Mixture of benzyl butyl and diisobutyl phthalates induces behavior alteration via BDNF/TrkB/ERK/CREB signaling pathway in zebrafish

김로사,허윤위,박준우 환경독성보건학회 2022 한국독성학회 심포지움 및 학술발표회 Vol.2022 No.10

샘터 속의 촌지

김로사 샘터사 1995 월간 샘터 Vol.26 No.7

A Case of Vesicular Mycosis Fungoides

김로사,권보람,변지연,최유원,최해영,박상휘,이민영 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5

A 44-year-old male presented with 7 months history of nonpruritic round oozing plaqueson the extremities and red papules on the trunk. The lesions were resistant to topical andoral steroid prescribed at the other local clinics. Histopathological examination showedparakeratosis with acanthosis and rete ridge elongation as well as spongiotic intraepidermalblisters and dense dermal infiltration of small to medium sized atypical lymphoid cells. Immunohistochemicalanalysis revealed the lymphocyte infiltrate to be predominantly CD4+ Tcells, with CD4/CD8 ratio to be greater than 10:1. Infiltration of large cells that were CD30+were also noted. This histopathologic findings are consistent with vesicular mycosis fungoides(MF). He was prescribed with narrow-band ultraviolet B twice per week and topicalsteroid, combined with interferon-α injection for 5 weeks, and his skin lesions significantlyfaded and were flattened. Vesicular MF is associated with poor prognosis, but our patientwas able to show benign course of disease thanks to timely diagnosis. One must considervesicular MF as a differential for recalcitrant eczematous lesions.

모유수유모(母乳授乳母)의 관리(管理)에 관한 고찰

김로사,김진환,조정훈,이진무,이창훈,장준복,이경섭,Kim, Ro-Sa,Kim, Jin-Hwan,Cho, Jung-Hoon,Lee, Jin-Moo,Lee, Chang-Hoon,Jang, Jun-Bock,Lee, Kyung-Sub 대한한방체열의학회 2010 대한한방체열의학회지 Vol.8 No.1

Purpose : Mothers and primary encounter and Korean traditional Gynecology clinician's perspective on breastfeeding, the importance and general knowledge, familiar with the breastfeeding-related issues to help resolve the maternal education and treatment. treatment options for a specific note down the need for Maternity and think that the existing studies and articles about breast diseases with reference to the view of the contemplated. Method : Maternity and breast disease with reference to research and review papers. Results : The first, from the past to encourage nursing mothers to eat a lot of nursing was given recently is changing the perception of adequate calories. and second, the posture of breastfeeding in prevention of mother's fatigue and pain and the baby's milk intake should be considered effective. The third, breast feeding is heavier than normal because of the surrounding muscle tissue in the breast to support the training may be helpful to. At last is emotional stability, and adequate nutritional intake and their milk is not enough awareness and interest in and education about breast-feeding mothers to breastfeed will help you look. Conclusion : Prenatal care program in order to facilitate breastfeeding and breast-feeding from the breast managed Postpartum Care Program consists of a map for the breast-related discomfort in advance to lead to prevention and to increase women's satisfaction seems to be.

