전립선염의 신지견

김광세 啓明大學校 醫科大學 1984 계명의대학술지 Vol.3 No.1

방광요관 역류의 제반 임상문제(Clinical Aspects of Vesicoureteral Reflux)

김광세 大韓泌尿器科學會 1994 Korean Journal of Urology Vol.35 No.12

Differential inhibition of endothelial cell proliferation and migration by urokinase subdomains: amino-terminal fragment and kringle domain

김광세,Yong-KilHong,YoonLee,Joo-YoungShin,Soo-IkChang,SooIlChung,YoungAeJoe 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.6

The serine protease urokinase-type plasminogen activator (uPA) is im plicated in pericellular proteolysis in a variety of physiological and pathological processes including angiogenesis and tumor metastasis. The kringle domain of uPA (UK1) has proven to be an anti-angiogenic molecule with unknown mechanism and amino terminal fragment of uPA (u-ATF) with additional growth factor-like domain can be used for blocking interaction of uPA and uPA receptor. Here, we compared anti-angiogenic activities of these two molecules in vitro and in vivo. The recombinant u-ATF from E. coli and refolded in vitro was found to bind to uPAR with high affinity, whereas E. coli-derived UK1 showed no binding by Biacore analysis. In contrast to UK1 having potent inhibitory effect, u-ATF exhibited low inhibitory effect on bovine capillary endothelial cell growth (ED50>320 nM). Furthermore, u-ATF inhibition of VEGF-induced migration of human umbilical vein endothelial cell was far less sensitive (IC50 = 600 nM) than those observed with UK1, and angiogenesis inhibition was marginal in chorioallantoic membrane. These results suggest that kringle domain alone is sufficient for potent antiangiogenic activity and additional growth factor-like domain diverts this molecule in undergoing different mechanism such as inhibition of uPA/uPAR interaction rather than undergoing distinct antiangiogenic mechanism driven by kringle domain.

