좌심실형성부전증후군 환아의 치과치료를 위한 전신마취 시 강화 후두마스크를 이용한 기도 유지

김경진,신터전,현홍근,김영재,김정욱,장기택,이상훈,김종철,서광석,Kim, Kyung Jin,Shin, Teo-Jeon,Hyun, Hong-Keun,Kim, Young-Jae,Kim, Jung-Wook,Jang, Ki-Taeg,Lee, Sang-Hoon,Kim, Chong-Chul,Seo, Kwang-Suk 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4

Despite the laryngeal mask airway (LMA) has been widely used in anesthesia, its use is rare in the field of dentistry. Placing LMA in the oral cavity may interrupt dental treatment. However, there are some circumstances in which LMA is more advantageous than tracheal intubation for managing the airway. Especially, the reinforced LMA has a flexible tube shaft, rendering it more accessible for dental treatment. We report a case of dental treatment of a 3-year-old patient with hypoplastic left heart syndrome combined with pulmonary hypertension using reinforced LMA for airway management under general anesthesia. We also discuss the considerations of utilizing the reinforced LMA for dental treatment.

심바스타틴이 인체망막색소상피세포에서 생산된 혈관내피성장인자에 미치는 효과

김경진,김경실,김나래,진희승,Kyoung Jin Kim,Kyong Sil Kim,Na Rae Kim,Hee Seung Chin 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To examine the effect of simvastatin on vascular endothelial growth factor (VEGF) expression in cultured human retinal pigment epithelial (RPE) cells under oxidative stress. Methods: RPE cell viability was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay after 24 hours of incubation with various concentrations of simvastatin or H2O2. Cultured human RPE cells were pretreated with various concentrations of simvastatin and then incubated with 100 μm H2O2. After 24 hours of incubation, an enzyme-linked immunosorbent assay (ELISA) was performed to evaluate the expression of VEGF. Results: Simvastatin showed no toxicity up to 10 μm, but cell viability gradually decreased with increased concentration of simvastatin. Human RPE cells showed increased VEGF expression when exposed only to H2O2. When RPE cells were preincubated with simvastatin and later exposed to H2O2, VEGF expression was relatively lower. Conclusions: Simvastatin downregulated the expression of VEGF in human RPE cells under oxidative stress. Simvastatin may have some clinical benefits in preventing retinal diseases associated with VEGF. J Korean Ophthalmol Soc 2012;53(6):849-855

HPLC-ICP/MS 와 ICP/MS를 이용한 FAPAS 07187 쌀의 총비소, 무기비소, 카드뮴 측정

노현명 ( Hyun Myung Noh ),김지영 ( Ji Young Kim ),김원일 ( Won Il Kim ),( Anitha Kunhikrishnan ),김민지 ( Min Ji Kim12 ),김경진 ( Gyeong Jin Kim ),박기문 ( Ki Moon Park ),류지혁 ( Ji Hyock Yoo ),김두호 ( Doo Ho Kim ),이영자 ( Y 한국환경농학회 2013 한국환경농학회 학술대회집 Vol.2013 No.-

Metal (loid)s such as environmental contaminants affect food safety. Metal (loid)s exist trace extremely in agriculture products. Therefore it is important to analyze accurately about trace these metals. High resolution techniques and quality controls are needed to analyze these materials. In order to achieve quality results, standardized methods and techniques are required. So ISO(International Organization for Standardization) of laboratory proficiency testing is determination of laboratory testing performance by means of inter-laboratory comparison. The values have been derived as a consensus of a number of laboratories using a variety of methods. Proficiency tests were applied to analyze the metal(loid)s [inorganic arsenic (As), total As and cadmium (Cd)] in powdered rice FAPAS 07187 (Food Analysis Performance Assessment Scheme; February-April 2013). The rice powder sample was extracted with 1% HNO3 for inorganic As for microwave-assisted extraction using water at 95℃ for 90 min and their analysis by HPLC/ICPMS. Also, HNO3 for total As and Cd using microwave-assisted extraction using at 200℃ for 50 mins and analysis by ICP/MS. Validation check was performed for accuracy using CRM (NMIJ CRM 7503-a) for inorganic As, and CRM (IRMM-Rice CRM) for total arsenic and cadmium. The result were satisfactory. FAPAS 07187 the z-scores of inorganic As, total As and Cd in powdered rice were-1.8,-0.9 and 0.2(lzl<2, respectively).

