediment for recycling in terrestrial environment. Toxicological information of six heavy metals (i.e., Cu, Zn, Cd, Pb, Cr, and Ni) was collected from ECOTOX of US Environmental Protection Agency, and screened and qualified for the use in the screening-level ecological risk assessment. According to the number of terrestrial ecological receptors for which toxicological information is available, PNEC (Predicted No Effect Concentration) of each heavy metal was derived using either stochastic approach (for Cu, Zn, and Cd), or deterministic approach (for Pb, Cr, and Ni). Hazard quotients of the six heavy metals were derived for a field-collected dredged sediment using the PNEC derived and the PEC (Predicted Environmental Concentration) determined for the dredged sediment. The HQs of Cu, Zn, Cr, Pb and Ni were higher than unity indicating a possibility of ecological risk of the five heavy metals when the dredged sediment is applied in terrestrial environment. Accordingly, remediation processes or a higher-level ecological risk assessment would be needed for the recycling of the material.

        • KCI등재

          증례보고 : 로봇 복강경하 광범위 자궁경부절제술 1예

          김문경 ( Moon Kyung Kim ),최철훈 ( Chel Hun Choi ),송태종 ( Tae Jong Song ),박황신 ( Hwang Shin Park ),이유영 ( Yoo Young Lee ),태중 ( Tae Joong Kim ),이정원 ( Jeong Won Lee ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo Bae ),병기 ( 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.6

          성공적으로 이루어진 로봇을 이용한 광범위 자궁경부절제술의 한 예를 보고하고자 한다. 임신 기왕력 없는 조기 자궁경부암의 미혼 여성이 다빈치 로봇을 이용하여 광범위 자궁경부절제술 및 골반림프절절제술을 시행 받았다. 골반 림프절 동결절편 조직검사에서 음성임을 확인한 후 자궁동맥의 상행 가지를 보전하면서 자궁방, 질 주위 조직, 천골자궁 인대를 절제하였고 질까지 절제하였다. 자궁경부의 절제와 질 봉합은 질식으로 시행되었다. 수술시간은 450분이 소요되었고 수술 중, 수술 후 합병증은 없었다. 광범위 자궁경부절제술에 있어서 로봇을 이용한 광범위 자궁경부절제술은 복강경 수술의 기술적 어려움과 개복술의 단점들을 해결하는 좋은 수술 방법이 될 것이다. To present a case of successful robotic assisted radical trachelectomy. A nulliparous woman with early cervical cancer underwent a laparoscopic radical trachelectomy and pelvic lymphadenectomy with the da Vinci robot (Intuitive Surgical Inc., Sunnyvale, CA). After the pelvic lymph nodes were found negative on frozen section, the parametria, paracolpia and uterosacral ligaments were dissected transabdominally sparing the ascending branches of the uterine arteries. Cervical transection and vaginal closure were performed transvaginally. Surgical time was 450 min. No perioperative complications were noted. Robotic laparoscopic radical trachelectomy may bridge the gap between laparotomy and laparoscopy for radical trachelectomy.

        • 담수 환경에서의 미세플라스틱 검출 및 위해성 평가에 관한 고찰

          김문경(Moon-Kyung Kim),조경덕(Kyung-Duk Zoh) 서울대학교 보건환경연구소 2019 보건학논집 Vol.56 No.1

          Microplastics (MPs), a plastic debris with a particle diameter of less than 5 mm, are a pollutant of environmental concern and have received attention in recent years. The effects of MPs on the human body and the cause of their occurrence have not been clarified, but there is no doubt that the concentration in the natural environment surrounding human life is increasing. Therefore, it is necessary to make efforts to establish the basis of MPs investigation system and risk. In the future, various researches should be carried out in order to establish scientific basis such as investigation of source and contamination status of MPs at the national level, the degree of bioaccumulation and influence of MPs emitted into aquatic ecosystem, and the harmfulness of MPs themselves. In this study, we intended to look into other studies on the collected sampling methods, pretreatment methods, and analysis methods in order to help better understand MPs in freshwater. In addition, we reviewed relating to the potential environmental risks and impacts on MPs in the freshwater environment, and proposed the risk assessment models of MPs in freshwater environments. This study will be helpful to the future research on the monitoring system, human health risk, and development of environmental policies to manage the MPs pollution.

