Cisternography 검사 시 사용되는 방사성의약품의 안정성 확보를 위한 검사도입 및 유용성 평가

김다은,유연욱,최호용,김윤철,김영석,원우재,김석기,Kim, Da-Eun,Yoo, Yeon-Wook,Choi, Ho-Yong,Kim, Yun-Cheol,Kim, Yeong-Seok,Won, Woo-Jae,Kim, Seok-Ki 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

뇌조 조영술에 이용되는 방사성의약품들 중 최근에는 Tc-99m DTPA를 이용한 뇌 척수액 영상이 대부분이다. 하지만 Tc-99m DTPA는 사용 시 무균수막염, 근육강직, 경련 등 여러 부작용이 발생할 우려가 있다. 따라서 Tc-99m DTPA의 이러한 부작용의 발생을 사전에 예방하기 위하여 안정성검사를 시행하였으며 그 유용성을 알아보고자 한다. 방사성의약품 Vial검사는 2008년 12월 16일 - 2009년 12월 30일에 뇌조조영술을 시행한 환자(n=12)를 대상으로 시행하였으며, 시술시 사용한 vial내의 DTPA 성분 (Mallinckrodt사의 Techscan-DTPA사용), NaPertechnate radiation dose 및 volume, 생리 식염수량, 환자주사용 용량 및 activity 등을 측정하여 순수 DTPA의 양을 계산하였다. 방사성의약품의 내독소평가(Bacterial endotoxin)는 2008년 12월 16일-2009년 12월 30일에 뇌조 조영술을 시행한 환자(n=12)를 대상으로 하였고, 이 때 사용한 DTPA vial의 Pyrogen test (LAL test)를 시행하였다. 시약이 함유된 Positive/Negative control vial(표준액)에 normal saline 0.2 mL을 주입하고, 동일한 Test control vial(실험액)에 normal saline 0.1mL 와 Tc-99m DTPA 0.1 mL로 주입하였으며 Digital hot plate에서 $37.5^{\circ}C$로 1시간 반응시킨 후 응고여부를 표준액과 대조하여 관찰하였다. 안정적인 제조절차 준수는 보존제(방부제)가 없는 미 개봉한 CaNa3 DTPA kit를 사용하였으며 Tc-99m DTPA는 한 Vial당 한명의 환자선량으로 뽑아 투여한다. 이때 적정 용량을 맞추기 위해 0.9% NaCl 멸균 생리 식염수를 사용하여 희석하였다. 방사성의약품 Vial검사는 측정된 성분값들로 순수 DTPA의 양을 얻어내었으며 이는 2가지의 계산식을 이용하여 선량 대비 DTPA의 용량(평균 0.88 mg), 용량 대비 DTPA의 용량(평균 0.74 mg)을 도출해내었다. 방사성의약품의 내독소 평가에서는 동일한 조건으로 시험(n=12)을 시행한 결과 모두 Bacterial endotoxin이 기준치인 단위 선량 당 14 endotoxin units (EU)미만의 반응인 Negative(-)로 나왔다. 안정적인 제조절차 준수에서는 검사 관련 sheet를 만들어 작성 및 제조절차 준수 여부를 확인하였으며 결과 모두 준수하여 제조과정 내에서 방사성의약품에 의하여 발생할 수 있는 부작용이 없었다. Tc-99m DTPA를 이용한 Cisternography 검사 시 항상 방사성의약품의 안정성문제가 제기되어 왔다. 수막강 내 주입용 방사성의약품으로서 제조 및 사용 시 불안정한 취급으로 부작용이 발생할 우려가 있으며, 이에 따른 사용지침이 확립되어야 한다고 생각되었다. 수막강 내 주입용 방사선의약품으로써 free acid 혹은 sodium을 포함하는 DTPA는 적절하지 않으며, 반면 Calcium이 포함된 DTPA는 적절한 것으로 알려져 있다. 위와 같이 Techscan-DTPA(Mallinckrodt): CaNa3으로 간단하며 편리하게 안정성검사를 시행할 수 있었으며 각 검사결과(n=12) 안정성검사를 모두 통과하여 검사 시 동반될 수 있는 부작용은 나타나지 않았다. 앞으로 위와 같은 SOP (Standard Operating Procedures)를 적용하여 보다 쉽고, 편리하게 안정성검사를 시행할 수 있으리라 사료된다. Purpose: Several radiopharmaceuticals were used for cisternography. But recently, due to more short acquisition time, high resolution than other radiopharmaceuticals like In-111 DTPA, we were using Tc-99m DTPA in cisternography. Using of Tc-99m DTPA for intrathecal, was not officially recognised by the FDA. And there are matters of aseptic meningitis, muscular tetany, seizures by inappropriate radiopharmaceuticals handling. So, it is necessary to prevent adverse reactions while handling the radiopharmaceuticals using in cisternography. Therefore, this study aims to evaluation of usefulness and procedures for safety of radiopharmaceuticals in cisternography. Materials and Methods: Subjects were 12radioactive tracer vials using in cisternography in 2008 Dec. 16 - 2009 Dec. 30. (1) Radioactive tracer Vial test - We were measured NaPertechnetate radiation dose and volume, normal saline volume for dilution, source volume and dose activity for patient injection. And then, calculated mass of pure DTPA. (2) Bacterial endotoxin test - We performed pyrogen test using by negative/positive control vials which was added normal saline 0.2 mL and added normal saline 0.1 mL, Tc-99m DTPA 0.1 mL in test control vial. And then, reacted by digital hot plate in $37.5^{\circ}C$ for 1 hour and compared of gel-clot in each control vials. (3) Compliance safety procedure - We were checked safety issues and wrote out a safety procedure exam sheet. Results: (1) Radioactive tracer Vial test - Mass of DTPA per dose for patient injection (mg) was 0.88 (mg) on average, and Mass of DTPA per volume for patient injection (mg) was 0.74 (mg) on average. (2) Bacterial endotoxin test - All control test vials showed negative reactions. (3) Compliance safety procedure - We were checked safety issues and wrote out a safety exam sheet in all the exams. So, there were no adverse reactions. Conclusion: We could examine easier to safety tests using by Techscan - DTPA (Mallinckrodt): CaNa3. Each test results were passed the safety tests and there are no adverse reactions. The use of Tc-99m DTPA for cisternography, always has been become an issue. Since it has occur adverse reaction while examine the cisternography using by Tc-99m DTPA, it needs to set up the 'Standard Operating procedures'.