Construction and characterization of the bacteriophage P4 derivatives whose genome size suitable for packaging into a P2_sir3-sized head

김경진,Kim, Kyoung-Jin The Microbiological Society of Korea 2015 미생물학회지 Vol.51 No.1

"P2 sir-관련 도움파지 비효율성"이라는 용어는 P2 sir 변이체가 그들의 위성 박테리오파지인 P4에 대해 도움파지 역할을 충분히 못하는 것을 가리키는 용어이다. 이 연구의 목적은 이러한 P2 sir-관련 도움파지 비효율성을 극복하는 요인들을 조사하는 것이다. 우선 P2의 cos 영역을 함유하는 P4 sid71 cosP2가 P2 sir3의 도움파지 비효율성을 극복하는지를 조사하였다. 그 결과 P4 sid71 cosP2는 P2 sir3의 도움파지 비효율성을 극복하지 못하였다. P2의 cos 영역 대신에 $P2_{sir}$-sized head에 packaging되는 DNA 크기가 도움파지 비효율성을 극복하는 중요한 요인으로 나타났다. 이 연구에서는, DNA 조작을 통해 packaging 되는 DNA 크기가 P4 ost1과 P4 ost2 사이가 되는 세 종류의 P4 유도체를 조성하였다. 그 중 하나인 P4 sid71 delRI::apr의 CsCl 균등밀도차실험을 거쳐 packaging되는 DNA의 크기를 확인하였다. P4 유도체들의 후손방출량 실험에 따르면 그들은 모두 P2sir3-관련 도움파지 비효율성을 극복하였다. $P2_{sir3}$-sized head에 잘 packaging되는 P4 유도체의 크기는 28-29 kb로 나타났다. The term "P2 sir-associated helper inefficiency" has been used to define the inefficient helper capability of P2 sir mutants for their satellite bacteriophage P4. The aim of this study was to investigate the factors overcoming P2 sir-associated helper inefficiency. At first, we verified whether the P2 cos region containing P4 sid71 cosP2 could overcome P2 sir-associated helper inefficiency with P2 sir3. The result was that P4 sid71 cosP2 could not overcome P2 sir-associated helper inefficiency with P2 sir3. Instead of cos region of P2, the size of the DNA packaged into a $P2_{sir}$-sized head seems to be important for overcoming P2 sir-associated helper inefficiency. In the present work, three kinds of P4 derivatives with packaged DNA sizes between those of P4 ost1 and P4 ost2, were constructed through DNA manipulation. In one P4 derivative, P4 sid71 delRI::apr, the size of the packaged DNA was identified with a CsCl buoyant equilibrium density gradient experiment. According to the burst sizes of the P4 derivatives, they could overcome P2 sir3-associated helper inefficiency. The size of the P4 derivative DNA suitable for packaging into a $P2_{sir3}$-sized head was 28-29 kb.

로지스틱회귀모형의 평가를 위한 그래픽적 방법

김경진,강명욱,Kim, Kyung Jin,Kahng, Myung Wook 한국통계학회 2015 응용통계연구 Vol.28 No.6

대부분의 통계분석방법은 요약통계량에 의존하지만 그래픽적 방법을 이용하면 자료의 특성을 파악하기 쉽고 통계량만으로는 알아낼 수 없는 부분까지도 접근이 가능하다. 그래프를 통한 로지스틱회귀모형의 평가 방법으로 로그-밀도비를 통한 검토, 차원 검토, 주변모형산점도, 카이잔차산점도, CERES 그림을 알아보고 모의자료들을 통해 다양한 상황에서 그래픽적 방법들 어떠한 결과를 나타내지를 비교 검토한다. Most statistical methods are dependent on the summary statistic. However, with graphical approaches, it is easier to identify the characteristics of the data and detect information that cannot be obtained by the summary statistic. We present various graphical methods to assess the adequacy of models in logistic regression that include checking log-density ratio, structural dimension, marginal model plot, chi-residual plot, and CERES plot. Through simulation data, we investigate and compare the results of graphical approaches under diverse conditions.

수소버스 측면충돌 시험방법 연구

김경진,신재호,한경희,인정민,심소정,김시우,Kim, Kyungjin,Shin, Jaeho,Han, Kyeonghee,In, Jeong Min,Shim, Sojung,Kim, Siwoo 한국자동차안전학회 2021 자동차안전학회지 Vol.13 No.4

Recently hydrogen fuel cell buses have been deployed for the public transportations. In order to introduce buses fueled by hydrogen successfully, the research results of hydrogen bus safety should be discussed and investigated significantly. Especially, Korean government drives research in terms of various applications of hydrogen energy to replace the conventional fuel energy resources and to improve the safety evaluation. Thus it is necessary to examine vehicle crashworthiness under side impact loadings. This study was focused on the simulation result evaluation of full bus model and simplified bus model with hydrogen fuel tank module and mounting system located below floor structure due to the significance of bus side impact accidents. The finite element models of hydrogen bus, fuel tank system and side impact moving barrier were set up and simulation results reported model performance and result comparison of two side impact models. Computational results and research discussion showed the conceptual side impact framework to evaluate hydrogen bus crashworthiness.