비만환자의 생활습관 양상에 대한 고찰

김로사,하지연,최정은,이경섭 대한한방부인과학회 2002 大韓韓方婦人科學會誌 Vol.15 No.2

설명의무에 대한 의사의 인식 변화 조사 연구-의료법 개정의 영향을 중심으로-

김로사 대한의료법학회 2018 의료법학 Vol.19 No.2

The Medical law stipulates regulations about the physician’s duty to inform to contribute to patient’s self-determination. This law was most recently revised on December 20, 2016, and came into effect on June 21, 2017. There has been much controversy about this, and it has been questioned whether or not it will be effective for physicians to comply with the duty to inform. Therefore, this study investigated perceptions of physicians of whether they observed the duty to inform and their legal judgment about that duty, and analyzed how the revision of the medical law may have affected the legal cognition of physician's duty to inform. This study was conducted through an online questionnaire survey involving 109 physicians over 2 weeks from March 29 to April 12, 2018, and 108 of the collected data were used for analysis. The questionnaire was developed by revising and supplementing the previous research (Lee, 2004). It consisted of 41 items, including 26 items related to the experience of and legal judgment about the duty to inform, 6 items related to awareness of revised medical law, and 9 items on general characteristics. The data were analyzed using SAS 9.4 program and descriptive statistics, Chi-square test, Fisher’s exact test and Binary logistic regression were performed. The results are as follows. ∙Out of eight situations, the median number of situations that did not fulfill the duty to inform was 5 (IQR, 4-6). In addition, 12 respondents (11%) answered that they did not fulfill the duty to inform in all eight cases, while only one (1%) responded that he/she performed explanation obligations in all cases. ∙The median number of the legal judgment score on the duty to inform was 8 out of 13 (IQR, 7-9), and the scores ranged from a minimum of 4 (4 respondents) to a maximum of 11 (3 respondents). ∙More than half of the respondents (n=26, 52%) were unaware of the revision of the medical law, 27 (25%) were aware of the fact that the medical law had been revised, 20(18%) had a rough knowledge of the contents of the law, and only 5(5%) said they knew the contents of the law in detail. The level of awareness of the revised medical law was statistically significant difference according to respondents' sex (p<.49), age (p<.0001), career (p< .0001), working type (p<.024), and department (p<.049). ∙There was no statistically significant relationship between the level of awareness of the revised medical law and the level of legal judgment on the duty to inform. These results suggest that efforts to improve the implementation and cognition of physician’s duty to inform are needed, and it is difficult to expect a direct positive effect from the legal regulations per se. Considering the distinct characteristics of medical institutions and hierarchical organizational culture of physicians, it is necessary to develop a credible guideline on the duty to inform within the medical system, and to strengthen the education of physicians about their duty to inform and its purpose. 2016년 12월 20일 신설된 「의료법」 상 설명의무 조항과 관련하여, 시행일(2017. 6. 21)이 일 년여가 지난 지금까지도 그 실효성을 둘러싼 논란이 끊이지 않고 있다. 본 연구에서는 의사 109명을 대상으로 온라인 설문조사를 실시하여 의료현장에서 의사의 설명의무 이행/미이행 경험과 그에 대한 법적 판단을 확인하고, 「의료법」 개정이 의사의 설명의무에 관한 법적 인식에 어떠한 영향을 주었는지 분석하고자 하였다. 연구도구는 기존의 한 연구(이윤영, 2004)에서 사용한 도구를 수정·보완하여 총 41 개 문항으로 구성되었으며 설명의무에 관한 경험 및 법적 판단 관련 26개 문항, 의료법 개정에 관한 인식 관련 6개 문항, 일반적 특성 9개 문항을 포함하였다. SAS 9.4 통계프로그램을 이용하여 자료를 분석한 결과 「의료법」에 설명의무에 관한 내용이 신설되었다는 사실을 모르고 있는 응답자가 전체의 절반 이상이었으며 대부분의 응답자가 설명의무를 이행하지 못한 경험이 있는 것으로 나타났다. 설명의무의 이행 혹은 생략에 관한 13개 사례에 대해 법적 판단을 물은 결과 응답자별 평균 8개 사례에 대해 옳은 판단을 내렸으며, 옳은 판단을 내린 개수는 응답자의 「의료법」 개정 사실에 대한 인식정도와 통계적으로 유의한 관련성을 찾아볼 수 없었다. 이러한 결과에 비추어 볼 때 공법적 제재만으로는 설명의무에 대한 의사의 인식 및 이행 강화에 충분한 효과를 기대하기 어려우며, 의료체계 내부에서 의료기관의 특성과 의사의 조직문화를 고려한 공신력 있는 설명의무 가이드라인 마련과 설명의무와 그 취지에 대한 의사교육 강화를 제언하는 바이다

뇌졸중 유사증상을 나타내는 갱년기 홧병환자 치험 1 례

김로사,김승은,고창남,이경섭 대한한의학회 부인과학회 2001 大韓韓方婦人科學會誌 Vol.14 No.1

In the postmenopose, symptoms related to a mental disorder as well as a physical disorder can be showed. "Hwabyung", the Korean culturally related syndrome, is more frequent to women than men. The symptom and mechanism of "Hwabyung" are similar to those of menopausal symptoms, so that it is manifested or deepened in the postmenopose and in severe case, it can show the symptoms of Stroke. We would like to report that it is effective to cure the climacteric "Hwabyung" case showed similar symptoms of Stroke through the herb-med Tx, Auriculoacupunctur therapy, and Negative Tx.

