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N,N-Diferuloyl-putrescine (DFP)과 그 유도체의 합성 및 항산화 활성
황준필 ( Jun Pil Hwang ),하지훈 ( Ji Hoon Ha ),김명규 ( Myung Kyoo Kim ),박수남 ( Soo Nam Park ) 한국공업화학회 2015 공업화학 Vol.26 No.1
N,N’-Diferuloyl-putrescine (DFP) present in plants such as Sophora japonica has been reported to have skin depigmentative and antioxidative activities. In this study, DFP, usually presents in nature a very little amount and its derivative (DFP-D) were synthesized in a large quantity for the use as functional cosmetical materials. The antioxidative activities of synthesized DFP and DFP-D were evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, chemiluminescence assay, and cell protective effect induced by 1O2, stress. DFP and DFP-D showed DPPH radical scavenging activities (FSC50) at 61.25 ± 2.25 μM and 12.92 ± 0.72 μM, respectively. ROS (reactive oxygen species) scavenging activities (OSC50) in the Fe3+-EDTA/H2O2 system of DFP and DFP-D were 2 times (1.84 ± 0.12 μM) and 13 times (0.174 ± 0.01 μM), respectively higher than that of L-ascorbic acid. 1O2, one of ROS playing a key role in the skin photo-aging, induces cellular membrane damages. DFP-D (50 μM) showed good cell protective effects (τ50 = 80.2 min) about 2 times more than that of (+)-α-tocopherol (τ50 = 43.6 min). These results suggest that the great antioxidative activities of DFP and DFP-D could be applied to cosmetic industries as functional cosmetic materials.
전혜정,박정희,신현준,최영칠,이상천,김명규,정규병 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
We analyzed the image findings of bone scan and plain radiographs of 23 patients. The thirteen patients were traumatic rib fractures. Five patients were metastatic rib tumors. Five patients were rib caries. Differential diagnostic point were discussed by using bone scan images. Although 50 lesions were seen as increased uptake in the bone scan, only 30 lesions were found in the plain radiographs. In metastatic tumors, multiple lesions are scattered over the whole body. In fracture cases, the lesions are located one by one in orders, multiple increased uptake lesions are found in the same rib. In the caries cases, rib lesions were easily found by bone scan rather than plain radiographs. Increased uptake is also noted in the soft tissue abscess pocket adjacent to rib. Bone scan is very useful in the early detection of bone abnormality, even the etiology of bone lesion by analysis of images of bone scan.
전혜정,박정희,신현준,최영칠,이상천,김명규,정규병 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
Bone scintigraphy using technetium is a simple, safe and accurate method in the diagnosis of osteomyelitis. Bone scan can find the exact site of osteomyelitis and the needle aspiration and surgical drainage. Bone scan is the choice of diagnostic method for determining bone infection in children who are unable to communicate of in those whose signs have been modified by previous inadequate antibiotic therapy. We had the eleven patients whose symptoms are suspicious bone infection taken both technetium bone scan and plain radiographs from March 1996 to April 1997. We analyzed the images of bone scans and plain radiographs retrospectively and studied that how useful the bone scan is. Among eleven patients, the bone scan showed all positive finding of bone infection, but the plain radiographs revealed normal finding in six cases, soft tissue swelling in three cases, bone destruction in one case and periosteal reaction in one case. Conclusively, bone scan is very useful in localization of exact lesion and early detection of osteomyelitis.