TiO₂ nanotube plate의 질산성질소 전기분해 효율 평가

김다은,이용호,최효연,한희주,박대원,Kim, Da Eun,Lee, Yongho,Han, Heeju,Choi, Hyo yeon,Pak, Daewon 한국응용과학기술학회 2018 한국응용과학기술학회지 Vol.35 No.3

본 연구에서는 전기분해 방법을 이용한 질산성질소($NO_3{^-}-N$) 분해가 $TiO_2$ nanotube plate 및 구리, 니켈, 스테인리스 스틸, 알루미늄, 주석, 티타늄을 환원전극으로 사용하였을 때 가능한지를 평가하였다. 전극의 전기화학적 특성 평가는 임피던스 측정을 하여 비교하였고, $TiO_2$ nanotube plate의 표면 분석은 주사전자현미경을 통해 SEM 및 BET 분석법을 이용한 비표면적 분석을 통해 비교하였다. 질산성질소 전해실험의 경우 90분의 실험을 진행하였으며, 실험 결과 전극 표면의 부식이 수반되지 않은 $TiO_2$ nanotube plate가 기타 금속 전극에 비해 질산성질소 환원 반응속도가 가장 뛰어난 것으로 확인되었다. In this study, $TiO_2$ nanotube plate and metal electrodes(Copper, Nickel, Stainless Steel, Aluminum, Tin, Titanium) were compared on cathodic reduction of nitrate ($NO_3{^-}-N$) during electrolysis. The electrochemical characteristics were compared based on electrochemical impedance spectroscopy (EIS). The surface morphology was obtained using scanning electron microscopy (SEM) method. Brunauer-Emmett-Teller (BET) method was implemented for the specific surface area analysis of the cathodes. To study kinetics, 90 minute batch electrolysis of nitrate solution was performed for each cathodes. In conclusion, under the condition of relatively low ($0.04 A\;cm^{-2}$) current density, $TiO_2$ nanotube plate showed no surface corrosion during the electrolysis, and the reaction rate was measured the highest in the kinetic analysis.