        • SCOPUSKCI등재후보

          Analysis of the Inter- and Intra-treatment Isocenter Deviations in Pelvic Radiotherapy With Small Bowel Displacement System

          김문경,대용,안용찬,허승재,임도훈,신경환,이규찬,Kim Moon Kyung,Kim Dae Yong,Ahn Yong Chan,Huh Seung Jae,Lim Do Hun,Shin Kyung Hwan,Lee Kyu Chan The Korean Society for Radiation Oncology 2000 Radiation Oncology Journal Vol.18 No.2

          목적 : small bowel displacement system (SBDS)을 이용한 골반부 방사선 치료시 치료간(intertreatment) 및 치료중(intratreatment) 중심점 위치변동의 편차를 분석하고, 그 결과를 임상적으로 이용하고자 하였다. 대상 및 방법 :자궁경부암 7명, 직장암 4명의 총 11명의 환자를 대상으로 electronic portal imaging device (EPID)를 이용하여 302건의 후-전문(postero-anterior port) 영상과 232건의 측문(lateral port) 영상을 얻었다. 모든 환자는 복와위 자세로 하복부에 SBDS를 사용하였다 방사선 조사야의 중심점과 배율을 맞추기 위하여 5개의 금속 기준점을 영상탐지판(image detection unit)에 부착시켰으며, EPID 영상의 골 기준점(bony landmark)을 정하여 모의치료시 촬영한 영상과 비교하여 정렬시킨 후 우-좌문, 두-미문, 그리고 후-전문 방향으로 중심점의 이동방향 및 거리를 분석하였다. 결과 : 우-좌문, 두-미문, 그리고 후-전문 방향으로의 치료간 중심점 이동의 평균값은 각각 1.2 mm ($\pm$1.6 mm), 1.0mm ($\pm$3.0 mm), 0.9 mm ($\pm$4.4 mm)이었으며, 각 방향으로의 5 mm 이상의 치료간 중심점 이동은 각각 2, 12, 24$\%$, 그리고 10 mm 이상의 치료간 중심점 이동은 각각 0, 0, 5$\%$이었다 큰 폭의 위치변동을 보인 방향은 후-전문 방향이었으며, 최대값은 11.5 mm 이었다. 우-좌문, 두-미문, 그리고 후-전문 방향으로의 치료중 중심점 이동의 평균값은 각각 0 mm ($\pm$0.9 mm), 0.1 mm ($\pm$1.9 mm), 0 mm ($\pm$1.6 mm)이었다. 5 mm 이상의 치료중 중심점 이동은 각각 0, 1 , 1$\%$이었다. 결론 : SBDS를 이용한 골반부 방사선 조사시 폭과 빈도가 가장 큰 치료간 위치변동은 후-전문 방향이므로, 측면의 후-전문 방향으로 추가적인 여유를 두는 것이 바람직할 것으로 판단된다. Purpose : To evaluate the e지ent and frequency of the inter- and intra-treatment isocenter deviations of the whole pelvis radiation field in using small bowel displacement system (SBDS). Methods and Materials : Using electronic portal imaging device (EPID), 302 postero-anterior 232 lateral portal images were prospectively collected from 11 patients who received pelvic radiation therapy (7 with cervix cancer and 4 with rectal cancer). All patients were treated in prone position with SBDS under the lower abdomen. Five metallic fiducial markers were placed on the image detection unit for the recognition of the isocenter and magnification. After aligning the bony landmarks of the EPID images on those of the reference image, the deviations of the isocenter were measured in right-left (RL), cranio-caudal (CC), and PA directions. Results : The mean inter-treatment deviation of the isocenter in each RL, CC, and PA direction was 1.2 mm ($\pm$ 1.6 mm), 1.0 mm ($\pm$3.0 mm), and 0.9 mm ($\pm$4.4 mm), respectively. Inter-treatment isocenter deviations over 5 mm and 10 mm in RL, CC, and PA direction were 2, 12, 24$\%$, and 0, 0, 5$\%$, respectively. Maximal deviation was detected in PA direction, and was 11.5 mm. The mean intratreatment deviation of the isocenter in RL, CC, and PA direction was 0 mm ($\pm$0.9 mm), 0.1 mm ($\pm$ 1.9mm), and 0 mm ($\pm$1.6 mm), respectively. All intra-treatment isocenter deviations over 5 mm in each direction were 0, 1, 1$\pm$, respectively. Conclusions : As the greatest and the most frequent inter-treatment deviation of the isocenter was along the PA direction, it is recommended to put more generous safety margin toward the PA direction on the lateral fields if clinically acceptable in pelvic radiotherapy with SBDD.

