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김나영 ( Na Young Kim ),이남실 ( Nam-sil Lee ),전은지 ( Eun Ji Jeon ),서정수 ( Jung Soo Seo ),우수지 ( Soo Ji Woo ),김명석 ( Myung Sug Kim ),강소영 ( So Young Kang ),정승희 ( Sung Hee Jung ) 한국수산과학회 2021 한국수산과학회지 Vol.54 No.5
Han In-jin (Artemisia iwayomogi Kitamura) and Cham Dang-gwi (Angelica gigas Nakai) exhibit antibacterial, antiparasitic, antifungal, and antiviral properties in vitro. In this study, mixture of the extracts of these two medicinal plants was absorbed on pellets. Thereafter, these pellets were fed to olive flounder Paralichthys olivaceus for 12 weeks at laboratory (1<sup>st</sup> experiment) and 24 weeks at field test (2<sup>nd</sup> experiment), and the immune activity and disease resistance properties of the extracts were examined. It was observed that lysozyme activities of plasma, spleen, and kidney improved after 12 weeks. Furthermore, when the olive flounders were artificially infected with bacterial pathogens, their cumulative mortality decreased in the group that was fed the extracts for 12 weeks compared to that in control group, and the relative percent survival also improved. This study concluded that mixture of Han In-jin and Cham Dang-gwi extracts provides disease resistance in vivo.