중환자실 간호사의 신체보호대 간호수행의 영향요인

김다은,민혜숙,Kim, Da Eun,Min, Hye Sook 한국중환자간호학회 2022 중환자간호학회지 Vol.15 No.3

Purpose : This study aimed to identify the factors influencing physical restraint-related practice among nurses working in the intensive care unit (ICU). Methods : The participants consisted of 169 ICU nurses in three general hospitals in B and U cities. Data were collected from December 2021 to January 2022 through a structured self-administered questionnaire. Demographic characteristics, physical restraint-related practice, Person-centered Critical Care Nursing (PCCN), work environment, and attitudes toward physical restraint use were measured. For data analyses, hierarchical multiple regressions were conducted using SPSS/WIN 25.0. Results : Clinical careers in the ICU, better work environments, higher PCCN levels, and more positive attitudes toward physical restraint use were associated with a better practice of physical restraints, which together explained 35.5% of the total variance of the outcome. Conclusion : Our findings suggest that to promote a safe physical restraint-related practice among ICU nurses, it is important to improve the nursing environment, prepare guidelines for applying PCCN, and provide education for endorsing positive attitudes toward the use of physical restraints.

지역 무질서가 범죄두려움에 미치는 영향 - 민간경비의 조절효과 -

김다은,박종승,Kim, Da-Eun,Park, Jong-Seung 한국경호경비학회 2017 시큐리티연구 Vol.- No.50

사회 안전과 관련해 범죄두려움의 중요성이 날로 더해가는 현실에서 민간경비의 활용이 범죄두려움에 어떠한 영향을 미치는 지에 대한 실증적 논의는 그 적실성이 높다 할 수 있다. 이에 이 연구는 범죄피해에 대한 위험인식과 그 두려움을 가중하는 대표적 요인인 지역 무질서가 범죄두려움에 영향을 미치는지 살펴보고, 지역 무질서와 범죄두려움의 관계에서 민간경비 유무의 영향력과 방향성을 검증해보았다. 이를 위해 한국 형사정책연구원에서 제공하는 전국범죄피해조사 2014년도 자료를 활용하고, STATA 13.0을 통해 위계적 회귀분석을 실시하였다. 그 결과, 민간경비 중 경비원의 경우 일반적 두려움에 주효과만을 나타냈으며, 지역 무질서와의 상호작용에서 유의미한 영향력을 갖지 못했다. 이와 달리 보안장치의 유무는 범죄두려움에 정적인 효과를 보였고, 이는 개인이 특수 잠금장치, 방범장치, 도난 경보시스템을 사용하더라도 여전히 높은 수준의 범죄두려움을 형성하고 있음을 뜻한다. 지역 무질서가 범죄두려움을 가중하는 상황에서 보안장치 유무의 조절효과는 통계적으로 유의미했다. 물리적 무질서가 높은 곳에서는 보안장치가 있는 경우, 보안장치가 없을 때에 비해 범죄두려움이 상대적으로 낮게 나타났다. 보안장치의 존재가 물리적 무질서가 높은 곳에서 범죄불안을 해소하는데 도움이 된다는 것을 의미한다. 이러한 결과를 바탕으로 효율성과 적합성 측면에서 보안장치의 설치를 유인할 수 있는 정책을 강구하고, 강화된 경비원의 역할과 책임, 재량을 논의하였다. Today, crime has become a serious threat to social safety so citizen's desire for safety has increased. So the private security has emerged as a new industry for safety and security and became a crucial component. Private security is responsible not only covers the limitations of the police work, but also fills citizen's desire of security. However, quantitative research on private security has rarely been done and the results of the private security study are not effectively utilized due to biased research trends in Korea. Therefore, the purpose of this study is to evaluate the effects of community incivility on fear of crime and the moderation effect of private security. To accomplish this purpose, this research uses 6,919 samples from the National Crime Victimization Survey(2014) and conducts hierarchical regression through STATA 13.0 program. As a results, private security guard showed the main effect on the generalized fear of crime, but had not a significant influence on the interaction effect with the community incivility. On the other hand, the moderation effect of electronic security was statistically significant in relation to the community incivility and specific fear of crime. In other words, in a place with high physical disorder, the fear of crime is relatively low in the case of the electronic machine, compared with the case where there is no electronic machine. The implications and limitations based on these results are discussed in the conclusion.