당뇨흰쥐의 콜라겐 감소 및 인간 피부 섬유아세포의 MMP-1 증가에 대한 목단피(牧丹皮)의 항피부노화 효과

김경진,김경준,Kim, Kyung-Jin,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.1

Objective : Skin aging is commonly observed in patients with diabetes mellitus, which can be accessed by the amount of skin collagen and matrix metalloproteinase-1 (MMP-1). In the present study, anti-skin-aging effects of Root Cortex of Paeonia Suffruticosa Andrews (PSA), which has been widely used to treat diabetes mellitus, are investigated. Methods : Streptozotocin (STZ) was intraperitoneally injected to rats to induce diabetes. Body weights, feed intake, organ weights, blood glucose, and other biochemical index are determined in both normal and diabetic rats. In order to study the effect of PSA on skin aging, the amount of skin collagen was measured in diabetic rats after PSA treatments. Also, MMP-1 synthesis in UVB-irradiated human skin fibroblasts was investigated. Results : 1. When PSA was administered to STZ-induced diabetic rats, feed intake was significantly increased and blood glucose and total cholesterol were decreased in a dose-dependent manner. However, there are no differences in individual organ weights, GOT, and GPT. 2. A decrease of skin collagen in diabetic rats was significantly suppressed when PSA was treated. 3. PSA also inhibited MMP-1 synthesis in UVB-irradiated normal human skin fibroblasts, similar to retinoid, a well-known effective anti-skin-aging substance. Conclusion: PSA suppressed a collagen decrease in diabetic rats and inhibited MMP-1 synthesis in UVB-irradiated human skin fibroblasts. Therefore, the treatment of PSA is very effective to slow down the skin aging process.

경사 정체점 유동이 적용된 미세 홀 레이저 가공 공정의 흄 오염입자 산포특성 연구

김경진,박중윤,Kim, Kyoungjin,Park, Joong-Youn 한국반도체디스플레이기술학회 2021 반도체디스플레이기술학회지 Vol.20 No.3

This numerical study focuses on the analysis of fume particle dispersion characteristics over the surface of target workpiece in laser micro-hole machining process. The effects of oblique stagnation flow over fume generating machining point are examined by carrying out a series of three-dimensional random particle simulations along with probabilistic particle generation model and particle drag correlation of low Reynolds number. Present computational model of fume particle dispersion is found to be capable of assessing and quantifying the fume particle contamination in precision hole machining which may influenced by different types of air flow patterns and their flow intensity. The particle size dependence on dispersion distance of fume particles from laser machining point is significant and the effects of increasing flow oblique angle are shown quite differently when slot blowing or slot suction flows are applied in micro-hole machining.

신경섬유종증에서 드물게 나타나는 안과 소견: 증례보고 및 고찰

김경진,박상준,이강훈,강성모,Kyoung Jin Kim,Sang Jun Park,Kang Hun Lee,Sung Mo Kang 대한안과학회 2012 대한안과학회지 Vol.53 No.8

Purpose: To report and review several cases of uncommon ocular manifestations in neurofibromatosis patients. Case summary: A 19-year-old woman diagnosed with type 2 neurofibromatosis visited our hospital with amblyopia of the right eye and mild visual disturbance of the left eye. Best corrected visual acuity was 20/250 in the right eye, 20/25 in the left eye and relative afferent pupillary defect in the right eye was observed. Fundus examination of both eyes showed papilledema. Magnetic resonance imaging showed schwannoma from the optic nerve to the optic chiasm. A 28-year-old woman diagnosed with type 2 neurofibromatosis visited our hospital with amblyopia of the right eye. Best corrected visual acuity was finger count in the right eye, 20/20 in the left eye and relative afferent pupillary defect in the right eye was observed. Fundus examination of the right eye showed a slightly elevated lesion at the macula, as well as dragged optic disc and retinal vessels to the macula. An 8-year-old girl diagnosed with type 1 neurofibromatosis visited our hospital with enophthalmos and strabismus of the left eye. On exophthalmometry, enophthalmos in the left eye was found; measurements were 15.0 mm in the right eye and 13.0 mm in the left eye. Three-dimensional computed tomography revealed sphenoidal hypoplasia and a left lateral orbital wall defect. Conclusions: The authors of the present study report on neurofibromatosis patients who had an uncommon ocular manifestation. Neurofibromatosis can represent various ocular manifestations but reports of compressive optic neuropathy, dragged disc syndrome and sphenoidal hypoplasia are rare. J Korean Ophthalmol Soc 2012;53(8):1200-1207

특별직교이방성 적층복합판의 형상비 변화에 따른 진동특성

김경진(Kyeong Jin Kim),박제선(Je Seon Park),민창동(Chang Min Min) 한국강구조학회 1995 韓國鋼構造學會誌 Vol.7 No.4

Recently, the application of high strength advanced composites in the aeronautics, aerospace and automobile industries has been extremely developed because of the advantages of such materials over the traditional materials. Today, advanced composites has been used in limited scale in civil engineering structures. One of the reasons for this has been mainly their complex nature of properties, manufacturing techniques and analysis methods on the part of civil engineers. Therefore, Vibration analysis is carried-out by classical theory and new vibration theory with increasing aspect ratios(b/a) in this paper. The comparisons of the classical energy method and Kim`s theory in beams and special orthotropic laminated composite plates is made. Suggestions are made with respect to plate analysis for structures composed of advanced composite materials.