Methoxyflurane 麻醉가 腎의 微細構造에 미치는 影響

金光世,李養璿,洪錫宰 慶北大學校 醫科大學 1977 慶北醫大誌 Vol.18 No.1

白鼠를 實驗動物로 하여 halothane 및 methoxyflurane의 中等度 吸入麻醉를 2時間 施行하고, 經時的으로 腎組織에 惹起되는 變化를 光學 및 電子顯微鏡的으로 檢索하나 效果를 要約하면 다음과 같다. 光學顯微鏡的으로는, halothane 및 methoxyfluurane麻醉에 있어서 다같이 腎組織에서 特記할 만한 變化를 全혀 認定할 수 없었다. 電子顯微鏡的으로는, halothane 麻醉群에 있어서는 麻醉 直後에 皮質의 近位曲尿細管에서 sER의 輕度 增殖을, 그리고 髓質의 尿細管에서는 輕度의 sER 增殖과 mitochondria의 輕微한 變性이 觀察되었으며, 麻醉後 24時間에는 皮質의 近位曲尿細管에서 sER의 中等度 增殖, mitochondria의 輕한 變性 및 減少, 여러 가지型의 lysosome의 出現, 基底膜의 部分的 肥厚 等이 認定되었고, 髓質의 尿細管에서는 sER의 增殖, mitochondria의 輕度 腫脹 및 變性, lysosome의 增加, 基底膜의 肥厚 等의 變化가 皮質에서보다 더 좀 著明하게 認定되었다. Methoxyflurane麻醉群에 있어서는, 麻醉 直後에는 皮質의 近位曲尿細管에서 輕한 sER의 增殖을, 그리고 髓質의 尿細管에서는 mitochondria의 變性 및 lysosome의 增加를 輕度로 볼 수 있었으며, 麻醉後 24時間에는 皮質의 近位曲尿細管에서 內腔의 擴張, mitochondria의 腫脹 및 變性, lysosome의 增加, focal cytoplasmic degradation의 出現, 輕度의 基底膜 肥厚 等의 所見이 觀察되었고, 髓質의 尿細管에서는 顯著한 sER의 增殖, mitochondria의 減少, lysosome의 著明한 增加, 基底膜의 部分的 肥厚와 basal intussusception의 顯著한 減少 等의 所見이 認定되었다. 以上의 實驗成績으로 보아 methoxyflurane麻醉에 있어서는 腎의 皮質 近位曲尿細管과 髓質의 尿細管 上皮細胞에 輕度의 變性性變化와 基底膜의 部分的 肥厚 및 basal intussusception의 消失 等의 變化가 halothane麻醉時보다 더욱 顯著하게 惹起되며, 이와같은 尿細管의 病變들이 methoxyflurane麻醉時에 惹起되는 腎機能不全과 關聯이 있는 것으로 推測된다. The author studied the ultrastructural changes of rat kidney following inhalation anesthesia with methoxyflurane, utilizing halothane for control. Fifteen albino rats of both sexes, weighing between 200 and 250 gm., were used in this study. The rats were divided into three groups; three as normal control, six as control with halothane anesthesia in the moderate depth for two hours, and the rest six were anesthesized with methoxyflurane in the moderate depth for two hours. The results were summarized as follow: Light microscopic examination of the kidney reveals no significant changes in all groups. Electron microscopically, in the rats immediately after halothane anesthesia, mild proliferation of sER and slight degeneration of mitochondria were observed in the tubular epithelial cells of the cortex and the medulla. In the 24 hours after halothane anesthesia, slight degeneration and diminution of mitochondria, moderate proliferation of sER, appearance of lysosomes in varying shape and focal thickening of basement membrane were observed in the proximal tubules. These changes were more prominent in the tubules of the medulla than in the cortex. In the rats immediately after methoxyflurane anesthesia, mile proliferation of sER was observed in the proximal tubules, and mild degeneration of mitochondria and slight increase of lysosomes were observed in the tubules of the medulla. In the 24 hours after methoxyflurane anesthesia, widening of the tubual lumen, swelling and degeneration of mitochondria, increase of varying shaped lysosomes, appearance of focal cytoplasmic degradation and mild thickening of basement membrane were observed in the proximal tubules. In the tubules of medulla, marked proliferation of sER, increase of lysosomes, diminution of mitochondria, focal thickening of basement membrane and marked diminution of basal intussusecption were observed. The results obtained in this study suggest that methoxyflurane anesthesia causes focal thickening of basement membrane, diminution of basal intussusception, and mild degenerative changes in the tubules of the cortex and the medulla. These changes are considered to be related with renal insufficiency induced by methoxyflurance anesthesia in human practice.

배뇨이상과 역류

金光世 대한의학협회 1994 대한의학협회지 Vol.37 No.8

Methoxyflurance 痲醉가 腎의 微細構造에 미치는 影響

金光世,李養璿,洪錫宰 慶北大學校 醫科大學 1977 慶北醫大雜誌 Vol.18 No.1

§ Hand-Schueller-Christian disease 의 症例

金光洗 대한신경정신의학회 1964 신경정신의학 Vol.3 No.1

The author has observed 11 year old male patient with Hand-Schuller-Ghristian disease for the past 5 years. The onset was at age of 5 years. This disese is charcterized by classical triad of exophalmos, defects in membranous bone of skull and diabetes insipidus. Following Roentgen therapy, the patient appeared slightghly improved, but the above signs have been persisted with marked growth disturbance and slight behavior disorder. The etiology of this disease is unknown, though many authors had believed this was caused from lipid accumulation as state of cholesterol and its ester. The present tendency is to regard this disease as being closely related to Letterer-Siwe disease and to eosinophilic granuloma