T자형 단면형상을 가진 성형품의 싱크마크 불량 감소 방안에 대한 연구

김다은,이춘규,Kim, Da-Eun,Lee, Chun-Kyu 한국금형공학회 2018 한국금형공학회지 Vol.12 No.2

In the automotive industry these days, plastic parts have been developed and replaced with plastic parts by maintaining the same function of existing press parts for a variety of reasons. Injection molding plastic parts are subject to molding defects due to various factors, among which the sink marks usually occur in the areas where bosses and ribs are installed. In this study, we analyzed the influence of various factors on the occurrence of sink marks by using the flow analysis of the forming analysis program(Moldflow analysis) using the rib model with the T-shape. Tests have shown that the greatest influence on the sink mark of cosmetic products is the thickness and pressure of the ribs, and the thickness of the basic moulding thickness of the product increases. However, it was considered that the resin temperature and the mold temperature do not greatly affect the occurrence of the sink mark.

북한이탈주민의 정신건강서비스 이용 실태

김다은,안지현,이경은,문승연,전진용,장혜인,홍진표,Kim, Da Eun,An, Ji Hyun,Lee, Kyoung Eun,Moon, Carolyn Seungyoun,Jun, Jin Yong,Chang, Hye In,Hong, Jin Pyo 대한불안의학회 2018 대한불안의학회지 Vol.14 No.1

Objective : The purpose of this study was to assess the use of mental health services by North Korean defectors. The study sought to understand the determinants of use with socio-demographical characteristics and the barriers of using mental health service. Methods : Data were collected from a sample of the 300 North Korean defectors who have settled in South Korea within the last three years, aged 18 years and older. Face-to-face interviews and a survey using the North Korean version of the Composite International Diagnostic Interview were conducted. Results : 21.0% of respondents reported the use of mental health services. Among them, 16.0% reported the use of mental health specialty, 2.0% reported the use of general medical services, and 3.0% reported the use of others. Of the respondents who had one or more psychiatric disorders, 28.8% used mental health services. The highest rate of use of mental health services was by respondents who are aged over 50 years old, had less than 10 years of education, and were unemployed. Of those who suffered from a psychiatric disorder but did not seek for consultation, 74.4% said that they could handle the problem by themselves, and 74.6% asserted that they had no psychiatric disorder. Conclusion : North Korean defectors in South Korea used mental health services more than the general South Korean population. It would be crucial to provide appropriate mental health services based on the needs of North Korean.

통합물관리 시대의 기본 원칙과 방향

김다은,Kim, Da-Eun 한국수자원학회 2021 물과 미래(한국수자원학회지) Vol.54 No.6

전류흐름에 따른 TiO₂ nanotube 광촉매의 OH radical 생성량 평가

김다은,이용호,김대원,박대원,Kim, Da-Eun,Lee, Yong-Ho,Kim, Dae-Won,Pak, Dae-Won 한국응용과학기술학회 2017 한국응용과학기술학회지 Vol.34 No.2