        • 자동차 보수도장용 수용성 도료의 도장특성에 관한 연구

          순경(KIM Soon Kyung),김문경(KIM Moon Kyung) 한국기계가공학회 2008 한국기계가공학회 춘추계학술대회 논문집 Vol.2008 No.-

          This paper investigates the correlation between surface roughness and gloss of aluminium sheet painted waterborne paint. One customer criterion of automotive quality is the as-painted appearance of the final products. Especially, the current emphasis on control of surface roughness of sanded aluminium sheet has been prompted by the automotive industry's concern with the as-painted appearance. because the influence of such characteristics on paintability, and painted appearance is important in defining outer panel requirements for automobile. This paper is dedicated primarily to the issue of painted appearance and reviews for improvement of roughness. The conclusions are obtained as follows ; 1) Painted aluminium sheet appearance is strongly affected by surface roughness of base-metal and influenced by sand paper and sanding method. 2) The painted appearance of aluminium sheets was determined and related to surface roughness parameters, combination of sand paper.

        • KCI등재

          자동차 보수도장용 수용성 도료의 도장특성에 관한 연구

          순경(Soon-Kyung Kim),김문경(Moon-Kyung Kim) 한국기계가공학회 2008 한국기계가공학회지 Vol.7 No.4

          This paper investigates the correlation between surface roughness and gloss of aluminium sheet painted waterborne paint. One customer criterion of automotive quality is the as-painted appearance of the final products. Especially, the current emphasis on control of surface roughness of sanded aluminium sheet has been prompted by the automotive industry's concern with the as-painted appearance. because the influence of such characteristics on paintability, and painted appearance is important in defining outer panel requirements for automobile. This paper is dedicated primarily to the issue of painted appearance and reviews for improvement of roughness. The conclusions are obtained as follows ; 1) Painted aluminium sheet appearance is strongly affected by surface roughness of base-metal and influenced by sand paper and sanding method. 2) The painted appearance of aluminium sheets was determined and related to surface roughness parameters, combination of sand paper.

        • KCI등재후보

          공기 압축기의 피스톤용 알루미늄 합금 소재 개발

          순경(Soon-Kyung Kim),김문경(Moon-Kyung Kim) 한국기계가공학회 2008 한국기계가공학회지 Vol.7 No.1

          It is important not only to reduce the casting defects of piston but also to improvement in the mechanical properties(hardness) of piston for the air compressor. The blow hole is typical casting defects in the conventional cast of aluminium alloy(AC8A-T6) piston. Because of the heat treatment method, mechanical properties of the aluminium alloy for piston was decided on the heat treatment method and cycle. Therefore, we tested on the development of mechanical properties and on the casting defects of piston for the air compressor in accordance with the heat treatment and casting condition. After the heat treatment and casting was carried out as several times, and was compared with the imported piston. As a result of several investigations; microstructure, hardness and casting defects of piston was changed under the influence of the heat treatment and casting method. When the cooling rate was controlled and the uni-cast method used, it bas the same mechanical properties and microstructure.

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