紫河車가 老化생쥐의 生殖能力에 미치는 영향

김로사,조정훈,장준복,이경섭 대한한방부인과학회 2002 大韓韓方婦人科學會誌 Vol.15 No.2

DITI를 이용한 갱년기 환자의 체열분포 양상

김로사,최정은,김용석,이경섭,Kim, Ro-Sa,Choi, Jung-Eun,Kim, Young-Suk,Lee, Kyung-Sub 대한한방체열의학회 2002 대한한방체열의학회지 Vol.1 No.1

1. Objectives Among many symptoms that the climacteric patients complain of, the major subjective symptom is both heat in the upper part and cold in the lower part of the body(e.g foot, knee, and leg). We use DITI as a method to prove the symptoms of climacteric patients such as both heat in the upper part and cold in the lower part of the body, diagnose these symptoms, and follow up the progress of the clinical treatments. 2. Subjects and Methods We compare the subcutaneous heat of the climacteric patients with the symptom of heat in the upper part and cold in the lower part of the body with young women without any specific disease. The age distribution of the experimental group is 28 patients in 40's, and 22 in 50's. The mean age of the experimental group is $48.5{\pm}4.25$. The age distribution of the control group is 17 patients in teen, 26 in 20's, 7 in 30's. The mean age of the control group is $23.31{\pm}6.45$. We measure the subcutaneous heat on the cheeks, upper arms, palms, thighs, knees, dorsum pedis, lower back, hip, upper abdomen, lower abdomen of both groups and analyse the results. 3. Statistical methods All the results are statiscally analysed using student T-test of Microsoft Exel program. Statistically significant value by the analysis of variance procedure is P<0.05. 4. Results 1. The subcutaneous heat of the whole body of the experimental group shows hypothermia compared with control group, and the hypothermic pattern gets severe on the periphery. ${\Delta}T$ between the right and left side of the body in experimental group is larger than that of control group. 2. ${\Delta}T$ between the cheeks and the hypogastric in the experimental group is significantly larger than that of the control group, which shows cold face. 3. ${\Delta}T$ between the upper arms and the palms in the experimental group is significantly larger than that of the control group, which shows cold hand. 4. ${\Delta}T$ between the thighs and the knees in the experimental group is significantly larger than that of the control group, which shows cold knee. 5. ${\Delta}T$ between the thighs and the feet in the experimental group is significantly larger than that of the control group, which shows cold foot. 6. ${\Delta}T$ between the hip and the lower back in the experimental group is significantly larger than that of the control group. That shows the Lower back is warmer than the hip. 7. ${\Delta}T$ between the upper and the lower abdomen in the experimental group is significantly larger than that of the control group, which shows cold hypogastric.

연구관리기록물 관리 매뉴얼 연구 - 과학기술분야 정부출연연구기관을 중심으로 -

김로사,장우권 한국기록관리학회 2016 한국기록관리학회지 Vol.16 No.3

This study suggested the necessity of the management of R & D management records produced from government-supported science research institutes (the so-called “gwagichulyeon”) and of a record management manual (item). As such, it gathered rules with regard to record management, conducted a survey, and interviewed general R & D managers. As a result of the research, the ratio of the arrangement of R & D managers to R & D management departments is 100%; however, the ratio of the arrangement of record managers is 33.3%-50%, and the ratio of the arrangement of record management departments is 23.1%, which was poor. The enactment ratio of record management rules is 26.4%, and 73.7% of institutes has managed their records under the provision only of document management rules or only of office management rules. R & D management records has been collected according to an institute’s capability without a prescribed collection scope, and the conditions with regard to the omission, damage, and loss of records were poor. There are institutes that did not comprehend the production status of R & D management records. Thus, as a response, this study suggested a record management manual (item) established for the arrangement duties of record managers and record management departments as well as for notifications on the status of R & D management records. In addition, this study produced a standardized collection scope and described how to manage R & D management records. 이 연구는 과학기술분야 정부출연연구기관(이하 ‘과기출연’)에서 생산하는 연구관리기록물의 관리 필요성을 제기하고 ‘관리 매뉴얼(안)’을 제시하였다. 이를 위해 과기출연의 기록물 관련 규정을 수집하고 연구관리 총괄담당자를 대상으로 설문조사와 인터뷰를 시행하였다. 조사 결과 연구관리 담당자 및 담당부서 배치율(100.0%)에 비해 기록물관리 전문요원(33.3%~50.0%) 및 기록관리부서 배치율(23.1%)은 저조했다. 기록물관리규정 제정율은 26.4%였고, 73.7%의 기관이 문서관리규정 혹은 사무관리규정만으로 기록물을 관리했다. 연구관리기록물은 규정된 수집범위 없이 기관 역량에 따라 수집되며, 기록물 누락․훼손․망실 대비책 또한 미진했다. 연구관리기록물의 생산현황을 파악하지 않은 기관도 있었다. 이에 대응방안으로 ‘관리 매뉴얼(안)’을 제시하여 기록물관리 전문요원 배치, 기록물관리 담당부서의 설치, 생산현황 통보를 의무화하고 기록관에 준하는 시설․장비 설치를 권장하였다. 덧붙여 표준화된 수집범위를 제시하고, 연구관리기록물 관리 방법을 구체적으로 기술하였다.