본 연구에서는 $TiO_2$ nanotube 광촉매의 고도산화처리능을 비교하기 위해서 OH 라디칼 생성력을 평가하고자 하였다. 자외선 조사에 따른 Probe compound인 4-Chlorobenzoic acid (pCBA)의 농도 감소에 따라 OH radical 생성량을 산정하는 방법으로 광촉매 효율을 평가하였는데, $TiO_2$ nanotube 표면에서의 전자의 흐름을 원활하게 하기 위하여 전기적 에너지를 주었을 시 광촉매 효율의 증가 가능성 또한 확인하고자 자외선 조사 시 전류밀도를 인가하는 방법으로 실험을 진행하였다. 실험에 사용된 $TiO_2$ nanotube는 전극효과를 부여하기 위해 양극산화법으로 티타늄판을 이용하여 제조하였으며, pCBA 용액에는 전도도를 부여하기 위하여 NaCl을 첨가하여 전해질로 사용하였다. 정전류 정전압 조건하에서 자외선조사 실험을 진행하였으며, 전류가 흐르는 광촉매에 자외선 조사 시 OH 라디칼 생성량은 광촉매 없이 자외선만 조사하였을 때에 비해 약 5.6배, $TiO_2$ 광촉매와 함께 자외선을 조사하였을 보다 약 2.2배 증가하였다. 결과적으로 광촉매반응에 전기적 에너지를 부여하였을 시 시너지효과를 가져올 수 있는 가능성을 확인할 수 있었다. OH radical generation is one of the common method to evaluate photocatalytic activity. In many of previous studies, only the UV(Ultraviolet) light was applied to test photocatalytic ability of $TiO_2$ nanotubes by studying probe compound(4-Chlorobenzoic acid) concentration change in solution. Also, $TiO_2$ nanotubes were found to show some electrochemical characteristics when the flow of electric current was applied. In this study, the flow of electric current and UV light were applied at the same time to determine whether electrochemical characteristics of $TiO_2$ nanotube plate can give synergetic effect on the photocatalytic activity. $TiO_2$ nanotube was grown on Ti by anodic oxidation to create $TiO_2$ nanotube plate which can be used as a photocatalyst and a electrode that can undergo AOP(Advanced Oxidation Process) for water treatment. Probe compound solution was prepared using 4-chlorobenzoic acid and $H_2O$ as a solvent. NaCl was added to give conductivity to work as electrolyte. As a result, enough level of electric current flow was found to give synergetic photocatalytic effect which can be used for efficient AOP water treatment method.

지면 모형의 소개

김다은,최민하,Kim, Da-Eun,Choe, Min-Ha 한국수자원학회 2018 물과 미래(한국수자원학회지) Vol.51 No.2

건강한 어린 소아에서 수두 백신 접종 후 발생한 대상포진 2예: 백신주에 의한 1예

김다은,강혜지,한명국,염혜영,장성희,Kim, Da-Eun,Kang, Hae Ji,Han, Myung-Guk,Yeom, Hye-young,Chang, Sung Hee 대한소아감염학회 2022 Pediatric Infection and Vaccine Vol.29 No.2

Herpes zoster (HZ) has been reported in immunocompetent children who received the varicella vaccine. In vaccinated children, HZ can be caused by vaccine-strain or by wild-type varicella-zoster virus (VZV). Like wild-type VZV, varicella vaccine virus can establish latency and reactivate as HZ. We report two cases of HZ in otherwise healthy 16- and 14-month-old boys who received varicella vaccine at 12 months of age. They presented with a vesicular rash on their upper extremities three to four months after varicella vaccination. In one case, a swab was obtained by abrading skin vesicles and VZV was detected in skin specimens by polymerase chain reaction. The VZV open-reading frame 62 was sequenced and single nucleotide polymorphism analysis confirmed that the virus from skin specimen was vaccine-strain. This is the first HZ case following varicella vaccination confirmed to be caused by vaccine-strain VZV in the immunocompetent children in Korea. Pediatricians should be aware of the potential for varicella vaccine virus reactivation in vaccinated young children.