정상 한국 남성의 연령별 야간 음경 발기 양상

이성원,김광세 啓明大學校 醫科大學 1998 계명의대학술지 Vol.7 No.1

Nocturnal penile tumescence (NPT) evaluation is the single most important step and widely used technique for the differential diagnosis between psychogenic and organic impotence. It is based on findings that male subjects have erection in association with rapid eye movement sleep. A normal pattern of NPT indicates that neural supply, vascular supply and penile structures are intact. Nocturnal penile tumescence monitoring (NPTM) in the abscence of rigidity evaluation in the assessment of the impotent male is of questionable value, but a study of NPT in 41 healthy male subjects aged 20 to 69 was done by means of portable tumistore NPT monitor to provide normotive data for clinical tility in determining diagnosis and prognosis of impotence. The results indicate that NPT occurs consistently in a healthy male population and its expression significantly affected by age; gradual reduction of nocturnal tumescence by increasing age.

신결석에서 체외충격파쇄석술 전 요관카테타 유치의 역활

김광세,박철희,강흥원,김천일,윤재식 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.3

신결석의 치료에서 결석의 크기에 따른 요판카테타의 유치는 치료의 성공률과는 상관관계가 없었다. 신결석의 크기가 25 mm 미만인 군에서는 요판카테타를 유치한군에서 배뇨증상만 유의하게 증각되었고, 요관폐쇄나 측복통 등은 유의한 차이가 없었다. 신결석의 크기가 25 mm 이상인 군에서는 요관카테타를 유치한 군에서 통계학적으로 유의하게 측복통과 요관폐쇄는 감소하였으나 배뇨증상은 유의하게 증가하였다. 이상에서 요관카테타의 유치는 신결석의 크기가 25mm 이상인 군에서 요관폐쇄, 측복통 등의 감소목적과 동통에 예민한 환자에서 사용하는 것이 바람직하며 또한 단일신이거나 결석의 위치를 용이하게 할 경우에도 고려된다. Purpose : To ascertain whether insertion of a ureteral stent improves the outcome of renal stones and benefits treated with extracorporeal shock wave lithotripsy(ESWL). Materials and Methods : We retrospectively reviewed the results of ureteral stent use with ESWL in renal calculi. From the August 1995 to June 1997, 45 patients with renal calculi underwent ESWL with or without stents. Patients with renal calculi at least one diameter between 11 and 53mm were eligible for the study. of 45 patients . 30 patients were treated without stents, while 15 patients underwent Double-J stenting before ESWL. Results : There was no significant difference in the stone-free rate in both groups(80% stented group versus 73.3% nonstented group). In renal calculi 25 mm ≤ in diameter, the incidence of ureteral obstruction and pain/renal colic were similar for the two treatment group but voiding symptom was more severe than nonstented group compared with stented group. In renal calculi 25 mm> in diameter, the patients with ureteral stents experienced a significantly lower incidence of flank pain and ureteral obstruction(25%, 37.5% stented group versus 60%, 60% nonstented group) and higher incidence of voiding symptoms(37.5% stented group versus 20% nonstented group). Conclusions: These results suggested that use of an indwelling ureteral stent might not contribute to a higher stone-free for the treatment of renal calculi. But in renal calculi>25 mm in diameter, placement of double-J stent for the purpose of alleviating pain, preventing ureteral obstruction, or in selected cases for example, solitary kidney and aid in stone localization, has a useful adjunctive role in ESWL.

다방성 신낭종 1례

김광세,김상규,박철희 啓明大學校 醫科大學 1989 계명의대학술지 Vol.8 No.1

Multilocular renal cyst having a distinctive gross feature of multiple, variable sized, noncommunicating cysts is uncommon and uncertain natured lesion. As a treatment modality of multilocular renal cyst, local excision or partial nephrectomy could be done. However, simple or radical nephrectomy might have been performed because of the documented association with malignancy such as Wilms tumor. Herein, we report a case of multilocular renal cyst in an 11-month old infant treated by radical nephrectomy with possibility of combined malignancy.